Pathway ID Pathway Name Source Organism Number of Genes Number of Interactions
pathway0002773 Hs_Energy_Metabolism_WP1541_91584 WikiPathways Homo sapiens 13 34
Secreted
Membrane
Cytoplasm
Cytoplasm/4
Cytoskeleton
Cytoskeleton/Cytoplasm
Membrane/Nucleus
Cytoplasm/Nucleus
Cytoskeleton/Nucleus
Nucleus
Secreted/Nucleus
Unknown
Annotated genes
Unannotated genes
Symbol
Ensembl ID
Entrez ID
Subcellular localization
Description
Type
Edge
Symbol Ensembl ID Entrez ID Subcellular localization Closeness Degree Betweenness Transitivity
ATF2 ENSG00000115966 1386 Cytoplasm/Nucleus 0.05555556 17.0 4.557155 0.04411765
FOXO1 ENSG00000150907 2308 Cytoplasm/Nucleus 0.04545455 10.0 0.1153846 0.04444444
FOXO3 ENSG00000118689 2309 Cytoplasm/Nucleus 0.05555556 14.0 5.049764 0.05494505
GABPA ENSG00000154727 2551 Cytoplasm/Nucleus 0.05263158 9.0 4.918682 0.08333333
SIRT1 ENSG00000096717 23411 Cytoplasm/Nucleus 0.05555556 12.0 3.261143 0.09090909
MAPK14 ENSG00000112062 1432 Unknown 0.05263158 17.0 2.261975 0.04411765
ESRRA ENSG00000173153 2101 Nucleus 0.04761905 7.0 0.04545455 0.0952381
HDAC1 ENSG00000116478 3065 Nucleus 0.05263158 7.0 1.787273 0.19047619
MYBBP1A ENSG00000132382 10514 Nucleus 0.04545455 3.0 0.09090909 0.66666667
NRF1 ENSG00000106459 4899 Nucleus 0.05 9.0 3.012425 0.08333333
PPARGC1A ENSG00000109819 10891 Nucleus 0.06666667 32.0 25.52804 0.01612903
PPRC1 ENSG00000148840 23082 Nucleus 0.04166667 5.0 0.3333333 0.1
BMP7 ENSG00000101144 655 Secreted 0.04347826 2.0 0.03846154 0.0
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
ATF2 ENSG00000115966 1386 Cytoplasm/Nucleus 2727.0 293000.0 1.56E-6 0.004011675
FOXO1 ENSG00000150907 2308 Cytoplasm/Nucleus 1320.0 45800.0 1.56E-6 0.001618536
FOXO3 ENSG00000118689 2309 Cytoplasm/Nucleus 1569.0 45500.0 1.56E-6 0.002198202
GABPA ENSG00000154727 2551 Cytoplasm/Nucleus 57.0 39400.0 1.55E-6 0.04197995
SIRT1 ENSG00000096717 23411 Cytoplasm/Nucleus 674.0 56900.0 1.56E-6 0.023311185
MAPK14 ENSG00000112062 1432 Unknown 9287.0 427000.0 1.56E-6 2.56589E-4
ESRRA ENSG00000173153 2101 Nucleus 75.0 1590.0 1.55E-6 0.068108108
HDAC1 ENSG00000116478 3065 Nucleus 3183.0 336000.0 1.56E-6 0.003442629
MYBBP1A ENSG00000132382 10514 Nucleus 99.0 9.77 1.55E-6 0.761904762
NRF1 ENSG00000106459 4899 Nucleus 93.0 10900.0 1.55E-6 0.021972885
PPARGC1A ENSG00000109819 10891 Nucleus 604.0 39600.0 1.56E-6 0.010032618
PPRC1 ENSG00000148840 23082 Nucleus 22.0 171.0 1.54E-6 0.090909091
BMP7 ENSG00000101144 655 Secreted 697.0 18700.0 1.55E-6 0.00826201
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
ATF2 ENSG00000115966 1386 Cytoplasm/Nucleus 369.0 17824.34 2.17E-5 0.01832214
FOXO1 ENSG00000150907 2308 Cytoplasm/Nucleus 203.0 4853.744 2.14E-5 0.011266644
FOXO3 ENSG00000118689 2309 Cytoplasm/Nucleus 235.0 9482.103 2.15E-5 0.012220404
GABPA ENSG00000154727 2551 Cytoplasm/Nucleus 20.0 644.7507 2.07E-5 0.063157895
SIRT1 ENSG00000096717 23411 Cytoplasm/Nucleus 85.0 9803.826 2.15E-5 0.058263305
MAPK14 ENSG00000112062 1432 Unknown 1219.0 74227.51 2.17E-5 0.002559367
ESRRA ENSG00000173153 2101 Nucleus 14.0 1.468107 2.07E-5 0.032967033
HDAC1 ENSG00000116478 3065 Nucleus 133.0 9236.154 2.15E-5 0.052517658
MYBBP1A ENSG00000132382 10514 Nucleus 6.0 3.335274 2.11E-5 0.533333333
NRF1 ENSG00000106459 4899 Nucleus 21.0 67.86612 2.07E-5 0.047619048
PPARGC1A ENSG00000109819 10891 Nucleus 98.0 7184.623 2.13E-5 0.007153377
PPRC1 ENSG00000148840 23082 Nucleus 11.0 89.57463 2.08E-5 0.109090909
BMP7 ENSG00000101144 655 Secreted 49.0 7607.409 2.1E-5 0.037414966
Gene1 Gene2 Weight KEGG humanCyc PID BioGRID IntAct HPRD BIND Reactome CORUM DIP WikiPathways ReconX INOH SMPDB PhosphoSite PANTHER CTD NetPath TRANSFAC DrugBank
ATF2 PPARGC1A 4
ESRRA PPARGC1A 4
FOXO1 SIRT1 7
FOXO3 SIRT1 7
MAPK14 ATF2 8
MAPK14 FOXO3 1
MAPK14 PPARGC1A 4
NRF1 PPARGC1A 4
NRF1 PPRC1 5
PPARGC1A FOXO1 2
PPARGC1A GABPA 2
PPARGC1A SIRT1 3
ATF2 HDAC1 1
ATF2 PPRC1 1
ATF2 SIRT1 1
ESRRA GABPA 1
ESRRA SIRT1 1
FOXO3 ATF2 1
FOXO3 BMP7 1
FOXO3 FOXO1 1
FOXO3 HDAC1 1
GABPA HDAC1 1
GABPA NRF1 1
GABPA PPRC1 1
HDAC1 MAPK14 1
HDAC1 MYBBP1A 1
MAPK14 MYBBP1A 1
MYBBP1A PPARGC1A 1
NRF1 SIRT1 1
PPARGC1A BMP7 1
Pathway1 Pathway2 Intersect Similarity Scores Pathway Name Source Number of Genes Number of Interactions Detail