Pathway ID Pathway Name Source Organism Number of Genes Number of Interactions
pathway0002669 Small cell lung cancer KEGG Homo sapiens 83 807
Secreted
Membrane
Cytoplasm
Cytoplasm/4
Cytoskeleton
Cytoskeleton/Cytoplasm
Membrane/Nucleus
Cytoplasm/Nucleus
Cytoskeleton/Nucleus
Nucleus
Secreted/Nucleus
Unknown
Annotated genes
Unannotated genes
Symbol
Ensembl ID
Entrez ID
Subcellular localization
Description
Type
Edge
Symbol Ensembl ID Entrez ID Subcellular localization Closeness Degree Betweenness Transitivity
BIRC2 ENSG00000110330 329 Cytoplasm 0.00625 43.0 9.06 0.128460687
BIRC3 ENSG00000023445 330 Cytoplasm 0.006329114 45.0 9.43 0.132323232
CDK4 ENSG00000135446 1019 Cytoplasm 0.006097561 45.0 9.09 0.053535354
CDKN2B ENSG00000147883 1030 Cytoplasm 0.005649718 30.0 8.66 0.064367816
CHUK ENSG00000213341 1147 Cytoplasm 0.006578947 120.0 23.6 0.023809524
CKS1B ENSG00000173207 1163 Cytoplasm 0.005747126 18.0 1.72 0.300653595
CYCS ENSG00000172115 54205 Cytoplasm 0.005952381 29.0 17.2 0.027093596
LAMC2 ENSG00000058085 3918 Cytoplasm 0.006666667 53.0 17.4 0.122641509
NOS2 ENSG00000007171 4843 Cytoplasm 0.005494505 8.0 0.266 0.285714286
TRAF1 ENSG00000056558 7185 Cytoplasm 0.005780347 31.0 5.38 0.148387097
TRAF2 ENSG00000127191 7186 Cytoplasm 0.006944444 49.0 27.2 0.086734694
TRAF3 ENSG00000131323 7187 Cytoplasm 0.005847953 25.0 1.77 0.196666667
TRAF6 ENSG00000175104 7189 Cytoplasm 0.006896552 61.0 30.6 0.104371585
AKT2 ENSG00000105221 208 Cytoplasm/Nucleus 0.007092199 358.0 50.7 0.001940441
BCL2 ENSG00000171791 596 Cytoplasm/Nucleus 0.006993007 33.0 42.1 0.149621212
BCL2L1 ENSG00000171552 598 Cytoplasm/Nucleus 0.00617284 30.0 6.19 0.135632184
CASP9 ENSG00000132906 842 Cytoplasm/Nucleus 0.005882353 76.0 24.3 0.010175439
CCND1 ENSG00000110092 595 Cytoplasm/Nucleus 0.006329114 53.0 18.7 0.056603774
CDK2 ENSG00000123374 1017 Cytoplasm/Nucleus 0.006756757 64.0 47.1 0.079861111
CDK6 ENSG00000105810 1021 Cytoplasm/Nucleus 0.00617284 40.0 9.16 0.083333333
E2F1 ENSG00000101412 1869 Cytoplasm/Nucleus 0.008064516 88.0 215.0 0.062434692
FHIT ENSG00000189283 2272 Cytoplasm/Nucleus 0.005025126 4.0 0.165 0.5
IKBKB ENSG00000104365 3551 Cytoplasm/Nucleus 0.00621118 112.0 6.98 0.016731017
IKBKG ENSG00000269335 8517 Cytoplasm/Nucleus 0.006451613 106.0 22.4 0.025157233
MYC ENSG00000136997 4609 Cytoplasm/Nucleus 0.0078125 73.0 227.0 0.085235921
NFKB1 ENSG00000109320 4790 Cytoplasm/Nucleus 0.007575758 147.0 88.8 0.019849036
NFKBIA ENSG00000100906 4792 Cytoplasm/Nucleus 0.006097561 179.0 7.22 0.005335509
PIAS1 ENSG00000033800 8554 Cytoplasm/Nucleus 0.006535948 18.0 5.73 0.248366013
PIAS3 ENSG00000131788 10401 Cytoplasm/Nucleus 0.005649718 11.0 0.483 0.363636364
PTEN ENSG00000171862 5728 Cytoplasm/Nucleus 0.006493506 74.0 13.2 0.026656794
PTGS2 ENSG00000073756 5743 Cytoplasm/Nucleus 0.00591716 14.0 0.188 0.318681319
RARB ENSG00000077092 5915 Cytoplasm/Nucleus 0.005952381 14.0 7.7 0.164835165
RELA ENSG00000173039 5970 Cytoplasm/Nucleus 0.007751938 156.0 169.0 0.022911497
