Pathway ID Pathway Name Source Organism Number of Genes Number of Interactions
pathway0002712 Hs_Leptin_signaling_pathway_WP2034_89856 WikiPathways Homo sapiens 37 264
Secreted
Membrane
Cytoplasm
Cytoplasm/4
Cytoskeleton
Cytoskeleton/Cytoplasm
Membrane/Nucleus
Cytoplasm/Nucleus
Cytoskeleton/Nucleus
Nucleus
Secreted/Nucleus
Unknown
Annotated genes
Unannotated genes
Symbol
Ensembl ID
Entrez ID
Subcellular localization
Description
Type
Edge
Symbol Ensembl ID Entrez ID Subcellular localization Closeness Degree Betweenness Transitivity
FYN ENSG00000010810 2534 Cytoplasm 0.01960784 58.0 4.035628 0.068360557
IRS1 ENSG00000169047 3667 Cytoplasm 0.01960784 74.0 9.126013 0.041466124
PTPN11 ENSG00000179295 5781 Cytoplasm 0.01818182 65.0 0.9704119 0.044711538
SOS1 ENSG00000115904 6654 Cytoplasm 0.01886792 118.0 1.638362 0.016514559
CFL2 ENSG00000165410 1073 Cytoplasm/Nucleus 0.01234568 2.0 0.1 0.0
EIF4EBP1 ENSG00000187840 1978 Cytoplasm/Nucleus 0.01470588 25.0 0.2271474 0.023333333
ELK1 ENSG00000126767 2002 Cytoplasm/Nucleus 0.01587302 27.0 1.112687 0.048433048
ESR1 ENSG00000091831 2099 Cytoplasm/Nucleus 0.02222222 64.0 33.70249 0.07093254
IKBKG ENSG00000269335 8517 Cytoplasm/Nucleus 0.01639344 37.0 1.99945 0.054054054
JAK2 ENSG00000096968 3717 Cytoplasm/Nucleus 0.02040816 105.0 18.34861 0.025091575
MAPK1 ENSG00000100030 5594 Cytoplasm/Nucleus 0.02222222 115.0 67.83553 0.020900076
NFKB1 ENSG00000109320 4790 Cytoplasm/Nucleus 0.01818182 40.0 9.306453 0.096153846
PRKAA2 ENSG00000162409 5563 Cytoplasm/Nucleus 0.01666667 26.0 11.17305 0.092307692
ROCK2 ENSG00000134318 9475 Cytoplasm/Nucleus 0.01449275 5.0 2.361115 0.3
RPS6 ENSG00000137154 6194 Cytoplasm/Nucleus 0.01587302 22.0 1.790565 0.060606061
RPS6KB1 ENSG00000108443 6198 Cytoplasm/Nucleus 0.01694915 62.0 4.270974 0.022739291
SOCS7 ENSG00000274211 30837 Cytoplasm/Nucleus 0.01587302 12.0 0.04660652 0.333333333
STAT1 ENSG00000115415 6772 Cytoplasm/Nucleus 0.01960784 66.0 10.97728 0.05034965
STAT5B ENSG00000173757 6777 Cytoplasm/Nucleus 0.01960784 56.0 14.89937 0.071428571
AKT1 ENSG00000142208 207 Membrane 0.02272727 202.0 62.88517 0.008718782
HRAS ENSG00000174775 3265 Membrane 0.02040816 116.0 10.27156 0.02143928
MTOR ENSG00000198793 2475 Membrane 0.02040816 90.0 19.44506 0.030212235
PIK3R1 ENSG00000145675 5295 Membrane 0.02040816 121.0 17.92822 0.017355372
