Pathway ID Pathway Name Source Organism Number of Genes Number of Interactions
pathway0002768 Hs_Heart_Development_WP1591_90186 WikiPathways Homo sapiens 28 78
Secreted
Membrane
Cytoplasm
Cytoplasm/4
Cytoskeleton
Cytoskeleton/Cytoplasm
Membrane/Nucleus
Cytoplasm/Nucleus
Cytoskeleton/Nucleus
Nucleus
Secreted/Nucleus
Unknown
Annotated genes
Unannotated genes
Symbol
Ensembl ID
Entrez ID
Subcellular localization
Description
Type
Edge
Symbol Ensembl ID Entrez ID Subcellular localization Closeness Degree Betweenness Transitivity
HAND1 ENSG00000113196 9421 Cytoplasm/Nucleus 0.01785714 5.0 7.934814 0.2
ISL1 ENSG00000016082 3670 Cytoplasm/Nucleus 0.01724138 3.0 0.7714286 0.33333333
MAPK1 ENSG00000100030 5594 Cytoplasm/Nucleus 0.01886792 17.0 14.40023 0.06617647
SMAD1 ENSG00000170365 4086 Cytoplasm/Nucleus 0.02083333 27.0 42.58862 0.03133903
SMAD4 ENSG00000141646 4089 Cytoplasm/Nucleus 0.02173913 23.0 26.01198 0.05928854
TBX20 ENSG00000164532 57057 Cytoplasm/Nucleus 0.01639344 3.0 1.972448 0.0
ERBB3 ENSG00000065361 2065 Membrane 0.01785714 8.0 7.586689 0.14285714
NOTCH1 ENSG00000148400 4851 Membrane 0.01960784 20.0 14.90107 0.02631579
CTNNB1 ENSG00000168036 1499 Unknown 0.02222222 35.0 59.1885 0.01848739
PITX2 ENSG00000164093 5308 Unknown 0.01851852 9.0 23.20723 0.11111111
BHLHE40 ENSG00000134107 8553 Nucleus 0.01639344 4.0 6.535578 0.0
FOXA2 ENSG00000125798 3170 Nucleus 0.01388889 3.0 1.083333 0.0
FOXC1 ENSG00000054598 2296 Nucleus 0.01408451 3.0 0.0 0.33333333
FOXH1 ENSG00000160973 8928 Nucleus 0.01724138 10.0 0.5121018 0.11111111
GATA4 ENSG00000136574 2626 Nucleus 0.02040816 16.0 43.3527 0.075
HAND2 ENSG00000164107 9464 Nucleus 0.01492537 5.0 3.819784 0.2
HEY1 ENSG00000164683 23462 Nucleus 0.01666667 9.0 1.277738 0.08333333
HEY2 ENSG00000135547 23493 Nucleus 0.01587302 10.0 5.007145 0.08888889
IRX4 ENSG00000113430 50805 Nucleus 0.01449275 1.0 0.0 0.0
MEF2C ENSG00000081189 4208 Nucleus 0.02040816 12.0 39.34151 0.09090909
NKX2-5 ENSG00000183072 1482 Nucleus 0.02325581 18.0 74.6969 0.07843137
SMYD1 ENSG00000115593 150572 Nucleus 0.01449275 4.0 2.650408 0.0
TBX1 ENSG00000184058 6899 Nucleus 0.01886792 9.0 32.32675 0.05555556
TBX2 ENSG00000121068 6909 Nucleus 0.01851852 6.0 19.18855 0.0
TBX5 ENSG00000089225 6910 Nucleus 0.01785714 6.0 0.6411255 0.26666667
BMP10 ENSG00000163217 27302 Secreted 0.01587302 4.0 0.6701218 0.33333333
BMP2 ENSG00000125845 650 Secreted 0.01470588 5.0 1.251165 0.1
FGF8 ENSG00000107831 2253 Secreted 0.01492537 9.0 1.082089 0.02777778
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
