Pathway ID Pathway Name Source Organism Number of Genes Number of Interactions
pathway0002853 Hs_TGF-beta_Signaling_Pathway_WP366_90028 WikiPathways Homo sapiens 67 576
Secreted
Membrane
Cytoplasm
Cytoplasm/4
Cytoskeleton
Cytoskeleton/Cytoplasm
Membrane/Nucleus
Cytoplasm/Nucleus
Cytoskeleton/Nucleus
Nucleus
Secreted/Nucleus
Unknown
Annotated genes
Unannotated genes
Symbol
Ensembl ID
Entrez ID
Subcellular localization
Description
Type
Edge
Symbol Ensembl ID Entrez ID Subcellular localization Closeness Degree Betweenness Transitivity
MLST8 ENSG00000167965 64223 Cytoplasm 0.006369427 6.0 0.6632759 0.06666667
PAK2 ENSG00000180370 5062 Cytoplasm 0.00862069 46.0 37.52912 0.0763285
PJA1 ENSG00000181191 64219 Cytoplasm 0.006622517 5.0 0.2040404 0.2
SOS1 ENSG00000115904 6654 Cytoplasm 0.0078125 79.0 3.668076 0.0227199
SPTBN1 ENSG00000115306 6711 Cytoplasm 0.008196721 22.0 19.41779 0.20779221
TRAP1 ENSG00000126602 10131 Cytoplasm 0.007692308 9.0 0.08996306 0.63888889
ZFYVE16 ENSG00000039319 9765 Cytoplasm 0.007142857 9.0 0.0 0.27777778
ATF2 ENSG00000115966 1386 Cytoplasm/Nucleus 0.01 57.0 49.87858 0.13721805
AXIN1 ENSG00000103126 8312 Cytoplasm/Nucleus 0.008130081 23.0 4.291665 0.21343874
BCAR1 ENSG00000050820 9564 Cytoplasm/Nucleus 0.008474576 28.0 4.020077 0.20634921
CDKN1A ENSG00000124762 1026 Cytoplasm/Nucleus 0.00877193 47.0 10.86697 0.09435708
COPS5 ENSG00000121022 10987 Cytoplasm/Nucleus 0.007936508 15.0 1.176575 0.22857143
DCP1A ENSG00000272886 55802 Cytoplasm/Nucleus 0.00729927 8.0 2.113217 0.17857143
E2F4 ENSG00000205250 1874 Cytoplasm/Nucleus 0.009259259 36.0 21.15625 0.22222222
ETS1 ENSG00000134954 2113 Cytoplasm/Nucleus 0.008547009 23.0 2.424358 0.28853755
JUN ENSG00000177606 3725 Cytoplasm/Nucleus 0.011111111 116.0 223.4491 0.04242879
KLF10 ENSG00000155090 7071 Cytoplasm/Nucleus 0.006493506 8.0 0.5062745 0.0
MAP2K2 ENSG00000126934 5605 Cytoplasm/Nucleus 0.007936508 110.0 6.228419 0.01201001
MAPK1 ENSG00000100030 5594 Cytoplasm/Nucleus 0.009708738 149.0 134.5996 0.01732269
MAPK4 ENSG00000141639 5596 Cytoplasm/Nucleus 0.006666667 3.0 0.0 0.33333333
MAPK8 ENSG00000107643 5599 Cytoplasm/Nucleus 0.009615385 99.0 58.08573 0.03957947
MAPK9 ENSG00000050748 5601 Cytoplasm/Nucleus 0.009090909 70.0 16.91855 0.05010352
RBL2 ENSG00000103479 5934 Cytoplasm/Nucleus 0.009345794 33.0 26.74882 0.27083333
RNF111 ENSG00000157450 54778 Cytoplasm/Nucleus 0.007633588 20.0 1.057914 0.16315789
RPA1 ENSG00000132383 6117 Cytoplasm/Nucleus 0.007575758 6.0 0.3877821 0.4
SKI ENSG00000157933 6497 Cytoplasm/Nucleus 0.008 21.0 2.008319 0.17619048
SMAD3 ENSG00000166949 4088 Cytoplasm/Nucleus 0.010638298 123.0 189.4115 0.03385313
