Pathway ID Pathway Name Source Organism Number of Genes Number of Interactions
pathway0002725 Hs_Endochondral_Ossification_WP474_87977 WikiPathways Homo sapiens 43 117
Secreted
Membrane
Cytoplasm
Cytoplasm/4
Cytoskeleton
Cytoskeleton/Cytoplasm
Membrane/Nucleus
Cytoplasm/Nucleus
Cytoskeleton/Nucleus
Nucleus
Secreted/Nucleus
Unknown
Annotated genes
Unannotated genes
Symbol
Ensembl ID
Entrez ID
Subcellular localization
Description
Type
Edge
Symbol Ensembl ID Entrez ID Subcellular localization Closeness Degree Betweenness Transitivity
BMP6 ENSG00000153162 654 Cytoplasm 0.01 3.0 1.208333 0.666666667
CHST11 ENSG00000171310 50515 Cytoplasm 0.007936508 1.0 0.0 0.0
DIABLO ENSG00000184047 56616 Cytoplasm 0.008403361 3.0 0.0 0.333333333
IFT88 ENSG00000032742 8100 Cytoplasm 0.00952381 4.0 0.0 0.5
KIF3A ENSG00000131437 11127 Cytoplasm 0.00952381 4.0 0.0 0.5
SERPINB2 ENSG00000197632 5055 Cytoplasm 0.007874016 1.0 0.0 0.0
ALOX15B ENSG00000179593 247 Cytoplasm/Nucleus 0.008547009 3.0 3.439957 0.333333333
CRADD ENSG00000169372 8738 Cytoplasm/Nucleus 0.010416667 4.0 15.38789 0.0
E2F1 ENSG00000101412 1869 Cytoplasm/Nucleus 0.011235955 12.0 46.66798 0.121212121
FOXO3 ENSG00000118689 2309 Cytoplasm/Nucleus 0.010526316 11.0 14.78121 0.018181818
GLI3 ENSG00000106571 2737 Cytoplasm/Nucleus 0.010416667 14.0 23.04247 0.054945055
HDAC4 ENSG00000068024 9759 Cytoplasm/Nucleus 0.009803922 7.0 5.530066 0.095238095
PRKCQ ENSG00000065675 5588 Cytoplasm/Nucleus 0.009009009 9.0 6.078448 0.027777778
SRPK1 ENSG00000096063 6732 Cytoplasm/Nucleus 0.010204082 3.0 41.38595 0.0
STAT1 ENSG00000115415 6772 Cytoplasm/Nucleus 0.012048193 24.0 67.35456 0.032608696
DDR2 ENSG00000162733 4921 Membrane 0.008 2.0 0.0 1.0
FRZB ENSG00000162998 2487 Membrane 0.007194245 1.0 0.0 0.0
GJB3 ENSG00000188910 2707 Membrane 0.007633588 1.0 0.0 0.0
IGF1R ENSG00000140443 3480 Membrane 0.011904762 16.0 44.07999 0.125
PTCH1 ENSG00000185920 5727 Membrane 0.009708738 16.0 25.38933 0.008333333
PTH1R ENSG00000160801 5745 Membrane 0.010204082 5.0 8.873322 0.0
ADRA1A ENSG00000120907 148 Unknown 0.007936508 1.0 0.0 0.0
FGFR3 ENSG00000068078 2261 Unknown 0.009803922 23.0 15.51502 0.035573123
GABBR1 ENSG00000204681 2550 Unknown 0.014925373 18.0 267.6992 0.098039216
MAPK14 ENSG00000112062 1432 Unknown 0.011627907 21.0 89.20469 0.023809524