HAND1 ENSG00000113196 9421 Cytoplasm/Nucleus 10.0 687.0 1.54E-6 0.133
ISL1 ENSG00000016082 3670 Cytoplasm/Nucleus 7.0 11.9 1.54E-6 0.143
MAPK1 ENSG00000100030 5594 Cytoplasm/Nucleus 33563.0 1130000.0 1.56E-6 2.83E-5
SMAD1 ENSG00000170365 4086 Cytoplasm/Nucleus 1377.0 43300.0 1.56E-6 0.003
SMAD4 ENSG00000141646 4089 Cytoplasm/Nucleus 2908.0 151000.0 1.56E-6 0.00134
TBX20 ENSG00000164532 57057 Cytoplasm/Nucleus 3.0 1.25 1.53E-6 0.0
ERBB3 ENSG00000065361 2065 Membrane 2002.0 21100.0 1.56E-6 0.00449
NOTCH1 ENSG00000148400 4851 Membrane 1691.0 361000.0 1.56E-6 0.00125
CTNNB1 ENSG00000168036 1499 Unknown 12389.0 1400000.0 1.57E-6 3.14E-4
PITX2 ENSG00000164093 5308 Unknown 49.0 2190.0 1.55E-6 0.12
BHLHE40 ENSG00000134107 8553 Nucleus 91.0 2440.0 1.55E-6 0.0398
FOXA2 ENSG00000125798 3170 Nucleus 113.0 94200.0 1.55E-6 0.0207
FOXC1 ENSG00000054598 2296 Nucleus 10.0 238.0 1.54E-6 0.156
FOXH1 ENSG00000160973 8928 Nucleus 135.0 132.0 1.55E-6 0.00619
GATA4 ENSG00000136574 2626 Nucleus 69.0 8270.0 1.55E-6 0.0384
HAND2 ENSG00000164107 9464 Nucleus 5.0 5.26 1.53E-6 0.2
HEY1 ENSG00000164683 23462 Nucleus 149.0 169.0 1.55E-6 0.0193
HEY2 ENSG00000135547 23493 Nucleus 172.0 4690.0 1.55E-6 0.0114
IRX4 ENSG00000113430 50805 Nucleus 1.0 0.0 1.52E-6 0.0
MEF2C ENSG00000081189 4208 Nucleus 316.0 28200.0 1.55E-6 0.00922
NKX2-5 ENSG00000183072 1482 Nucleus 49.0 10400.0 1.55E-6 0.0306
SMYD1 ENSG00000115593 150572 Nucleus 6.0 33.1 1.53E-6 0.0
TBX1 ENSG00000184058 6899 Nucleus 13.0 51.9 1.54E-6 0.0256
TBX2 ENSG00000121068 6909 Nucleus 6.0 180.0 1.54E-6 0.0
TBX5 ENSG00000089225 6910 Nucleus 22.0 24.1 1.54E-6 0.0866
BMP10 ENSG00000163217 27302 Secreted 489.0 258.0 1.54E-6 0.0155
BMP2 ENSG00000125845 650 Secreted 852.0 36600.0 1.55E-6 0.00634
FGF8 ENSG00000107831 2253 Secreted 3057.0 29700.0 1.56E-6 0.00147
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
HAND1 ENSG00000113196 9421 Cytoplasm/Nucleus 10.0 192.0 2.08E-5 0.088888889
ISL1 ENSG00000016082 3670 Cytoplasm/Nucleus 6.0 5.05 2.1E-5 0.2
MAPK1 ENSG00000100030 5594 Cytoplasm/Nucleus 3584.0 115000.0 2.18E-5 4.95738E-4
SMAD1 ENSG00000170365 4086 Cytoplasm/Nucleus 198.0 16000.0 2.14E-5 0.01317746
SMAD4 ENSG00000141646 4089 Cytoplasm/Nucleus 339.0 27300.0 2.16E-5 0.012672148
TBX20 ENSG00000164532 57057 Cytoplasm/Nucleus 3.0 1.58 2.05E-5 0.0
ERBB3 ENSG00000065361 2065 Membrane 113.0 534.0 2.13E-5 0.040139065
NOTCH1 ENSG00000148400 4851 Membrane 114.0 24500.0 2.14E-5 0.010091601
CTNNB1 ENSG00000168036 1499 Unknown 1273.0 177000.0 2.18E-5 0.002996438
