Pathway ID Pathway Name Source Organism Number of Genes Number of Interactions
pathway0002862 Hs_AGE-RAGE_pathway_WP2324_89798 WikiPathways Homo sapiens 27 130
Secreted
Membrane
Cytoplasm
Cytoplasm/4
Cytoskeleton
Cytoskeleton/Cytoplasm
Membrane/Nucleus
Cytoplasm/Nucleus
Cytoskeleton/Nucleus
Nucleus
Secreted/Nucleus
Unknown
Annotated genes
Unannotated genes
Symbol
Ensembl ID
Entrez ID
Subcellular localization
Description
Type
Edge
Symbol Ensembl ID Entrez ID Subcellular localization Closeness Degree Betweenness Transitivity
DDOST ENSG00000244038 1650 Cytoplasm 0.01785714 3.0 0.01818182 0.666666667
DIAPH1 ENSG00000131504 1729 Cytoplasm 0.01818182 6.0 0.3095238 0.266666667
RAC1 ENSG00000136238 5879 Cytoplasm 0.02380952 28.0 10.06754 0.071428571
ATF2 ENSG00000115966 1386 Cytoplasm/Nucleus 0.02439024 21.0 16.78191 0.10952381
FOXO1 ENSG00000150907 2308 Cytoplasm/Nucleus 0.01785714 18.0 0.0 0.006535948
FOXO4 ENSG00000184481 4303 Cytoplasm/Nucleus 0.01851852 16.0 0.377027 0.025
HIF1A ENSG00000100644 3091 Cytoplasm/Nucleus 0.02222222 12.0 1.366507 0.196969697
IKBKB ENSG00000104365 3551 Cytoplasm/Nucleus 0.02325581 71.0 8.579608 0.013279678
NFKB1 ENSG00000109320 4790 Cytoplasm/Nucleus 0.02380952 82.0 7.761047 0.012345679
NFKBIA ENSG00000100906 4792 Cytoplasm/Nucleus 0.02040816 127.0 0.9318261 0.002249719
PRKCB ENSG00000166501 5579 Cytoplasm/Nucleus 0.02325581 33.0 3.77753 0.039772727
RELA ENSG00000173039 5970 Cytoplasm/Nucleus 0.02631579 81.0 14.37157 0.014506173
STAT5A ENSG00000126561 6776 Cytoplasm/Nucleus 0.02564103 43.0 8.252112 0.052048726
STAT5B ENSG00000173757 6777 Cytoplasm/Nucleus 0.025 37.0 6.064138 0.055555556
AKT1 ENSG00000142208 207 Membrane 0.03125 95.0 71.22439 0.018141097
CDC42 ENSG00000070831 998 Membrane 0.02040816 17.0 3.15288 0.080882353
IRAK4 ENSG00000198001 51135 Membrane 0.01886792 12.0 0.2210394 0.106060606
RAF1 ENSG00000132155 5894 Membrane 0.02173913 24.0 0.2908136 0.065217391
SHC1 ENSG00000160691 6464 Membrane 0.02631579 31.0 27.62752 0.103225806
PRKCZ ENSG00000067606 5590 Membrane/Nucleus 0.02631579 39.0 12.84825 0.05802969
AGER ENSG00000204305 177 Unknown 0.01960784 7.0 2.107568 0.238095238
EGFR ENSG00000146648 1956 Unknown 0.02702703 47.0 52.05582 0.035152636
MAPK14 ENSG00000112062 1432 Unknown 0.02702703 48.0 14.84468 0.04787234
NCF1 ENSG00000158517 653361 Unknown 0.0212766 21.0 2.098262 0.071428571
RFC3 ENSG00000133119 5983 Nucleus 0.01785714 3.0 0.01818182 0.666666667
SP1 ENSG00000185591 6667 Nucleus 0.02272727 15.0 0.8520815 0.257142857
INHBB ENSG00000163083 3625 Secreted 0.01587302 1.0 0.0 0.0
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
DDOST ENSG00000244038 1650 Cytoplasm 165.0 102065.0 1.55E-6 0.382
DIAPH1 ENSG00000131504 1729 Cytoplasm 191.0 2445.746 1.55E-6 0.018
RAC1 ENSG00000136238 5879 Cytoplasm 14443.0 873934.7 1.56E-6 1.69E-4
