Pathway ID Pathway Name Source Organism Number of Genes Number of Interactions
pathway0002717 Hs_Hepatitis_C_and_Hepatocellular_Carcinoma_WP3646_88640 WikiPathways Homo sapiens 36 226
Secreted
Membrane
Cytoplasm
Cytoplasm/4
Cytoskeleton
Cytoskeleton/Cytoplasm
Membrane/Nucleus
Cytoplasm/Nucleus
Cytoskeleton/Nucleus
Nucleus
Secreted/Nucleus
Unknown
Annotated genes
Unannotated genes
Symbol
Ensembl ID
Entrez ID
Subcellular localization
Description
Type
Edge
Symbol Ensembl ID Entrez ID Subcellular localization Closeness Degree Betweenness Transitivity
BIRC3 ENSG00000023445 330 Cytoplasm 0.01428571 10.0 2.617876 0.28888889
JAK1 ENSG00000162434 3716 Cytoplasm 0.01923077 57.0 13.56081 0.05451128
PTPN11 ENSG00000179295 5781 Cytoplasm 0.01639344 49.0 2.618917 0.04591837
RAC1 ENSG00000136238 5879 Cytoplasm 0.01818182 52.0 11.48634 0.04901961
SOS1 ENSG00000115904 6654 Cytoplasm 0.01818182 69.0 5.050583 0.03026428
UCHL1 ENSG00000154277 7345 Cytoplasm 0.01388889 4.0 0.0 0.5
CASP9 ENSG00000132906 842 Cytoplasm/Nucleus 0.01587302 24.0 5.045549 0.04710145
CDKN1A ENSG00000124762 1026 Cytoplasm/Nucleus 0.01639344 44.0 1.786194 0.0422833
HIF1A ENSG00000100644 3091 Cytoplasm/Nucleus 0.01754386 29.0 4.44437 0.13546798
JUN ENSG00000177606 3725 Cytoplasm/Nucleus 0.02173913 67.0 57.69249 0.05246495
MAPK3 ENSG00000102882 5595 Cytoplasm/Nucleus 0.02083333 73.0 65.33902 0.03843227
MAPK8 ENSG00000107643 5599 Cytoplasm/Nucleus 0.01694915 47.0 2.538729 0.03792784
MYC ENSG00000136997 4609 Cytoplasm/Nucleus 0.02040816 44.0 44.71695 0.09408034
PLCG1 ENSG00000124181 5335 Cytoplasm/Nucleus 0.01612903 35.0 10.68552 0.05714286
RRM2 ENSG00000171848 6241 Cytoplasm/Nucleus 0.01408451 7.0 0.08807709 0.61904762
TP53 ENSG00000141510 7157 Cytoplasm/Nucleus 0.01960784 59.0 30.69158 0.04441847
VAV2 ENSG00000160293 7410 Cytoplasm/Nucleus 0.01612903 32.0 3.358203 0.0625
AKT1 ENSG00000142208 207 Membrane 0.02222222 97.0 77.57534 0.0294244
CD44 ENSG00000026508 960 Membrane 0.01666667 14.0 11.31845 0.23076923
CXCR1 ENSG00000163464 3577 Membrane 0.01492537 14.0 0.7266979 0.28571429
IL6R ENSG00000160712 3570 Membrane 0.01515152 24.0 0.3008009 0.11231884
TGFBR1 ENSG00000106799 7046 Membrane 0.01587302 24.0 4.755742 0.08333333
BIRC5 ENSG00000089685 332 Unknown 0.01587302 12.0 0.9930142 0.37878788
BRCA1 ENSG00000012048 672 Unknown 0.01724138 21.0 0.5076236 0.23809524
