Pathway ID Pathway Name Source Organism Number of Genes Number of Interactions
pathway0002841 Hs_Ectoderm_Differentiation_WP2858_89329 WikiPathways Homo sapiens 56 137
Secreted
Membrane
Cytoplasm
Cytoplasm/4
Cytoskeleton
Cytoskeleton/Cytoplasm
Membrane/Nucleus
Cytoplasm/Nucleus
Cytoskeleton/Nucleus
Nucleus
Secreted/Nucleus
Unknown
Annotated genes
Unannotated genes
Symbol
Ensembl ID
Entrez ID
Subcellular localization
Description
Type
Edge
Symbol Ensembl ID Entrez ID Subcellular localization Closeness Degree Betweenness Transitivity
AHI1 ENSG00000135541 54806 Cytoplasm 0.004 3.0 0.0 1.0
ARHGAP10 ENSG00000071205 79658 Cytoplasm 0.004098361 3.0 0.0 0.0
ARHGAP15 ENSG00000075884 55843 Cytoplasm 0.003703704 3.0 3.485714 0.0
CCDC88C ENSG00000015133 440193 Cytoplasm 0.003584229 2.0 0.0 0.0
CTNNA2 ENSG00000066032 1496 Cytoplasm 0.004273504 15.0 20.31038 0.08571429
FYN ENSG00000010810 2534 Cytoplasm 0.004464286 28.0 29.02879 0.04761905
KRT6A ENSG00000205420 3853 Cytoplasm 0.003558719 3.0 0.5 0.0
MKS1 ENSG00000011143 54903 Cytoplasm 0.004310345 5.0 45.01167 0.5
PAN2 ENSG00000135473 9924 Cytoplasm 0.003717472 5.0 8.217951 0.1
RAB8B ENSG00000166128 51762 Cytoplasm 0.004166667 4.0 0.0 0.16666667
SCHIP1 ENSG00000151967 29970 Cytoplasm 0.003460208 2.0 0.0 0.0
CTBP1 ENSG00000159692 1487 Cytoplasm/Nucleus 0.004484305 12.0 4.264815 0.21212121
HDAC10 ENSG00000100429 83933 Cytoplasm/Nucleus 0.003861004 5.0 9.552169 0.0
HDAC6 ENSG00000094631 10013 Cytoplasm/Nucleus 0.004329004 7.0 7.236621 0.14285714
JUP ENSG00000173801 3728 Cytoplasm/Nucleus 0.004504505 30.0 88.75179 0.05287356
NLK ENSG00000087095 51701 Cytoplasm/Nucleus 0.004310345 12.0 0.8333367 0.12121212
NUMA1 ENSG00000137497 4926 Cytoplasm/Nucleus 0.003584229 2.0 0.0 0.0
OGT ENSG00000147162 8473 Cytoplasm/Nucleus 0.004032258 3.0 6.04 0.0
PAX6 ENSG00000007372 5080 Cytoplasm/Nucleus 0.004219409 8.0 66.8006 0.10714286
SMAD4 ENSG00000141646 4089 Cytoplasm/Nucleus 0.00462963 21.0 100.654 0.07142857
SMURF1 ENSG00000198742 57154 Cytoplasm/Nucleus 0.004405286 18.0 215.6699 0.0130719
SNCA ENSG00000145335 6622 Cytoplasm/Nucleus 0.004310345 10.0 39.01685 0.06666667
ARHGEF9 ENSG00000131089 23229 Membrane 0.003584229 2.0 0.0 0.0
BOC ENSG00000144857 91653 Membrane 0.004219409 7.0 0.408003 0.19047619
CDH6 ENSG00000113361 1004 Membrane 0.004310345 11.0 1.316561 0.18181818
