Pathway ID Pathway Name Source Organism Number of Genes Number of Interactions
pathway0002760 Hs_Oncostatin_M_Signaling_Pathway_WP2374_73668 WikiPathways Homo sapiens 44 408
Secreted
Membrane
Cytoplasm
Cytoplasm/4
Cytoskeleton
Cytoskeleton/Cytoplasm
Membrane/Nucleus
Cytoplasm/Nucleus
Cytoskeleton/Nucleus
Nucleus
Secreted/Nucleus
Unknown
Annotated genes
Unannotated genes
Symbol
Ensembl ID
Entrez ID
Subcellular localization
Description
Type
Edge
Symbol Ensembl ID Entrez ID Subcellular localization Closeness Degree Betweenness Transitivity
IRS1 ENSG00000169047 3667 Cytoplasm 0.009174312 77.0 5.918983 0.04989747
JAK1 ENSG00000162434 3716 Cytoplasm 0.009615385 119.0 11.78609 0.03090728
JAK3 ENSG00000105639 3718 Cytoplasm 0.009345794 79.0 4.205733 0.06361571
PTPN11 ENSG00000179295 5781 Cytoplasm 0.009433962 97.0 6.646452 0.04445876
CASP3 ENSG00000164305 836 Cytoplasm/Nucleus 0.008264463 13.0 0.3713832 0.3974359
CDKN1B ENSG00000111276 1027 Cytoplasm/Nucleus 0.008474576 21.0 13.53662 0.17142857
CEBPB ENSG00000172216 1051 Cytoplasm/Nucleus 0.008474576 26.0 13.90672 0.09846154
CRKL ENSG00000099942 1399 Cytoplasm/Nucleus 0.00862069 25.0 0.5037571 0.19
FOS ENSG00000170345 2353 Cytoplasm/Nucleus 0.008928571 46.0 32.40627 0.08405797
JAK2 ENSG00000096968 3717 Cytoplasm/Nucleus 0.010526316 141.0 39.46676 0.03120567
MAP2K2 ENSG00000126934 5605 Cytoplasm/Nucleus 0.009174312 165.0 2.918947 0.0120473
MAPK1 ENSG00000100030 5594 Cytoplasm/Nucleus 0.010309278 151.0 42.75926 0.02357616
MAPK3 ENSG00000102882 5595 Cytoplasm/Nucleus 0.010204082 140.0 38.69568 0.02641316
MAPK8 ENSG00000107643 5599 Cytoplasm/Nucleus 0.009615385 58.0 14.90641 0.10707804
NFKB1 ENSG00000109320 4790 Cytoplasm/Nucleus 0.009090909 87.0 3.856401 0.02967121
NFKBIA ENSG00000100906 4792 Cytoplasm/Nucleus 0.00862069 117.0 1.353591 0.01046272
PIAS3 ENSG00000131788 10401 Cytoplasm/Nucleus 0.0078125 15.0 0.02760241 0.12380952
PTK2B ENSG00000120899 2185 Cytoplasm/Nucleus 0.008928571 52.0 3.463432 0.08823529
RELA ENSG00000173039 5970 Cytoplasm/Nucleus 0.009615385 92.0 14.9491 0.03774486
RPS6 ENSG00000137154 6194 Cytoplasm/Nucleus 0.007194245 4.0 0.0 0.16666667
SOCS3 ENSG00000184557 9021 Cytoplasm/Nucleus 0.00877193 76.0 4.220421 0.03859649
SRC ENSG00000197122 6714 Cytoplasm/Nucleus 0.00990099 97.0 19.06861 0.04896907
STAT1 ENSG00000115415 6772 Cytoplasm/Nucleus 0.009803922 105.0 20.5146 0.04102564
STAT5B ENSG00000173757 6777 Cytoplasm/Nucleus 0.01 85.0 16.40949 0.06582633
TYK2 ENSG00000105397 7297 Cytoplasm/Nucleus 0.009259259 65.0 7.95668 0.07211538