PIK3R3 ENSG00000117461 8503 Unknown 0.012048193 16.0 53.50581 0.125
RUNX2 ENSG00000124813 860 Unknown 0.012987013 13.0 107.2858 0.141025641
SOX6 ENSG00000110693 55553 Unknown 0.009433962 4.0 1.103704 0.333333333
GATA3 ENSG00000107485 2625 Nucleus 0.011764706 9.0 57.69773 0.138888889
MEF2C ENSG00000081189 4208 Nucleus 0.010416667 10.0 9.915575 0.044444444
NKX3-2 ENSG00000109705 579 Nucleus 0.008474576 1.0 0.0 0.0
SOX5 ENSG00000134532 6660 Nucleus 0.011235955 9.0 25.31251 0.138888889
THRA ENSG00000126351 7067 Nucleus 0.011111111 6.0 44.20893 0.333333333
TWIST1 ENSG00000122691 7291 Nucleus 0.011764706 10.0 64.38993 0.155555556
COL10A1 ENSG00000123500 1300 Secreted 0.011111111 6.0 18.64367 0.4
COL2A1 ENSG00000139219 1280 Secreted 0.011627907 10.0 47.25047 0.2
CST5 ENSG00000170367 1473 Secreted 0.01010101 3.0 2.586463 0.0
FGF18 ENSG00000156427 8817 Secreted 0.00952381 14.0 0.4082687 0.098901099
FGF2 ENSG00000138685 2247 Secreted 0.011235955 16.0 41.06054 0.1
IHH ENSG00000163501 3549 Secreted 0.011627907 11.0 72.37239 0.036363636
MMP13 ENSG00000137745 4322 Secreted 0.00952381 4.0 2.253023 0.333333333
PTH ENSG00000152266 5741 Secreted 0.00952381 5.0 4.43216 0.0
VEGFA ENSG00000112715 7422 Secreted 0.011363636 12.0 24.93462 0.227272727
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
BMP6 ENSG00000153162 654 Cytoplasm 590.0 5200.0 1.55E-6 0.011274496
CHST11 ENSG00000171310 50515 Cytoplasm 45.0 5440.0 1.53E-6 0.103030303
DIABLO ENSG00000184047 56616 Cytoplasm 156.0 106.0 1.55E-6 0.009594706
IFT88 ENSG00000032742 8100 Cytoplasm 73.0 3080.0 1.54E-6 0.271689498
KIF3A ENSG00000131437 11127 Cytoplasm 154.0 20900.0 1.54E-6 0.113318055
SERPINB2 ENSG00000197632 5055 Cytoplasm 30.0 4520.0 1.54E-6 0.027586207
ALOX15B ENSG00000179593 247 Cytoplasm/Nucleus 377.0 2940.0 1.54E-6 0.002271573
CRADD ENSG00000169372 8738 Cytoplasm/Nucleus 196.0 899.0 1.55E-6 0.015855573
E2F1 ENSG00000101412 1869 Cytoplasm/Nucleus 2673.0 379000.0 1.56E-6 0.003714233
FOXO3 ENSG00000118689 2309 Cytoplasm/Nucleus 1569.0 45500.0 1.56E-6 0.002198202
GLI3 ENSG00000106571 2737 Cytoplasm/Nucleus 1107.0 62300.0 1.55E-6 0.003503923
HDAC4 ENSG00000068024 9759 Cytoplasm/Nucleus 367.0 13300.0 1.56E-6 0.020502971
PRKCQ ENSG00000065675 5588 Cytoplasm/Nucleus 2613.0 50700.0 1.56E-6 0.002681844
