Pathway ID Pathway Name Source Organism Number of Genes Number of Interactions
pathway0002855 Hs_NAD_metabolism,_sirtuins_and_aging_WP3630_88178 WikiPathways Homo sapiens 8 17
Secreted
Membrane
Cytoplasm
Cytoplasm/4
Cytoskeleton
Cytoskeleton/Cytoplasm
Membrane/Nucleus
Cytoplasm/Nucleus
Cytoskeleton/Nucleus
Nucleus
Secreted/Nucleus
Unknown
Annotated genes
Unannotated genes
Symbol
Ensembl ID
Entrez ID
Subcellular localization
Description
Type
Edge
Symbol Ensembl ID Entrez ID Subcellular localization Closeness Degree Betweenness Transitivity
SIRT3 ENSG00000142082 23410 Cytoplasm 0.09090909 3.0 1.809524 0.33333333
FOXO1 ENSG00000150907 2308 Cytoplasm/Nucleus 0.09090909 9.0 0.4107143 0.11111111
FOXO3 ENSG00000118689 2309 Cytoplasm/Nucleus 0.1 10.0 3.695238 0.04444444
NFKB1 ENSG00000109320 4790 Cytoplasm/Nucleus 0.1 11.0 4.733333 0.03636364
PARP1 ENSG00000143799 142 Cytoplasm/Nucleus 0.1 5.0 2.152381 0.3
SIRT1 ENSG00000096717 23411 Cytoplasm/Nucleus 0.1 9.0 3.073809 0.08333333
TFAM ENSG00000108064 7019 Cytoplasm/Nucleus 0.07142857 2.0 0.0 1.0
NAMPT ENSG00000105835 10135 Secreted/Nucleus 0.08333333 3.0 0.125 0.66666667
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
SIRT3 ENSG00000142082 23410 Cytoplasm 33.0 2274.503 1.55E-6 0.142045455
FOXO1 ENSG00000150907 2308 Cytoplasm/Nucleus 1320.0 45804.93 1.56E-6 0.001618536
FOXO3 ENSG00000118689 2309 Cytoplasm/Nucleus 1569.0 45471.36 1.56E-6 0.002198202
NFKB1 ENSG00000109320 4790 Cytoplasm/Nucleus 11386.0 279636.5 1.56E-6 2.06234E-4
PARP1 ENSG00000143799 142 Cytoplasm/Nucleus 382.0 53479.07 1.56E-6 0.047793764
SIRT1 ENSG00000096717 23411 Cytoplasm/Nucleus 674.0 56887.81 1.56E-6 0.023311185
TFAM ENSG00000108064 7019 Cytoplasm/Nucleus 26.0 3122.351 1.55E-6 0.101538462
NAMPT ENSG00000105835 10135 Secreted/Nucleus 75.0 28317.83 1.54E-6 0.038918919
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
SIRT3 ENSG00000142082 23410 Cytoplasm 3.0 7.245329 2.09E-5 0.333333333
FOXO1 ENSG00000150907 2308 Cytoplasm/Nucleus 203.0 4853.744 2.14E-5 0.011266644
FOXO3 ENSG00000118689 2309 Cytoplasm/Nucleus 235.0 9482.103 2.15E-5 0.012220404
NFKB1 ENSG00000109320 4790 Cytoplasm/Nucleus 1684.0 71951.94 2.17E-5 9.77358E-4
PARP1 ENSG00000143799 142 Cytoplasm/Nucleus 32.0 124.4741 2.12E-5 0.20766129
SIRT1 ENSG00000096717 23411 Cytoplasm/Nucleus 85.0 9803.826 2.15E-5 0.058263305
TFAM ENSG00000108064 7019 Cytoplasm/Nucleus 10.0 1671.189 2.09E-5 0.266666667
NAMPT ENSG00000105835 10135 Secreted/Nucleus 7.0 11.4526 2.08E-5 0.095238095
Gene1 Gene2 Weight KEGG humanCyc PID BioGRID IntAct HPRD BIND Reactome CORUM DIP WikiPathways ReconX INOH SMPDB PhosphoSite PANTHER CTD NetPath TRANSFAC DrugBank
FOXO1 SIRT1 7
FOXO3 SIRT1 7
FOXO1 NAMPT 1
FOXO1 PARP1 1
FOXO3 FOXO1 1
FOXO3 NAMPT 1
FOXO3 SIRT3 2
NFKB1 PARP1 3
NFKB1 SIRT3 1
NFKB1 TFAM 1
PARP1 NAMPT 1
SIRT1 NFKB1 1
SIRT1 PARP1 1
SIRT3 TFAM 1
Pathway1 Pathway2 Intersect Similarity Scores Pathway Name Source Number of Genes Number of Interactions Detail
pathway0002855 pathway0002035 4 0.5 Signaling events mediated by HDAC Class III PID 41 421