AKT1 ENSG00000142208 207 Membrane 0.00990099 136.0 25.78364 0.02614379
ATP8B2 ENSG00000143515 57198 Membrane 0.00729927 2.0 0.0 1.0
HRAS ENSG00000174775 3265 Membrane 0.009708738 92.0 28.78985 0.05040612
LDLR ENSG00000130164 3949 Membrane 5.28541E-4 12.0 0.0 0.0
OSMR ENSG00000145623 9180 Membrane 0.008196721 28.0 0.06459021 0.10846561
PIK3R1 ENSG00000145675 5295 Membrane 0.009615385 130.0 42.45173 0.02075134
PXN ENSG00000089159 5829 Membrane 0.008695652 44.0 16.30612 0.07505285
RAF1 ENSG00000132155 5894 Membrane 0.008849558 123.0 30.31153 0.01226176
SHC1 ENSG00000160691 6464 Membrane 0.009433962 91.0 3.469459 0.05152625
GRB2 ENSG00000177885 2885 Unknown 0.009433962 95.0 24.81371 0.0356103
IL6ST ENSG00000134352 3572 Unknown 0.009174312 61.0 3.18876 0.07431694
MAPK14 ENSG00000112062 1432 Unknown 0.00990099 61.0 11.40288 0.11967213
STAT3 ENSG00000168610 6774 Unknown 0.010526316 124.0 54.99723 0.03789667
EGR1 ENSG00000120738 1958 Nucleus 0.008333333 14.0 1.000421 0.32967033
JUND ENSG00000130522 3727 Nucleus 0.007874016 19.0 0.4340089 0.06432749
CCL2 ENSG00000108691 6347 Secreted 0.008064516 14.0 0.02029471 0.1978022
CYR61 ENSG00000142871 3491 Secreted 0.006802721 2.0 0.0 1.0
SERPINE1 ENSG00000106366 5054 Secreted 0.006944444 2.0 0.01369863 0.0
VEGFA ENSG00000112715 7422 Secreted 0.009090909 41.0 4.103073 0.12682927
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
IRS1 ENSG00000169047 3667 Cytoplasm 4154.0 22000.0 1.56E-6 7.58E-4
JAK1 ENSG00000162434 3716 Cytoplasm 8612.0 95400.0 1.56E-6 2.71E-4
JAK3 ENSG00000105639 3718 Cytoplasm 4002.0 22800.0 1.56E-6 9.36E-4
PTPN11 ENSG00000179295 5781 Cytoplasm 9733.0 167000.0 1.56E-6 2.5E-4
CASP3 ENSG00000164305 836 Cytoplasm/Nucleus 2196.0 185000.0 1.56E-6 9.2E-4
CDKN1B ENSG00000111276 1027 Cytoplasm/Nucleus 1796.0 58900.0 1.56E-6 0.00264
CEBPB ENSG00000172216 1051 Cytoplasm/Nucleus 740.0 78400.0 1.56E-6 0.0187
CRKL ENSG00000099942 1399 Cytoplasm/Nucleus 2208.0 9050.0 1.55E-6 0.00119
FOS ENSG00000170345 2353 Cytoplasm/Nucleus 3623.0 68600.0 1.56E-6 7.3E-4
JAK2 ENSG00000096968 3717 Cytoplasm/Nucleus 9806.0 203000.0 1.56E-6 2.47E-4
MAP2K2 ENSG00000126934 5605 Cytoplasm/Nucleus 22859.0 10500.0 1.55E-6 9.5E-6
MAPK1 ENSG00000100030 5594 Cytoplasm/Nucleus 33563.0 1130000.0 1.56E-6 2.83E-5
MAPK3 ENSG00000102882 5595 Cytoplasm/Nucleus 29207.0 850000.0 1.56E-6 3.17E-5
MAPK8 ENSG00000107643 5599 Cytoplasm/Nucleus 11158.0 360000.0 1.56E-6 1.42E-4
NFKB1 ENSG00000109320 4790 Cytoplasm/Nucleus 11386.0 280000.0 1.56E-6 2.06E-4
NFKBIA ENSG00000100906 4792 Cytoplasm/Nucleus 12604.0 63600.0 1.56E-6 3.76E-5
