Pathway ID Pathway Name Source Organism Number of Genes Number of Interactions
pathway0002686 Hs_Tryptophan_metabolism_WP465_85055 WikiPathways Homo sapiens 45 103
Secreted
Membrane
Cytoplasm
Cytoplasm/4
Cytoskeleton
Cytoskeleton/Cytoplasm
Membrane/Nucleus
Cytoplasm/Nucleus
Cytoskeleton/Nucleus
Nucleus
Secreted/Nucleus
Unknown
Annotated genes
Unannotated genes
Symbol
Ensembl ID
Entrez ID
Subcellular localization
Description
Type
Edge
Symbol Ensembl ID Entrez ID Subcellular localization Closeness Degree Betweenness Transitivity
ACAT1 ENSG00000075239 38 Cytoplasm 0.007407407 6.0 7.956105 0.0
ARF1 ENSG00000143761 375 Cytoplasm 0.007194245 1.0 0.0 0.0
LAMC2 ENSG00000058085 3918 Cytoplasm 0.008403361 3.0 27.19572 0.0
NDUFA4 ENSG00000189043 4697 Cytoplasm 0.008130081 3.0 4.436787 0.0
NDUFS1 ENSG00000023228 4719 Cytoplasm 0.007633588 4.0 4.172168 0.0
RPS29 ENSG00000213741 6235 Cytoplasm 0.008849558 4.0 60.59694 0.166666667
STMN1 ENSG00000117632 3925 Cytoplasm 0.009803922 10.0 25.35438 0.133333333
CALR ENSG00000179218 811 Cytoplasm/Nucleus 0.010204082 6.0 82.95283 0.133333333
E2F4 ENSG00000205250 1874 Cytoplasm/Nucleus 0.010869565 11.0 62.05386 0.109090909
HSPB1 ENSG00000106211 3315 Cytoplasm/Nucleus 0.009803922 7.0 68.29868 0.095238095
IRF1 ENSG00000125347 3659 Cytoplasm/Nucleus 0.00862069 7.0 44.72362 0.095238095
RPL34 ENSG00000109475 6164 Cytoplasm/Nucleus 0.007936508 5.0 54.66418 0.1
RPL35A ENSG00000182899 6165 Cytoplasm/Nucleus 0.008547009 7.0 78.70433 0.095238095
STAT5A ENSG00000126561 6776 Cytoplasm/Nucleus 0.010869565 22.0 165.3505 0.038961039
STAT6 ENSG00000166888 6778 Cytoplasm/Nucleus 0.010638298 15.0 63.59974 0.085714286
TP53 ENSG00000141510 7157 Cytoplasm/Nucleus 0.012048193 22.0 272.7928 0.047619048
ABCC1 ENSG00000103222 4363 Membrane 0.00625 1.0 0.0 0.0
CHRM1 ENSG00000168539 1128 Membrane 0.00877193 3.0 42.71294 0.0
CYSLTR1 ENSG00000173198 10800 Membrane 0.008333333 4.0 31.17811 0.166666667
DRD4 ENSG00000069696 1815 Membrane 0.00862069 4.0 18.8039 0.0
OPN1LW ENSG00000102076 5956 Membrane 0.006896552 1.0 0.0 0.0
OR2D2 ENSG00000166368 120776 Membrane 0.008333333 3.0 12.94105 0.333333333
PIK3R2 ENSG00000105647 5296 Membrane 0.010309278 10.0 47.64581 0.155555556
PLAUR ENSG00000011422 5329 Membrane 0.007692308 7.0 3.944639 0.047619048