SRPK1 ENSG00000096063 6732 Cytoplasm/Nucleus 3.0 8.12 1.54E-6 0.0
STAT1 ENSG00000115415 6772 Cytoplasm/Nucleus 9900.0 278000.0 1.56E-6 2.89632E-4
DDR2 ENSG00000162733 4921 Membrane 2.0 0.0 1.53E-6 1.0
FRZB ENSG00000162998 2487 Membrane 311.0 122.0 1.54E-6 5.18618E-4
GJB3 ENSG00000188910 2707 Membrane 1.0 0.0 1.52E-6 0.0
IGF1R ENSG00000140443 3480 Membrane 2050.0 25200.0 1.56E-6 0.002012165
PTCH1 ENSG00000185920 5727 Membrane 542.0 10600.0 1.55E-6 0.001173173
PTH1R ENSG00000160801 5745 Membrane 43.0 770.0 1.55E-6 0.274640089
ADRA1A ENSG00000120907 148 Unknown 102.0 223.0 1.54E-6 0.057658707
FGFR3 ENSG00000068078 2261 Unknown 3427.0 7000.0 1.56E-6 0.001266002
GABBR1 ENSG00000204681 2550 Unknown 125.0 21400.0 1.55E-6 0.067225807
MAPK14 ENSG00000112062 1432 Unknown 9287.0 427000.0 1.56E-6 2.56589E-4
PIK3R3 ENSG00000117461 8503 Unknown 10628.0 40100.0 1.56E-6 1.93884E-4
RUNX2 ENSG00000124813 860 Unknown 207.0 22300.0 1.56E-6 0.041180057
SOX6 ENSG00000110693 55553 Unknown 10.0 4.44 1.54E-6 0.311111111
GATA3 ENSG00000107485 2625 Nucleus 107.0 9400.0 1.55E-6 0.046023629
MEF2C ENSG00000081189 4208 Nucleus 316.0 28200.0 1.55E-6 0.009222423
NKX3-2 ENSG00000109705 579 Nucleus 1.0 0.0 1.53E-6 0.0
SOX5 ENSG00000134532 6660 Nucleus 21.0 145.0 1.55E-6 0.128571429
THRA ENSG00000126351 7067 Nucleus 37.0 11400.0 1.55E-6 0.097597598
TWIST1 ENSG00000122691 7291 Nucleus 31.0 927.0 1.55E-6 0.16344086
COL10A1 ENSG00000123500 1300 Secreted 254.0 5670.0 1.55E-6 0.194422832
COL2A1 ENSG00000139219 1280 Secreted 772.0 39400.0 1.55E-6 0.022291217
CST5 ENSG00000170367 1473 Secreted 3.0 0.0508 1.54E-6 0.0
FGF18 ENSG00000156427 8817 Secreted 2802.0 2980.0 1.55E-6 0.001579175
FGF2 ENSG00000138685 2247 Secreted 3268.0 46500.0 1.56E-6 0.001404573
IHH ENSG00000163501 3549 Secreted 400.0 15400.0 1.54E-6 0.002694236
MMP13 ENSG00000137745 4322 Secreted 70.0 2520.0 1.55E-6 0.049275362
PTH ENSG00000152266 5741 Secreted 37.0 1560.0 1.55E-6 0.280780781
VEGFA ENSG00000112715 7422 Secreted 2210.0 75200.0 1.56E-6 0.002944761
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
BMP6 ENSG00000153162 654 Cytoplasm 3.0 4.3 2.03E-5 0.666666667
CHST11 ENSG00000171310 50515 Cytoplasm 1.0 0.0 2.02E-5 0.0
DIABLO ENSG00000184047 56616 Cytoplasm 43.0 159.0 2.11E-5 0.049833887