PIAS3 ENSG00000131788 10401 Cytoplasm/Nucleus 462.0 7230.0 1.56E-6 0.00912
PTK2B ENSG00000120899 2185 Cytoplasm/Nucleus 2732.0 39900.0 1.56E-6 0.00291
RELA ENSG00000173039 5970 Cytoplasm/Nucleus 11059.0 663000.0 1.57E-6 3.08E-4
RPS6 ENSG00000137154 6194 Cytoplasm/Nucleus 2882.0 391000.0 1.56E-6 0.0031
SOCS3 ENSG00000184557 9021 Cytoplasm/Nucleus 2446.0 25700.0 1.56E-6 0.00128
SRC ENSG00000197122 6714 Cytoplasm/Nucleus 14851.0 1350000.0 1.57E-6 2.68E-4
STAT1 ENSG00000115415 6772 Cytoplasm/Nucleus 9900.0 278000.0 1.56E-6 2.9E-4
STAT5B ENSG00000173757 6777 Cytoplasm/Nucleus 6515.0 71100.0 1.56E-6 5.43E-4
TYK2 ENSG00000105397 7297 Cytoplasm/Nucleus 2515.0 18400.0 1.56E-6 0.00193
AKT1 ENSG00000142208 207 Membrane 52751.0 2150000.0 1.57E-6 1.74E-5
ATP8B2 ENSG00000143515 57198 Membrane 2.0 0.0 1.54E-6 1.0
HRAS ENSG00000174775 3265 Membrane 21752.0 305000.0 1.56E-6 6.79E-5
LDLR ENSG00000130164 3949 Membrane 263.0 8820.0 1.55E-6 0.00122
OSMR ENSG00000145623 9180 Membrane 460.0 20500.0 1.55E-6 0.0368
PIK3R1 ENSG00000145675 5295 Membrane 31452.0 734000.0 1.56E-6 4.03E-5
PXN ENSG00000089159 5829 Membrane 3210.0 123000.0 1.56E-6 0.00188
RAF1 ENSG00000132155 5894 Membrane 23706.0 140000.0 1.56E-6 1.64E-5
SHC1 ENSG00000160691 6464 Membrane 13549.0 312000.0 1.56E-6 2.6E-4
GRB2 ENSG00000177885 2885 Unknown 29079.0 822000.0 1.57E-6 5.64E-5
IL6ST ENSG00000134352 3572 Unknown 1212.0 3660.0 1.55E-6 0.00746
MAPK14 ENSG00000112062 1432 Unknown 9287.0 427000.0 1.56E-6 2.57E-4
STAT3 ENSG00000168610 6774 Unknown 10644.0 313000.0 1.56E-6 2.82E-4
EGR1 ENSG00000120738 1958 Nucleus 229.0 1580.0 1.56E-6 0.0265
JUND ENSG00000130522 3727 Nucleus 405.0 8110.0 1.56E-6 0.00956
CCL2 ENSG00000108691 6347 Secreted 443.0 9660.0 1.55E-6 0.00914
CYR61 ENSG00000142871 3491 Secreted 33.0 32.7 1.55E-6 0.108
SERPINE1 ENSG00000106366 5054 Secreted 269.0 23500.0 1.55E-6 0.00946
VEGFA ENSG00000112715 7422 Secreted 2210.0 75200.0 1.56E-6 0.00294
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
IRS1 ENSG00000169047 3667 Cytoplasm 525.0 3270.0 2.15E-5 0.006732097
JAK1 ENSG00000162434 3716 Cytoplasm 1248.0 8450.0 2.15E-5 0.002257983
JAK3 ENSG00000105639 3718 Cytoplasm 377.0 335.0 2.14E-5 0.008324398
PTPN11 ENSG00000179295 5781 Cytoplasm 1537.0 16400.0 2.15E-5 0.001603672
CASP3 ENSG00000164305 836 Cytoplasm/Nucleus 467.0 23800.0 2.16E-5 0.006139085
CDKN1B ENSG00000111276 1027 Cytoplasm/Nucleus 271.0 4530.0 2.14E-5 0.007325407
CEBPB ENSG00000172216 1051 Cytoplasm/Nucleus 73.0 3530.0 2.14E-5 0.036149163
CRKL ENSG00000099942 1399 Cytoplasm/Nucleus 195.0 291.0 2.13E-5 0.022310336
