Pathway ID Pathway Name Source Organism Number of Genes Number of Interactions
pathway0002797 Hs_Lung_fibrosis_WP3624_91475 WikiPathways Homo sapiens 23 45
Secreted
Membrane
Cytoplasm
Cytoplasm/4
Cytoskeleton
Cytoskeleton/Cytoplasm
Membrane/Nucleus
Cytoplasm/Nucleus
Cytoskeleton/Nucleus
Nucleus
Secreted/Nucleus
Unknown
Annotated genes
Unannotated genes
Symbol
Ensembl ID
Entrez ID
Subcellular localization
Description
Type
Edge
Symbol Ensembl ID Entrez ID Subcellular localization Closeness Degree Betweenness Transitivity
CCR2 ENSG00000121807 729230 Cytoplasm 0.01694915 13.0 22.94737 0.01282051
IGF1 ENSG00000017427 3479 Cytoplasm 0.01428571 1.0 0.0 0.0
CEBPB ENSG00000172216 1051 Cytoplasm/Nucleus 0.02272727 9.0 27.1685 0.05555556
PARN ENSG00000140694 5073 Cytoplasm/Nucleus 0.01587302 1.0 0.0 0.0
SMAD7 ENSG00000101665 4092 Cytoplasm/Nucleus 0.01851852 4.0 0.0 0.16666667
PLAU ENSG00000122861 5328 Membrane 0.01818182 5.0 5.092246 0.0
CREB3L1 ENSG00000157613 90993 Unknown 0.0125 1.0 0.0 0.0
FAM13A ENSG00000138640 10144 Unknown 0.01538462 1.0 0.0 0.0
SKIL ENSG00000136603 6498 Nucleus 0.01449275 1.0 0.0 0.0
CCL2 ENSG00000108691 6347 Secreted 0.0212766 19.0 16.22502 0.03508772
CCL3 ENSG00000277632 6348 Secreted 0.02 8.0 16.45966 0.0
CCL5 ENSG00000271503 6352 Secreted 0.02040816 8.0 5.506767 0.14285714
CMA1 ENSG00000092009 1215 Secreted 0.01666667 2.0 0.0 0.0
FGF2 ENSG00000138685 2247 Secreted 0.01785714 5.0 24.33636 0.1
HGF ENSG00000019991 3082 Secreted 0.01754386 5.0 8.121263 0.0
IL12B ENSG00000113302 3593 Secreted 0.02083333 9.0 22.38921 0.08333333
PDGFA ENSG00000197461 5154 Secreted 0.01785714 5.0 2.299465 0.2
PTX3 ENSG00000163661 5806 Secreted 0.01298701 2.0 0.0 0.0
SPP1 ENSG00000118785 6696 Secreted 0.02040816 4.0 24.45721 0.16666667
TGFB1 ENSG00000105329 7040 Secreted 0.02325581 12.0 29.17467 0.04545455
TNF ENSG00000232810 7124 Secreted 0.025 20.0 56.47474 0.04210526
IL1B ENSG00000125538 3553 Secreted/Nucleus 0.02564103 26.0 59.27895 0.02769231
PDGFB ENSG00000100311 5155 Secreted/Nucleus 0.02380952 9.0 63.06856 0.11111111
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
CCR2 ENSG00000121807 729230 Cytoplasm 513.0 19900.0 1.55E-6 0.010454739
IGF1 ENSG00000017427 3479 Cytoplasm 1260.0 84400.0 1.56E-6 0.002150863
CEBPB ENSG00000172216 1051 Cytoplasm/Nucleus 740.0 78400.0 1.56E-6 0.018662912
PARN ENSG00000140694 5073 Cytoplasm/Nucleus 45.0 479.0 1.54E-6 0.106060606
SMAD7 ENSG00000101665 4092 Cytoplasm/Nucleus 920.0 7960.0 1.56E-6 0.003510432
PLAU ENSG00000122861 5328 Membrane 359.0 26400.0 1.55E-6 0.006426915
CREB3L1 ENSG00000157613 90993 Unknown 135.0 1130.0 1.55E-6 0.059480376
FAM13A ENSG00000138640 10144 Unknown 20.0 36.8 1.54E-6 0.105263158
SKIL ENSG00000136603 6498 Nucleus 198.0 321.0 1.55E-6 0.084397272
CCL2 ENSG00000108691 6347 Secreted 443.0 9660.0 1.55E-6 0.009141701
CCL3 ENSG00000277632 6348 Secreted 330.0 2360.0 1.55E-6 0.012010684
CCL5 ENSG00000271503 6352 Secreted 554.0 19600.0 1.56E-6 0.00904812
CMA1 ENSG00000092009 1215 Secreted 10.0 1.48 1.54E-6 0.066666667