SMAD4 ENSG00000141646 4089 Cytoplasm/Nucleus 0.01010101 92.0 104.3125 0.04634496
SMAD7 ENSG00000101665 4092 Cytoplasm/Nucleus 0.009009009 56.0 30.35964 0.07922078
SMURF1 ENSG00000198742 57154 Cytoplasm/Nucleus 0.008695652 36.0 9.05356 0.14126984
SRC ENSG00000197122 6714 Cytoplasm/Nucleus 0.00952381 86.0 40.82534 0.0495212
STAMBPL1 ENSG00000138134 57559 Cytoplasm/Nucleus 0.007352941 6.0 0.06714744 0.8
STRAP ENSG00000023734 11171 Cytoplasm/Nucleus 0.008130081 22.0 0.8769229 0.19480519
UCHL5 ENSG00000116750 51377 Cytoplasm/Nucleus 0.0078125 12.0 2.655496 0.53030303
YAP1 ENSG00000137693 10413 Cytoplasm/Nucleus 0.008 19.0 2.449735 0.25730994
RHOA ENSG00000067560 387 Cytoskeleton/Nucleus 0.008547009 40.0 16.93557 0.12692308
AKT1 ENSG00000142208 207 Membrane 0.010416667 179.0 173.4864 0.01832904
CDC42 ENSG00000070831 998 Membrane 0.008695652 51.0 18.20732 0.07921569
ITCH ENSG00000078747 83737 Membrane 0.008333333 23.0 21.72213 0.18181818
ITGB1 ENSG00000150093 3688 Membrane 0.008 18.0 2.273884 0.2875817
MTOR ENSG00000198793 2475 Membrane 0.007751938 39.0 5.832782 0.08502024
PIK3R2 ENSG00000105647 5296 Membrane 0.007936508 95.0 5.955369 0.01545353
RAF1 ENSG00000132155 5894 Membrane 0.008474576 76.0 29.64997 0.01964912
SHC1 ENSG00000160691 6464 Membrane 0.00952381 87.0 21.18733 0.04998663
TGFBR1 ENSG00000106799 7046 Membrane 0.009345794 82.0 73.98337 0.04336043
TGFBR3 ENSG00000069702 7049 Membrane 0.007352941 11.0 0.1876071 0.2
PARD6A ENSG00000102981 50855 Membrane/Nucleus 0.007575758 17.0 1.0244 0.16176471
EGFR ENSG00000146648 1956 Unknown 0.008928571 94.0 44.96548 0.03042782
GRB2 ENSG00000177885 2885 Unknown 0.009174312 137.0 31.49806 0.01470588
LIMK2 ENSG00000182541 3985 Unknown 0.007092199 7.0 0.1474794 0.19047619
MAP2K4 ENSG00000065559 6416 Unknown 0.008130081 46.0 3.763038 0.03864734
MAP3K7 ENSG00000135341 6885 Unknown 0.009259259 51.0 20.92901 0.09960784
MAPK14 ENSG00000112062 1432 Unknown 0.009803922 78.0 55.42375 0.06227106
PDPK1 ENSG00000140992 5170 Unknown 0.008474576 63.0 9.831039 0.04915515
SMAD2 ENSG00000175387 4087 Unknown 0.010526316 109.0 127.4686 0.0382263
TGFBR2 ENSG00000163513 7048 Unknown 0.009615385 80.0 64.45373 0.05822785
CITED1 ENSG00000125931 4435 Nucleus 0.007518797 12.0 0.0 0.31818182
JUNB ENSG00000171223 3726 Nucleus 0.008474576 27.0 43.49049 0.2022792
KLF11 ENSG00000172059 8462 Nucleus 0.005952381 3.0 0.0 0.0
KLF6 ENSG00000067082 1316 Nucleus 0.006802721 6.0 0.0 0.66666667
MEF2C ENSG00000081189 4208 Nucleus 0.008064516 18.0 23.10334 0.20261438
SKIL ENSG00000136603 6498 Nucleus 0.007575758 16.0 0.6967447 0.21666667
SMYD1 ENSG00000115593 150572 Nucleus 0.005649718 2.0 0.03846154 0.0