PIK3R2 ENSG00000105647 5296 Membrane 0.01923077 102.0 12.01114 0.019607843
RAF1 ENSG00000132155 5894 Membrane 0.01538462 65.0 0.0 0.013461538
SHC1 ENSG00000160691 6464 Membrane 0.02 82.0 13.66746 0.038843722
ACACA ENSG00000278540 31 Unknown 0.01369863 9.0 0.3671329 0.111111111
GRB2 ENSG00000177885 2885 Unknown 0.02 130.0 42.05697 0.013118664
KHDRBS1 ENSG00000121774 10657 Unknown 0.01538462 10.0 0.03027465 0.4
SH2B1 ENSG00000178188 25970 Unknown 0.01538462 14.0 0.1762354 0.186813187
STAT3 ENSG00000168610 6774 Unknown 0.02325581 80.0 25.11711 0.055696203
NCOA1 ENSG00000084676 8648 Nucleus 0.01470588 8.0 0.0 0.214285714
RPS6KA1 ENSG00000117676 6195 Nucleus 0.01666667 31.0 1.887747 0.092473118
SP1 ENSG00000185591 6667 Nucleus 0.01694915 17.0 1.721424 0.272058824
AGRP ENSG00000159723 181 Secreted 0.01369863 3.0 0.0 1.0
IL1B ENSG00000125538 3553 Secreted/Nucleus 0.01694915 31.0 1.512755 0.096774194
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
FYN ENSG00000010810 2534 Cytoplasm 9828.0 511000.0 1.56E-6 4.85E-4
IRS1 ENSG00000169047 3667 Cytoplasm 4154.0 22000.0 1.56E-6 7.58E-4
PTPN11 ENSG00000179295 5781 Cytoplasm 9733.0 167000.0 1.56E-6 2.5E-4
SOS1 ENSG00000115904 6654 Cytoplasm 23511.0 177000.0 1.56E-6 6.54E-5
CFL2 ENSG00000165410 1073 Cytoplasm/Nucleus 109.0 1090.0 1.55E-6 0.0133
EIF4EBP1 ENSG00000187840 1978 Cytoplasm/Nucleus 1189.0 11000.0 1.55E-6 4.81E-4
ELK1 ENSG00000126767 2002 Cytoplasm/Nucleus 3468.0 49000.0 1.56E-6 3.9E-4
ESR1 ENSG00000091831 2099 Cytoplasm/Nucleus 1715.0 361000.0 1.56E-6 0.00554
IKBKG ENSG00000269335 8517 Cytoplasm/Nucleus 7020.0 201000.0 1.56E-6 2.07E-4
JAK2 ENSG00000096968 3717 Cytoplasm/Nucleus 9806.0 203000.0 1.56E-6 2.47E-4
MAPK1 ENSG00000100030 5594 Cytoplasm/Nucleus 33563.0 1130000.0 1.56E-6 2.83E-5
NFKB1 ENSG00000109320 4790 Cytoplasm/Nucleus 11386.0 280000.0 1.56E-6 2.06E-4
PRKAA2 ENSG00000162409 5563 Cytoplasm/Nucleus 811.0 20600.0 1.55E-6 0.00343
ROCK2 ENSG00000134318 9475 Cytoplasm/Nucleus 1010.0 7660.0 1.56E-6 0.00175
RPS6 ENSG00000137154 6194 Cytoplasm/Nucleus 2882.0 391000.0 1.56E-6 0.0031
RPS6KB1 ENSG00000108443 6198 Cytoplasm/Nucleus 3539.0 54900.0 1.56E-6 3.46E-4
SOCS7 ENSG00000274211 30837 Cytoplasm/Nucleus 152.0 153.0 1.55E-6 0.103
STAT1 ENSG00000115415 6772 Cytoplasm/Nucleus 9900.0 278000.0 1.56E-6 2.9E-4