FGF2 ENSG00000138685 2247 Secreted 3268.0 46500.0 1.56E-6 0.001404573
HGF ENSG00000019991 3082 Secreted 734.0 9540.0 1.55E-6 0.003799101
IL12B ENSG00000113302 3593 Secreted 903.0 4270.0 1.55E-6 0.005618129
PDGFA ENSG00000197461 5154 Secreted 1728.0 13900.0 1.55E-6 0.003569399
PTX3 ENSG00000163661 5806 Secreted 2.0 0.0 1.53E-6 0.0
SPP1 ENSG00000118785 6696 Secreted 317.0 1520.0 1.55E-6 0.010821387
TGFB1 ENSG00000105329 7040 Secreted 2432.0 180000.0 1.56E-6 0.001777682
TNF ENSG00000232810 7124 Secreted 4479.0 293000.0 1.56E-6 0.001018001
IL1B ENSG00000125538 3553 Secreted/Nucleus 2345.0 54300.0 1.56E-6 0.001728316
PDGFB ENSG00000100311 5155 Secreted/Nucleus 2493.0 26100.0 1.56E-6 0.002563196
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
CCR2 ENSG00000121807 729230 Cytoplasm 13.0 1877.812 2.05E-5 0.012820513
IGF1 ENSG00000017427 3479 Cytoplasm 64.0 825.4007 2.12E-5 0.021825397
CEBPB ENSG00000172216 1051 Cytoplasm/Nucleus 73.0 3530.719 2.14E-5 0.036149163
PARN ENSG00000140694 5073 Cytoplasm/Nucleus 1.0 0.0 2.04E-5 0.0
SMAD7 ENSG00000101665 4092 Cytoplasm/Nucleus 113.0 1008.096 2.15E-5 0.046302149
PLAU ENSG00000122861 5328 Membrane 49.0 1478.137 2.13E-5 0.06547619
CREB3L1 ENSG00000157613 90993 Unknown 1.0 0.0 1.98E-5 0.0
FAM13A ENSG00000138640 10144 Unknown 1.0 0.0 2.05E-5 0.0
SKIL ENSG00000136603 6498 Nucleus 17.0 71.22303 2.1E-5 0.191176471
CCL2 ENSG00000108691 6347 Secreted 105.0 3151.239 2.13E-5 0.011721612
CCL3 ENSG00000277632 6348 Secreted 8.0 135.6853 2.07E-5 0.0
CCL5 ENSG00000271503 6352 Secreted 24.0 777.2044 2.12E-5 0.115942029
CMA1 ENSG00000092009 1215 Secreted 2.0 0.0 2.07E-5 0.0
FGF2 ENSG00000138685 2247 Secreted 54.0 3160.375 2.13E-5 0.046121593
HGF ENSG00000019991 3082 Secreted 6.0 91.221 2.08E-5 0.0
IL12B ENSG00000113302 3593 Secreted 9.0 45.44983 2.09E-5 0.083333333
PDGFA ENSG00000197461 5154 Secreted 9.0 336.9882 2.08E-5 0.083333333
PTX3 ENSG00000163661 5806 Secreted 2.0 0.0 2.04E-5 0.0
SPP1 ENSG00000118785 6696 Secreted 24.0 215.9236 2.12E-5 0.047101449
TGFB1 ENSG00000105329 7040 Secreted 116.0 13725.91 2.15E-5 0.035082459
TNF ENSG00000232810 7124 Secreted 462.0 55799.23 2.17E-5 0.008057019
IL1B ENSG00000125538 3553 Secreted/Nucleus 271.0 11865.25 2.15E-5 0.00932076
PDGFB ENSG00000100311 5155 Secreted/Nucleus 39.0 2036.433 2.12E-5 0.067476383
Gene1 Gene2 Weight KEGG humanCyc PID BioGRID IntAct HPRD BIND Reactome CORUM DIP WikiPathways ReconX INOH SMPDB PhosphoSite PANTHER CTD NetPath TRANSFAC DrugBank
CCL2 CCR2 5
CCL3 CCR2 2
CCL5 CCR2 2
IL1B CCL2 1
IL1B CCL5 1
IL1B IL12B 2
IL1B TGFB1 2
PDGFA PDGFB 4
PLAU HGF 2
SMAD7 TGFB1 2
TNF CCL2 2
TNF CCL5 1
TNF IL1B 1
TNF PLAU 1
TNF TGFB1 2
CCL3 CEBPB 2
CCL5 CCL2 1
CEBPB FAM13A 1
CEBPB IL1B 1
CEBPB PDGFB 1
CEBPB TNF 1
CMA1 IL1B 1
CREB3L1 CCR2 1
FGF2 HGF 2
IL12B CCL2 1
IL12B CCL3 1
IL12B TNF 1
IL1B PDGFB 1
PDGFA FGF2 1
PDGFA SPP1 1
PDGFB FGF2 1
PDGFB PARN 1
PDGFB SPP1 1
PTX3 FGF2 1
SKIL IL12B 1
SPP1 IGF1 1
TGFB1 CCL3 1
TGFB1 HGF 1
TGFB1 PDGFB 1
TNF SMAD7 1
TNF SPP1 1
Pathway1 Pathway2 Intersect Similarity Scores Pathway Name Source Number of Genes Number of Interactions Detail