TP53 ENSG00000141510 7157 Cytoplasm/Nucleus 0.008064516 66.0 132.0 0.116550117
TRAF4 ENSG00000076604 9618 Cytoplasm/Nucleus 0.005882353 14.0 0.328 0.318681319
TRAF5 ENSG00000082512 7188 Cytoplasm/Nucleus 0.005714286 11.0 0.185 0.527272727
XIAP ENSG00000101966 331 Cytoplasm/Nucleus 0.006410256 38.0 13.5 0.174964438
PIK3CD ENSG00000171608 5293 Cytoskeleton 0.006493506 148.0 3.03 0.005975363
AKT1 ENSG00000142208 207 Membrane 0.008403361 438.0 525.0 0.002967514
AKT3 ENSG00000117020 10000 Membrane 0.006944444 351.0 43.3 0.001497761
ITGA2 ENSG00000164171 3673 Membrane 0.006024096 97.0 32.9 0.046606529
ITGA2B ENSG00000005961 3674 Membrane 0.006493506 80.0 15.4 0.070253165
ITGA3 ENSG00000005884 3675 Membrane 0.007092199 100.0 61.9 0.046464646
ITGA6 ENSG00000091409 3655 Membrane 0.007142857 135.0 176.0 0.027971255
ITGAV ENSG00000138448 3685 Membrane 0.005988024 106.0 11.5 0.04097035
ITGB1 ENSG00000150093 3688 Membrane 0.007194245 140.0 164.0 0.024357657
PIK3CA ENSG00000121879 5290 Membrane 0.007042254 166.0 27.8 0.009638554
PIK3CG ENSG00000105851 5294 Membrane 0.006329114 147.0 2.13 0.006429969
PIK3R1 ENSG00000145675 5295 Membrane 0.007142857 171.0 41.4 0.009425525
PIK3R2 ENSG00000105647 5296 Membrane 0.006622517 157.0 17.8 0.006614405
PIK3R5 ENSG00000141506 23533 Membrane 0.006329114 120.0 4.26 0.003501401
APAF1 ENSG00000120868 317 Unknown 0.006024096 30.0 1.94 0.064367816
FN1 ENSG00000115414 2335 Unknown 0.006944444 60.0 18.5 0.127683616
LAMB4 ENSG00000091128 22798 Unknown 0.005376344 39.0 0.0 0.089068826
MAX ENSG00000125952 4149 Unknown 0.006756757 32.0 43.2 0.120967742
PIAS2 ENSG00000078043 9063 Unknown 0.006134969 20.0 17.3 0.231578947
PIK3CB ENSG00000051382 5291 Unknown 0.006289308 147.0 2.0 0.005870841
PIK3R3 ENSG00000117461 8503 Unknown 0.006666667 146.0 9.47 0.006896552
PTK2 ENSG00000169398 5747 Unknown 0.0078125 134.0 306.0 0.036022893
CCNE1 ENSG00000105173 898 Nucleus 0.005291005 31.0 0.416 0.062365591
CCNE2 ENSG00000175305 9134 Nucleus 0.005714286 20.0 1.18 0.136842105
E2F2 ENSG00000007968 1870 Nucleus 0.006666667 56.0 35.3 0.095454545
E2F3 ENSG00000112242 1871 Nucleus 0.007462687 63.0 74.9 0.087557604
PIAS4 ENSG00000105229 51588 Nucleus 0.005617978 12.0 0.92 0.303030303
RB1 ENSG00000139687 5925 Nucleus 0.007246377 160.0 101.0 0.0125
RXRA ENSG00000186350 6256 Nucleus 0.00617284 8.0 1.62 0.392857143
RXRB ENSG00000204231 6257 Nucleus 0.006410256 13.0 10.5 0.269230769
RXRG ENSG00000143171 6258 Nucleus 0.005988024 6.0 1.22 0.333333333
SKP2 ENSG00000145604 6502 Nucleus 0.006024096 26.0 4.48 0.110769231
COL4A1 ENSG00000187498 1282 Secreted 0.005780347 48.0 0.181 0.192375887
COL4A2 ENSG00000134871 1284 Secreted 0.005780347 48.0 0.181 0.192375887
COL4A4 ENSG00000081052 1286 Secreted 0.005882353 48.0 4.24 0.194148936
COL4A6 ENSG00000197565 1288 Secreted 0.005780347 47.0 0.181 0.200740056
LAMA2 ENSG00000196569 3908 Secreted 0.005494505 46.0 0.0181 0.114009662
LAMA3 ENSG00000053747 3909 Secreted 0.006802721 49.0 29.8 0.119047619