PTCH1 ENSG00000185920 5727 Membrane 0.008 3.0 0.0 0.333333333
SLC2A4 ENSG00000181856 6517 Membrane 0.008064516 4.0 23.53421 0.0
SLC9A1 ENSG00000090020 6548 Membrane 0.007751938 2.0 5.357964 0.0
AKAP12 ENSG00000131016 9590 Unknown 0.010416667 8.0 116.2981 0.107142857
PAK1 ENSG00000149269 5058 Unknown 0.009803922 16.0 62.00625 0.041666667
PIP4K2A ENSG00000150867 5305 Unknown 0.008474576 7.0 1.552259 0.095238095
UBE2F ENSG00000184182 140739 Unknown 0.005681818 1.0 0.0 0.0
EBF1 ENSG00000164330 1879 Nucleus 0.006289308 1.0 0.0 0.0
PPARGC1A ENSG00000109819 10891 Nucleus 0.009174312 8.0 6.420522 0.035714286
RARA ENSG00000131759 5914 Nucleus 0.010204082 8.0 57.19566 0.142857143
RPS6KA4 ENSG00000162302 8986 Nucleus 0.006410256 1.0 0.0 0.0
TFDP1 ENSG00000198176 7027 Nucleus 0.009708738 8.0 22.5888 0.107142857
C1QA ENSG00000173372 712 Secreted 0.007518797 4.0 47.04444 0.0
C2 ENSG00000166278 717 Secreted 0.007518797 4.0 16.09317 0.0
C9 ENSG00000113600 735 Secreted 0.00591716 1.0 0.0 0.0
IL4 ENSG00000113520 3565 Secreted 0.009803922 16.0 109.8481 0.008333333
LAMB1 ENSG00000091136 3912 Secreted 0.006756757 2.0 3.456667 0.0
MASP2 ENSG00000009724 10747 Secreted 0.008849558 4.0 26.65546 0.0
PLA2G5 ENSG00000127472 5322 Secreted 0.006666667 2.0 2.5 0.0
PLG ENSG00000122194 5340 Secreted 0.007874016 8.0 13.17466 0.035714286
SERPINE1 ENSG00000106366 5054 Secreted 0.009615385 10.0 45.19472 0.111111111
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
ACAT1 ENSG00000075239 38 Cytoplasm 2746.0 34500.0 1.54E-6 2.66E-4
ARF1 ENSG00000143761 375 Cytoplasm 370.0 84800.0 1.55E-6 0.0248
LAMC2 ENSG00000058085 3918 Cytoplasm 890.0 26000.0 1.56E-6 0.0126
NDUFA4 ENSG00000189043 4697 Cytoplasm 371.0 14700.0 1.55E-6 0.0153
NDUFS1 ENSG00000023228 4719 Cytoplasm 389.0 13400.0 1.54E-6 0.0198
RPS29 ENSG00000213741 6235 Cytoplasm 1770.0 5080.0 1.55E-6 0.00685
STMN1 ENSG00000117632 3925 Cytoplasm 98.0 684.0 1.55E-6 0.0259
CALR ENSG00000179218 811 Cytoplasm/Nucleus 175.0 25900.0 1.56E-6 0.0282
E2F4 ENSG00000205250 1874 Cytoplasm/Nucleus 668.0 42800.0 1.56E-6 0.0157
HSPB1 ENSG00000106211 3315 Cytoplasm/Nucleus 611.0 25100.0 1.56E-6 0.00722
IRF1 ENSG00000125347 3659 Cytoplasm/Nucleus 243.0 28500.0 1.56E-6 0.0298
RPL34 ENSG00000109475 6164 Cytoplasm/Nucleus 1637.0 2520.0 1.54E-6 0.00631