FOS ENSG00000170345 2353 Cytoplasm/Nucleus 346.0 5090.0 2.15E-5 0.007975203
JAK2 ENSG00000096968 3717 Cytoplasm/Nucleus 1156.0 5740.0 2.15E-5 0.002151021
MAP2K2 ENSG00000126934 5605 Cytoplasm/Nucleus 1788.0 2290.0 2.14E-5 3.47401E-4
MAPK1 ENSG00000100030 5594 Cytoplasm/Nucleus 3584.0 115000.0 2.18E-5 4.95738E-4
MAPK3 ENSG00000102882 5595 Cytoplasm/Nucleus 1631.0 42300.0 2.17E-5 0.001551233
MAPK8 ENSG00000107643 5599 Cytoplasm/Nucleus 1392.0 35600.0 2.17E-5 0.001997653
NFKB1 ENSG00000109320 4790 Cytoplasm/Nucleus 1684.0 72000.0 2.17E-5 9.77358E-4
NFKBIA ENSG00000100906 4792 Cytoplasm/Nucleus 1925.0 28300.0 2.16E-5 3.726E-4
PIAS3 ENSG00000131788 10401 Cytoplasm/Nucleus 36.0 1.73 2.12E-5 0.053968254
PTK2B ENSG00000120899 2185 Cytoplasm/Nucleus 294.0 927.0 2.14E-5 0.01602006
RELA ENSG00000173039 5970 Cytoplasm/Nucleus 1031.0 37600.0 2.16E-5 0.002083
RPS6 ENSG00000137154 6194 Cytoplasm/Nucleus 202.0 807.0 2.13E-5 0.004679572
SOCS3 ENSG00000184557 9021 Cytoplasm/Nucleus 262.0 1120.0 2.14E-5 0.007224123
SRC ENSG00000197122 6714 Cytoplasm/Nucleus 1835.0 67000.0 2.17E-5 0.001945688
STAT1 ENSG00000115415 6772 Cytoplasm/Nucleus 1494.0 36500.0 2.17E-5 0.002204845
STAT5B ENSG00000173757 6777 Cytoplasm/Nucleus 893.0 6570.0 2.15E-5 0.004022316
TYK2 ENSG00000105397 7297 Cytoplasm/Nucleus 140.0 140.0 2.13E-5 0.030215827
AKT1 ENSG00000142208 207 Membrane 6565.0 233000.0 2.19E-5 2.13911E-4
ATP8B2 ENSG00000143515 57198 Membrane 2.0 0.0 2.09E-5 1.0
HRAS ENSG00000174775 3265 Membrane 1733.0 25200.0 2.17E-5 0.001844377
LDLR ENSG00000130164 3949 Membrane 107.0 4870.0 2.1E-5 0.00123435
OSMR ENSG00000145623 9180 Membrane 28.0 0.0237 2.11E-5 0.108465609
PIK3R1 ENSG00000145675 5295 Membrane 2347.0 18200.0 2.15E-5 6.63995E-4
PXN ENSG00000089159 5829 Membrane 325.0 3870.0 2.14E-5 0.010826211
RAF1 ENSG00000132155 5894 Membrane 1624.0 13700.0 2.15E-5 6.27525E-4
SHC1 ENSG00000160691 6464 Membrane 1636.0 9720.0 2.16E-5 0.00189094
GRB2 ENSG00000177885 2885 Unknown 3192.0 57100.0 2.17E-5 5.90241E-4
IL6ST ENSG00000134352 3572 Unknown 89.0 24.6 2.12E-5 0.034729316
MAPK14 ENSG00000112062 1432 Unknown 1219.0 74200.0 2.17E-5 0.002559367
STAT3 ENSG00000168610 6774 Unknown 1753.0 59100.0 2.17E-5 0.001825963
EGR1 ENSG00000120738 1958 Nucleus 28.0 51.5 2.13E-5 0.132275132
JUND ENSG00000130522 3727 Nucleus 78.0 4010.0 2.14E-5 0.027972028
CCL2 ENSG00000108691 6347 Secreted 105.0 3150.0 2.13E-5 0.011721612
CYR61 ENSG00000142871 3491 Secreted 2.0 0.0 2.08E-5 1.0
SERPINE1 ENSG00000106366 5054 Secreted 82.0 5990.0 2.12E-5 0.009936766
