Pathway ID Pathway Name Source Organism Number of Genes Number of Interactions
pathway0002824 Hs_RIG-I-like_Receptor_Signaling_WP3865_88186 WikiPathways Homo sapiens 19 60
Secreted
Membrane
Cytoplasm
Cytoplasm/4
Cytoskeleton
Cytoskeleton/Cytoplasm
Membrane/Nucleus
Cytoplasm/Nucleus
Cytoskeleton/Nucleus
Nucleus
Secreted/Nucleus
Unknown
Annotated genes
Unannotated genes
Symbol
Ensembl ID
Entrez ID
Subcellular localization
Description
Type
Edge
Symbol Ensembl ID Entrez ID Subcellular localization Closeness Degree Betweenness Transitivity
CYP4A11 ENSG00000187048 1579 Cytoplasm 0.02380952 1.0 0.0 0.0
DDX58 ENSG00000107201 23586 Cytoplasm 0.04 37.0 38.97773 0.03753754
DHX58 ENSG00000108771 79132 Cytoplasm 0.02631579 7.0 0.7384615 0.0
IFIH1 ENSG00000115267 64135 Cytoplasm 0.03703704 21.0 24.124 0.07619048
TRAF2 ENSG00000127191 7186 Cytoplasm 0.03703704 21.0 3.836065 0.10952381
TRAF3 ENSG00000131323 7187 Cytoplasm 0.03703704 24.0 2.957348 0.10144928
IKBKG ENSG00000269335 8517 Cytoplasm/Nucleus 0.03846154 27.0 21.20724 0.07407407
PIN1 ENSG00000127445 5300 Cytoplasm/Nucleus 0.02941176 10.0 1.592864 0.13333333
TRIM25 ENSG00000121060 7706 Cytoplasm/Nucleus 0.03571429 18.0 2.676256 0.15686275
DAK ENSG00000149476 26007 Unknown 0.02272727 2.0 0.0 0.0
MAP3K7 ENSG00000135341 6885 Unknown 0.02631579 12.0 0.0 0.04545455
MAVS ENSG00000088888 57506 Unknown 0.04166667 39.0 15.84001 0.04588394
NLRX1 ENSG00000160703 79671 Unknown 0.03225806 13.0 0.6672065 0.16666667
OTUD5 ENSG00000068308 55593 Unknown 0.03030303 9.0 0.1668016 0.22222222
RNF125 ENSG00000101695 54941 Unknown 0.02857143 7.0 0.5538462 0.0952381
DDX17 ENSG00000100201 10521 Nucleus 0.02564103 7.0 2.5 0.14285714
IRF3 ENSG00000126456 3661 Nucleus 0.03846154 24.0 14.44022 0.0942029
SNW1 ENSG00000100603 22938 Nucleus 0.02564103 4.0 1.386654 0.0
ISG15 ENSG00000187608 9636 Secreted 0.03030303 13.0 5.335303 0.07692308
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
CYP4A11 ENSG00000187048 1579 Cytoplasm 524.0 34800.0 1.55E-6 0.00179528
DDX58 ENSG00000107201 23586 Cytoplasm 424.0 16200.0 1.55E-6 0.004025603
DHX58 ENSG00000108771 79132 Cytoplasm 21.0 0.362 1.53E-6 0.0
IFIH1 ENSG00000115267 64135 Cytoplasm 175.0 17700.0 1.55E-6 0.009655172
TRAF2 ENSG00000127191 7186 Cytoplasm 2474.0 66200.0 1.56E-6 0.001881925
TRAF3 ENSG00000131323 7187 Cytoplasm 737.0 30800.0 1.55E-6 0.003082414
IKBKG ENSG00000269335 8517 Cytoplasm/Nucleus 7020.0 201000.0 1.56E-6 2.06887E-4
PIN1 ENSG00000127445 5300 Cytoplasm/Nucleus 172.0 1220.0 1.56E-6 0.049571603
TRIM25 ENSG00000121060 7706 Cytoplasm/Nucleus 243.0 10700.0 1.55E-6 0.015270551
DAK ENSG00000149476 26007 Unknown 4.0 0.0 1.52E-6 0.0
MAP3K7 ENSG00000135341 6885 Unknown 5836.0 93700.0 1.56E-6 2.59125E-4
MAVS ENSG00000088888 57506 Unknown 423.0 11500.0 1.55E-6 0.004145519
NLRX1 ENSG00000160703 79671 Unknown 55.0 1.23 1.54E-6 0.020875421
OTUD5 ENSG00000068308 55593 Unknown 39.0 36.3 1.54E-6 0.028340081
RNF125 ENSG00000101695 54941 Unknown 32.0 7.56 1.54E-6 0.034274194