RPL35A ENSG00000182899 6165 Cytoplasm/Nucleus 1673.0 20400.0 1.55E-6 0.00635
STAT5A ENSG00000126561 6776 Cytoplasm/Nucleus 7688.0 196000.0 1.56E-6 4.69E-4
STAT6 ENSG00000166888 6778 Cytoplasm/Nucleus 2021.0 83000.0 1.56E-6 0.00506
TP53 ENSG00000141510 7157 Cytoplasm/Nucleus 8418.0 2450000.0 1.57E-6 7.36E-4
ABCC1 ENSG00000103222 4363 Membrane 55.0 79300.0 1.54E-6 0.0566
CHRM1 ENSG00000168539 1128 Membrane 123.0 2240.0 1.55E-6 0.0633
CYSLTR1 ENSG00000173198 10800 Membrane 58.0 1570.0 1.55E-6 0.165
DRD4 ENSG00000069696 1815 Membrane 1333.0 29700.0 1.55E-6 0.00303
OPN1LW ENSG00000102076 5956 Membrane 20.0 5.22 1.54E-6 0.874
OR2D2 ENSG00000166368 120776 Membrane 10.0 6060.0 1.54E-6 0.133
PIK3R2 ENSG00000105647 5296 Membrane 17436.0 144000.0 1.56E-6 9.14E-5
PLAUR ENSG00000011422 5329 Membrane 267.0 219000.0 1.55E-6 0.00915
PTCH1 ENSG00000185920 5727 Membrane 542.0 10600.0 1.55E-6 0.00117
SLC2A4 ENSG00000181856 6517 Membrane 256.0 35300.0 1.55E-6 0.0126
SLC9A1 ENSG00000090020 6548 Membrane 184.0 100000.0 1.55E-6 0.0132
AKAP12 ENSG00000131016 9590 Unknown 8.0 717.0 1.55E-6 0.107
PAK1 ENSG00000149269 5058 Unknown 5363.0 83300.0 1.56E-6 2.49E-4
PIP4K2A ENSG00000150867 5305 Unknown 1054.0 6960.0 1.56E-6 0.0104
UBE2F ENSG00000184182 140739 Unknown 181.0 3370.0 1.55E-6 0.0848
EBF1 ENSG00000164330 1879 Nucleus 9.0 0.212 1.55E-6 0.806
PPARGC1A ENSG00000109819 10891 Nucleus 604.0 39600.0 1.56E-6 0.01
RARA ENSG00000131759 5914 Nucleus 385.0 11800.0 1.56E-6 0.0894
RPS6KA4 ENSG00000162302 8986 Nucleus 165.0 104.0 1.55E-6 0.0085
TFDP1 ENSG00000198176 7027 Nucleus 790.0 30900.0 1.56E-6 0.0121
C1QA ENSG00000173372 712 Secreted 142.0 2050.0 1.54E-6 0.0216
C2 ENSG00000166278 717 Secreted 154.0 10700.0 1.54E-6 0.0219
C9 ENSG00000113600 735 Secreted 149.0 1570.0 1.54E-6 0.00317
IL4 ENSG00000113520 3565 Secreted 1181.0 24100.0 1.55E-6 0.00471
LAMB1 ENSG00000091136 3912 Secreted 949.0 9000.0 1.55E-6 0.00957
MASP2 ENSG00000009724 10747 Secreted 81.0 27500.0 1.54E-6 0.013
PLA2G5 ENSG00000127472 5322 Secreted 476.0 25600.0 1.55E-6 0.005
PLG ENSG00000122194 5340 Secreted 704.0 36600.0 1.55E-6 0.00106
SERPINE1 ENSG00000106366 5054 Secreted 269.0 23500.0 1.55E-6 0.00946
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
ACAT1 ENSG00000075239 38 Cytoplasm 11.0 8.4 2.08E-5 0.0