PITX2 ENSG00000164093 5308 Unknown 12.0 473.0 2.11E-5 0.075757576
BHLHE40 ENSG00000134107 8553 Nucleus 4.0 147.0 2.1E-5 0.0
FOXA2 ENSG00000125798 3170 Nucleus 40.0 12500.0 2.1E-5 0.021794872
FOXC1 ENSG00000054598 2296 Nucleus 10.0 62.9 2.07E-5 0.111111111
FOXH1 ENSG00000160973 8928 Nucleus 39.0 35.5 2.09E-5 0.020242915
GATA4 ENSG00000136574 2626 Nucleus 35.0 5680.0 2.11E-5 0.042016807
HAND2 ENSG00000164107 9464 Nucleus 5.0 10.9 2.04E-5 0.2
HEY1 ENSG00000164683 23462 Nucleus 9.0 26.4 2.1E-5 0.083333333
HEY2 ENSG00000135547 23493 Nucleus 13.0 133.0 2.06E-5 0.051282051
IRX4 ENSG00000113430 50805 Nucleus 1.0 0.0 2.01E-5 0.0
MEF2C ENSG00000081189 4208 Nucleus 60.0 4300.0 2.13E-5 0.032768362
NKX2-5 ENSG00000183072 1482 Nucleus 18.0 1940.0 2.09E-5 0.078431373
SMYD1 ENSG00000115593 150572 Nucleus 6.0 18.9 2.06E-5 0.0
TBX1 ENSG00000184058 6899 Nucleus 13.0 164.0 2.07E-5 0.025641026
TBX2 ENSG00000121068 6909 Nucleus 6.0 159.0 2.1E-5 0.0
TBX5 ENSG00000089225 6910 Nucleus 6.0 26.8 2.1E-5 0.266666667
BMP10 ENSG00000163217 27302 Secreted 4.0 0.631 2.06E-5 0.333333333
BMP2 ENSG00000125845 650 Secreted 22.0 207.0 2.08E-5 0.021645022
FGF8 ENSG00000107831 2253 Secreted 43.0 6720.0 2.12E-5 0.007751938
Gene1 Gene2 Weight KEGG humanCyc PID BioGRID IntAct HPRD BIND Reactome CORUM DIP WikiPathways ReconX INOH SMPDB PhosphoSite PANTHER CTD NetPath TRANSFAC DrugBank
BHLHE40 SMYD1 3
BMP10 SMAD1 1
BMP2 SMAD1 2
CTNNB1 NOTCH1 4
CTNNB1 PITX2 4
CTNNB1 SMAD4 5
ERBB3 CTNNB1 1
ERBB3 MAPK1 2
FOXC1 TBX1 1
FOXH1 MEF2C 2
FOXH1 NKX2-5 2
FOXH1 SMAD4 8
GATA4 HAND2 3
GATA4 MEF2C 2
GATA4 NKX2-5 4
HEY1 HEY2 2
MAPK1 SMAD1 6
MAPK1 SMAD4 2
NKX2-5 SMAD4 3
NKX2-5 TBX5 4
NOTCH1 HEY1 3
NOTCH1 HEY2 3
SMAD1 SMAD4 10
TBX1 SMAD1 1
BMP10 BMP2 1
BMP2 TBX2 1
CTNNB1 BHLHE40 1
CTNNB1 HEY1 1
CTNNB1 ISL1 1
CTNNB1 MAPK1 2
CTNNB1 SMAD1 1
CTNNB1 TBX2 1
CTNNB1 TBX5 1
ERBB3 FGF8 1
FOXA2 TBX1 1
FOXA2 TBX2 1
FOXC1 PITX2 2
FOXH1 SMAD1 1
GATA4 ERBB3 1
GATA4 TBX5 2
HAND1 BHLHE40 1
HAND1 HAND2 1
HAND1 HEY2 2
HAND1 MEF2C 1
HAND2 HEY2 1
HEY1 GATA4 1
HEY2 GATA4 1
ISL1 MEF2C 1
MAPK1 FGF8 1
MAPK1 GATA4 1
MAPK1 NOTCH1 1
MEF2C NOTCH1 2
MEF2C SMYD1 1
NKX2-5 BMP10 1
NKX2-5 HAND1 1
NKX2-5 IRX4 1
NKX2-5 MEF2C 1
NKX2-5 SMAD1 1
NKX2-5 TBX1 1
NOTCH1 SMAD1 1
PITX2 ERBB3 1
PITX2 ISL1 1
PITX2 TBX20 1
SMAD4 GATA4 1
SMAD4 MEF2C 2
SMAD4 PITX2 1
SMAD4 TBX5 1
SMYD1 HAND2 1
TBX1 FGF8 1
TBX1 PITX2 1
TBX20 MEF2C 1
TBX20 TBX2 1
TBX2 NKX2-5 1
Pathway1 Pathway2 Intersect Similarity Scores Pathway Name Source Number of Genes Number of Interactions Detail