SP1 ENSG00000185591 6667 Nucleus 0.009615385 48.0 53.44767 0.16489362
TGIF1 ENSG00000177426 7050 Nucleus 0.008264463 21.0 3.033469 0.22857143
WWP1 ENSG00000123124 11059 Nucleus 0.007936508 15.0 2.553783 0.36190476
TNF ENSG00000232810 7124 Secreted 0.008695652 43.0 5.207435 0.11960133
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
MLST8 ENSG00000167965 64223 Cytoplasm 569.0 1650.0 1.55E-6 0.00434
PAK2 ENSG00000180370 5062 Cytoplasm 2174.0 15000.0 1.56E-6 0.00109
PJA1 ENSG00000181191 64219 Cytoplasm 59.0 546.0 1.55E-6 0.157
SOS1 ENSG00000115904 6654 Cytoplasm 23511.0 177000.0 1.56E-6 6.54E-5
SPTBN1 ENSG00000115306 6711 Cytoplasm 239.0 59900.0 1.55E-6 0.0814
TRAP1 ENSG00000126602 10131 Cytoplasm 39.0 7.71 1.55E-6 0.171
ZFYVE16 ENSG00000039319 9765 Cytoplasm 106.0 223.0 1.55E-6 0.0345
ATF2 ENSG00000115966 1386 Cytoplasm/Nucleus 2727.0 293000.0 1.56E-6 0.00401
AXIN1 ENSG00000103126 8312 Cytoplasm/Nucleus 2431.0 35300.0 1.56E-6 0.00127
BCAR1 ENSG00000050820 9564 Cytoplasm/Nucleus 2452.0 62200.0 1.56E-6 0.00243
CDKN1A ENSG00000124762 1026 Cytoplasm/Nucleus 3911.0 109000.0 1.56E-6 8.1E-4
COPS5 ENSG00000121022 10987 Cytoplasm/Nucleus 255.0 20800.0 1.56E-6 0.0465
DCP1A ENSG00000272886 55802 Cytoplasm/Nucleus 79.0 29300.0 1.55E-6 0.0714
E2F4 ENSG00000205250 1874 Cytoplasm/Nucleus 668.0 42800.0 1.56E-6 0.0157
ETS1 ENSG00000134954 2113 Cytoplasm/Nucleus 716.0 15200.0 1.56E-6 0.00784
JUN ENSG00000177606 3725 Cytoplasm/Nucleus 12667.0 3720000.0 1.57E-6 4.67E-4
KLF10 ENSG00000155090 7071 Cytoplasm/Nucleus 25.0 1.16 1.55E-6 0.0667
MAP2K2 ENSG00000126934 5605 Cytoplasm/Nucleus 22859.0 10500.0 1.55E-6 9.5E-6
MAPK1 ENSG00000100030 5594 Cytoplasm/Nucleus 33563.0 1130000.0 1.56E-6 2.83E-5
MAPK4 ENSG00000141639 5596 Cytoplasm/Nucleus 56.0 7.73 1.55E-6 0.0195
MAPK8 ENSG00000107643 5599 Cytoplasm/Nucleus 11158.0 360000.0 1.56E-6 1.42E-4
MAPK9 ENSG00000050748 5601 Cytoplasm/Nucleus 6317.0 61100.0 1.56E-6 1.86E-4
RBL2 ENSG00000103479 5934 Cytoplasm/Nucleus 742.0 36500.0 1.56E-6 0.0155
RNF111 ENSG00000157450 54778 Cytoplasm/Nucleus 222.0 965.0 1.55E-6 0.0401
RPA1 ENSG00000132383 6117 Cytoplasm/Nucleus 1985.0 65100.0 1.56E-6 0.00428
SKI ENSG00000157933 6497 Cytoplasm/Nucleus 212.0 4610.0 1.56E-6 0.0301
SMAD3 ENSG00000166949 4088 Cytoplasm/Nucleus 3869.0 321000.0 1.56E-6 9.74E-4
SMAD4 ENSG00000141646 4089 Cytoplasm/Nucleus 2908.0 151000.0 1.56E-6 0.00134
SMAD7 ENSG00000101665 4092 Cytoplasm/Nucleus 920.0 7960.0 1.56E-6 0.00351
SMURF1 ENSG00000198742 57154 Cytoplasm/Nucleus 782.0 41500.0 1.56E-6 0.00834
SRC ENSG00000197122 6714 Cytoplasm/Nucleus 14851.0 1350000.0 1.57E-6 2.68E-4
STAMBPL1 ENSG00000138134 57559 Cytoplasm/Nucleus 14.0 0.0519 1.55E-6 0.242