ARF1 ENSG00000143761 375 Cytoplasm 4.0 5.09 2.08E-5 0.333333333
LAMC2 ENSG00000058085 3918 Cytoplasm 4.0 2080.0 2.1E-5 0.0
NDUFA4 ENSG00000189043 4697 Cytoplasm 4.0 381.0 2.09E-5 0.0
NDUFS1 ENSG00000023228 4719 Cytoplasm 4.0 10.5 2.08E-5 0.0
RPS29 ENSG00000213741 6235 Cytoplasm 10.0 412.0 2.11E-5 0.111111111
STMN1 ENSG00000117632 3925 Cytoplasm 43.0 299.0 2.13E-5 0.03654485
CALR ENSG00000179218 811 Cytoplasm/Nucleus 6.0 1580.0 2.11E-5 0.133333333
E2F4 ENSG00000205250 1874 Cytoplasm/Nucleus 53.0 8530.0 2.14E-5 0.118287373
HSPB1 ENSG00000106211 3315 Cytoplasm/Nucleus 83.0 12300.0 2.15E-5 0.046135763
IRF1 ENSG00000125347 3659 Cytoplasm/Nucleus 7.0 1880.0 2.09E-5 0.095238095
RPL34 ENSG00000109475 6164 Cytoplasm/Nucleus 5.0 241.0 2.07E-5 0.1
RPL35A ENSG00000182899 6165 Cytoplasm/Nucleus 11.0 3680.0 2.1E-5 0.090909091
STAT5A ENSG00000126561 6776 Cytoplasm/Nucleus 1017.0 56800.0 2.16E-5 0.003613763
STAT6 ENSG00000166888 6778 Cytoplasm/Nucleus 109.0 2950.0 2.15E-5 0.059802922
TP53 ENSG00000141510 7157 Cytoplasm/Nucleus 1691.0 145000.0 2.18E-5 0.001606136
ABCC1 ENSG00000103222 4363 Membrane 1.0 0.0 2.02E-5 0.0
CHRM1 ENSG00000168539 1128 Membrane 3.0 73.7 2.1E-5 0.0
CYSLTR1 ENSG00000173198 10800 Membrane 6.0 236.0 2.06E-5 0.2
DRD4 ENSG00000069696 1815 Membrane 4.0 35.3 2.06E-5 0.0
OPN1LW ENSG00000102076 5956 Membrane 1.0 0.0 2.05E-5 0.0
OR2D2 ENSG00000166368 120776 Membrane 4.0 2060.0 2.04E-5 0.166666667
PIK3R2 ENSG00000105647 5296 Membrane 1499.0 14900.0 2.15E-5 0.001001112
PLAUR ENSG00000011422 5329 Membrane 29.0 97.7 2.13E-5 0.155172414
PTCH1 ENSG00000185920 5727 Membrane 22.0 1990.0 2.1E-5 0.017316017
SLC2A4 ENSG00000181856 6517 Membrane 10.0 2890.0 2.08E-5 0.022222222
SLC9A1 ENSG00000090020 6548 Membrane 7.0 5240.0 2.08E-5 0.0
AKAP12 ENSG00000131016 9590 Unknown 8.0 2470.0 2.11E-5 0.107142857
PAK1 ENSG00000149269 5058 Unknown 708.0 9870.0 2.16E-5 0.00427125
PIP4K2A ENSG00000150867 5305 Unknown 23.0 516.0 2.12E-5 0.098814229
UBE2F ENSG00000184182 140739 Unknown 2.0 9.95 2.03E-5 0.0
EBF1 ENSG00000164330 1879 Nucleus 1.0 0.0 2.01E-5 0.0
PPARGC1A ENSG00000109819 10891 Nucleus 98.0 7180.0 2.13E-5 0.007153377
RARA ENSG00000131759 5914 Nucleus 8.0 95.8 2.11E-5 0.142857143
RPS6KA4 ENSG00000162302 8986 Nucleus 7.0 2.67 2.09E-5 0.047619048