CDH8 ENSG00000150394 1006 Membrane 0.004219409 10.0 0.4501905 0.15555556
CDON ENSG00000064309 50937 Membrane 0.004273504 7.0 0.8707175 0.19047619
CTNND2 ENSG00000169862 1501 Membrane 0.004149378 12.0 0.375 0.07575758
EDA2R ENSG00000131080 60401 Membrane 3.30579E-4 4.0 0.0 0.0
FGFR2 ENSG00000066468 2263 Membrane 0.004237288 8.0 2.593407 0.07142857
NLGN1 ENSG00000169760 22871 Membrane 0.003236246 1.0 0.0 0.0
PTPN13 ENSG00000163629 5783 Membrane 0.004115226 4.0 0.0 0.16666667
RIT1 ENSG00000143622 6016 Membrane 0.003676471 4.0 9.466667 0.0
SGSM3 ENSG00000100359 27352 Membrane 0.003610108 3.0 1.535714 0.0
CTNNB1 ENSG00000168036 1499 Unknown 0.005208333 103.0 779.0608 0.01123168
EDA ENSG00000158813 1896 Unknown 3.30579E-4 4.0 0.0 0.0
NF2 ENSG00000186575 4771 Unknown 0.004219409 10.0 104.5758 0.02222222
PPARD ENSG00000112033 5467 Unknown 0.004255319 7.0 1.364886 0.28571429
SDCBP ENSG00000137575 6386 Unknown 0.004166667 3.0 0.0 0.33333333
TTC14 ENSG00000163728 151613 Unknown 0.003236246 1.0 0.0 0.0
CCDC130 ENSG00000104957 81576 Nucleus 0.004219409 5.0 1.774564 0.3
FOXA2 ENSG00000125798 3170 Nucleus 0.003891051 10.0 160.1372 0.02222222
HESX1 ENSG00000163666 8820 Nucleus 0.003759399 2.0 5.314119 0.0
LHX1 ENSG00000273706 3975 Nucleus 0.003236246 3.0 0.0 0.0
MAFB ENSG00000204103 9935 Nucleus 0.003875969 3.0 1.324074 0.33333333
PAX3 ENSG00000135903 5077 Nucleus 0.004329004 7.0 15.75677 0.28571429
SOX2 ENSG00000181449 6657 Nucleus 0.00456621 13.0 183.8775 0.14102564
TBL1X ENSG00000101849 6907 Nucleus 0.004444444 9.0 80.54315 0.08333333
TCF3 ENSG00000071564 6929 Nucleus 0.004784689 19.0 176.5025 0.15204678
TCF7L1 ENSG00000152284 83439 Nucleus 0.004405286 29.0 48.57027 0.02463054
TFAP2A ENSG00000137203 7020 Nucleus 0.004310345 7.0 10.47019 0.19047619
TRIM33 ENSG00000197323 51592 Nucleus 0.004405286 7.0 1.017251 0.28571429
VAX2 ENSG00000116035 25806 Nucleus 0.003460208 1.0 0.0 0.0
ZBTB16 ENSG00000109906 7704 Nucleus 0.004048583 6.0 1.484273 0.13333333
ZBTB7B ENSG00000160685 51043 Nucleus 0.003875969 3.0 2.835857 0.0
ZFHX4 ENSG00000091656 79776 Nucleus 0.003773585 2.0 0.0 1.0
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
AHI1 ENSG00000135541 54806 Cytoplasm 105.0 69.3 1.55E-6 0.800915751
ARHGAP10 ENSG00000071205 79658 Cytoplasm 65.0 8250.0 1.55E-6 0.065384615
ARHGAP15 ENSG00000075884 55843 Cytoplasm 30.0 90.3 1.54E-6 0.188505747