LAMA4 ENSG00000112769 3910 Secreted 0.006993007 50.0 37.6 0.110204082
LAMA5 ENSG00000130702 3911 Secreted 0.005524862 48.0 0.0408 0.117021277
LAMB1 ENSG00000091136 3912 Secreted 0.006711409 59.0 22.3 0.112799532
LAMB2 ENSG00000172037 3913 Secreted 0.005780347 52.0 2.04 0.131221719
LAMB3 ENSG00000196878 3914 Secreted 0.005524862 45.0 0.00866 0.105050505
LAMC1 ENSG00000135862 3915 Secreted 0.005649718 51.0 0.116 0.125490196
LAMC3 ENSG00000050555 10319 Secreted 0.005555556 46.0 0.0342 0.127536232
LAMA1 ENSG00000101680 284217 Secreted/Nucleus 0.006756757 56.0 35.9 0.098701299
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
BIRC2 ENSG00000110330 329 Cytoplasm 1231.0 17300.0 1.56E-6 0.00548
BIRC3 ENSG00000023445 330 Cytoplasm 1481.0 25300.0 1.56E-6 0.00403
CDK4 ENSG00000135446 1019 Cytoplasm 2094.0 33700.0 1.56E-6 0.00259
CDKN2B ENSG00000147883 1030 Cytoplasm 315.0 143.0 1.55E-6 0.00736
CHUK ENSG00000213341 1147 Cytoplasm 9301.0 163000.0 1.56E-6 1.35E-4
CKS1B ENSG00000173207 1163 Cytoplasm 164.0 26.2 1.55E-6 0.149
CYCS ENSG00000172115 54205 Cytoplasm 717.0 113000.0 1.55E-6 0.00153
LAMC2 ENSG00000058085 3918 Cytoplasm 890.0 26000.0 1.56E-6 0.0126
NOS2 ENSG00000007171 4843 Cytoplasm 420.0 34300.0 1.56E-6 0.00985
TRAF1 ENSG00000056558 7185 Cytoplasm 464.0 2780.0 1.55E-6 0.00599
TRAF2 ENSG00000127191 7186 Cytoplasm 2474.0 66200.0 1.56E-6 0.00188
TRAF3 ENSG00000131323 7187 Cytoplasm 737.0 30800.0 1.55E-6 0.00308
TRAF6 ENSG00000175104 7189 Cytoplasm 4812.0 283000.0 1.56E-6 6.24E-4
AKT2 ENSG00000105221 208 Cytoplasm/Nucleus 23612.0 163000.0 1.56E-6 4.86E-5
BCL2 ENSG00000171791 596 Cytoplasm/Nucleus 1236.0 33900.0 1.56E-6 0.00248
BCL2L1 ENSG00000171552 598 Cytoplasm/Nucleus 1045.0 12300.0 1.56E-6 0.0021
CASP9 ENSG00000132906 842 Cytoplasm/Nucleus 2323.0 28000.0 1.55E-6 2.13E-4
CCND1 ENSG00000110092 595 Cytoplasm/Nucleus 2739.0 100000.0 1.56E-6 0.00164
CDK2 ENSG00000123374 1017 Cytoplasm/Nucleus 4222.0 396000.0 1.56E-6 0.00141
CDK6 ENSG00000105810 1021 Cytoplasm/Nucleus 1202.0 2340.0 1.55E-6 0.00147
E2F1 ENSG00000101412 1869 Cytoplasm/Nucleus 2673.0 379000.0 1.56E-6 0.00371
FHIT ENSG00000189283 2272 Cytoplasm/Nucleus 31.0 428.0 1.54E-6 0.501
IKBKB ENSG00000104365 3551 Cytoplasm/Nucleus 10428.0 206000.0 1.56E-6 1.03E-4
IKBKG ENSG00000269335 8517 Cytoplasm/Nucleus 7020.0 201000.0 1.56E-6 2.07E-4
MYC ENSG00000136997 4609 Cytoplasm/Nucleus 4967.0 1640000.0 1.57E-6 0.00195
NFKB1 ENSG00000109320 4790 Cytoplasm/Nucleus 11386.0 280000.0 1.56E-6 2.06E-4
NFKBIA ENSG00000100906 4792 Cytoplasm/Nucleus 12604.0 63600.0 1.56E-6 3.76E-5
PIAS1 ENSG00000033800 8554 Cytoplasm/Nucleus 440.0 6670.0 1.56E-6 0.0131
PIAS3 ENSG00000131788 10401 Cytoplasm/Nucleus 462.0 7230.0 1.56E-6 0.00912
PTEN ENSG00000171862 5728 Cytoplasm/Nucleus 3065.0 151000.0 1.56E-6 0.00178
PTGS2 ENSG00000073756 5743 Cytoplasm/Nucleus 1253.0 121000.0 1.56E-6 0.00105
RARB ENSG00000077092 5915 Cytoplasm/Nucleus 255.0 2610.0 1.56E-6 0.175
RELA ENSG00000173039 5970 Cytoplasm/Nucleus 11059.0 663000.0 1.57E-6 3.08E-4