STAT5B ENSG00000173757 6777 Cytoplasm/Nucleus 6515.0 71100.0 1.56E-6 5.43E-4
AKT1 ENSG00000142208 207 Membrane 52751.0 2150000.0 1.57E-6 1.74E-5
HRAS ENSG00000174775 3265 Membrane 21752.0 305000.0 1.56E-6 6.79E-5
MTOR ENSG00000198793 2475 Membrane 6209.0 146000.0 1.56E-6 2.1E-4
PIK3R1 ENSG00000145675 5295 Membrane 31452.0 734000.0 1.56E-6 4.03E-5
PIK3R2 ENSG00000105647 5296 Membrane 17436.0 144000.0 1.56E-6 9.14E-5
RAF1 ENSG00000132155 5894 Membrane 23706.0 140000.0 1.56E-6 1.64E-5
SHC1 ENSG00000160691 6464 Membrane 13549.0 312000.0 1.56E-6 2.6E-4
ACACA ENSG00000278540 31 Unknown 320.0 41400.0 1.55E-6 0.00594
GRB2 ENSG00000177885 2885 Unknown 29079.0 822000.0 1.57E-6 5.64E-5
KHDRBS1 ENSG00000121774 10657 Unknown 135.0 10300.0 1.55E-6 0.0458
SH2B1 ENSG00000178188 25970 Unknown 168.0 78.2 1.55E-6 0.0157
STAT3 ENSG00000168610 6774 Unknown 10644.0 313000.0 1.56E-6 2.82E-4
NCOA1 ENSG00000084676 8648 Nucleus 813.0 64700.0 1.56E-6 0.00959
RPS6KA1 ENSG00000117676 6195 Nucleus 1675.0 7420.0 1.56E-6 6.33E-4
SP1 ENSG00000185591 6667 Nucleus 1577.0 413000.0 1.56E-6 0.00757
AGRP ENSG00000159723 181 Secreted 14.0 57.0 1.54E-6 0.385
IL1B ENSG00000125538 3553 Secreted/Nucleus 2345.0 54300.0 1.56E-6 0.00173
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
FYN ENSG00000010810 2534 Cytoplasm 939.0 21700.0 2.16E-5 0.005181759
IRS1 ENSG00000169047 3667 Cytoplasm 525.0 3270.0 2.15E-5 0.006732097
PTPN11 ENSG00000179295 5781 Cytoplasm 1537.0 16400.0 2.15E-5 0.001603672
SOS1 ENSG00000115904 6654 Cytoplasm 1954.0 4650.0 2.15E-5 9.81615E-4
CFL2 ENSG00000165410 1073 Cytoplasm/Nucleus 11.0 524.0 2.09E-5 0.018181818
EIF4EBP1 ENSG00000187840 1978 Cytoplasm/Nucleus 294.0 214.0 2.13E-5 0.001671658
ELK1 ENSG00000126767 2002 Cytoplasm/Nucleus 481.0 2810.0 2.15E-5 0.003005891
ESR1 ENSG00000091831 2099 Cytoplasm/Nucleus 299.0 6490.0 2.16E-5 0.02471325
IKBKG ENSG00000269335 8517 Cytoplasm/Nucleus 595.0 27800.0 2.15E-5 0.00444784
JAK2 ENSG00000096968 3717 Cytoplasm/Nucleus 1156.0 5740.0 2.15E-5 0.002151021
MAPK1 ENSG00000100030 5594 Cytoplasm/Nucleus 3584.0 115000.0 2.18E-5 4.95738E-4
NFKB1 ENSG00000109320 4790 Cytoplasm/Nucleus 1684.0 72000.0 2.17E-5 9.77358E-4
PRKAA2 ENSG00000162409 5563 Cytoplasm/Nucleus 41.0 1330.0 2.12E-5 0.046341463
ROCK2 ENSG00000134318 9475 Cytoplasm/Nucleus 99.0 2350.0 2.14E-5 0.028035457
RPS6 ENSG00000137154 6194 Cytoplasm/Nucleus 202.0 807.0 2.13E-5 0.004679572