CTTN ENSG00000085733 2017 Unknown 0.01388889 6.0 0.1696671 0.26666667
CXCL8 ENSG00000169429 3576 Unknown 0.01612903 16.0 2.846478 0.2
GRB2 ENSG00000177885 2885 Unknown 0.01851852 88.0 14.74435 0.02063741
MIR34A ENSG00000207865 407040 Unknown 0.01333333 4.0 1.472814 0.33333333
MYOF ENSG00000138119 26509 Unknown 0.01388889 5.0 1.799693 0.1
STAT3 ENSG00000168610 6774 Unknown 0.0212766 71.0 33.65278 0.04828974
E2F2 ENSG00000007968 1870 Nucleus 0.01785714 17.0 5.754437 0.41911765
CFB ENSG00000243649 629 Secreted 0.01265823 2.0 0.01041667 0.0
IL6 ENSG00000136244 3569 Secreted 0.01754386 34.0 4.160308 0.11229947
MMP1 ENSG00000196611 4312 Secreted 0.01538462 9.0 0.5632969 0.22222222
TGFB1 ENSG00000105329 7040 Secreted 0.01694915 33.0 7.708142 0.07575758
VEGFA ENSG00000112715 7422 Secreted 0.01851852 37.0 23.21873 0.1006006
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
BIRC3 ENSG00000023445 330 Cytoplasm 1481.0 25300.0 1.56E-6 0.00403
JAK1 ENSG00000162434 3716 Cytoplasm 8612.0 95400.0 1.56E-6 2.71E-4
PTPN11 ENSG00000179295 5781 Cytoplasm 9733.0 167000.0 1.56E-6 2.5E-4
RAC1 ENSG00000136238 5879 Cytoplasm 14443.0 874000.0 1.56E-6 1.69E-4
SOS1 ENSG00000115904 6654 Cytoplasm 23511.0 177000.0 1.56E-6 6.54E-5
UCHL1 ENSG00000154277 7345 Cytoplasm 16.0 5.44 1.55E-6 0.175
CASP9 ENSG00000132906 842 Cytoplasm/Nucleus 2323.0 28000.0 1.55E-6 2.13E-4
CDKN1A ENSG00000124762 1026 Cytoplasm/Nucleus 3911.0 109000.0 1.56E-6 8.1E-4
HIF1A ENSG00000100644 3091 Cytoplasm/Nucleus 971.0 114000.0 1.56E-6 0.00577
JUN ENSG00000177606 3725 Cytoplasm/Nucleus 12667.0 3720000.0 1.57E-6 4.67E-4
MAPK3 ENSG00000102882 5595 Cytoplasm/Nucleus 29207.0 850000.0 1.56E-6 3.17E-5
MAPK8 ENSG00000107643 5599 Cytoplasm/Nucleus 11158.0 360000.0 1.56E-6 1.42E-4
MYC ENSG00000136997 4609 Cytoplasm/Nucleus 4967.0 1640000.0 1.57E-6 0.00195
PLCG1 ENSG00000124181 5335 Cytoplasm/Nucleus 11809.0 263000.0 1.56E-6 2.37E-4
RRM2 ENSG00000171848 6241 Cytoplasm/Nucleus 1369.0 47700.0 1.55E-6 6.54E-4
TP53 ENSG00000141510 7157 Cytoplasm/Nucleus 8418.0 2450000.0 1.57E-6 7.36E-4
VAV2 ENSG00000160293 7410 Cytoplasm/Nucleus 3851.0 27300.0 1.56E-6 0.00136
AKT1 ENSG00000142208 207 Membrane 52751.0 2150000.0 1.57E-6 1.74E-5
CD44 ENSG00000026508 960 Membrane 658.0 66200.0 1.56E-6 0.0285