TP53 ENSG00000141510 7157 Cytoplasm/Nucleus 8418.0 2450000.0 1.57E-6 7.36E-4
TRAF4 ENSG00000076604 9618 Cytoplasm/Nucleus 78.0 2840.0 1.55E-6 0.0679
TRAF5 ENSG00000082512 7188 Cytoplasm/Nucleus 73.0 775.0 1.55E-6 0.0464
XIAP ENSG00000101966 331 Cytoplasm/Nucleus 735.0 8940.0 1.55E-6 0.00467
PIK3CD ENSG00000171608 5293 Cytoskeleton 14967.0 29900.0 1.56E-6 1.22E-4
AKT1 ENSG00000142208 207 Membrane 52751.0 2150000.0 1.57E-6 1.74E-5
AKT3 ENSG00000117020 10000 Membrane 22158.0 86500.0 1.56E-6 5.25E-5
ITGA2 ENSG00000164171 3673 Membrane 1691.0 19700.0 1.55E-6 0.00499
ITGA2B ENSG00000005961 3674 Membrane 1567.0 17800.0 1.55E-6 0.00623
ITGA3 ENSG00000005884 3675 Membrane 1618.0 12700.0 1.55E-6 0.00544
ITGA6 ENSG00000091409 3655 Membrane 2275.0 38500.0 1.56E-6 0.00291
ITGAV ENSG00000138448 3685 Membrane 2732.0 55800.0 1.55E-6 0.00218
ITGB1 ENSG00000150093 3688 Membrane 3891.0 368000.0 1.56E-6 0.00113
PIK3CA ENSG00000121879 5290 Membrane 27859.0 414000.0 1.56E-6 5.51E-5
PIK3CG ENSG00000105851 5294 Membrane 13674.0 58900.0 1.56E-6 1.37E-4
PIK3R1 ENSG00000145675 5295 Membrane 31452.0 734000.0 1.56E-6 4.03E-5
PIK3R2 ENSG00000105647 5296 Membrane 17436.0 144000.0 1.56E-6 9.14E-5
PIK3R5 ENSG00000141506 23533 Membrane 7488.0 14200.0 1.56E-6 3.32E-4
APAF1 ENSG00000120868 317 Unknown 620.0 1880.0 1.55E-6 0.00124
FN1 ENSG00000115414 2335 Unknown 2115.0 124000.0 1.56E-6 0.00399
LAMB4 ENSG00000091128 22798 Unknown 422.0 411.0 1.55E-6 0.0337
MAX ENSG00000125952 4149 Unknown 704.0 74800.0 1.56E-6 0.0166
PIAS2 ENSG00000078043 9063 Unknown 247.0 4530.0 1.55E-6 0.0205
PIK3CB ENSG00000051382 5291 Unknown 17496.0 62500.0 1.56E-6 1.07E-4
PIK3R3 ENSG00000117461 8503 Unknown 10628.0 40100.0 1.56E-6 1.94E-4
PTK2 ENSG00000169398 5747 Unknown 9391.0 242000.0 1.56E-6 3.21E-4
CCNE1 ENSG00000105173 898 Nucleus 1165.0 18600.0 1.56E-6 0.00595
CCNE2 ENSG00000175305 9134 Nucleus 468.0 1660.0 1.55E-6 0.0238
E2F2 ENSG00000007968 1870 Nucleus 895.0 5110.0 1.56E-6 0.00857
E2F3 ENSG00000112242 1871 Nucleus 1112.0 29600.0 1.56E-6 0.00863
PIAS4 ENSG00000105229 51588 Nucleus 524.0 2890.0 1.55E-6 0.0202
RB1 ENSG00000139687 5925 Nucleus 4373.0 218000.0 1.56E-6 0.00126
RXRA ENSG00000186350 6256 Nucleus 1193.0 410000.0 1.56E-6 0.0127
RXRB ENSG00000204231 6257 Nucleus 309.0 36700.0 1.56E-6 0.0177
RXRG ENSG00000143171 6258 Nucleus 253.0 21400.0 1.55E-6 0.0186
SKP2 ENSG00000145604 6502 Nucleus 587.0 5370.0 1.56E-6 0.0275
COL4A1 ENSG00000187498 1282 Secreted 1037.0 6700.0 1.55E-6 0.012
COL4A2 ENSG00000134871 1284 Secreted 1030.0 13200.0 1.55E-6 0.0121
COL4A4 ENSG00000081052 1286 Secreted 963.0 5510.0 1.55E-6 0.0138
COL4A6 ENSG00000197565 1288 Secreted 901.0 31600.0 1.55E-6 0.0158
LAMA2 ENSG00000196569 3908 Secreted 735.0 3160.0 1.55E-6 0.0133
LAMA3 ENSG00000053747 3909 Secreted 895.0 17000.0 1.55E-6 0.0101
LAMA4 ENSG00000112769 3910 Secreted 729.0 19500.0 1.55E-6 0.0141
LAMA5 ENSG00000130702 3911 Secreted 786.0 1600.0 1.55E-6 0.0124
LAMB1 ENSG00000091136 3912 Secreted 949.0 9000.0 1.55E-6 0.00957