CCDC88C ENSG00000015133 440193 Cytoplasm 6.0 0.0101 1.54E-6 0.2
CTNNA2 ENSG00000066032 1496 Cytoplasm 335.0 2170.0 1.55E-6 0.010528197
FYN ENSG00000010810 2534 Cytoplasm 9828.0 511000.0 1.56E-6 4.85071E-4
KRT6A ENSG00000205420 3853 Cytoplasm 19.0 299.0 1.55E-6 0.356725146
MKS1 ENSG00000011143 54903 Cytoplasm 118.0 327.0 1.55E-6 0.640446183
PAN2 ENSG00000135473 9924 Cytoplasm 24.0 673.0 1.54E-6 0.40942029
RAB8B ENSG00000166128 51762 Cytoplasm 4.0 0.0 1.54E-6 0.166666667
SCHIP1 ENSG00000151967 29970 Cytoplasm 2.0 0.0 1.52E-6 0.0
CTBP1 ENSG00000159692 1487 Cytoplasm/Nucleus 448.0 3790.0 1.55E-6 0.008778763
HDAC10 ENSG00000100429 83933 Cytoplasm/Nucleus 177.0 2560.0 1.55E-6 0.148433487
HDAC6 ENSG00000094631 10013 Cytoplasm/Nucleus 288.0 14700.0 1.56E-6 0.034238289
JUP ENSG00000173801 3728 Cytoplasm/Nucleus 504.0 14600.0 1.56E-6 0.010445265
NLK ENSG00000087095 51701 Cytoplasm/Nucleus 662.0 4980.0 1.55E-6 0.001604271
NUMA1 ENSG00000137497 4926 Cytoplasm/Nucleus 18.0 41.4 1.54E-6 0.287581699
OGT ENSG00000147162 8473 Cytoplasm/Nucleus 29.0 89.6 1.54E-6 0.610837438
PAX6 ENSG00000007372 5080 Cytoplasm/Nucleus 126.0 19700.0 1.55E-6 0.510476191
SMAD4 ENSG00000141646 4089 Cytoplasm/Nucleus 2908.0 151000.0 1.56E-6 0.00134405
SMURF1 ENSG00000198742 57154 Cytoplasm/Nucleus 782.0 41500.0 1.56E-6 0.008340674
SNCA ENSG00000145335 6622 Cytoplasm/Nucleus 474.0 71300.0 1.56E-6 0.012337089
ARHGEF9 ENSG00000131089 23229 Membrane 52.0 54400.0 1.54E-6 0.035444947
BOC ENSG00000144857 91653 Membrane 81.0 1520.0 1.55E-6 0.038580247
CDH6 ENSG00000113361 1004 Membrane 87.0 13.8 1.55E-6 0.095696338
CDH8 ENSG00000150394 1006 Membrane 70.0 9.09 1.55E-6 0.085714286
CDON ENSG00000064309 50937 Membrane 86.0 1600.0 1.55E-6 0.036662107
CTNND2 ENSG00000169862 1501 Membrane 302.0 304.0 1.55E-6 0.023233812
EDA2R ENSG00000131080 60401 Membrane 12.0 0.0 1.5E-6 0.0
FGFR2 ENSG00000066468 2263 Membrane 3779.0 10600.0 1.56E-6 0.001074311
NLGN1 ENSG00000169760 22871 Membrane 7.0 21500.0 1.53E-6 0.0
PTPN13 ENSG00000163629 5783 Membrane 49.0 4.55 1.55E-6 0.095238095
RIT1 ENSG00000143622 6016 Membrane 25.0 8.53 1.54E-6 0.076666667
SGSM3 ENSG00000100359 27352 Membrane 3.0 2.77 1.53E-6 0.0
CTNNB1 ENSG00000168036 1499 Unknown 12389.0 1400000.0 1.57E-6 3.14058E-4
EDA ENSG00000158813 1896 Unknown 20.0 10200.0 1.53E-6 0.005263158