DDX17 ENSG00000100201 10521 Nucleus 27.0 87.5 1.55E-6 0.236467237
IRF3 ENSG00000126456 3661 Nucleus 760.0 29300.0 1.55E-6 0.001608765
SNW1 ENSG00000100603 22938 Nucleus 356.0 3700.0 1.55E-6 0.013752176
ISG15 ENSG00000187608 9636 Secreted 241.0 18500.0 1.55E-6 0.014419087
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
CYP4A11 ENSG00000187048 1579 Cytoplasm 1.0 0.0 2.0E-5 0.0
DDX58 ENSG00000107201 23586 Cytoplasm 37.0 4610.0 2.07E-5 0.037537538
DHX58 ENSG00000108771 79132 Cytoplasm 7.0 0.738 2.0E-5 0.0
IFIH1 ENSG00000115267 64135 Cytoplasm 21.0 2960.0 2.07E-5 0.076190476
TRAF2 ENSG00000127191 7186 Cytoplasm 186.0 4920.0 2.14E-5 0.024353386
TRAF3 ENSG00000131323 7187 Cytoplasm 121.0 5340.0 2.12E-5 0.022727273
IKBKG ENSG00000269335 8517 Cytoplasm/Nucleus 595.0 27800.0 2.15E-5 0.00444784
PIN1 ENSG00000127445 5300 Cytoplasm/Nucleus 10.0 82.2 2.06E-5 0.133333333
TRIM25 ENSG00000121060 7706 Cytoplasm/Nucleus 18.0 321.0 2.07E-5 0.156862745
DAK ENSG00000149476 26007 Unknown 2.0 0.0 2.0E-5 0.0
MAP3K7 ENSG00000135341 6885 Unknown 710.0 23100.0 2.16E-5 0.003210235
MAVS ENSG00000088888 57506 Unknown 39.0 898.0 2.09E-5 0.045883941
NLRX1 ENSG00000160703 79671 Unknown 13.0 0.667 2.07E-5 0.166666667
OTUD5 ENSG00000068308 55593 Unknown 18.0 918.0 2.1E-5 0.052287582
RNF125 ENSG00000101695 54941 Unknown 7.0 0.554 2.01E-5 0.095238095
DDX17 ENSG00000100201 10521 Nucleus 7.0 26.0 2.02E-5 0.142857143
IRF3 ENSG00000126456 3661 Nucleus 41.0 2330.0 2.09E-5 0.041463415
SNW1 ENSG00000100603 22938 Nucleus 12.0 1260.0 2.09E-5 0.075757576
ISG15 ENSG00000187608 9636 Secreted 13.0 5.44 2.02E-5 0.076923077
Gene1 Gene2 Weight KEGG humanCyc PID BioGRID IntAct HPRD BIND Reactome CORUM DIP WikiPathways ReconX INOH SMPDB PhosphoSite PANTHER CTD NetPath TRANSFAC DrugBank
DAK IFIH1 2
DDX17 PIN1 2
DDX17 SNW1 2
DDX58 IKBKG 2
DDX58 IRF3 2
DDX58 MAVS 8
DDX58 TRAF3 3
DDX58 TRIM25 4
DHX58 DDX58 3
DHX58 IFIH1 3
IFIH1 IKBKG 1
IFIH1 IRF3 1
IFIH1 MAVS 7
IKBKG MAP3K7 5
IKBKG MAVS 3
IKBKG TRAF2 4
IRF3 MAVS 4
IRF3 PIN1 3
IRF3 TRAF3 2
ISG15 DDX58 3
ISG15 TRIM25 2
MAP3K7 TRAF2 6
MAVS TRAF2 5
MAVS TRAF3 6
NLRX1 DDX58 1
NLRX1 IFIH1 1
NLRX1 MAVS 3
NLRX1 TRIM25 1
OTUD5 TRAF3 5
RNF125 DDX58 2
RNF125 IFIH1 2
TRAF2 TRAF3 5
CYP4A11 DDX58 1
DDX17 IRF3 2
DDX58 TRAF2 1
IFIH1 TRAF2 1
IFIH1 TRAF3 1
IKBKG IRF3 1
IKBKG NLRX1 1
IKBKG TRAF3 1
IRF3 ISG15 1
IRF3 TRAF2 2
ISG15 DDX17 1
ISG15 PIN1 1
MAP3K7 MAVS 2
MAVS PIN1 2
MAVS RNF125 1
MAVS TRIM25 1
NLRX1 TRAF3 1
OTUD5 DDX58 1
OTUD5 IFIH1 1
OTUD5 MAVS 1
OTUD5 TRIM25 1
PIN1 TRAF2 3
SNW1 IKBKG 1
TRAF2 TRIM25 1
TRAF3 TRIM25 1
TRIM25 IKBKG 1
TRIM25 IRF3 1
Pathway1 Pathway2 Intersect Similarity Scores Pathway Name Source Number of Genes Number of Interactions Detail
pathway0002824 pathway0002604 16 0.8421053 RIG-I-like receptor signaling pathway KEGG 71 471
pathway0002824 pathway0001469 11 0.5789474 Negative regulators of RIG-I/MDA5 signaling Reactome 34 215
pathway0002824 pathway0001907 7 0.5384615 RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Reactome 13 32