CXCR1 ENSG00000163464 3577 Membrane 2282.0 71700.0 1.55E-6 0.00323
IL6R ENSG00000160712 3570 Membrane 796.0 333.0 1.55E-6 0.015
TGFBR1 ENSG00000106799 7046 Membrane 2531.0 39000.0 1.56E-6 0.00147
BIRC5 ENSG00000089685 332 Unknown 834.0 23900.0 1.56E-6 0.0182
BRCA1 ENSG00000012048 672 Unknown 3825.0 180000.0 1.56E-6 0.00194
CTTN ENSG00000085733 2017 Unknown 262.0 621.0 1.55E-6 0.0156
CXCL8 ENSG00000169429 3576 Unknown 1129.0 129000.0 1.56E-6 0.0124
GRB2 ENSG00000177885 2885 Unknown 29079.0 822000.0 1.57E-6 5.64E-5
MIR34A ENSG00000207865 407040 Unknown 5.0 50.9 1.54E-6 0.2
MYOF ENSG00000138119 26509 Unknown 14.0 25.4 1.55E-6 0.132
STAT3 ENSG00000168610 6774 Unknown 10644.0 313000.0 1.56E-6 2.82E-4
E2F2 ENSG00000007968 1870 Nucleus 895.0 5110.0 1.56E-6 0.00857
CFB ENSG00000243649 629 Secreted 76.0 2600.0 1.54E-6 0.0151
IL6 ENSG00000136244 3569 Secreted 1764.0 36100.0 1.56E-6 0.00384
MMP1 ENSG00000196611 4312 Secreted 247.0 51600.0 1.56E-6 0.0207
TGFB1 ENSG00000105329 7040 Secreted 2432.0 180000.0 1.56E-6 0.00178
VEGFA ENSG00000112715 7422 Secreted 2210.0 75200.0 1.56E-6 0.00294
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
BIRC3 ENSG00000023445 330 Cytoplasm 189.0 4670.0 2.15E-5 0.028031071
JAK1 ENSG00000162434 3716 Cytoplasm 1248.0 8450.0 2.15E-5 0.002257983
PTPN11 ENSG00000179295 5781 Cytoplasm 1537.0 16400.0 2.15E-5 0.001603672
RAC1 ENSG00000136238 5879 Cytoplasm 1094.0 29000.0 2.16E-5 0.003408762
SOS1 ENSG00000115904 6654 Cytoplasm 1954.0 4650.0 2.15E-5 9.81615E-4
UCHL1 ENSG00000154277 7345 Cytoplasm 4.0 0.0 2.12E-5 0.5
CASP9 ENSG00000132906 842 Cytoplasm/Nucleus 360.0 6670.0 2.14E-5 0.003203343
CDKN1A ENSG00000124762 1026 Cytoplasm/Nucleus 647.0 16600.0 2.16E-5 0.003363942
HIF1A ENSG00000100644 3091 Cytoplasm/Nucleus 63.0 159.0 2.14E-5 0.077316948
JUN ENSG00000177606 3725 Cytoplasm/Nucleus 1533.0 157000.0 2.18E-5 0.002673984
MAPK3 ENSG00000102882 5595 Cytoplasm/Nucleus 1631.0 42300.0 2.17E-5 0.001551233
MAPK8 ENSG00000107643 5599 Cytoplasm/Nucleus 1392.0 35600.0 2.17E-5 0.001997653
MYC ENSG00000136997 4609 Cytoplasm/Nucleus 604.0 90500.0 2.17E-5 0.009110079
PLCG1 ENSG00000124181 5335 Cytoplasm/Nucleus 752.0 6800.0 2.15E-5 0.005223532
RRM2 ENSG00000171848 6241 Cytoplasm/Nucleus 7.0 0.131 2.12E-5 0.619047619
TP53 ENSG00000141510 7157 Cytoplasm/Nucleus 1691.0 145000.0 2.18E-5 0.001606136