VEGFA ENSG00000112715 7422 Secreted 244.0 7400.0 2.15E-5 0.025399717
Gene1 Gene2 Weight KEGG humanCyc PID BioGRID IntAct HPRD BIND Reactome CORUM DIP WikiPathways ReconX INOH SMPDB PhosphoSite PANTHER CTD NetPath TRANSFAC DrugBank
AKT1 CDKN1B 9
AKT1 IRS1 3
AKT1 NFKB1 3
AKT1 RAF1 6
AKT1 RELA 4
AKT1 STAT1 3
AKT1 STAT3 2
CEBPB EGR1 4
CEBPB NFKB1 4
CEBPB RELA 4
CEBPB STAT3 3
CRKL GRB2 4
CRKL MAPK8 3
CRKL PIK3R1 5
CRKL PTPN11 5
CRKL PXN 5
CRKL STAT5B 3
FOS JUND 6
FOS VEGFA 2
GRB2 AKT1 3
GRB2 HRAS 4
GRB2 IL6ST 3
GRB2 IRS1 8
GRB2 JAK1 5
GRB2 JAK2 5
GRB2 MAPK1 2
GRB2 PIK3R1 9
GRB2 PTPN11 9
GRB2 PXN 2
GRB2 SHC1 13
GRB2 SRC 5
GRB2 STAT3 1
HRAS FOS 1
HRAS MAP2K2 2
HRAS MAPK1 3
HRAS MAPK3 3
HRAS PIK3R1 7
HRAS RAF1 14
IL6ST IRS1 1
IL6ST JAK1 9
IL6ST JAK2 7
IL6ST JAK3 5
IL6ST OSMR 4
IL6ST PTPN11 7
IL6ST SHC1 3
IL6ST SOCS3 7
IL6ST STAT1 5
IL6ST STAT3 9
IL6ST TYK2 7
IRS1 CRKL 1
IRS1 JAK1 5
IRS1 JAK2 4
IRS1 JAK3 4
IRS1 PIK3R1 11
IRS1 PTPN11 5
IRS1 PXN 1
IRS1 SHC1 7
IRS1 TYK2 2
JAK1 AKT1 4
JAK1 JAK2 4
JAK1 JAK3 5
JAK1 MAPK1 2
JAK1 MAPK3 2
JAK1 OSMR 3
JAK1 PIK3R1 6
JAK1 PTK2B 4
JAK1 PTPN11 7
JAK1 SHC1 4
JAK1 SOCS3 7
JAK1 STAT1 9
JAK1 STAT3 11
JAK1 STAT5B 7
JAK1 TYK2 4
JAK2 AKT1 2
JAK2 CRKL 1
JAK2 JAK3 3
JAK2 MAPK1 3
JAK2 MAPK3 3
JAK2 NFKB1 1
JAK2 NFKBIA 2
JAK2 OSMR 3
JAK2 PIK3R1 8
JAK2 PTK2B 3
JAK2 PTPN11 6
JAK2 PXN 1
JAK2 RAF1 3
JAK2 RELA 1
JAK2 SHC1 7
JAK2 SOCS3 8
JAK2 SRC 4
JAK2 STAT1 11
JAK2 STAT3 11
JAK2 STAT5B 8
JAK2 TYK2 4
JAK3 AKT1 3
JAK3 MAPK14 1
JAK3 PIK3R1 7
JAK3 PTK2B 5
JAK3 PTPN11 2
JAK3 SHC1 3
JAK3 SOCS3 4
JAK3 STAT1 5
JAK3 STAT3 8
JAK3 STAT5B 6
JAK3 TYK2 2
MAP2K2 AKT1 1
MAP2K2 MAPK1 10
MAP2K2 MAPK14 1
MAP2K2 MAPK3 11
MAP2K2 MAPK8 4
MAP2K2 RAF1 7
MAP2K2 STAT1 1
MAP2K2 STAT3 2
MAP2K2 STAT5B 1
MAPK14 CASP3 1
MAPK14 CEBPB 1
MAPK14 FOS 3
MAPK14 MAPK3 5
MAPK14 NFKB1 1
MAPK14 NFKBIA 2
MAPK14 PXN 1
MAPK14 RELA 2
MAPK14 SHC1 2
MAPK14 STAT1 5
MAPK14 STAT3 4
MAPK14 STAT5B 1
MAPK1 AKT1 2
MAPK1 CDKN1B 1
MAPK1 CEBPB 4
MAPK1 FOS 5
MAPK1 IRS1 4
MAPK1 JUND 3
MAPK1 MAPK3 4
MAPK1 PXN 5
MAPK1 RAF1 5
MAPK1 RELA 1
MAPK1 SHC1 5
MAPK1 SRC 3
MAPK1 STAT1 2
MAPK1 STAT3 6
MAPK1 STAT5B 3
MAPK3 AKT1 1
MAPK3 CDKN1B 1
MAPK3 CEBPB 4
MAPK3 FOS 5
MAPK3 IRS1 3
MAPK3 JUND 2
MAPK3 PTPN11 4
MAPK3 PXN 3
MAPK3 RAF1 5
MAPK3 RELA 1
MAPK3 SHC1 2
MAPK3 STAT1 3
MAPK3 STAT3 5
MAPK3 STAT5B 2
MAPK8 FOS 4
MAPK8 IRS1 3
MAPK8 JUND 5
MAPK8 PXN 3
MAPK8 STAT1 2
MAPK8 STAT3 6
MAPK8 STAT5B 2
NFKB1 NFKBIA 12
NFKB1 RELA 12
NFKB1 SOCS3 3
NFKBIA PIK3R1 4
NFKBIA RELA 14
OSMR TYK2 3
PIAS3 STAT1 2
PIAS3 STAT3 6
PIAS3 STAT5B 2
PIK3R1 AKT1 6
PIK3R1 PTPN11 7
PIK3R1 PXN 3
PIK3R1 RELA 3
PIK3R1 SHC1 8