IFT88 ENSG00000032742 8100 Cytoplasm 4.0 0.0 2.02E-5 0.5
KIF3A ENSG00000131437 11127 Cytoplasm 4.0 0.0 2.02E-5 0.5
SERPINB2 ENSG00000197632 5055 Cytoplasm 10.0 300.0 2.08E-5 0.066666667
ALOX15B ENSG00000179593 247 Cytoplasm/Nucleus 5.0 60.7 2.07E-5 0.1
CRADD ENSG00000169372 8738 Cytoplasm/Nucleus 38.0 640.0 2.1E-5 0.102418208
E2F1 ENSG00000101412 1869 Cytoplasm/Nucleus 575.0 28000.0 2.16E-5 0.007586729
FOXO3 ENSG00000118689 2309 Cytoplasm/Nucleus 235.0 9480.0 2.15E-5 0.012220404
GLI3 ENSG00000106571 2737 Cytoplasm/Nucleus 14.0 303.0 2.04E-5 0.054945055
HDAC4 ENSG00000068024 9759 Cytoplasm/Nucleus 20.0 71.6 2.12E-5 0.105263158
PRKCQ ENSG00000065675 5588 Cytoplasm/Nucleus 120.0 1860.0 2.13E-5 0.049019608
SRPK1 ENSG00000096063 6732 Cytoplasm/Nucleus 3.0 1880.0 2.09E-5 0.0
STAT1 ENSG00000115415 6772 Cytoplasm/Nucleus 1494.0 36500.0 2.17E-5 0.002204845
DDR2 ENSG00000162733 4921 Membrane 2.0 0.0 2.03E-5 1.0
FRZB ENSG00000162998 2487 Membrane 1.0 0.0 2.01E-5 0.0
GJB3 ENSG00000188910 2707 Membrane 1.0 0.0 2.01E-5 0.0
IGF1R ENSG00000140443 3480 Membrane 104.0 3510.0 2.14E-5 0.021284541
PTCH1 ENSG00000185920 5727 Membrane 22.0 1990.0 2.1E-5 0.017316017
PTH1R ENSG00000160801 5745 Membrane 8.0 260.0 2.1E-5 0.0
ADRA1A ENSG00000120907 148 Unknown 1.0 0.0 2.03E-5 0.0
FGFR3 ENSG00000068078 2261 Unknown 41.0 855.0 2.12E-5 0.058536585
GABBR1 ENSG00000204681 2550 Unknown 18.0 4580.0 2.1E-5 0.098039216
MAPK14 ENSG00000112062 1432 Unknown 1219.0 74200.0 2.17E-5 0.002559367
PIK3R3 ENSG00000117461 8503 Unknown 16.0 251.0 2.1E-5 0.125
RUNX2 ENSG00000124813 860 Unknown 33.0 5010.0 2.12E-5 0.073863636
SOX6 ENSG00000110693 55553 Unknown 4.0 5.78 2.08E-5 0.333333333
GATA3 ENSG00000107485 2625 Nucleus 11.0 3460.0 2.1E-5 0.109090909
MEF2C ENSG00000081189 4208 Nucleus 60.0 4300.0 2.13E-5 0.032768362
NKX3-2 ENSG00000109705 579 Nucleus 1.0 0.0 2.04E-5 0.0
SOX5 ENSG00000134532 6660 Nucleus 21.0 758.0 2.12E-5 0.1
THRA ENSG00000126351 7067 Nucleus 8.0 1930.0 2.08E-5 0.178571429
TWIST1 ENSG00000122691 7291 Nucleus 15.0 3170.0 2.11E-5 0.104761905
COL10A1 ENSG00000123500 1300 Secreted 8.0 394.0 2.08E-5 0.214285714
COL2A1 ENSG00000139219 1280 Secreted 36.0 6930.0 2.11E-5 0.026984127
CST5 ENSG00000170367 1473 Secreted 3.0 2.15 2.06E-5 0.0