LAMB2 ENSG00000172037 3913 Secreted 797.0 1630.0 1.55E-6 0.0125
LAMB3 ENSG00000196878 3914 Secreted 943.0 7460.0 1.55E-6 0.0129
LAMC1 ENSG00000135862 3915 Secreted 876.0 17300.0 1.55E-6 0.0105
LAMC3 ENSG00000050555 10319 Secreted 541.0 1810.0 1.55E-6 0.0248
LAMA1 ENSG00000101680 284217 Secreted/Nucleus 919.0 10200.0 1.55E-6 0.0103
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
BIRC2 ENSG00000110330 329 Cytoplasm 290.0 4960.0 4.19E-6 0.0178
BIRC3 ENSG00000023445 330 Cytoplasm 300.0 663.0 4.19E-6 0.017
CDK4 ENSG00000135446 1019 Cytoplasm 711.0 7090.0 4.2E-6 0.00407
CDKN2B ENSG00000147883 1030 Cytoplasm 139.0 85.1 4.17E-6 0.0243
CHUK ENSG00000213341 1147 Cytoplasm 2599.0 36200.0 4.21E-6 6.51E-4
CKS1B ENSG00000173207 1163 Cytoplasm 55.0 28.2 4.17E-6 0.109
CYCS ENSG00000172115 54205 Cytoplasm 429.0 47500.0 4.19E-6 0.00293
LAMC2 ENSG00000058085 3918 Cytoplasm 397.0 5730.0 4.19E-6 0.0257
NOS2 ENSG00000007171 4843 Cytoplasm 254.0 96800.0 4.2E-6 0.0148
TRAF1 ENSG00000056558 7185 Cytoplasm 77.0 70.9 4.17E-6 0.056
TRAF2 ENSG00000127191 7186 Cytoplasm 628.0 33100.0 4.21E-6 0.0076
TRAF3 ENSG00000131323 7187 Cytoplasm 244.0 5340.0 4.18E-6 0.0138
TRAF6 ENSG00000175104 7189 Cytoplasm 1291.0 89700.0 4.22E-6 0.00367
AKT2 ENSG00000105221 208 Cytoplasm/Nucleus 12922.0 78100.0 4.22E-6 9.13E-5
BCL2 ENSG00000171791 596 Cytoplasm/Nucleus 458.0 29500.0 4.21E-6 0.00984
BCL2L1 ENSG00000171552 598 Cytoplasm/Nucleus 333.0 1700.0 4.2E-6 0.0103
CASP9 ENSG00000132906 842 Cytoplasm/Nucleus 975.0 20300.0 4.2E-6 8.09E-4
CCND1 ENSG00000110092 595 Cytoplasm/Nucleus 1212.0 11900.0 4.2E-6 0.00216
CDK2 ENSG00000123374 1017 Cytoplasm/Nucleus 809.0 69500.0 4.21E-6 0.00899
CDK6 ENSG00000105810 1021 Cytoplasm/Nucleus 544.0 1030.0 4.18E-6 0.00481
E2F1 ENSG00000101412 1869 Cytoplasm/Nucleus 962.0 20400.0 4.21E-6 0.00696
FHIT ENSG00000189283 2272 Cytoplasm/Nucleus 31.0 3420.0 4.16E-6 0.482
IKBKB ENSG00000104365 3551 Cytoplasm/Nucleus 3098.0 92800.0 4.21E-6 5.25E-4
IKBKG ENSG00000269335 8517 Cytoplasm/Nucleus 2435.0 52500.0 4.21E-6 7.02E-4
MYC ENSG00000136997 4609 Cytoplasm/Nucleus 1499.0 110000.0 4.22E-6 0.00512
NFKB1 ENSG00000109320 4790 Cytoplasm/Nucleus 3288.0 55500.0 4.21E-6 4.97E-4
NFKBIA ENSG00000100906 4792 Cytoplasm/Nucleus 3700.0 14800.0 4.21E-6 1.6E-4
PIAS1 ENSG00000033800 8554 Cytoplasm/Nucleus 132.0 364.0 4.19E-6 0.0365
PIAS3 ENSG00000131788 10401 Cytoplasm/Nucleus 111.0 119.0 4.18E-6 0.0391
PTEN ENSG00000171862 5728 Cytoplasm/Nucleus 1080.0 18300.0 4.2E-6 0.00586
PTGS2 ENSG00000073756 5743 Cytoplasm/Nucleus 173.0 64100.0 4.2E-6 0.0339
RARB ENSG00000077092 5915 Cytoplasm/Nucleus 68.0 73.6 4.19E-6 0.0852
RELA ENSG00000173039 5970 Cytoplasm/Nucleus 3598.0 133000.0 4.22E-6 6.78E-4
TP53 ENSG00000141510 7157 Cytoplasm/Nucleus 2254.0 393000.0 4.23E-6 0.00213
TRAF4 ENSG00000076604 9618 Cytoplasm/Nucleus 45.0 76.7 4.18E-6 0.104
TRAF5 ENSG00000082512 7188 Cytoplasm/Nucleus 25.0 0.255 4.17E-6 0.167
XIAP ENSG00000101966 331 Cytoplasm/Nucleus 258.0 962.0 4.19E-6 0.0179
