Pathway ID Pathway Name Source Organism Number of Genes Number of Interactions
pathway0002750 Hs_Serotonin_Receptor_4-6-7_and_NR3C_Signaling_WP734_74438 WikiPathways Homo sapiens 15 37
Secreted
Membrane
Cytoplasm
Cytoplasm/4
Cytoskeleton
Cytoskeleton/Cytoplasm
Membrane/Nucleus
Cytoplasm/Nucleus
Cytoskeleton/Nucleus
Nucleus
Secreted/Nucleus
Unknown
Annotated genes
Unannotated genes
Symbol
Ensembl ID
Entrez ID
Subcellular localization
Description
Type
Edge
Symbol Ensembl ID Entrez ID Subcellular localization Closeness Degree Betweenness Transitivity
BRAF ENSG00000157764 673 Cytoplasm 0.015151515 45.0 0.0 0.003030303
ELK1 ENSG00000126767 2002 Cytoplasm/Nucleus 0.016666667 50.0 3.009213 0.010612245
MAP2K2 ENSG00000126934 5605 Cytoplasm/Nucleus 0.015151515 125.0 0.0 3.87097E-4
MAPK1 ENSG00000100030 5594 Cytoplasm/Nucleus 0.017241379 96.0 11.74388 0.003289474
MAPK3 ENSG00000102882 5595 Cytoplasm/Nucleus 0.017241379 91.0 11.5532 0.003663004
MAPKAPK2 ENSG00000162889 9261 Cytoplasm/Nucleus 0.016129032 18.0 2.07583 0.026143791
RPS6KA5 ENSG00000100784 9252 Cytoplasm/Nucleus 0.016393443 19.0 6.092708 0.035087719
GNAS ENSG00000087460 2778 Membrane 0.005494505 6.0 1.0 0.0
HTR4 ENSG00000164270 3360 Membrane 0.005464481 3.0 0.0 0.0
HTR7 ENSG00000148680 3363 Membrane 0.005464481 3.0 0.0 0.0
NR3C1 ENSG00000113580 2908 Unknown 0.015873016 7.0 0.05882353 0.238095238
ATF1 ENSG00000123268 466 Nucleus 0.014925373 6.0 0.205042 0.0
EGR1 ENSG00000120738 1958 Nucleus 0.016393443 11.0 1.843614 0.109090909
ELK4 ENSG00000158711 2005 Nucleus 0.015625 19.0 0.6330805 0.023391813
SRF ENSG00000112658 6722 Nucleus 0.015625 29.0 1.784601 0.009852217
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
BRAF ENSG00000157764 673 Cytoplasm 12094.0 42600.0 1.56E-6 4.04E-5
ELK1 ENSG00000126767 2002 Cytoplasm/Nucleus 3468.0 49000.0 1.56E-6 3.9E-4
MAP2K2 ENSG00000126934 5605 Cytoplasm/Nucleus 22859.0 10500.0 1.55E-6 9.5E-6
MAPK1 ENSG00000100030 5594 Cytoplasm/Nucleus 33563.0 1130000.0 1.56E-6 2.83E-5
MAPK3 ENSG00000102882 5595 Cytoplasm/Nucleus 29207.0 850000.0 1.56E-6 3.17E-5
MAPKAPK2 ENSG00000162889 9261 Cytoplasm/Nucleus 1421.0 8100.0 1.55E-6 4.69E-4
RPS6KA5 ENSG00000100784 9252 Cytoplasm/Nucleus 627.0 4510.0 1.55E-6 0.00267
GNAS ENSG00000087460 2778 Membrane 4371.0 208000.0 1.56E-6 4.75E-4
HTR4 ENSG00000164270 3360 Membrane 73.0 28.8 1.54E-6 0.0906
HTR7 ENSG00000148680 3363 Membrane 69.0 28.8 1.54E-6 0.0904
NR3C1 ENSG00000113580 2908 Unknown 541.0 236000.0 1.56E-6 0.0177
ATF1 ENSG00000123268 466 Nucleus 146.0 409.0 1.55E-6 0.0251
EGR1 ENSG00000120738 1958 Nucleus 229.0 1580.0 1.56E-6 0.0265
ELK4 ENSG00000158711 2005 Nucleus 277.0 134.0 1.55E-6 0.00181
SRF ENSG00000112658 6722 Nucleus 617.0 15200.0 1.56E-6 0.00547
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
BRAF ENSG00000157764 673 Cytoplasm 520.0 6514.381 2.15E-5 0.003282941
ELK1 ENSG00000126767 2002 Cytoplasm/Nucleus 481.0 2807.184 2.15E-5 0.003005891
MAP2K2 ENSG00000126934 5605 Cytoplasm/Nucleus 1788.0 2294.128 2.14E-5 3.47401E-4
MAPK1 ENSG00000100030 5594 Cytoplasm/Nucleus 3584.0 114767.9 2.18E-5 4.95738E-4
MAPK3 ENSG00000102882 5595 Cytoplasm/Nucleus 1631.0 42300.66 2.17E-5 0.001551233
MAPKAPK2 ENSG00000162889 9261 Cytoplasm/Nucleus 155.0 6378.235 2.13E-5 0.007875995
RPS6KA5 ENSG00000100784 9252 Cytoplasm/Nucleus 149.0 2355.815 2.14E-5 0.012787956
GNAS ENSG00000087460 2778 Membrane 98.0 21012.46 2.12E-5 0.00673259
HTR4 ENSG00000164270 3360 Membrane 3.0 0.0 2.04E-5 0.0