NF2 ENSG00000186575 4771 Unknown 23.0 11800.0 1.55E-6 0.071146245
PPARD ENSG00000112033 5467 Unknown 156.0 12300.0 1.55E-6 0.036393714
SDCBP ENSG00000137575 6386 Unknown 81.0 5020.0 1.55E-6 0.038271605
TTC14 ENSG00000163728 151613 Unknown 1.0 0.0 1.53E-6 0.0
CCDC130 ENSG00000104957 81576 Nucleus 5.0 0.293 1.54E-6 0.3
FOXA2 ENSG00000125798 3170 Nucleus 113.0 94200.0 1.55E-6 0.020701644
HESX1 ENSG00000163666 8820 Nucleus 2.0 0.16 1.53E-6 0.0
LHX1 ENSG00000273706 3975 Nucleus 7.0 0.0 1.54E-6 0.047619048
MAFB ENSG00000204103 9935 Nucleus 93.0 71.9 1.55E-6 0.85483871
PAX3 ENSG00000135903 5077 Nucleus 87.0 1320.0 1.55E-6 0.356856456
SOX2 ENSG00000181449 6657 Nucleus 164.0 39800.0 1.55E-6 0.026485112
TBL1X ENSG00000101849 6907 Nucleus 503.0 14500.0 1.55E-6 0.033274457
TCF3 ENSG00000071564 6929 Nucleus 263.0 19400.0 1.56E-6 0.036716687
TCF7L1 ENSG00000152284 83439 Nucleus 1248.0 10700.0 1.55E-6 0.005080141
TFAP2A ENSG00000137203 7020 Nucleus 43.0 741.0 1.55E-6 0.03875969
TRIM33 ENSG00000197323 51592 Nucleus 49.0 31.6 1.55E-6 0.167517007
VAX2 ENSG00000116035 25806 Nucleus 1.0 0.0 1.53E-6 0.0
ZBTB16 ENSG00000109906 7704 Nucleus 85.0 1060.0 1.55E-6 0.177030812
ZBTB7B ENSG00000160685 51043 Nucleus 3.0 0.0329 1.53E-6 0.0
ZFHX4 ENSG00000091656 79776 Nucleus 2.0 0.0 1.53E-6 1.0
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
AHI1 ENSG00000135541 54806 Cytoplasm 3.0 0.0 2.03E-5 1.0
ARHGAP10 ENSG00000071205 79658 Cytoplasm 3.0 0.0 2.1E-5 0.0
ARHGAP15 ENSG00000075884 55843 Cytoplasm 3.0 28.2 2.05E-5 0.0
CCDC88C ENSG00000015133 440193 Cytoplasm 2.0 0.0 2.05E-5 0.0
CTNNA2 ENSG00000066032 1496 Cytoplasm 15.0 794.0 2.1E-5 0.085714286
FYN ENSG00000010810 2534 Cytoplasm 939.0 21700.0 2.16E-5 0.005181759
KRT6A ENSG00000205420 3853 Cytoplasm 3.0 0.5 2.02E-5 0.0
MKS1 ENSG00000011143 54903 Cytoplasm 5.0 2040.0 2.1E-5 0.5
PAN2 ENSG00000135473 9924 Cytoplasm 5.0 27.1 2.02E-5 0.1
RAB8B ENSG00000166128 51762 Cytoplasm 4.0 0.0 2.1E-5 0.166666667
SCHIP1 ENSG00000151967 29970 Cytoplasm 2.0 0.0 2.02E-5 0.0
CTBP1 ENSG00000159692 1487 Cytoplasm/Nucleus 20.0 334.0 2.12E-5 0.157894737
HDAC10 ENSG00000100429 83933 Cytoplasm/Nucleus 5.0 21.0 2.03E-5 0.0
HDAC6 ENSG00000094631 10013 Cytoplasm/Nucleus 36.0 8190.0 2.13E-5 0.057142857
JUP ENSG00000173801 3728 Cytoplasm/Nucleus 30.0 2840.0 2.1E-5 0.052873563
NLK ENSG00000087095 51701 Cytoplasm/Nucleus 68.0 277.0 2.12E-5 0.011852502