PIK3CD ENSG00000171608 5293 Cytoskeleton 7623.0 27500.0 4.21E-6 2.8E-4
AKT1 ENSG00000142208 207 Membrane 15717.0 483000.0 4.23E-6 9.3E-5
AKT3 ENSG00000117020 10000 Membrane 12844.0 58500.0 4.22E-6 8.89E-5
ITGA2 ENSG00000164171 3673 Membrane 809.0 12500.0 4.19E-6 0.0108
ITGA2B ENSG00000005961 3674 Membrane 730.0 11900.0 4.19E-6 0.0141
ITGA3 ENSG00000005884 3675 Membrane 777.0 1680.0 4.17E-6 0.0113
ITGA6 ENSG00000091409 3655 Membrane 1015.0 20700.0 4.19E-6 0.00716
ITGAV ENSG00000138448 3685 Membrane 1032.0 18600.0 4.19E-6 0.00758
ITGB1 ENSG00000150093 3688 Membrane 1551.0 58200.0 4.2E-6 0.00342
PIK3CA ENSG00000121879 5290 Membrane 8869.0 407000.0 4.23E-6 3.0E-4
PIK3CG ENSG00000105851 5294 Membrane 7696.0 36500.0 4.21E-6 2.71E-4
PIK3R1 ENSG00000145675 5295 Membrane 9027.0 146000.0 4.22E-6 2.65E-4
PIK3R2 ENSG00000105647 5296 Membrane 7733.0 62100.0 4.21E-6 2.71E-4
PIK3R5 ENSG00000141506 23533 Membrane 6010.0 17400.0 4.21E-6 3.4E-4
APAF1 ENSG00000120868 317 Unknown 199.0 338.0 4.17E-6 0.00477
FN1 ENSG00000115414 2335 Unknown 758.0 45900.0 4.21E-6 0.0146
LAMB4 ENSG00000091128 22798 Unknown 297.0 213.0 4.15E-6 0.0309
MAX ENSG00000125952 4149 Unknown 204.0 4900.0 4.2E-6 0.0449
PIAS2 ENSG00000078043 9063 Unknown 127.0 2160.0 4.19E-6 0.0417
PIK3CB ENSG00000051382 5291 Unknown 7887.0 42600.0 4.21E-6 3.07E-4
PIK3R3 ENSG00000117461 8503 Unknown 7005.0 28500.0 4.21E-6 3.03E-4
PTK2 ENSG00000169398 5747 Unknown 2103.0 45600.0 4.21E-6 0.00292
CCNE1 ENSG00000105173 898 Nucleus 299.0 1400.0 4.19E-6 0.0137
CCNE2 ENSG00000175305 9134 Nucleus 199.0 349.0 4.16E-6 0.025
E2F2 ENSG00000007968 1870 Nucleus 536.0 2260.0 4.19E-6 0.00852
E2F3 ENSG00000112242 1871 Nucleus 621.0 4500.0 4.2E-6 0.00958
PIAS4 ENSG00000105229 51588 Nucleus 83.0 57.2 4.17E-6 0.062
RB1 ENSG00000139687 5925 Nucleus 1685.0 9770.0 4.2E-6 0.00173
RXRA ENSG00000186350 6256 Nucleus 275.0 154000.0 4.2E-6 0.0188
RXRB ENSG00000204231 6257 Nucleus 175.0 53400.0 4.2E-6 0.0316
RXRG ENSG00000143171 6258 Nucleus 143.0 35600.0 4.2E-6 0.0388
SKP2 ENSG00000145604 6502 Nucleus 149.0 378.0 4.18E-6 0.0524
COL4A1 ENSG00000187498 1282 Secreted 371.0 592.0 4.17E-6 0.0384
COL4A2 ENSG00000134871 1284 Secreted 361.0 417.0 4.16E-6 0.0396
COL4A4 ENSG00000081052 1286 Secreted 351.0 1350.0 4.17E-6 0.0418
COL4A6 ENSG00000197565 1288 Secreted 347.0 1270.0 4.17E-6 0.0423
LAMA2 ENSG00000196569 3908 Secreted 347.0 305.0 4.16E-6 0.0281
LAMA3 ENSG00000053747 3909 Secreted 370.0 3330.0 4.18E-6 0.0284
LAMA4 ENSG00000112769 3910 Secreted 359.0 4020.0 4.19E-6 0.0279
LAMA5 ENSG00000130702 3911 Secreted 362.0 455.0 4.16E-6 0.0276
LAMB1 ENSG00000091136 3912 Secreted 434.0 3940.0 4.18E-6 0.0218
LAMB2 ENSG00000172037 3913 Secreted 381.0 575.0 4.16E-6 0.0267
LAMB3 ENSG00000196878 3914 Secreted 360.0 818.0 4.17E-6 0.0345
LAMC1 ENSG00000135862 3915 Secreted 386.0 1220.0 4.17E-6 0.0257
LAMC3 ENSG00000050555 10319 Secreted 342.0 1140.0 4.16E-6 0.0291
LAMA1 ENSG00000101680 284217 Secreted/Nucleus 420.0 4620.0 4.18E-6 0.0224