RPS6KB1 ENSG00000108443 6198 Cytoplasm/Nucleus 808.0 13200.0 2.16E-5 0.001852602
SOCS7 ENSG00000274211 30837 Cytoplasm/Nucleus 12.0 0.00418 2.11E-5 0.333333333
STAT1 ENSG00000115415 6772 Cytoplasm/Nucleus 1494.0 36500.0 2.17E-5 0.002204845
STAT5B ENSG00000173757 6777 Cytoplasm/Nucleus 893.0 6570.0 2.15E-5 0.004022316
AKT1 ENSG00000142208 207 Membrane 6565.0 233000.0 2.19E-5 2.13911E-4
HRAS ENSG00000174775 3265 Membrane 1733.0 25200.0 2.17E-5 0.001844377
MTOR ENSG00000198793 2475 Membrane 1113.0 11400.0 2.16E-5 0.001538392
PIK3R1 ENSG00000145675 5295 Membrane 2347.0 18200.0 2.15E-5 6.63995E-4
PIK3R2 ENSG00000105647 5296 Membrane 1499.0 14900.0 2.15E-5 0.001001112
RAF1 ENSG00000132155 5894 Membrane 1624.0 13700.0 2.15E-5 6.27525E-4
SHC1 ENSG00000160691 6464 Membrane 1636.0 9720.0 2.16E-5 0.00189094
ACACA ENSG00000278540 31 Unknown 18.0 3.17 2.11E-5 0.039215686
GRB2 ENSG00000177885 2885 Unknown 3192.0 57100.0 2.17E-5 5.90241E-4
KHDRBS1 ENSG00000121774 10657 Unknown 10.0 0.00923 2.12E-5 0.4
SH2B1 ENSG00000178188 25970 Unknown 21.0 7.05 2.12E-5 0.119047619
STAT3 ENSG00000168610 6774 Unknown 1753.0 59100.0 2.17E-5 0.001825963
NCOA1 ENSG00000084676 8648 Nucleus 8.0 0.0 2.11E-5 0.214285714
RPS6KA1 ENSG00000117676 6195 Nucleus 239.0 219.0 2.14E-5 0.00762983
SP1 ENSG00000185591 6667 Nucleus 262.0 17100.0 2.16E-5 0.031294785
AGRP ENSG00000159723 181 Secreted 3.0 0.0 2.1E-5 1.0
IL1B ENSG00000125538 3553 Secreted/Nucleus 271.0 11900.0 2.15E-5 0.00932076
Gene1 Gene2 Weight KEGG humanCyc PID BioGRID IntAct HPRD BIND Reactome CORUM DIP WikiPathways ReconX INOH SMPDB PhosphoSite PANTHER CTD NetPath TRANSFAC DrugBank
AKT1 EIF4EBP1 4
AKT1 ESR1 3
AKT1 IKBKG 5
AKT1 IRS1 3
AKT1 MTOR 11
AKT1 NFKB1 3
AKT1 RAF1 6
AKT1 RPS6KB1 6
AKT1 SP1 1
AKT1 STAT1 3
AKT1 STAT3 2
ESR1 GRB2 4
ESR1 HRAS 2
ESR1 IRS1 2
ESR1 JAK2 4
ESR1 MAPK1 3
ESR1 NCOA1 6
ESR1 PIK3R1 6
ESR1 ROCK2 2
ESR1 SHC1 4
ESR1 SOS1 3
ESR1 SP1 5
FYN AKT1 2
FYN GRB2 3
FYN HRAS 3
FYN IRS1 4
FYN JAK2 3
FYN PIK3R1 6
FYN PIK3R2 4
FYN PTPN11 5
FYN RAF1 3
FYN SHC1 7
FYN SOS1 4
FYN STAT1 3
FYN STAT3 5
FYN STAT5B 2
GRB2 AKT1 3
GRB2 HRAS 4
GRB2 IRS1 8
GRB2 JAK2 5
GRB2 MAPK1 2
GRB2 MTOR 1
GRB2 PIK3R1 9
GRB2 PIK3R2 6
GRB2 PTPN11 9
GRB2 SH2B1 3
GRB2 SHC1 13
GRB2 SOS1 12
GRB2 STAT3 1
HRAS MAPK1 3
HRAS PIK3R1 7
HRAS PIK3R2 2
HRAS RAF1 14
HRAS SOS1 7