PIK3R1 SRC 8
PIK3R1 STAT3 4
PTK2B AKT1 1
PTK2B MAPK8 1
PTK2B PIK3R1 1
PTK2B PTPN11 4
PTK2B PXN 8
PTK2B SRC 6
PTK2B STAT1 1
PTK2B STAT3 4
PTK2B STAT5B 2
PTPN11 AKT1 2
PTPN11 MAPK1 3
PTPN11 PXN 4
PTPN11 SHC1 4
PTPN11 SOCS3 4
PTPN11 SRC 3
PTPN11 STAT1 3
PTPN11 STAT5B 3
PXN SRC 8
RAF1 SRC 5
RAF1 STAT1 1
RAF1 STAT3 1
RAF1 STAT5B 1
RELA SOCS3 2
RELA VEGFA 2
SHC1 AKT1 3
SHC1 SRC 6
SHC1 STAT5B 3
SOCS3 OSMR 2
SOCS3 STAT1 2
SOCS3 TYK2 3
SRC AKT1 4
SRC HRAS 4
SRC MAPK14 2
SRC MAPK8 1
SRC NFKB1 1
SRC NFKBIA 2
SRC STAT1 6
SRC STAT3 10
SRC STAT5B 4
STAT1 STAT3 8
STAT1 STAT5B 3
STAT1 VEGFA 1
STAT3 SOCS3 3
STAT3 STAT5B 6
STAT3 VEGFA 2
STAT5B AKT1 2
STAT5B IRS1 1
TYK2 AKT1 1
TYK2 NFKB1 1
TYK2 NFKBIA 1
TYK2 PIK3R1 2
TYK2 PTPN11 2
TYK2 RELA 1
TYK2 STAT1 4
TYK2 STAT3 4
TYK2 STAT5B 2
VEGFA AKT1 2
VEGFA MAPK1 1
VEGFA MAPK14 2
VEGFA MAPK3 1
VEGFA PIK3R1 2
VEGFA PTK2B 1
VEGFA RAF1 1
VEGFA SRC 4
AKT1 CASP3 2
AKT1 MAPK14 3
AKT1 MAPK8 2
AKT1 NFKBIA 1
ATP8B2 HRAS 1
CASP3 MAPK8 1
CASP3 PXN 1
CASP3 STAT1 1
CASP3 STAT3 2
CCL2 FOS 1
CCL2 RELA 1
CCL2 SRC 1
CCL2 STAT3 2
CDKN1B GRB2 4
CDKN1B JAK2 2
CDKN1B MAPK8 1
CDKN1B SRC 3
CEBPB CDKN1B 1
CEBPB NFKBIA 1
CEBPB PIK3R1 1
CEBPB SERPINE1 1
CRKL MAPK1 1
CRKL RAF1 1
CRKL SHC1 3
CRKL TYK2 2
CYR61 CDKN1B 1
EGR1 CASP3 1
EGR1 JUND 1
EGR1 MAPK1 1
EGR1 MAPK14 1
EGR1 MAPK3 1
EGR1 PXN 1
EGR1 RELA 4
EGR1 VEGFA 1
FOS CDKN1B 1
FOS CYR61 1
FOS IL6ST 1
FOS NFKB1 2
FOS RELA 4
FOS STAT1 3
FOS STAT3 2
GRB2 ATP8B2 1
GRB2 JAK3 2
GRB2 MAP2K2 1
GRB2 MAPK14 1
GRB2 OSMR 1
GRB2 PTK2B 4
HRAS AKT1 1
HRAS MAPK14 1
HRAS MAPK8 2
HRAS NFKB1 1
HRAS RELA 1
IL6ST MAP2K2 1
IL6ST MAPK1 1
IL6ST MAPK3 1
IL6ST PIAS3 1
IL6ST PIK3R1 1
IL6ST STAT5B 1
IRS1 CASP3 1
IRS1 HRAS 2
IRS1 SOCS3 2
IRS1 SRC 2
JAK1 HRAS 2
JAK1 MAP2K2 2
JAK1 PIAS3 1
JAK1 RAF1 2
JAK1 SRC 1
JAK2 CASP3 1
JAK2 CCL2 1
JAK2 FOS 1
JAK2 HRAS 2
JAK2 MAP2K2 1
JAK3 HRAS 2
JAK3 MAP2K2 1
JAK3 MAPK1 1
JAK3 MAPK3 1
JAK3 MAPK8 1
JUND RAF1 2
MAPK14 JAK1 1
MAPK14 JAK2 1
MAPK14 MAPK8 2
MAPK14 PTPN11 1
MAPK14 SOCS3 1
MAPK1 MAPK14 4
MAPK1 MAPK8 2
MAPK1 NFKB1 1
MAPK1 NFKBIA 1
MAPK3 GRB2 1
MAPK3 MAPK8 1
MAPK3 NFKB1 1
MAPK3 NFKBIA 1
MAPK8 JAK1 1
MAPK8 JAK2 1
MAPK8 PIK3R1 2
MAPK8 RAF1 2
NFKB1 IRS1 1
NFKB1 SHC1 2
NFKB1 STAT3 3
NFKB1 VEGFA 1
NFKBIA SOCS3 1
NFKBIA STAT1 1
OSMR JAK3 1
OSMR STAT1 1
OSMR STAT3 1
OSMR STAT5B 1
PIAS3 RELA 3
PIK3R1 MAP2K2 1
PIK3R1 NFKB1 1
PIK3R1 RPS6 2
PTK2B CRKL 1
PTK2B HRAS 1
PTK2B SHC1 1
PTPN11 HRAS 2
PTPN11 MAP2K2 2
PTPN11 STAT3 3
PXN RPS6 1
RAF1 MAPK14 1
RAF1 SERPINE1 1
RELA CASP3 1
RELA IL6ST 1
RELA JAK3 1
RELA SHC1 2
RELA SRC 2
RELA STAT1 3
RELA STAT3 3