Gene1 Gene2 Weight KEGG humanCyc PID BioGRID IntAct HPRD BIND Reactome CORUM DIP WikiPathways ReconX INOH SMPDB PhosphoSite PANTHER CTD NetPath TRANSFAC DrugBank
AKT1 AKT2 2
AKT1 BCL2L1 5
AKT1 CASP9 7
AKT1 CHUK 10
AKT1 E2F2 2
AKT1 IKBKB 7
AKT1 IKBKG 5
AKT1 NFKB1 3
AKT1 RELA 4
AKT1 TP53 4
AKT1 XIAP 4
AKT2 CASP9 3
AKT2 CHUK 8
AKT2 IKBKB 2
AKT2 TP53 2
AKT2 XIAP 3
AKT3 CASP9 3
AKT3 CHUK 3
AKT3 IKBKB 2
AKT3 NFKB1 3
APAF1 CASP9 14
APAF1 CYCS 7
BCL2 CYCS 3
BCL2L1 CYCS 5
BCL2L1 TP53 6
BCL2 TP53 5
BIRC2 BIRC3 5
BIRC2 CASP9 6
BIRC2 CHUK 2
BIRC2 IKBKB 2
BIRC2 IKBKG 6
BIRC2 TRAF1 6
BIRC2 TRAF2 8
BIRC2 TRAF3 4
BIRC3 CASP9 6
BIRC3 CHUK 2
BIRC3 IKBKB 4
BIRC3 IKBKG 4
BIRC3 TRAF1 5
BIRC3 TRAF2 6
BIRC3 TRAF3 5
CASP9 CYCS 7
CASP9 XIAP 6
CCND1 CDK2 6
CCND1 CDK4 11
CCND1 CDK6 10
CCND1 E2F1 3
CCND1 E2F2 3
CCND1 E2F3 3
CCND1 RB1 10
CCNE1 CDK2 12
CCNE1 RB1 5
CCNE1 SKP2 4
CCNE2 CDK2 7
CCNE2 RB1 2
CDK2 AKT1 1
CDK2 AKT2 1
CDK2 AKT3 1
CDK2 CKS1B 7
CDK2 E2F1 7
CDK2 E2F2 2
CDK2 E2F3 4
CDK2 RB1 12
CDK2 SKP2 6
CDK2 TP53 8
CDK4 AKT1 1
CDK4 AKT2 1
CDK4 AKT3 1
CDK4 CDK6 5
CDK4 CDKN2B 4
CDK4 E2F1 4
CDK4 RB1 11
CDK6 AKT1 1
CDK6 AKT2 1
CDK6 AKT3 1
CDK6 CDKN2B 3
CDK6 RB1 11
CDKN2B CCND1 2
CHUK CCND1 2
CHUK IKBKB 11
CHUK IKBKG 10
CHUK MYC 4
CHUK NFKB1 10
CHUK NFKBIA 14
CHUK RELA 11
CHUK TRAF2 5
CHUK TRAF4 2
CKS1B SKP2 8
COL4A1 COL4A2 5
COL4A1 FN1 3
COL4A1 ITGA2 4
COL4A1 ITGA2B 3
COL4A1 ITGA3 3
COL4A1 ITGA6 3
COL4A1 ITGAV 4
COL4A1 ITGB1 5
COL4A2 FN1 3
COL4A2 ITGA2 4
COL4A2 ITGA2B 3
COL4A2 ITGA3 3
COL4A2 ITGA6 3
COL4A2 ITGAV 5
COL4A2 ITGB1 4
COL4A4 FN1 3
COL4A4 ITGA2 4
COL4A4 ITGA2B 3
COL4A4 ITGA3 3
COL4A4 ITGA6 3
COL4A4 ITGAV 5
COL4A4 ITGB1 4
COL4A6 FN1 3
COL4A6 ITGA2 4
COL4A6 ITGA2B 3
COL4A6 ITGA3 3
COL4A6 ITGA6 3
COL4A6 ITGAV 4
COL4A6 ITGB1 4
E2F1 CCNE1 3
E2F1 CCNE2 2
E2F1 E2F2 4
E2F1 E2F3 2
E2F1 MYC 3
E2F1 PIAS1 2
E2F1 PIK3R3 2
E2F1 PTGS2 2
E2F1 RB1 10
E2F1 SKP2 3
E2F2 CCNE1 2
E2F2 CCNE2 2
E2F2 MYC 2
E2F2 RB1 8
E2F3 CCNE1 2
E2F3 CCNE2 2
E2F3 RB1 8
FN1 ITGA2 5
FN1 ITGA2B 6
FN1 ITGA3 4
FN1 ITGA6 3
FN1 ITGAV 8
FN1 ITGB1 9
FN1 PTK2 4
IKBKB IKBKG 12
IKBKB NFKB1 9
IKBKB NFKBIA 14
IKBKB RELA 11
IKBKB TRAF2 5
IKBKB TRAF6 6
IKBKG AKT2 1
IKBKG AKT3 1
IKBKG NFKB1 8
IKBKG NFKBIA 11
IKBKG RELA 6
IKBKG TRAF2 4
ITGA2B PTK2 5
ITGA2 ITGB1 10
ITGA2 LAMA1 5
ITGA2 PTK2 3
ITGA3 ITGB1 9
ITGA3 LAMA4 3
ITGA3 PTK2 3
ITGA6 AKT1 1
ITGA6 ITGB1 9
ITGA6 LAMA1 6
ITGA6 LAMA2 6
ITGA6 LAMA3 6
ITGA6 LAMA4 4
ITGA6 LAMA5 9
ITGA6 LAMB1 8
ITGA6 LAMB2 9
ITGA6 LAMB3 7
ITGA6 LAMB4 2
ITGA6 LAMC1 9
ITGA6 LAMC2 6
ITGA6 LAMC3 2
ITGA6 PIK3CA 1
ITGA6 PIK3R1 1
ITGA6 PTK2 3
ITGAV ITGB1 10
ITGAV PTK2 7
ITGB1 LAMA1 6
ITGB1 LAMA2 4
ITGB1 LAMA3 4
ITGB1 LAMA4 5
ITGB1 LAMA5 4
ITGB1 LAMB1 4
ITGB1 LAMB2 4
ITGB1 LAMB3 5
ITGB1 LAMB4 2
ITGB1 LAMC1 4
ITGB1 LAMC2 4
ITGB1 LAMC3 2
ITGB1 PTK2 6
LAMA1 AKT1 1
LAMA1 ITGA2B 1
LAMA1 LAMB1 7
LAMA1 LAMB2 4
LAMA1 LAMC1 7
LAMA2 ITGA2B 1
LAMA2 ITGAV 1
LAMA2 LAMB1 7
LAMA2 LAMC3 4
LAMA3 ITGA2B 1
LAMA3 ITGAV 1
LAMA3 LAMB3 7
LAMA4 ITGA2 1
LAMA4 ITGA2B 1
LAMA5 ITGA2 1
LAMA5 ITGA2B 1
LAMA5 ITGAV 1
LAMA5 LAMB1 7
LAMA5 LAMB2 8