IKBKG IRS1 2
IKBKG NFKB1 8
IKBKG STAT1 1
IKBKG STAT3 1
IKBKG STAT5B 1
IL1B AKT1 1
IL1B ELK1 1
IL1B JAK2 2
IL1B MAPK1 1
IL1B NFKB1 3
IRS1 JAK2 4
IRS1 KHDRBS1 2
IRS1 PIK3R1 11
IRS1 PIK3R2 8
IRS1 PTPN11 5
IRS1 SH2B1 4
IRS1 SHC1 7
IRS1 SOS1 6
JAK2 AKT1 2
JAK2 MAPK1 3
JAK2 NFKB1 1
JAK2 PIK3R1 8
JAK2 PIK3R2 4
JAK2 PTPN11 6
JAK2 RAF1 3
JAK2 SH2B1 5
JAK2 SHC1 7
JAK2 SOS1 3
JAK2 STAT1 11
JAK2 STAT3 11
JAK2 STAT5B 8
KHDRBS1 PIK3R1 5
MAPK1 AKT1 2
MAPK1 ELK1 9
MAPK1 IRS1 4
MAPK1 NCOA1 2
MAPK1 RAF1 5
MAPK1 RPS6KA1 10
MAPK1 RPS6KB1 5
MAPK1 SH2B1 1
MAPK1 SHC1 5
MAPK1 SOS1 5
MAPK1 SP1 3
MAPK1 STAT1 2
MAPK1 STAT3 6
MAPK1 STAT5B 3
MTOR EIF4EBP1 8
MTOR ESR1 1
MTOR IRS1 2
MTOR NFKB1 1
MTOR RPS6 2
MTOR RPS6KB1 8
MTOR STAT1 3
MTOR STAT3 4
MTOR STAT5B 1
NCOA1 NFKB1 4
PIK3R1 AKT1 6
PIK3R1 MTOR 2
PIK3R1 PIK3R2 5
PIK3R1 PTPN11 7
PIK3R1 RPS6KB1 2
PIK3R1 SHC1 8
PIK3R1 SOS1 8
PIK3R1 STAT3 4
PIK3R2 AKT1 4
PIK3R2 MTOR 1
PIK3R2 PTPN11 4
PIK3R2 RPS6KB1 1
PIK3R2 SHC1 5
PIK3R2 SOS1 4
PIK3R2 STAT3 3
PRKAA2 ACACA 4
PRKAA2 AKT1 1
PRKAA2 MTOR 2
PRKAA2 RPS6 1
PRKAA2 STAT1 1
PRKAA2 STAT5B 1
PTPN11 AKT1 2
PTPN11 MAPK1 3
PTPN11 SHC1 4
PTPN11 SOS1 5
PTPN11 STAT1 3
PTPN11 STAT5B 3
RAF1 STAT1 1
RAF1 STAT3 1
RAF1 STAT5B 1
RPS6KA1 AKT1 1
RPS6KA1 SOS1 1
RPS6KA1 STAT1 1
RPS6KA1 STAT3 1
RPS6KA1 STAT5B 1
RPS6KB1 ESR1 1
RPS6KB1 IRS1 4
RPS6KB1 RPS6 7
RPS6KB1 STAT1 2
RPS6KB1 STAT3 1
RPS6KB1 STAT5B 1
SHC1 AKT1 3
SHC1 MTOR 1
SHC1 SOS1 10
SHC1 STAT5B 3
SOCS7 JAK2 2
SOS1 AKT1 3
SOS1 MTOR 1
STAT1 STAT3 8
STAT1 STAT5B 3
STAT3 STAT5B 6
STAT5B AKT1 2
STAT5B IRS1 1
ACACA NFKB1 1
ACACA PIK3R2 1
ACACA SHC1 1
AKT1 AGRP 1
CFL2 GRB2 1
EIF4EBP1 MAPK1 2
EIF4EBP1 RPS6 1
EIF4EBP1 RPS6KB1 1
ELK1 FYN 1
ELK1 GRB2 1
ELK1 HRAS 1
ELK1 RPS6 1
ELK1 SHC1 1
ESR1 KHDRBS1 2
ESR1 NFKB1 2
ESR1 PIK3R2 1
ESR1 PRKAA2 1
ESR1 RPS6 2
ESR1 RPS6KA1 2
ESR1 SH2B1 1
ESR1 SOCS7 1
ESR1 STAT1 1
ESR1 STAT3 5
FYN IKBKG 1
FYN IL1B 1
FYN KHDRBS1 3
FYN MAPK1 1
GRB2 KHDRBS1 4
GRB2 RPS6KA1 1
GRB2 SOCS7 1
HRAS AKT1 1
HRAS MTOR 1
HRAS NFKB1 1
HRAS SP1 1
IKBKG IL1B 1
IKBKG JAK2 2
IKBKG MTOR 1
IKBKG RPS6 2
IL1B ESR1 1
IL1B PIK3R1 1
IL1B SP1 2
IRS1 HRAS 2
JAK2 HRAS 2
KHDRBS1 MAPK1 1
KHDRBS1 STAT3 5
MAPK1 NFKB1 1
MAPK1 ROCK2 1
MTOR RPS6KA1 1
MTOR SP1 2
NCOA1 STAT3 3
NFKB1 IRS1 1
NFKB1 PIK3R2 1
NFKB1 SHC1 2
NFKB1 SP1 1
NFKB1 STAT3 3
PIK3R1 NFKB1 1
PIK3R1 PRKAA2 1
PIK3R1 RPS6 2
PIK3R1 SOCS7 1