SHC1 HRAS 3
SHC1 MAP2K2 1
SHC1 MAPK8 1
SHC1 STAT3 1
SOCS3 HRAS 1
SOCS3 PTK2B 1
SOCS3 SRC 1
SRC MAP2K2 1
SRC MAPK3 1
STAT1 HRAS 1
STAT1 SHC1 1
STAT3 CDKN1B 1
STAT3 EGR1 1
STAT3 HRAS 1
STAT5B CCL2 2
STAT5B FOS 2
STAT5B HRAS 1
STAT5B NFKBIA 1
STAT5B PIK3R1 1
STAT5B SOCS3 1
TYK2 CCL2 1
TYK2 FOS 1
TYK2 MAP2K2 1
TYK2 MAPK1 1
TYK2 MAPK3 1
VEGFA GRB2 2
VEGFA PTPN11 1
VEGFA PXN 1
VEGFA SHC1 1
Pathway1 Pathway2 Intersect Similarity Scores Pathway Name Source Number of Genes Number of Interactions Detail
pathway0002760 pathway0001227 4 0.8 JAK degradation signaling ( JAK-STAT pathway and regulation pathway Diagram ) INOH 5 12
pathway0002760 pathway0001454 4 0.8 Negative regulation of (Phosphorylation of JAK) in JAK STAT pathway ( JAK-STAT pathway and regulation pathway Diagram ) INOH 5 12
pathway0002760 pathway0001320 7 0.7777778 MAPK1 (ERK2) activation Reactome 9 40
pathway0002760 pathway0002879 8 0.7272727 Hs_IL-9_Signaling_Pathway_WP22_79264 WikiPathways 11 49
pathway0002760 pathway0001188 8 0.7272727 Interleukin-6 signaling Reactome 11 57
pathway0002760 pathway0000658 30 0.6818182 EGFR1 NetPath 475 10010
pathway0002760 pathway0000700 4 0.6666667 ERK cascade ( EGF signaling pathway Diagram ) INOH 6 15
pathway0002760 pathway0000708 4 0.6666667 ERK cascade ( HGF signaling pathway ) INOH 6 15
pathway0002760 pathway0000714 4 0.6666667 ERK cascade ( VEGF signaling pathway ) INOH 6 15
pathway0002760 pathway0001111 4 0.6666667 IL-6 signaling pathway(JAK1 JAK2 STAT3) ( IL-6 signaling(JAK1 JAK2 STAT3) ) INOH 6 19
pathway0002760 pathway0001446 4 0.6666667 Negative feedback regulation of MAPK pathway Reactome 6 16
pathway0002760 pathway0002718 11 0.6470588 Hs_Interleukin-11_Signaling_Pathway_WP2332_79525 WikiPathways 17 80
pathway0002760 pathway0001727 28 0.6363636 Prolactin NetPath 105 1733
pathway0002760 pathway0001135 15 0.625 IL9 NetPath 24 200
pathway0002760 pathway0000704 3 0.6 ERK cascade ( GPCR Adenosine A2A receptor signaling pathway ) INOH 5 11
pathway0002760 pathway0000707 3 0.6 ERK cascade ( GPCR signaling (G alpha s, Epac and ERK) ) INOH 5 11
pathway0002760 pathway0001321 6 0.6 MAPK3 (ERK1) activation Reactome 10 41
pathway0002760 pathway0002466 3 0.6 ERK cascade ( Integrin signaling pathway ) INOH 5 11
pathway0002760 pathway0001132 26 0.5909091 IL6 NetPath 85 1335
pathway0002760 pathway0002355 14 0.5833333 TSLP NetPath 24 159
pathway0002760 pathway0000697 4 0.5714286 ERK cascade ( B cell receptor signaling ) INOH 7 22
pathway0002760 pathway0000699 4 0.5714286 ERK cascade ( CD4 T cell receptor signaling ) INOH 7 22