STRAP ENSG00000023734 11171 Cytoplasm/Nucleus 133.0 15700.0 1.55E-6 0.033
UCHL5 ENSG00000116750 51377 Cytoplasm/Nucleus 40.0 20.4 1.55E-6 0.145
YAP1 ENSG00000137693 10413 Cytoplasm/Nucleus 242.0 24700.0 1.55E-6 0.0159
RHOA ENSG00000067560 387 Cytoskeleton/Nucleus 5830.0 484000.0 1.56E-6 6.32E-4
AKT1 ENSG00000142208 207 Membrane 52751.0 2150000.0 1.57E-6 1.74E-5
CDC42 ENSG00000070831 998 Membrane 6876.0 628000.0 1.56E-6 5.19E-4
ITCH ENSG00000078747 83737 Membrane 729.0 33800.0 1.56E-6 0.0124
ITGB1 ENSG00000150093 3688 Membrane 3891.0 368000.0 1.56E-6 0.00113
MTOR ENSG00000198793 2475 Membrane 6209.0 146000.0 1.56E-6 2.1E-4
PIK3R2 ENSG00000105647 5296 Membrane 17436.0 144000.0 1.56E-6 9.14E-5
RAF1 ENSG00000132155 5894 Membrane 23706.0 140000.0 1.56E-6 1.64E-5
SHC1 ENSG00000160691 6464 Membrane 13549.0 312000.0 1.56E-6 2.6E-4
TGFBR1 ENSG00000106799 7046 Membrane 2531.0 39000.0 1.56E-6 0.00147
TGFBR3 ENSG00000069702 7049 Membrane 49.0 13.9 1.55E-6 0.0459
PARD6A ENSG00000102981 50855 Membrane/Nucleus 334.0 23700.0 1.55E-6 0.00806
EGFR ENSG00000146648 1956 Unknown 12590.0 758000.0 1.56E-6 2.83E-4
GRB2 ENSG00000177885 2885 Unknown 29079.0 822000.0 1.57E-6 5.64E-5
LIMK2 ENSG00000182541 3985 Unknown 266.0 1240.0 1.55E-6 0.00516
MAP2K4 ENSG00000065559 6416 Unknown 4071.0 5050.0 1.55E-6 1.59E-4
MAP3K7 ENSG00000135341 6885 Unknown 5836.0 93700.0 1.56E-6 2.59E-4
MAPK14 ENSG00000112062 1432 Unknown 9287.0 427000.0 1.56E-6 2.57E-4
PDPK1 ENSG00000140992 5170 Unknown 7752.0 22600.0 1.56E-6 2.91E-4
SMAD2 ENSG00000175387 4087 Unknown 3335.0 192000.0 1.56E-6 0.001
TGFBR2 ENSG00000163513 7048 Unknown 2260.0 45400.0 1.56E-6 0.00186
CITED1 ENSG00000125931 4435 Nucleus 81.0 8.78 1.55E-6 0.0562
JUNB ENSG00000171223 3726 Nucleus 350.0 6650.0 1.56E-6 0.0159
KLF11 ENSG00000172059 8462 Nucleus 18.0 0.378 1.55E-6 0.0588
KLF6 ENSG00000067082 1316 Nucleus 8.0 1140.0 1.55E-6 0.429
MEF2C ENSG00000081189 4208 Nucleus 316.0 28200.0 1.55E-6 0.00922
SKIL ENSG00000136603 6498 Nucleus 198.0 321.0 1.55E-6 0.0844
SMYD1 ENSG00000115593 150572 Nucleus 6.0 33.1 1.53E-6 0.0
SP1 ENSG00000185591 6667 Nucleus 1577.0 413000.0 1.56E-6 0.00757
TGIF1 ENSG00000177426 7050 Nucleus 217.0 4310.0 1.56E-6 0.029
WWP1 ENSG00000123124 11059 Nucleus 246.0 149000.0 1.55E-6 0.0242
TNF ENSG00000232810 7124 Secreted 4479.0 293000.0 1.56E-6 0.00102
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
MLST8 ENSG00000167965 64223 Cytoplasm 19.0 1060.0 2.11E-5 0.087719298
PAK2 ENSG00000180370 5062 Cytoplasm 174.0 2030.0 2.15E-5 0.03202445
PJA1 ENSG00000181191 64219 Cytoplasm 5.0 0.2 2.08E-5 0.2
SOS1 ENSG00000115904 6654 Cytoplasm 1954.0 4650.0 2.15E-5 9.81615E-4