PIK3R2 PRKAA2 1
PIK3R2 SOCS7 1
PRKAA2 AGRP 1
PTPN11 HRAS 2
PTPN11 MTOR 1
PTPN11 STAT3 3
ROCK2 CFL2 1
ROCK2 SP1 1
RPS6KA1 HRAS 1
RPS6 RPS6KA1 1
SH2B1 SP1 1
SH2B1 STAT3 1
SHC1 HRAS 3
SHC1 SP1 1
SHC1 STAT3 1
SOCS7 STAT3 2
SOS1 STAT1 1
SOS1 STAT3 1
SOS1 STAT5B 1
SP1 STAT3 3
STAT1 ELK1 1
STAT1 HRAS 1
STAT1 IL1B 1
STAT1 SHC1 1
STAT1 SOCS7 1
STAT3 HRAS 1
STAT3 IL1B 1
STAT3 PRKAA2 1
STAT5B AGRP 1
STAT5B HRAS 1
STAT5B PIK3R1 1
STAT5B SOCS7 1
Pathway1 Pathway2 Intersect Similarity Scores Pathway Name Source Number of Genes Number of Interactions Detail
pathway0002712 pathway0001264 31 0.8378378 Leptin NetPath 98 1355
pathway0002712 pathway0000658 25 0.6756757 EGFR1 NetPath 475 10010
pathway0002712 pathway0001727 25 0.6756757 Prolactin NetPath 105 1733
pathway0002712 pathway0002880 4 0.6666667 Hs_Insulin_signalling_in_adipocytes_(diabetic_condition)_WP3635_86059 WikiPathways 6 9
pathway0002712 pathway0002881 4 0.6666667 Hs_Insulin_signalling_in_adipocytes_(normal_condition)_WP3634_86060 WikiPathways 6 9
pathway0002712 pathway0002721 3 0.6 Hs_Target_Of_Rapamycin_(TOR)_Signaling_WP1471_90258 WikiPathways 5 11
pathway0002712 pathway0002718 10 0.5882353 Hs_Interleukin-11_Signaling_Pathway_WP2332_79525 WikiPathways 17 80
pathway0002712 pathway0002869 11 0.5789474 Hs_Alpha_6_Beta_4_signaling_pathway_WP244_85199 WikiPathways 19 136
pathway0002712 pathway0002079 4 0.5714286 SOS-mediated signalling Reactome 7 21
pathway0002712 pathway0001120 21 0.5675676 IL2 NetPath 81 1364
pathway0002712 pathway0001246 21 0.5675676 KitReceptor NetPath 104 1591
pathway0002712 pathway0000655 5 0.5555556 EGFR-dependent Endothelin signaling events PID 9 30
pathway0002712 pathway0002022 6 0.5454545 Signaling by Leptin Reactome 11 48
pathway0002712 pathway0000270 19 0.5135135 BCR NetPath 161 2850
pathway0002712 pathway0000688 6 0.5 EPO signaling pathway(JAK2 STAT1 STAT3 STAT5) ( EPO signaling pathway(JAK2 STAT1 STAT3 STAT5) ) INOH 12 59
pathway0002712 pathway0000700 3 0.5 ERK cascade ( EGF signaling pathway Diagram ) INOH 6 15
pathway0002712 pathway0000708 3 0.5 ERK cascade ( HGF signaling pathway ) INOH 6 15
pathway0002712 pathway0000714 3 0.5 ERK cascade ( VEGF signaling pathway ) INOH 6 15
pathway0002712 pathway0001995 4 0.5 SHC1 events in EGFR signaling Reactome 8 29
pathway0002712 pathway0002003 5 0.5 Signal attenuation Reactome 10 45