FGF18 ENSG00000156427 8817 Secreted 14.0 0.295 2.08E-5 0.098901099
FGF2 ENSG00000138685 2247 Secreted 54.0 3160.0 2.13E-5 0.046121593
IHH ENSG00000163501 3549 Secreted 12.0 103.0 2.07E-5 0.03030303
MMP13 ENSG00000137745 4322 Secreted 7.0 109.0 2.09E-5 0.19047619
PTH ENSG00000152266 5741 Secreted 9.0 2000.0 2.1E-5 0.0
VEGFA ENSG00000112715 7422 Secreted 244.0 7400.0 2.15E-5 0.025399717
Gene1 Gene2 Weight KEGG humanCyc PID BioGRID IntAct HPRD BIND Reactome CORUM DIP WikiPathways ReconX INOH SMPDB PhosphoSite PANTHER CTD NetPath TRANSFAC DrugBank
COL2A1 MMP13 2
DIABLO IGF1R 1
E2F1 FOXO3 2
E2F1 PIK3R3 2
FGF18 FGF2 2
FGF18 FGFR3 8
FGF2 FGFR3 5
FGF2 MAPK14 1
FGFR3 STAT1 5
GLI3 PTCH1 3
HDAC4 MEF2C 4
HDAC4 RUNX2 3
HDAC4 STAT1 2
IFT88 GLI3 2
IGF1R PIK3R3 5
IGF1R STAT1 1
IHH PTCH1 7
KIF3A GLI3 2
MAPK14 FOXO3 1
MAPK14 MEF2C 9
MAPK14 STAT1 5
MAPK14 TWIST1 1
PTH PTH1R 4
SOX5 SOX6 2
STAT1 VEGFA 1
VEGFA MAPK14 2
ADRA1A TWIST1 1
ALOX15B CRADD 1
BMP6 GABBR1 1
CHST11 GATA3 1
COL10A1 COL2A1 1
COL10A1 DDR2 1
COL2A1 DDR2 1
CRADD GABBR1 1
CRADD PIK3R3 1
CRADD PRKCQ 1
CST5 GABBR1 1
CST5 PIK3R3 1
CST5 PRKCQ 1
DIABLO E2F1 1
E2F1 FGF2 1
E2F1 IGF1R 1
E2F1 MEF2C 1
E2F1 SOX6 1
E2F1 STAT1 2
FGF18 IGF1R 1
FGF2 IGF1R 1
FGF2 IHH 1
FGF2 PTH1R 1
FGFR3 PRKCQ 1
FOXO3 COL10A1 1
FOXO3 COL2A1 1
FOXO3 PTCH1 1
FRZB SRPK1 1
GABBR1 COL10A1 1
GABBR1 COL2A1 1
GABBR1 IHH 1
GATA3 BMP6 1
GATA3 GABBR1 1
GATA3 HDAC4 1
GATA3 MAPK14 1
GATA3 PIK3R3 1
GATA3 SOX5 1
GLI3 BMP6 1
GLI3 GABBR1 1
GLI3 TWIST1 1
IFT88 GABBR1 1
IFT88 KIF3A 1
IGF1R GABBR1 1
IHH ALOX15B 1
IHH SERPINB2 1
KIF3A GABBR1 1
MAPK14 SRPK1 2
MEF2C COL10A1 1
MEF2C RUNX2 1
NKX3-2 RUNX2 1
PIK3R3 FGF18 1
PIK3R3 FGF2 1
PIK3R3 FGFR3 1
PIK3R3 THRA 1
PTCH1 ALOX15B 1
PTH1R GABBR1 1
PTH MAPK14 1
PTH RUNX2 1
RUNX2 COL10A1 1
RUNX2 COL2A1 1
RUNX2 GABBR1 1
RUNX2 IHH 1
RUNX2 MMP13 1
RUNX2 PIK3R3 1
RUNX2 VEGFA 1
SOX5 COL2A1 1
SOX5 E2F1 1
SOX5 MAPK14 1
SOX5 PTCH1 1
SRPK1 GABBR1 1
STAT1 GABBR1 1
STAT1 GATA3 2
STAT1 PRKCQ 1
THRA E2F1 1
THRA FGFR3 1
THRA GABBR1 1
THRA GJB3 1
THRA IGF1R 1
TWIST1 COL2A1 1
TWIST1 GABBR1 1
TWIST1 RUNX2 1
TWIST1 SOX5 1
TWIST1 SOX6 1
VEGFA FGF18 1
VEGFA FGF2 1
VEGFA FGFR3 1
VEGFA IGF1R 1
VEGFA MMP13 1
VEGFA PIK3R3 1
Pathway1 Pathway2 Intersect Similarity Scores Pathway Name Source Number of Genes Number of Interactions Detail