TFDP1 ENSG00000198176 7027 Nucleus 8.0 307.0 2.1E-5 0.107142857
C1QA ENSG00000173372 712 Secreted 7.0 150.0 2.03E-5 0.0
C2 ENSG00000166278 717 Secreted 5.0 1940.0 2.05E-5 0.0
C9 ENSG00000113600 735 Secreted 3.0 9.44 2.02E-5 0.0
IL4 ENSG00000113520 3565 Secreted 54.0 12000.0 2.13E-5 0.022361985
LAMB1 ENSG00000091136 3912 Secreted 2.0 9.06 2.02E-5 0.0
MASP2 ENSG00000009724 10747 Secreted 4.0 172.0 2.08E-5 0.0
PLA2G5 ENSG00000127472 5322 Secreted 29.0 350.0 2.11E-5 0.022167488
PLG ENSG00000122194 5340 Secreted 58.0 3090.0 2.11E-5 0.005444646
SERPINE1 ENSG00000106366 5054 Secreted 82.0 5990.0 2.12E-5 0.009936766
Gene1 Gene2 Weight KEGG humanCyc PID BioGRID IntAct HPRD BIND Reactome CORUM DIP WikiPathways ReconX INOH SMPDB PhosphoSite PANTHER CTD NetPath TRANSFAC DrugBank
C1QA C2 2
E2F4 TFDP1 9
E2F4 TP53 2
HSPB1 PLG 2
IL4 STAT5A 2
NDUFA4 NDUFS1 3
PAK1 STAT5A 1
PAK1 STAT6 1
PAK1 STMN1 3
PIP4K2A PIK3R2 4
PLAUR SERPINE1 4
PLG PLAUR 3
RPL34 RPL35A 3
STAT6 IL4 2
TFDP1 TP53 3
TP53 SERPINE1 3
ACAT1 PLA2G5 1
AKAP12 ACAT1 1
AKAP12 ARF1 1
AKAP12 E2F4 1
AKAP12 PAK1 1
AKAP12 STMN1 1
AKAP12 TP53 1
CALR C1QA 1
CALR E2F4 1
CALR HSPB1 2
CALR TP53 1
CHRM1 MASP2 1
CYSLTR1 OR2D2 1
CYSLTR1 RPL35A 1
DRD4 CALR 1
DRD4 IL4 1
DRD4 SLC2A4 1
DRD4 TFDP1 1
E2F4 IL4 1
E2F4 IRF1 1
E2F4 RARA 1
E2F4 SERPINE1 1
HSPB1 PAK1 2
HSPB1 RPL34 2
HSPB1 STMN1 1
HSPB1 TP53 3
IL4 C2 1
IL4 CYSLTR1 1
IRF1 EBF1 1
IRF1 PPARGC1A 1
IRF1 STAT6 1
LAMB1 LAMC2 1
LAMC2 TP53 1
MASP2 C2 1
MASP2 CYSLTR1 1
NDUFS1 SERPINE1 1
OPN1LW IL4 1
OR2D2 AKAP12 1
OR2D2 RPL35A 1
PAK1 NDUFS1 1
PAK1 PLAUR 1
PIK3R2 AKAP12 1
PIK3R2 RARA 1
PIK3R2 SLC2A4 1
PIK3R2 STAT5A 1
PIP4K2A RARA 1
PIP4K2A STAT6 1
PLA2G5 CHRM1 1
PLG LAMC2 1
PLG SERPINE1 2
PPARGC1A TP53 1
RARA RPL35A 1
RARA TP53 1
RPL34 C9 1
RPL34 RPS29 2
RPL35A ABCC1 1
RPL35A RPS29 2
RPS29 RPS6KA4 1
RPS29 TP53 2
SLC2A4 LAMB1 1
SLC2A4 SLC9A1 1
STAT5A CALR 1
STAT5A IRF1 1
STAT5A MASP2 1
STAT5A PPARGC1A 1
STAT5A PTCH1 1
STAT5A RARA 1
STAT5A SLC9A1 1
STAT5A STAT6 1
STAT5A STMN1 1
STAT6 PIK3R2 1
STAT6 SERPINE1 1
STAT6 STMN1 1
STAT6 TP53 1
STMN1 PTCH1 1
TFDP1 PIP4K2A 1
TFDP1 SERPINE1 1
TFDP1 STMN1 1
TP53 CHRM1 1
TP53 NDUFA4 1
TP53 PIK3R2 1
UBE2F C1QA 1
Pathway1 Pathway2 Intersect Similarity Scores Pathway Name Source Number of Genes Number of Interactions Detail