SPTBN1 ENSG00000115306 6711 Cytoplasm 22.0 236.0 2.12E-5 0.207792208
TRAP1 ENSG00000126602 10131 Cytoplasm 9.0 0.209 2.11E-5 0.638888889
ZFYVE16 ENSG00000039319 9765 Cytoplasm 9.0 0.0 2.09E-5 0.277777778
ATF2 ENSG00000115966 1386 Cytoplasm/Nucleus 369.0 17800.0 2.17E-5 0.01832214
AXIN1 ENSG00000103126 8312 Cytoplasm/Nucleus 100.0 3430.0 2.14E-5 0.030909091
BCAR1 ENSG00000050820 9564 Cytoplasm/Nucleus 166.0 8250.0 2.15E-5 0.033150785
CDKN1A ENSG00000124762 1026 Cytoplasm/Nucleus 647.0 16600.0 2.16E-5 0.003363942
COPS5 ENSG00000121022 10987 Cytoplasm/Nucleus 15.0 2.7 2.12E-5 0.228571429
DCP1A ENSG00000272886 55802 Cytoplasm/Nucleus 8.0 5.96 2.11E-5 0.178571429
E2F4 ENSG00000205250 1874 Cytoplasm/Nucleus 53.0 8530.0 2.14E-5 0.118287373
ETS1 ENSG00000134954 2113 Cytoplasm/Nucleus 116.0 3280.0 2.15E-5 0.055472264
JUN ENSG00000177606 3725 Cytoplasm/Nucleus 1533.0 157000.0 2.18E-5 0.002673984
KLF10 ENSG00000155090 7071 Cytoplasm/Nucleus 8.0 0.427 2.09E-5 0.0
MAP2K2 ENSG00000126934 5605 Cytoplasm/Nucleus 1788.0 2290.0 2.14E-5 3.47401E-4
MAPK1 ENSG00000100030 5594 Cytoplasm/Nucleus 3584.0 115000.0 2.18E-5 4.95738E-4
MAPK4 ENSG00000141639 5596 Cytoplasm/Nucleus 21.0 5.65 2.12E-5 0.090476191
MAPK8 ENSG00000107643 5599 Cytoplasm/Nucleus 1392.0 35600.0 2.17E-5 0.001997653
MAPK9 ENSG00000050748 5601 Cytoplasm/Nucleus 700.0 3660.0 2.16E-5 0.002987942
RBL2 ENSG00000103479 5934 Cytoplasm/Nucleus 94.0 2200.0 2.15E-5 0.084648822
RNF111 ENSG00000157450 54778 Cytoplasm/Nucleus 20.0 5.07 2.1E-5 0.163157895
RPA1 ENSG00000132383 6117 Cytoplasm/Nucleus 6.0 1.5 2.12E-5 0.4
SKI ENSG00000157933 6497 Cytoplasm/Nucleus 21.0 28.4 2.12E-5 0.176190476
SMAD3 ENSG00000166949 4088 Cytoplasm/Nucleus 328.0 39900.0 2.16E-5 0.010628776
SMAD4 ENSG00000141646 4089 Cytoplasm/Nucleus 339.0 27300.0 2.16E-5 0.012672148
SMAD7 ENSG00000101665 4092 Cytoplasm/Nucleus 113.0 1010.0 2.15E-5 0.046302149
SMURF1 ENSG00000198742 57154 Cytoplasm/Nucleus 64.0 10800.0 2.13E-5 0.060515873
SRC ENSG00000197122 6714 Cytoplasm/Nucleus 1835.0 67000.0 2.17E-5 0.001945688
STAMBPL1 ENSG00000138134 57559 Cytoplasm/Nucleus 6.0 0.0922 2.11E-5 0.8
STRAP ENSG00000023734 11171 Cytoplasm/Nucleus 22.0 3.76 2.12E-5 0.194805195
UCHL5 ENSG00000116750 51377 Cytoplasm/Nucleus 12.0 34.2 2.11E-5 0.53030303
YAP1 ENSG00000137693 10413 Cytoplasm/Nucleus 59.0 4030.0 2.13E-5 0.046756283
RHOA ENSG00000067560 387 Cytoskeleton/Nucleus 242.0 4160.0 2.15E-5 0.021809952
AKT1 ENSG00000142208 207 Membrane 6565.0 233000.0 2.19E-5 2.13911E-4
CDC42 ENSG00000070831 998 Membrane 494.0 10900.0 2.15E-5 0.007752256
ITCH ENSG00000078747 83737 Membrane 38.0 202.0 2.13E-5 0.081081081