NUMA1 ENSG00000137497 4926 Cytoplasm/Nucleus 2.0 0.0 2.05E-5 0.0
OGT ENSG00000147162 8473 Cytoplasm/Nucleus 3.0 6.27 2.05E-5 0.0
PAX6 ENSG00000007372 5080 Cytoplasm/Nucleus 8.0 2050.0 2.08E-5 0.107142857
SMAD4 ENSG00000141646 4089 Cytoplasm/Nucleus 339.0 27300.0 2.16E-5 0.012672147
SMURF1 ENSG00000198742 57154 Cytoplasm/Nucleus 64.0 10800.0 2.13E-5 0.060515873
SNCA ENSG00000145335 6622 Cytoplasm/Nucleus 32.0 10300.0 2.1E-5 0.038306452
ARHGEF9 ENSG00000131089 23229 Membrane 2.0 0.0 2.05E-5 0.0
BOC ENSG00000144857 91653 Membrane 7.0 1.43 2.1E-5 0.19047619
CDH6 ENSG00000113361 1004 Membrane 11.0 1.51 2.1E-5 0.181818182
CDH8 ENSG00000150394 1006 Membrane 10.0 0.712 2.1E-5 0.155555556
CDON ENSG00000064309 50937 Membrane 7.0 0.832 2.1E-5 0.19047619
CTNND2 ENSG00000169862 1501 Membrane 12.0 0.375 2.1E-5 0.075757576
EDA2R ENSG00000131080 60401 Membrane 4.0 0.0 2.78E-7 0.0
FGFR2 ENSG00000066468 2263 Membrane 48.0 200.0 2.13E-5 0.076241135
NLGN1 ENSG00000169760 22871 Membrane 1.0 0.0 2.02E-5 0.0
PTPN13 ENSG00000163629 5783 Membrane 4.0 0.0 2.1E-5 0.166666667
RIT1 ENSG00000143622 6016 Membrane 4.0 10.7 2.05E-5 0.0
SGSM3 ENSG00000100359 27352 Membrane 3.0 15.4 2.03E-5 0.0
CTNNB1 ENSG00000168036 1499 Unknown 1273.0 177000.0 2.18E-5 0.002996438
EDA ENSG00000158813 1896 Unknown 4.0 0.0 2.78E-7 0.0
NF2 ENSG00000186575 4771 Unknown 10.0 3090.0 2.1E-5 0.022222222
PPARD ENSG00000112033 5467 Unknown 9.0 126.0 2.1E-5 0.166666667
SDCBP ENSG00000137575 6386 Unknown 3.0 0.0 2.1E-5 0.333333333
TTC14 ENSG00000163728 151613 Unknown 1.0 0.0 2.02E-5 0.0
CCDC130 ENSG00000104957 81576 Nucleus 5.0 38.5 2.1E-5 0.3
FOXA2 ENSG00000125798 3170 Nucleus 40.0 12500.0 2.1E-5 0.021794872
HESX1 ENSG00000163666 8820 Nucleus 2.0 9.35 2.04E-5 0.0
LHX1 ENSG00000273706 3975 Nucleus 7.0 0.0 2.05E-5 0.047619048
MAFB ENSG00000204103 9935 Nucleus 3.0 3.83 2.08E-5 0.333333333
PAX3 ENSG00000135903 5077 Nucleus 20.0 1200.0 2.11E-5 0.105263158
SOX2 ENSG00000181449 6657 Nucleus 74.0 7140.0 2.12E-5 0.029248427
TBL1X ENSG00000101849 6907 Nucleus 9.0 774.0 2.1E-5 0.083333333
TCF3 ENSG00000071564 6929 Nucleus 19.0 3030.0 2.11E-5 0.152046784
TCF7L1 ENSG00000152284 83439 Nucleus 40.0 3590.0 2.11E-5 0.026923077
TFAP2A ENSG00000137203 7020 Nucleus 34.0 1190.0 2.12E-5 0.039215686
TRIM33 ENSG00000197323 51592 Nucleus 7.0 5.05 2.1E-5 0.285714286