pathway0002760 pathway0000705 4 0.5714286 ERK cascade ( GPCR GroupI metabotropic glutamate receptor signaling pathway ) INOH 7 22
pathway0002760 pathway0000706 4 0.5714286 ERK cascade ( GPCR signaling (G alpha q) ) INOH 7 22
pathway0002760 pathway0000712 4 0.5714286 ERK cascade ( JAK-STAT pathway and regulation pathway Diagram ) INOH 7 22
pathway0002760 pathway0002467 4 0.5714286 ERK cascade ( PDGF signaling pathway ) INOH 7 18
pathway0002760 pathway0001120 24 0.5454545 IL2 NetPath 81 1364
pathway0002760 pathway0001264 24 0.5454545 Leptin NetPath 98 1355
pathway0002760 pathway0002022 6 0.5454545 Signaling by Leptin Reactome 11 48
pathway0002760 pathway0002199 24 0.5454545 TCR NetPath 261 4161
pathway0002760 pathway0002844 17 0.5151515 Hs_IL-2_Signaling_Pathway_WP49_91243 WikiPathways 33 332
pathway0002760 pathway0002867 6 0.5 Hs_Nanoparticle-mediated_activation_of_receptor_signaling_WP2643_87898 WikiPathways 12 55
pathway0002760 pathway0002880 3 0.5 Hs_Insulin_signalling_in_adipocytes_(diabetic_condition)_WP3635_86059 WikiPathways 6 9
pathway0002760 pathway0002881 3 0.5 Hs_Insulin_signalling_in_adipocytes_(normal_condition)_WP3634_86060 WikiPathways 6 9
pathway0002760 pathway0000080 5 0.5 Activation of the AP-1 family of transcription factors Reactome 10 35
pathway0002760 pathway0000698 5 0.5 ERK cascade ( CD4 T cell receptor signaling (ERK cascade) ) INOH 10 42
pathway0002760 pathway0000701 4 0.5 ERK cascade ( FGF signaling pathway ) INOH 8 26
pathway0002760 pathway0000709 4 0.5 ERK cascade ( IGF1 signaling pathway ) INOH 8 26
pathway0002760 pathway0000710 4 0.5 ERK cascade ( Insulin receptor signaling (D. melanogaster) ) INOH 8 26
pathway0002760 pathway0000711 4 0.5 ERK cascade ( Insulin receptor signaling (Mammal) ) INOH 8 26
pathway0002760 pathway0000713 4 0.5 ERK cascade ( NGF signaling pathway ) INOH 8 26
pathway0002760 pathway0000901 4 0.5 Gene expression of SOCS3 by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram ) INOH 8 29
pathway0002760 pathway0001084 3 0.5 IFN gamma signaling pathway(JAK1 JAK2 STAT1) ( IFN gamma signaling(JAK1 JAK2 STAT1) ) INOH 6 18
pathway0002760 pathway0001102 3 0.5 IL-10 signaling pathway(JAK1 TYK2 STAT3) ( IL-10 signaling(JAK1 TYK2 STAT3) ) INOH 6 16
pathway0002760 pathway0001106 3 0.5 IL-23 signaling pathway(JAK2 TYK2 STAT3 STAT4) ( IL-23 signaling(JAK2 TYK2 STAT3 STAT4) ) INOH 6 17
pathway0002760 pathway0001128 22 0.5 IL4 NetPath 75 1239
pathway0002760 pathway0002003 5 0.5 Signal attenuation Reactome 10 45
pathway0002760 pathway0002656 22 0.5 Pathways in cancer KEGG 321 8293