ITGB1 ENSG00000150093 3688 Membrane 141.0 4480.0 2.14E-5 0.035866261
MTOR ENSG00000198793 2475 Membrane 1113.0 11400.0 2.16E-5 0.001538392
PIK3R2 ENSG00000105647 5296 Membrane 1499.0 14900.0 2.15E-5 0.001001112
RAF1 ENSG00000132155 5894 Membrane 1624.0 13700.0 2.15E-5 6.27525E-4
SHC1 ENSG00000160691 6464 Membrane 1636.0 9720.0 2.16E-5 0.00189094
TGFBR1 ENSG00000106799 7046 Membrane 166.0 2980.0 2.15E-5 0.025118656
TGFBR3 ENSG00000069702 7049 Membrane 11.0 0.488 2.1E-5 0.2
PARD6A ENSG00000102981 50855 Membrane/Nucleus 30.0 54.4 2.12E-5 0.082758621
EGFR ENSG00000146648 1956 Unknown 1156.0 40200.0 2.17E-5 0.002804116
GRB2 ENSG00000177885 2885 Unknown 3192.0 57100.0 2.17E-5 5.90241E-4
LIMK2 ENSG00000182541 3985 Unknown 38.0 369.0 2.11E-5 0.027027027
MAP2K4 ENSG00000065559 6416 Unknown 454.0 2510.0 2.14E-5 0.003607861
MAP3K7 ENSG00000135341 6885 Unknown 710.0 23100.0 2.16E-5 0.003210235
MAPK14 ENSG00000112062 1432 Unknown 1219.0 74200.0 2.17E-5 0.002559367
PDPK1 ENSG00000140992 5170 Unknown 471.0 1780.0 2.15E-5 0.008348015
SMAD2 ENSG00000175387 4087 Unknown 347.0 16900.0 2.15E-5 0.011060952
TGFBR2 ENSG00000163513 7048 Unknown 84.0 584.0 2.13E-5 0.053356282
CITED1 ENSG00000125931 4435 Nucleus 12.0 0.0 2.11E-5 0.318181818
JUNB ENSG00000171223 3726 Nucleus 33.0 693.0 2.13E-5 0.176136364
KLF11 ENSG00000172059 8462 Nucleus 9.0 0.777 2.1E-5 0.083333333
KLF6 ENSG00000067082 1316 Nucleus 8.0 2660.0 2.11E-5 0.392857143
MEF2C ENSG00000081189 4208 Nucleus 60.0 4300.0 2.13E-5 0.032768362
SKIL ENSG00000136603 6498 Nucleus 17.0 71.2 2.1E-5 0.191176471
SMYD1 ENSG00000115593 150572 Nucleus 6.0 18.9 2.06E-5 0.0
SP1 ENSG00000185591 6667 Nucleus 262.0 17100.0 2.16E-5 0.031294785
TGIF1 ENSG00000177426 7050 Nucleus 27.0 2110.0 2.12E-5 0.165242165
WWP1 ENSG00000123124 11059 Nucleus 15.0 12.3 2.11E-5 0.361904762
TNF ENSG00000232810 7124 Secreted 462.0 55800.0 2.17E-5 0.008057019
Gene1 Gene2 Weight KEGG humanCyc PID BioGRID IntAct HPRD BIND Reactome CORUM DIP WikiPathways ReconX INOH SMPDB PhosphoSite PANTHER CTD NetPath TRANSFAC DrugBank
AKT1 CDKN1A 9
AKT1 EGFR 4
AKT1 MAP2K4 4
AKT1 MTOR 11
AKT1 RAF1 6
AKT1 SKI 2
AKT1 SMAD3 4
AKT1 SP1 1
AKT1 YAP1 3
ATF2 JUN 7
ATF2 JUNB 3
ATF2 SMAD3 5
ATF2 SMAD4 6
ATF2 TRAP1 2
AXIN1 RNF111 4
AXIN1 SMAD3 5
AXIN1 SMAD7 4
AXIN1 TGFBR1 4
BCAR1 GRB2 3
BCAR1 MAP2K4 1
BCAR1 MAPK8 2
BCAR1 SOS1 2
BCAR1 SRC 8
CDC42 GRB2 5
CDC42 MAPK14 3
CDC42 MAPK8 3
CDC42 MAPK9 3
CDC42 PAK2 7
CDC42 PARD6A 7
CDKN1A E2F4 2
CDKN1A JUN 3
CDKN1A RBL2 4
CITED1 SMAD2 2
CITED1 SMAD3 2
CITED1 SMAD4 5
COPS5 JUN 4
COPS5 MAPK14 3
COPS5 SMAD4 4
DCP1A SMAD4 6
E2F4 RBL2 11
E2F4 SMAD2 2
E2F4 SMAD3 6
E2F4 SMAD4 6
EGFR GRB2 12
EGFR MAPK1 4
EGFR MTOR 2
EGFR PDPK1 3