VAX2 ENSG00000116035 25806 Nucleus 1.0 0.0 2.0E-5 0.0
ZBTB16 ENSG00000109906 7704 Nucleus 6.0 7.76 2.05E-5 0.133333333
ZBTB7B ENSG00000160685 51043 Nucleus 3.0 3.87 2.03E-5 0.0
ZFHX4 ENSG00000091656 79776 Nucleus 2.0 0.0 2.04E-5 1.0
Gene1 Gene2 Weight KEGG humanCyc PID BioGRID IntAct HPRD BIND Reactome CORUM DIP WikiPathways ReconX INOH SMPDB PhosphoSite PANTHER CTD NetPath TRANSFAC DrugBank
BOC CDON 3
BOC CTNNB1 5
CDH6 CTNNB1 3
CDH8 CTNNB1 5
CDON CTNNB1 4
CTBP1 CTNNB1 4
CTBP1 TCF7L1 3
CTNNA2 CTNNB1 4
CTNNB1 ARHGAP10 2
CTNNB1 HDAC6 3
CTNNB1 JUP 8
CTNNB1 SMAD4 5
CTNNB1 SOX2 3
CTNNB1 TBL1X 6
CTNNB1 TCF3 3
CTNNB1 TCF7L1 7
CTNND2 CDH6 1
CTNND2 CDH8 1
CTNND2 CTNNB1 2
EDA EDA2R 4
FGFR2 CTNNB1 1
FGFR2 FYN 4
FOXA2 SOX2 2
FYN CDH6 1
FYN CDH8 1
FYN CTNNB1 4
FYN JUP 3
FYN SNCA 5
HDAC10 ZBTB7B 2
JUP PPARD 2
LHX1 FOXA2 1
NF2 RIT1 2
NF2 SCHIP1 4
NF2 SDCBP 4
NF2 SGSM3 3
NLK CTNNB1 3
NLK SMAD4 3
NLK TCF7L1 3
PAX6 SOX2 2
PTPN13 FYN 1
SMAD4 TCF7L1 4
SMAD4 TRIM33 6
SMURF1 FGFR2 2
SMURF1 SMAD4 1
TCF7L1 JUP 1
ZBTB16 JUP 2
AHI1 JUP 1
AHI1 MKS1 1
ARHGAP15 SMURF1 3
ARHGAP15 SNCA 1
ARHGEF9 SMURF1 2
BOC CTNNA2 1
BOC SMAD4 2
CCDC130 CTNNB1 1
CCDC130 JUP 2
CCDC130 ZBTB16 3
CCDC88C SMURF1 1
CDH6 CTNNA2 1
CDH6 JUP 1
CDH8 CTNNA2 1
CDH8 JUP 1
CDON CTNNA2 1
CTBP1 PPARD 1
CTBP1 SMAD4 2
CTBP1 SOX2 1
CTBP1 TBL1X 1
CTNNA2 JUP 2
CTNNA2 PAN2 1
CTNNB1 MKS1 1
CTNNB1 PPARD 1
CTNNB1 PTPN13 2
CTNNB1 SDCBP 1
CTNNB1 SMURF1 1
CTNNB1 TFAP2A 3
CTNNB1 TRIM33 1
CTNND2 FYN 1
FOXA2 HESX1 1
FOXA2 NLGN1 1
FOXA2 TBL1X 1
FOXA2 TTC14 1
FOXA2 ZFHX4 1
FYN HDAC6 1
FYN PAX3 1
HDAC10 PAX3 1
HDAC10 PAX6 1
HDAC10 TBL1X 1
HDAC6 SMAD4 1
HDAC6 TBL1X 1
HDAC6 ZBTB16 2
MKS1 JUP 1
MKS1 KRT6A 1
NF2 CTNNB1 1
NLK CTBP1 1
NUMA1 SMURF1 1
OGT SMURF1 1
PAN2 JUP 1
PAN2 KRT6A 1
PAX3 CCDC130 1
PAX3 CTNNB1 1
PAX6 MAFB 1
PAX6 SMAD4 1
PAX6 VAX2 1
RAB8B CTNNB1 1
RAB8B JUP 1
RIT1 SMURF1 3
SGSM3 SNCA 1
SMAD4 MAFB 1
SMAD4 SOX2 1
SNCA CTNNB1 1
SOX2 TCF3 1
SOX2 TRIM33 1
SOX2 ZFHX4 1
TBL1X TRIM33 1
TCF3 AHI1 1
TCF3 CDH6 1
TCF3 CDON 1
TCF3 CTBP1 1
TCF3 FYN 1
TCF3 JUP 1
TCF3 MKS1 1
TCF3 NLK 1
TCF3 OGT 1
TCF3 PAX3 1
TCF3 PAX6 1
TCF3 SNCA 1
TCF3 TFAP2A 1
TCF3 TRIM33 1
TCF3 ZBTB16 1
TCF3 ZBTB7B 1
TCF7L1 HESX1 1
TCF7L1 PPARD 1
TFAP2A MAFB 1
TFAP2A PAX3 1
TFAP2A PPARD 1
Pathway1 Pathway2 Intersect Similarity Scores Pathway Name Source Number of Genes Number of Interactions Detail