VAV2 ENSG00000160293 7410 Cytoplasm/Nucleus 316.0 1020.0 2.13E-5 0.017821981
AKT1 ENSG00000142208 207 Membrane 6565.0 233000.0 2.19E-5 2.13911E-4
CD44 ENSG00000026508 960 Membrane 32.0 489.0 2.13E-5 0.102822581
CXCR1 ENSG00000163464 3577 Membrane 14.0 2.22 2.11E-5 0.285714286
IL6R ENSG00000160712 3570 Membrane 32.0 2.48 2.11E-5 0.084677419
TGFBR1 ENSG00000106799 7046 Membrane 166.0 2980.0 2.15E-5 0.025118656
BIRC5 ENSG00000089685 332 Unknown 38.0 70.0 2.14E-5 0.122332859
BRCA1 ENSG00000012048 672 Unknown 687.0 10700.0 2.16E-5 0.004922743
CTTN ENSG00000085733 2017 Unknown 6.0 0.202 2.11E-5 0.266666667
CXCL8 ENSG00000169429 3576 Unknown 28.0 566.0 2.12E-5 0.097883598
GRB2 ENSG00000177885 2885 Unknown 3192.0 57100.0 2.17E-5 5.90241E-4
MIR34A ENSG00000207865 407040 Unknown 5.0 72.2 2.09E-5 0.2
MYOF ENSG00000138119 26509 Unknown 5.0 12.3 2.1E-5 0.1
STAT3 ENSG00000168610 6774 Unknown 1753.0 59100.0 2.17E-5 0.001825963
E2F2 ENSG00000007968 1870 Nucleus 17.0 7.92 2.13E-5 0.419117647
CFB ENSG00000243649 629 Secreted 10.0 1150.0 2.09E-5 0.0
IL6 ENSG00000136244 3569 Secreted 163.0 6750.0 2.14E-5 0.011436795
MMP1 ENSG00000196611 4312 Secreted 40.0 621.0 2.14E-5 0.128205128
TGFB1 ENSG00000105329 7040 Secreted 116.0 13700.0 2.15E-5 0.035082459
VEGFA ENSG00000112715 7422 Secreted 244.0 7400.0 2.15E-5 0.025399717
Gene1 Gene2 Weight KEGG humanCyc PID BioGRID IntAct HPRD BIND Reactome CORUM DIP WikiPathways ReconX INOH SMPDB PhosphoSite PANTHER CTD NetPath TRANSFAC DrugBank
AKT1 BIRC5 2
AKT1 BRCA1 5
AKT1 CASP9 7
AKT1 CDKN1A 9
AKT1 E2F2 2
AKT1 PLCG1 4
AKT1 RAC1 5
AKT1 STAT3 2
AKT1 TP53 4
BIRC3 CASP9 6
BIRC5 CASP9 4
BRCA1 TP53 8
CD44 VAV2 3
CDKN1A JUN 3
CDKN1A STAT3 4
CXCL8 AKT1 1
CXCL8 CXCR1 9
CXCL8 JUN 4
CXCL8 MAPK3 1
E2F2 MYC 2
GRB2 AKT1 3
GRB2 JAK1 5
GRB2 PLCG1 7
GRB2 PTPN11 9
GRB2 RAC1 2
GRB2 SOS1 12
GRB2 STAT3 1
GRB2 VAV2 6
HIF1A STAT3 4
HIF1A TP53 4
HIF1A VEGFA 8
IL6 AKT1 1
IL6 IL6R 12
IL6 JAK1 4
IL6 PTPN11 2
IL6R JAK1 6
IL6R PTPN11 2
IL6R STAT3 5
IL6 STAT3 3
JAK1 AKT1 4
JAK1 MAPK3 2
JAK1 PTPN11 7
JAK1 SOS1 2
JAK1 STAT3 11
JUN IL6 3
JUN MMP1 5
JUN MYC 4
JUN TGFB1 2
JUN TP53 4
JUN VEGFA 3
MAPK3 AKT1 1
MAPK3 CTTN 1
MAPK3 JUN 4
MAPK3 MYC 6
MAPK3 PTPN11 4
MAPK3 RAC1 2
MAPK3 SOS1 2
MAPK3 STAT3 5
MAPK3 TP53 3
MAPK8 JUN 9
MAPK8 MYC 4
MAPK8 STAT3 6
MAPK8 TP53 7
MYC TP53 6
MYOF VEGFA 2
PLCG1 PTPN11 4
PLCG1 RAC1 3