EGFR PIK3R2 7
EGFR RHOA 1
EGFR SHC1 12
EGFR SOS1 9
EGFR SRC 8
ETS1 TNF 2
GRB2 AKT1 3
GRB2 MAPK1 2
GRB2 MTOR 1
GRB2 PAK2 3
GRB2 PDPK1 3
GRB2 PIK3R2 6
GRB2 SHC1 13
GRB2 SOS1 12
GRB2 SPTBN1 3
GRB2 SRC 5
ITCH KLF10 3
ITCH SMAD7 2
ITGB1 EGFR 2
ITGB1 SRC 3
JUNB SMAD3 4
JUNB SMAD4 5
JUNB SP1 2
JUN JUNB 5
JUN MEF2C 2
JUN SMAD2 5
JUN SMAD3 6
JUN SMAD4 8
JUN SRC 2
JUN TGFBR2 2
JUN TGIF1 5
JUN TNF 2
MAP2K2 AKT1 1
MAP2K2 MAPK1 10
MAP2K2 MAPK14 1
MAP2K2 MAPK8 4
MAP2K2 MAPK9 2
MAP2K2 RAF1 7
MAP2K4 MAPK14 7
MAP2K4 MAPK8 12
MAP2K4 MAPK9 10
MAP3K7 AKT1 1
MAP3K7 MAP2K2 1
MAP3K7 MAP2K4 4
MAP3K7 MAPK1 1
MAP3K7 MAPK14 4
MAP3K7 MAPK8 5
MAP3K7 MAPK9 2
MAP3K7 TGFBR1 3
MAP3K7 TNF 3
MAPK14 ATF2 8
MAPK14 CDKN1A 1
MAPK14 JUN 3
MAPK14 MEF2C 9
MAPK14 SHC1 2
MAPK14 SMAD3 2
MAPK1 AKT1 2
MAPK1 ATF2 4
MAPK1 CDKN1A 1
MAPK1 ETS1 7
MAPK1 RAF1 5
MAPK1 SHC1 5
MAPK1 SMAD2 5
MAPK1 SMAD3 7
MAPK1 SMAD4 2
MAPK1 SOS1 5
MAPK1 SP1 3
MAPK1 SRC 3
MAPK1 TGIF1 2
MAPK8 ATF2 5
MAPK8 DCP1A 1
MAPK8 ETS1 1
MAPK8 ITCH 1
MAPK8 JUN 9
MAPK8 MAPK9 4
MAPK8 SMAD3 3
MAPK8 SP1 2
MAPK9 AKT1 1
MAPK9 ATF2 4
MAPK9 ITCH 1
MAPK9 JUN 8
MLST8 AKT1 2
MLST8 MTOR 8
MTOR PDPK1 3
PAK2 AKT1 1
PAK2 JUN 1
PAK2 LIMK2 2
PAK2 MAPK14 2
PAK2 MAPK4 1
PAK2 MAPK8 1
PAK2 MAPK9 1
PAK2 RAF1 5
PAK2 SMAD2 1
PAK2 SRC 4
PARD6A SMURF1 4
PARD6A TGFBR1 7
PDPK1 AKT1 8
PDPK1 MAP2K2 1
PDPK1 SMAD7 2
PDPK1 STRAP 4
PIK3R2 AKT1 4
PIK3R2 CDC42 2
PIK3R2 MTOR 1
PIK3R2 PDPK1 3
PIK3R2 RHOA 1
PIK3R2 SHC1 5
PIK3R2 SOS1 4
PIK3R2 SRC 2
PJA1 SMAD3 2
PJA1 SPTBN1 2
RAF1 KLF10 1
RAF1 SRC 5
RHOA AKT1 2
RHOA LIMK2 1
RHOA MAPK1 1
RHOA MAPK8 2
RHOA MAPK9 1
RHOA SMURF1 4
RHOA TGFBR1 3
RNF111 SKI 3
RNF111 SKIL 3
RNF111 SMAD2 3
RNF111 SMAD3 3
RNF111 SMAD4 2
RNF111 SMAD7 5
SHC1 AKT1 3
SHC1 MTOR 1
SHC1 PDPK1 2
SHC1 SOS1 10
SHC1 SRC 6
SKIL SMAD2 9
SKIL SMAD3 9
SKIL SMAD4 10
SKI SKIL 4
SKI SMAD2 10
SKI SMAD3 10
SKI SMAD4 10
SMAD2 CDKN1A 2
SMAD2 SMAD3 9
SMAD2 SMAD4 12
SMAD2 SMURF1 4
SMAD2 SP1 6
SMAD2 STRAP 4
SMAD2 TGFBR1 8
SMAD2 TGIF1 4
SMAD3 CDKN1A 3
SMAD3 SMAD4 12
SMAD3 SMURF1 5
SMAD3 SP1 7
SMAD3 SPTBN1 4
SMAD3 STRAP 4
SMAD3 TGFBR1 8
SMAD3 TGFBR2 7
SMAD3 TGIF1 2
SMAD3 YAP1 2
SMAD4 SMAD7 4
SMAD4 SP1 8
SMAD4 TGFBR1 4
SMAD4 TGFBR2 3
SMAD4 ZFYVE16 2
SMAD7 SMAD2 3
SMAD7 SMAD3 3
SMAD7 SMURF1 10
SMAD7 STRAP 5
SMAD7 TGFBR1 7
SMAD7 TGFBR2 6
SMAD7 UCHL5 3
SMAD7 WWP1 3
SMAD7 YAP1 6
SMURF1 SMAD4 1
SMURF1 TGFBR1 7
SMURF1 TGFBR2 7
SOS1 AKT1 3
SOS1 MTOR 1
SOS1 SRC 3
SP1 CDKN1A 3
SP1 SRC 2
SRC AKT1 4
SRC CDC42 3
SRC MAPK14 2
SRC MAPK8 1
SRC PDPK1 3
SRC TGFBR2 2
STRAP TGFBR1 7
STRAP TGFBR2 5
TGFBR1 SHC1 2
TGFBR1 TGFBR2 13
TGFBR1 TGFBR3 2
TGFBR1 WWP1 2
TGFBR1 ZFYVE16 2
TGFBR2 AKT1 1
TGFBR2 MAP3K7 2
TGFBR2 SMAD2 4
TGFBR2 SPTBN1 1
TGFBR2 TGFBR3 5
