Pathway ID Pathway Name Source Organism Number of Genes Number of Interactions
pathway0002845 Hs_TLR4_Signaling_and_Tolerance_WP3851_90114 WikiPathways Homo sapiens 8 12
Secreted
Membrane
Cytoplasm
Cytoplasm/4
Cytoskeleton
Cytoskeleton/Cytoplasm
Membrane/Nucleus
Cytoplasm/Nucleus
Cytoskeleton/Nucleus
Nucleus
Secreted/Nucleus
Unknown
Annotated genes
Unannotated genes
Symbol
Ensembl ID
Entrez ID
Subcellular localization
Description
Type
Edge
Symbol Ensembl ID Entrez ID Subcellular localization Closeness Degree Betweenness Transitivity
IRS1 ENSG00000169047 3667 Cytoplasm 0.02040816 1.0 0.0 0.0
IRF7 ENSG00000185507 3665 Cytoplasm/Nucleus 0.04347826 9.0 2.0 0.05555556
MED15 ENSG00000099917 51586 Cytoplasm/Nucleus 0.03571429 1.0 0.0 0.0
NFKB1 ENSG00000109320 4790 Cytoplasm/Nucleus 0.02040816 7.0 0.0 0.0
NFATC1 ENSG00000131196 4772 Unknown 0.03571429 1.0 0.0 0.0
TICAM1 ENSG00000127666 148022 Unknown 0.04166667 7.0 4.0 0.04761905
IRF3 ENSG00000126456 3661 Nucleus 0.04347826 9.0 2.0 0.05555556
IFNB1 ENSG00000171855 3456 Secreted 0.04166667 7.0 4.0 0.04761905
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
IRS1 ENSG00000169047 3667 Cytoplasm 4154.0 22041.17 1.56E-6 7.58308E-4
IRF7 ENSG00000185507 3665 Cytoplasm/Nucleus 775.0 27409.34 1.55E-6 0.001623739
MED15 ENSG00000099917 51586 Cytoplasm/Nucleus 244.0 829.4386 1.55E-6 0.04354719
NFKB1 ENSG00000109320 4790 Cytoplasm/Nucleus 11386.0 279636.5 1.56E-6 2.06234E-4
NFATC1 ENSG00000131196 4772 Unknown 1194.0 6768.025 1.55E-6 0.001236976
TICAM1 ENSG00000127666 148022 Unknown 582.0 4672.75 1.55E-6 0.00336545
IRF3 ENSG00000126456 3661 Nucleus 760.0 29345.83 1.55E-6 0.001608765
IFNB1 ENSG00000171855 3456 Secreted 649.0 3562.363 1.55E-6 0.006596093
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
IRS1 ENSG00000169047 3667 Cytoplasm 525.0 3271.838 2.15E-5 0.006732097
IRF7 ENSG00000185507 3665 Cytoplasm/Nucleus 117.0 905.7334 2.09E-5 0.011788977
MED15 ENSG00000099917 51586 Cytoplasm/Nucleus 1.0 0.0 1.99E-5 0.0
NFKB1 ENSG00000109320 4790 Cytoplasm/Nucleus 1684.0 71951.94 2.17E-5 9.77358E-4
NFATC1 ENSG00000131196 4772 Unknown 59.0 1605.563 2.13E-5 0.034482759
TICAM1 ENSG00000127666 148022 Unknown 101.0 937.7331 2.1E-5 0.019009901
IRF3 ENSG00000126456 3661 Nucleus 41.0 2331.725 2.09E-5 0.041463415
IFNB1 ENSG00000171855 3456 Secreted 20.0 3142.014 2.07E-5 0.010526316
Gene1 Gene2 Weight KEGG humanCyc PID BioGRID IntAct HPRD BIND Reactome CORUM DIP WikiPathways ReconX INOH SMPDB PhosphoSite PANTHER CTD NetPath TRANSFAC DrugBank
IRF3 IFNB1 2
IRF3 IRF7 3
IRF3 TICAM1 3
IRF7 IFNB1 4
IRF7 TICAM1 2
MED15 IFNB1 1
NFKB1 IRS1 1
TICAM1 NFATC1 1
Pathway1 Pathway2 Intersect Similarity Scores Pathway Name Source Number of Genes Number of Interactions Detail
pathway0002845 pathway0002602 5 0.625 Toll-like receptor signaling pathway KEGG 100 1158
pathway0002845 pathway0002655 5 0.625 Hepatitis C KEGG 134 1627
pathway0002845 pathway0002604 4 0.5 RIG-I-like receptor signaling pathway KEGG 71 471
pathway0002845 pathway0002605 4 0.5 Cytosolic DNA-sensing pathway KEGG 56 233