PLCG1 SOS1 7
PLCG1 VAV2 4
PTPN11 AKT1 2
PTPN11 SOS1 5
PTPN11 VAV2 4
RAC1 CTTN 1
RAC1 MAPK8 5
RAC1 STAT3 4
SOS1 AKT1 3
SOS1 RAC1 2
SOS1 VAV2 3
STAT3 MYC 2
STAT3 VEGFA 2
TGFB1 AKT1 1
TGFB1 CDKN1A 2
TGFB1 MAPK3 2
TGFB1 STAT3 1
TGFB1 TGFBR1 13
TGFB1 TP53 3
TGFB1 VEGFA 1
TGFBR1 STAT3 1
TP53 CDKN1A 6
VAV2 RAC1 5
VEGFA AKT1 2
VEGFA MAPK3 1
VEGFA PLCG1 3
VEGFA VAV2 1
AKT1 HIF1A 1
AKT1 JUN 1
AKT1 MAPK8 2
AKT1 MYC 1
AKT1 TGFBR1 2
AKT1 UCHL1 2
BIRC3 BIRC5 1
BIRC3 E2F2 1
BIRC3 JUN 1
BIRC3 MYC 1
BIRC3 TP53 1
BIRC5 E2F2 1
BIRC5 JUN 1
BIRC5 STAT3 1
BIRC5 TGFBR1 2
BRCA1 CASP9 1
BRCA1 CDKN1A 1
BRCA1 E2F2 1
BRCA1 HIF1A 1
BRCA1 JAK1 3
BRCA1 JUN 5
BRCA1 MAPK3 1
BRCA1 MAPK8 2
BRCA1 MYC 5
BRCA1 STAT3 1
CASP9 JUN 1
CASP9 MAPK3 2
CASP9 TGFB1 2
CD44 CTTN 1
CD44 E2F2 1
CD44 JUN 1
CD44 MMP1 1
CD44 MYC 1
CD44 RAC1 1
CD44 STAT3 1
CD44 TGFBR1 3
CD44 TP53 1
CDKN1A E2F2 2
CDKN1A HIF1A 1
CDKN1A MAPK8 2
CFB MAPK3 1
CTTN GRB2 3
CXCL8 CDKN1A 1
CXCL8 IL6 1
CXCL8 IL6R 2
CXCL8 JAK1 1
CXCL8 SOS1 1
CXCR1 GRB2 1
CXCR1 IL6 2
CXCR1 IL6R 1
CXCR1 JAK1 1
CXCR1 SOS1 1
CXCR1 STAT3 1
CXCR1 TGFB1 1
CXCR1 VEGFA 1
E2F2 GRB2 2
E2F2 HIF1A 1
E2F2 JAK1 1
E2F2 JUN 1
E2F2 MMP1 1
E2F2 RRM2 1
E2F2 STAT3 1
E2F2 TP53 1
GRB2 JUN 1
GRB2 TP53 2
HIF1A JUN 3
HIF1A RRM2 1
HIF1A TGFBR1 2
IL6 GRB2 1
IL6 MAPK3 2
IL6R GRB2 1
IL6R MAPK3 1
IL6R SOS1 2
IL6 SOS1 2
IL6 VEGFA 1
JAK1 JUN 1
JAK1 MYC 1
JAK1 PLCG1 1
JAK1 RAC1 1
JAK1 VAV2 1
JUN MYOF 1
JUN RAC1 1
JUN RRM2 1
JUN STAT3 5
MAPK3 GRB2 1
MAPK3 HIF1A 1
MAPK3 MAPK8 1
MAPK3 MMP1 1
MAPK8 JAK1 1
MIR34A BIRC3 1
MIR34A CD44 1
MIR34A MYOF 1
MMP1 MYC 1
MYC BIRC5 1
MYC CDKN1A 1
MYC HIF1A 1
MYC MIR34A 1
MYC RRM2 1
MYC TGFBR1 3
MYC UCHL1 1
MYC VEGFA 1
PLCG1 CFB 1
PLCG1 MMP1 1
PLCG1 STAT3 1
PTPN11 RAC1 2
PTPN11 STAT3 3
RAC1 TP53 2
RRM2 TGFBR1 2
RRM2 TP53 4
SOS1 MYC 1
SOS1 STAT3 1
TGFB1 HIF1A 1
TGFB1 IL6 1
TGFBR1 TP53 2
TP53 BIRC5 2
TP53 IL6 1
UCHL1 TP53 1
VAV2 AKT1 1
VAV2 MAPK8 1
VEGFA GRB2 2
VEGFA PTPN11 1
VEGFA RAC1 1
VEGFA SOS1 1
Pathway1 Pathway2 Intersect Similarity Scores Pathway Name Source Number of Genes Number of Interactions Detail
pathway0002717 pathway0001111 4 0.6666667 IL-6 signaling pathway(JAK1 JAK2 STAT3) ( IL-6 signaling(JAK1 JAK2 STAT3) ) INOH 6 19
pathway0002717 pathway0002656 23 0.6388889 Pathways in cancer KEGG 321 8293
pathway0002717 pathway0001321 5 0.5 MAPK3 (ERK1) activation Reactome 10 41