TGFBR2 WWP1 2
TNF AKT1 1
TNF EGFR 1
TNF MAPK1 1
TNF MAPK14 2
TNF MAPK8 3
TNF MAPK9 2
AKT1 ATF2 1
AKT1 AXIN1 1
AKT1 E2F4 1
AKT1 ETS1 1
AKT1 JUN 1
AKT1 MAPK14 3
AKT1 MAPK8 2
AKT1 RBL2 1
AKT1 SMAD2 3
AKT1 SMAD4 3
AKT1 SMAD7 2
AKT1 SMURF1 2
AKT1 TGFBR1 2
ATF2 BCAR1 1
ATF2 CDC42 1
ATF2 CDKN1A 1
ATF2 CITED1 2
ATF2 E2F4 1
ATF2 ETS1 1
ATF2 GRB2 1
ATF2 ITGB1 2
ATF2 KLF6 1
ATF2 MAP3K7 1
ATF2 PARD6A 1
ATF2 RBL2 1
ATF2 SHC1 1
ATF2 SMAD2 1
ATF2 SP1 1
ATF2 SRC 1
ATF2 STAMBPL1 1
ATF2 TGFBR2 1
ATF2 TGFBR3 1
ATF2 TGIF1 1
ATF2 UCHL5 1
AXIN1 MAP2K4 1
AXIN1 SKI 1
AXIN1 SKIL 1
AXIN1 SMAD2 2
AXIN1 SMURF1 2
AXIN1 SRC 2
AXIN1 STRAP 1
AXIN1 TGIF1 1
AXIN1 YAP1 2
BCAR1 CDC42 2
BCAR1 E2F4 1
BCAR1 EGFR 1
BCAR1 JUN 1
BCAR1 MAPK14 2
BCAR1 RBL2 1
BCAR1 SMAD3 1
BCAR1 SP1 1
CDC42 CDKN1A 2
CDC42 EGFR 1
CDC42 JUN 1
CDC42 LIMK2 1
CDC42 MTOR 1
CDC42 RHOA 1
CDC42 TGFBR1 1
CDC42 TGFBR2 1
CDC42 TNF 1
CDKN1A MAPK8 2
CDKN1A MTOR 2
CDKN1A RPA1 1
CDKN1A SHC1 1
CDKN1A SMAD4 4
CITED1 E2F4 1
CITED1 JUN 2
CITED1 RBL2 1
COPS5 MAP2K2 2
COPS5 MAP3K7 2
COPS5 MEF2C 2
COPS5 RAF1 2
COPS5 SMAD2 3
COPS5 SMAD7 3
COPS5 SPTBN1 1
DCP1A MAPK1 2
DCP1A SMAD2 1
E2F4 GRB2 1
E2F4 ITGB1 1
E2F4 JUN 1
E2F4 JUNB 1
E2F4 KLF6 1
E2F4 MAP3K7 1
E2F4 SHC1 1
E2F4 SP1 1
E2F4 SRC 1
E2F4 STAMBPL1 1
E2F4 TGFBR2 1
E2F4 TGFBR3 1
E2F4 TGIF1 1
E2F4 TNF 1
E2F4 TRAP1 1
E2F4 UCHL5 1
EGFR MAP2K2 1
EGFR MAPK14 2
EGFR MAPK8 2
EGFR MAPK9 2
EGFR RAF1 2
EGFR RPA1 1
EGFR SMAD4 2
EGFR STRAP 1
EGFR YAP1 1
ETS1 JUN 3
ETS1 JUNB 1
ETS1 MAPK14 1
ETS1 MEF2C 1
ETS1 MTOR 1
ETS1 RAF1 2
ETS1 SHC1 1
ETS1 SMAD3 4
ETS1 SP1 3
ETS1 SRC 4
GRB2 ITCH 1
GRB2 JUN 1
GRB2 MAP2K2 1
GRB2 MAPK14 1
GRB2 MAPK9 1
GRB2 PARD6A 2
GRB2 RBL2 1
GRB2 SMAD4 2
ITCH EGFR 1
ITCH JUN 2
ITCH MAP2K4 1
ITCH MAP3K7 1
ITCH SMAD2 1
ITCH SMAD3 1
ITCH SMURF1 1
ITCH TGFBR1 1
ITCH TGIF1 2
ITCH YAP1 1
ITGB1 BCAR1 1
ITGB1 CDC42 1
ITGB1 JUN 1
ITGB1 RBL2 1
ITGB1 RPA1 1
ITGB1 SHC1 1
ITGB1 SMAD4 2
JUNB MAPK1 2
JUNB MAPK14 1
JUNB MAPK8 2
JUNB MAPK9 1
JUNB RAF1 2
JUNB RBL2 1
JUNB SMURF1 1
JUN KLF6 1
JUN LIMK2 1
JUN MAP2K4 1
JUN MAP3K7 1
JUN MAPK1 4
JUN RBL2 1
JUN RPA1 1
JUN SHC1 1
JUN SKI 2
JUN SMAD7 1
JUN SP1 4
JUN STAMBPL1 1
JUN STRAP 1
JUN TGFBR3 1
JUN TRAP1 2
JUN UCHL5 1
KLF10 SP1 3
KLF11 MAPK1 2
KLF6 RBL2 1
KLF6 SP1 2
MAP2K4 MAPK1 1
MAP3K7 MEF2C 1
MAP3K7 PDPK1 1
MAP3K7 RBL2 1
MAP3K7 SKIL 1
MAP3K7 SMAD3 2
MAP3K7 SMAD7 3
MAP3K7 SMURF1 1
MAP3K7 SP1 1
MAPK14 MAPK8 2
MAPK14 SMAD7 3
MAPK14 SP1 2
MAPK14 SPTBN1 2
MAPK14 TGFBR1 1
MAPK1 MAPK14 4
MAPK1 MAPK8 2
MAPK1 SMURF1 2
MAPK4 JUN 1
MAPK8 MTOR 1
MAPK8 PDPK1 1
MAPK8 RAF1 2
MAPK8 SMAD2 2
MAPK9 MAPK1 1
MAPK9 RNF111 1
MAPK9 SMAD2 1
MAPK9 SMAD3 1
MAPK9 SP1 1
MEF2C SMAD2 3
MEF2C SMAD3 1
MEF2C SMYD1 1
MEF2C SP1 2