Pathway ID Pathway Name Source Organism Number of Genes Number of Interactions
pathway0002771 Hs_BMP_Signaling_Pathway_in_Eyelid_Development_WP3927_90735 WikiPathways Homo sapiens 11 21
Secreted
Membrane
Cytoplasm
Cytoplasm/4
Cytoskeleton
Cytoskeleton/Cytoplasm
Membrane/Nucleus
Cytoplasm/Nucleus
Cytoskeleton/Nucleus
Nucleus
Secreted/Nucleus
Unknown
Annotated genes
Unannotated genes
Symbol
Ensembl ID
Entrez ID
Subcellular localization
Description
Type
Edge
Symbol Ensembl ID Entrez ID Subcellular localization Closeness Degree Betweenness Transitivity
JUN ENSG00000177606 3725 Cytoplasm/Nucleus 0.06666667 40.0 9.83602 0.003846154
MAPK3 ENSG00000102882 5595 Cytoplasm/Nucleus 0.0625 26.0 6.771797 0.015384615
MAPK9 ENSG00000050748 5601 Cytoplasm/Nucleus 0.0625 28.0 6.070466 0.002645503
FGFR2 ENSG00000066468 2263 Membrane 0.06666667 5.0 4.568326 0.4
TGFA ENSG00000163235 7039 Membrane 0.05 16.0 0.0 0.025
EGFR ENSG00000146648 1956 Unknown 0.05555556 23.0 2.007801 0.011857708
MAP3K1 ENSG00000095015 4214 Unknown 0.0625 8.0 5.111479 0.071428571
PITX2 ENSG00000164093 5308 Unknown 0.05263158 3.0 2.553858 0.0
BMP4 ENSG00000125378 652 Secreted 0.05882353 3.0 3.990842 0.0
DKK2 ENSG00000155011 27123 Secreted 0.04761905 2.0 0.08941059 0.0
INHBB ENSG00000163083 3625 Secreted 0.04761905 2.0 1.0 0.0
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
JUN ENSG00000177606 3725 Cytoplasm/Nucleus 12667.0 3718359.0 1.57E-6 4.67E-4
MAPK3 ENSG00000102882 5595 Cytoplasm/Nucleus 29207.0 849501.6 1.56E-6 3.17E-5
MAPK9 ENSG00000050748 5601 Cytoplasm/Nucleus 6317.0 61095.01 1.56E-6 1.86E-4
FGFR2 ENSG00000066468 2263 Membrane 3779.0 10553.34 1.56E-6 0.00107
TGFA ENSG00000163235 7039 Membrane 649.0 57264.03 1.55E-6 0.00494
EGFR ENSG00000146648 1956 Unknown 12590.0 758354.8 1.56E-6 2.83E-4
MAP3K1 ENSG00000095015 4214 Unknown 3556.0 48670.51 1.56E-6 6.01E-4
PITX2 ENSG00000164093 5308 Unknown 49.0 2185.328 1.55E-6 0.12
BMP4 ENSG00000125378 652 Secreted 773.0 22576.56 1.55E-6 0.00766
DKK2 ENSG00000155011 27123 Secreted 182.0 172.7293 1.55E-6 0.00304
INHBB ENSG00000163083 3625 Secreted 601.0 627.1353 1.55E-6 0.0108
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
JUN ENSG00000177606 3725 Cytoplasm/Nucleus 1533.0 157000.0 2.18E-5 0.002673984
MAPK3 ENSG00000102882 5595 Cytoplasm/Nucleus 1631.0 42300.0 2.17E-5 0.001551233
MAPK9 ENSG00000050748 5601 Cytoplasm/Nucleus 700.0 3660.0 2.16E-5 0.002987942
FGFR2 ENSG00000066468 2263 Membrane 48.0 200.0 2.13E-5 0.076241135
TGFA ENSG00000163235 7039 Membrane 70.0 1.42 2.12E-5 0.011594203
EGFR ENSG00000146648 1956 Unknown 1156.0 40200.0 2.17E-5 0.002804116
MAP3K1 ENSG00000095015 4214 Unknown 434.0 10600.0 2.16E-5 0.00909952
PITX2 ENSG00000164093 5308 Unknown 12.0 473.0 2.11E-5 0.075757576
BMP4 ENSG00000125378 652 Secreted 45.0 2460.0 2.11E-5 0.042424242
DKK2 ENSG00000155011 27123 Secreted 2.0 0.661 2.1E-5 0.0
INHBB ENSG00000163083 3625 Secreted 3.0 1.69 2.09E-5 0.333333333
Gene1 Gene2 Weight KEGG humanCyc PID BioGRID IntAct HPRD BIND Reactome CORUM DIP WikiPathways ReconX INOH SMPDB PhosphoSite PANTHER CTD NetPath TRANSFAC DrugBank
EGFR MAPK3 3
EGFR TGFA 5
MAP3K1 MAPK9 4
MAPK3 JUN 4
MAPK9 JUN 8
TGFA MAPK3 1
BMP4 INHBB 1
EGFR FGFR2 1
EGFR MAPK9 2
FGFR2 BMP4 1
FGFR2 JUN 1
INHBB MAP3K1 1
JUN DKK2 1
JUN MAP3K1 2
MAP3K1 MAPK3 3
MAPK3 FGFR2 2
PITX2 BMP4 1
PITX2 DKK2 1
PITX2 MAPK9 1
TGFA FGFR2 1
Pathway1 Pathway2 Intersect Similarity Scores Pathway Name Source Number of Genes Number of Interactions Detail
pathway0002771 pathway0002656 7 0.6363636 Pathways in cancer KEGG 321 8293
pathway0002771 pathway0002562 6 0.5454545 MAPK signaling pathway KEGG 264 4851