LAMA5 LAMC1 8
LAMB1 AKT1 1
LAMB1 ITGA2B 1
LAMB1 LAMC1 8
LAMB1 LAMC3 4
LAMB2 ITGA2 1
LAMB2 ITGA2B 1
LAMB2 ITGAV 1
LAMB2 LAMC1 8
LAMB3 LAMC2 7
LAMB4 ITGA2 1
LAMB4 ITGA2B 1
LAMB4 ITGA3 1
LAMB4 ITGAV 1
LAMC1 ITGA2B 1
LAMC2 AKT1 1
LAMC2 ITGA2B 1
LAMC2 ITGAV 1
LAMC3 ITGA2 1
LAMC3 ITGA2B 1
LAMC3 ITGA3 1
LAMC3 ITGAV 1
MAX CCND1 2
MAX CDK4 2
MAX CKS1B 1
MAX MYC 9
MAX PIAS1 2
MAX PIAS2 1
MAX PIAS3 1
MAX PIAS4 1
MAX TP53 3
MYC CCND1 1
MYC CDKN2B 2
MYC CKS1B 1
MYC PIAS1 2
MYC PIAS2 3
MYC PIAS3 1
MYC PIAS4 2
MYC RXRB 2
MYC SKP2 4
MYC TP53 6
NFKB1 BCL2 1
NFKB1 BCL2L1 2
NFKB1 BIRC2 1
NFKB1 NFKBIA 12
NFKB1 NOS2 1
NFKB1 PTGS2 1
NFKB1 RELA 12
NFKB1 TRAF1 2
NFKB1 TRAF3 1
NFKB1 TRAF4 1
NFKB1 TRAF5 1
NFKB1 TRAF6 5
NFKB1 XIAP 3
NFKBIA PIK3R1 4
NFKBIA RELA 14
PIAS1 CDKN2B 1
PIAS3 CDKN2B 1
PIAS4 CDKN2B 1
PIK3CA AKT1 5
PIK3CA AKT2 4
PIK3CA AKT3 4
PIK3CA PIK3CD 2
PIK3CA PIK3R1 14
PIK3CA PIK3R2 7
PIK3CA PIK3R3 7
PIK3CA PTK2 4
PIK3CA RELA 1
PIK3CB AKT1 4
PIK3CB AKT2 4
PIK3CB AKT3 4
PIK3CB PIK3CA 2
PIK3CB PIK3CD 2
PIK3CB PIK3CG 2
PIK3CB PIK3R1 10
PIK3CB PIK3R2 6
PIK3CB PIK3R3 7
PIK3CD AKT1 3
PIK3CD AKT2 3
PIK3CD AKT3 4
PIK3CD PIK3CG 3
PIK3CD PIK3R1 10
PIK3CD PIK3R2 9
PIK3CD PIK3R3 4
PIK3CG AKT1 5
PIK3CG AKT2 4
PIK3CG AKT3 4
PIK3CG PIK3CA 2
PIK3CG PIK3R1 2
PIK3CG PIK3R2 2
PIK3CG PIK3R3 2
PIK3CG PIK3R5 6
PIK3R1 AKT1 6
PIK3R1 AKT2 4
PIK3R1 AKT3 4
PIK3R1 PIK3R2 5
PIK3R1 PIK3R3 3
PIK3R1 PTK2 6
PIK3R1 RELA 3
PIK3R1 TP53 3
PIK3R2 AKT1 4
PIK3R2 AKT2 3
PIK3R2 AKT3 3
PIK3R2 PIK3R3 4
PIK3R2 PTK2 4
PIK3R3 AKT1 3
PIK3R3 AKT2 3
PIK3R3 AKT3 3
PIK3R3 PTEN 2
PIK3R3 PTK2 4
PIK3R5 AKT1 4
PIK3R5 AKT2 3
PIK3R5 AKT3 3
PTEN AKT1 4
PTEN AKT2 3
PTEN AKT3 3
PTEN PIK3CA 3
PTEN PIK3CB 2
PTEN PIK3CD 2
PTEN PIK3R1 2
PTEN PIK3R2 2
PTEN PIK3R5 1
PTEN PTK2 4
PTEN TP53 5
PTK2 AKT1 2
PTK2 AKT2 1
PTK2 AKT3 1
PTK2 PIK3CB 2
PTK2 PIK3CD 2
PTK2 PIK3CG 2
PTK2 PIK3R5 1
RARB AKT1 1
RARB RXRA 5
RARB RXRB 6
RARB RXRG 5
RB1 SKP2 4
RELA BCL2 1
RELA BCL2L1 2
RELA BIRC3 3
RELA NOS2 1
RELA TP53 3
RELA TRAF3 1
RELA TRAF4 2
RELA TRAF5 1
RELA TRAF6 3
RELA XIAP 3
SKP2 TP53 2
TRAF1 NFKBIA 1
TRAF1 TRAF2 8
TRAF1 TRAF3 2
TRAF1 TRAF6 3
TRAF1 XIAP 1
TRAF2 NFKBIA 2
TRAF2 RELA 1
TRAF2 TRAF3 5
TRAF2 XIAP 2
TRAF3 TRAF6 4
TRAF6 AKT1 1
TRAF6 CHUK 4
TRAF6 IKBKG 4
TRAF6 NFKBIA 2
AKT1 APAF1 2
AKT1 E2F1 1
AKT1 E2F3 1
AKT1 ITGA2B 1
AKT1 MYC 1
AKT1 NFKBIA 1
AKT1 PIAS1 1
AKT1 PIAS2 3
AKT1 RB1 3
AKT1 RXRA 1
AKT1 RXRB 1
AKT1 RXRG 1
AKT1 SKP2 1
AKT1 TRAF4 1
AKT2 BCL2L1 1
AKT2 NFKB1 1
AKT2 NFKBIA 1
AKT2 RELA 1
AKT3 BCL2L1 1
AKT3 NFKBIA 1
AKT3 RELA 1
AKT3 TP53 1
APAF1 BCL2L1 2
APAF1 CDK2 2
APAF1 XIAP 2
BCL2 BCL2L1 4
BCL2 CDK2 2
BCL2 CHUK 1
BCL2 E2F1 1
BCL2 IKBKB 1
BCL2 IKBKG 1
BCL2 ITGA3 2
BCL2 ITGB1 2
BCL2L1 CASP9 3
BCL2L1 CDK2 2
BCL2L1 RB1 2
BCL2L1 SKP2 2
BCL2 MYC 3
BCL2 PTK2 1
BCL2 RB1 3
BCL2 RXRA 1
BCL2 RXRB 1
BCL2 RXRG 1
BCL2 TRAF6 2
BIRC2 APAF1 1
BIRC2 E2F1 2
BIRC2 E2F2 1
BIRC2 E2F3 1
BIRC2 MYC 1
BIRC2 NFKBIA 1
BIRC2 PIAS2 1
BIRC2 RB1 1
BIRC2 RELA 2
BIRC2 TRAF6 2
BIRC2 XIAP 1
BIRC3 APAF1 1
BIRC3 E2F1 2
BIRC3 E2F2 1
BIRC3 E2F3 1
BIRC3 MYC 1