HTR7 ENSG00000148680 3363 Membrane 3.0 0.0 2.04E-5 0.0
NR3C1 ENSG00000113580 2908 Unknown 47.0 10655.42 2.12E-5 0.035152636
ATF1 ENSG00000123268 466 Nucleus 45.0 87.13115 2.13E-5 0.070707071
EGR1 ENSG00000120738 1958 Nucleus 28.0 51.49792 2.13E-5 0.132275132
ELK4 ENSG00000158711 2005 Nucleus 63.0 3313.3 2.12E-5 0.013824885
SRF ENSG00000112658 6722 Nucleus 118.0 3210.841 2.13E-5 0.010140519
Gene1 Gene2 Weight KEGG humanCyc PID BioGRID IntAct HPRD BIND Reactome CORUM DIP WikiPathways ReconX INOH SMPDB PhosphoSite PANTHER CTD NetPath TRANSFAC DrugBank
BRAF MAP2K2 11
BRAF MAPK1 6
BRAF MAPK3 6
ELK1 EGR1 3
ELK1 ELK4 3
ELK1 SRF 6
ELK4 SRF 7
HTR4 GNAS 2
HTR7 GNAS 2
MAP2K2 MAPK1 10
MAP2K2 MAPK3 11
MAPK1 ELK1 9
MAPK1 ELK4 3
MAPK1 MAPK3 4
MAPK1 MAPKAPK2 4
MAPK1 NR3C1 2
MAPK1 RPS6KA5 7
MAPK3 ELK1 8
MAPK3 ELK4 4
MAPK3 MAPKAPK2 3
MAPK3 NR3C1 2
MAPK3 RPS6KA5 6
MAPKAPK2 SRF 5
RPS6KA5 ATF1 5
RPS6KA5 ELK1 1
RPS6KA5 SRF 1
SRF EGR1 2
ATF1 EGR1 1
EGR1 MAPK1 1
EGR1 MAPK3 1
ELK1 MAPKAPK2 1
MAPKAPK2 ATF1 1
NR3C1 EGR1 2
NR3C1 RPS6KA5 1
Pathway1 Pathway2 Intersect Similarity Scores Pathway Name Source Number of Genes Number of Interactions Detail
pathway0002750 pathway0000704 4 0.8 ERK cascade ( GPCR Adenosine A2A receptor signaling pathway ) INOH 5 11
pathway0002750 pathway0000707 4 0.8 ERK cascade ( GPCR signaling (G alpha s, Epac and ERK) ) INOH 5 11
pathway0002750 pathway0002466 4 0.8 ERK cascade ( Integrin signaling pathway ) INOH 5 11
pathway0002750 pathway0002467 5 0.7142857 ERK cascade ( PDGF signaling pathway ) INOH 7 18
pathway0002750 pathway0000700 4 0.6666667 ERK cascade ( EGF signaling pathway Diagram ) INOH 6 15
pathway0002750 pathway0000708 4 0.6666667 ERK cascade ( HGF signaling pathway ) INOH 6 15
pathway0002750 pathway0000714 4 0.6666667 ERK cascade ( VEGF signaling pathway ) INOH 6 15
pathway0002750 pathway0001446 4 0.6666667 Negative feedback regulation of MAPK pathway Reactome 6 16
pathway0002750 pathway0000701 5 0.625 ERK cascade ( FGF signaling pathway ) INOH 8 26
pathway0002750 pathway0000709 5 0.625 ERK cascade ( IGF1 signaling pathway ) INOH 8 26
pathway0002750 pathway0000710 5 0.625 ERK cascade ( Insulin receptor signaling (D. melanogaster) ) INOH 8 26
pathway0002750 pathway0000711 5 0.625 ERK cascade ( Insulin receptor signaling (Mammal) ) INOH 8 26
pathway0002750 pathway0000713 5 0.625 ERK cascade ( NGF signaling pathway ) INOH 8 26
pathway0002750 pathway0000692 9 0.6 ErbB1 downstream signaling PID 105 1597
pathway0002750 pathway0001604 9 0.6 PDGF signaling pathway PANTHER 113 1684
pathway0002750 pathway0002562 9 0.6 MAPK signaling pathway KEGG 264 4851
pathway0002750 pathway0000697 4 0.5714286 ERK cascade ( B cell receptor signaling ) INOH 7 22
pathway0002750 pathway0000699 4 0.5714286 ERK cascade ( CD4 T cell receptor signaling ) INOH 7 22
pathway0002750 pathway0000705 4 0.5714286 ERK cascade ( GPCR GroupI metabotropic glutamate receptor signaling pathway ) INOH 7 22
pathway0002750 pathway0000706 4 0.5714286 ERK cascade ( GPCR signaling (G alpha q) ) INOH 7 22
pathway0002750 pathway0000712 4 0.5714286 ERK cascade ( JAK-STAT pathway and regulation pathway Diagram ) INOH 7 22
pathway0002750 pathway0002834 7 0.5384615 Hs_Serotonin_Receptor_2_and_ELK-SRF-GATA4_signaling_WP732_80010 WikiPathways 13 27
pathway0002750 pathway0000658 8 0.5333333 EGFR1 NetPath 475 10010
pathway0002750 pathway0002340 8 0.5333333 Trk receptor signaling mediated by the MAPK pathway PID 34 175