ATF2 ENSG00000115966 1386 Cytoplasm/Nucleus 2727.0 293017.3 1.56E-6 0.00401
FOXO1 ENSG00000150907 2308 Cytoplasm/Nucleus 1320.0 45804.93 1.56E-6 0.00162
FOXO4 ENSG00000184481 4303 Cytoplasm/Nucleus 623.0 15887.93 1.56E-6 0.0097
HIF1A ENSG00000100644 3091 Cytoplasm/Nucleus 971.0 113639.9 1.56E-6 0.00577
IKBKB ENSG00000104365 3551 Cytoplasm/Nucleus 10428.0 206047.6 1.56E-6 1.03E-4
NFKB1 ENSG00000109320 4790 Cytoplasm/Nucleus 11386.0 279636.5 1.56E-6 2.06E-4
NFKBIA ENSG00000100906 4792 Cytoplasm/Nucleus 12604.0 63578.71 1.56E-6 3.76E-5
PRKCB ENSG00000166501 5579 Cytoplasm/Nucleus 8548.0 259644.4 1.56E-6 3.64E-4
RELA ENSG00000173039 5970 Cytoplasm/Nucleus 11059.0 663081.0 1.57E-6 3.08E-4
STAT5A ENSG00000126561 6776 Cytoplasm/Nucleus 7688.0 195804.1 1.56E-6 4.69E-4
STAT5B ENSG00000173757 6777 Cytoplasm/Nucleus 6515.0 71134.33 1.56E-6 5.43E-4
AKT1 ENSG00000142208 207 Membrane 52751.0 2150216.0 1.57E-6 1.74E-5
CDC42 ENSG00000070831 998 Membrane 6876.0 628014.1 1.56E-6 5.19E-4
IRAK4 ENSG00000198001 51135 Membrane 1465.0 3792.873 1.55E-6 4.75E-4
RAF1 ENSG00000132155 5894 Membrane 23706.0 140463.2 1.56E-6 1.64E-5
SHC1 ENSG00000160691 6464 Membrane 13549.0 311909.8 1.56E-6 2.6E-4
PRKCZ ENSG00000067606 5590 Membrane/Nucleus 3319.0 59052.05 1.56E-6 0.00138
AGER ENSG00000204305 177 Unknown 96.0 103.8526 1.55E-6 0.0123
EGFR ENSG00000146648 1956 Unknown 12590.0 758354.8 1.56E-6 2.83E-4
MAPK14 ENSG00000112062 1432 Unknown 9287.0 426504.4 1.56E-6 2.57E-4
NCF1 ENSG00000158517 653361 Unknown 327.0 801.1523 1.55E-6 0.00512
RFC3 ENSG00000133119 5983 Nucleus 1217.0 6633.079 1.55E-6 0.00687
SP1 ENSG00000185591 6667 Nucleus 1577.0 412582.3 1.56E-6 0.00757
INHBB ENSG00000163083 3625 Secreted 601.0 627.1353 1.55E-6 0.0108
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
DDOST ENSG00000244038 1650 Cytoplasm 3.0 0.00648 2.09E-5 0.666666667
DIAPH1 ENSG00000131504 1729 Cytoplasm 17.0 160.0 2.1E-5 0.044117647
RAC1 ENSG00000136238 5879 Cytoplasm 1094.0 29000.0 2.16E-5 0.003408762
ATF2 ENSG00000115966 1386 Cytoplasm/Nucleus 369.0 17800.0 2.17E-5 0.01832214
FOXO1 ENSG00000150907 2308 Cytoplasm/Nucleus 203.0 4850.0 2.14E-5 0.011266644
FOXO4 ENSG00000184481 4303 Cytoplasm/Nucleus 102.0 1120.0 2.13E-5 0.0277616
HIF1A ENSG00000100644 3091 Cytoplasm/Nucleus 63.0 159.0 2.14E-5 0.077316948
IKBKB ENSG00000104365 3551 Cytoplasm/Nucleus 1168.0 22000.0 2.16E-5 0.001691787
NFKB1 ENSG00000109320 4790 Cytoplasm/Nucleus 1684.0 72000.0 2.17E-5 9.77358E-4
NFKBIA ENSG00000100906 4792 Cytoplasm/Nucleus 1925.0 28300.0 2.16E-5 3.726E-4
PRKCB ENSG00000166501 5579 Cytoplasm/Nucleus 373.0 11100.0 2.15E-5 0.015451584
RELA ENSG00000173039 5970 Cytoplasm/Nucleus 1031.0 37600.0 2.16E-5 0.002083
STAT5A ENSG00000126561 6776 Cytoplasm/Nucleus 1017.0 56800.0 2.16E-5 0.003613763
STAT5B ENSG00000173757 6777 Cytoplasm/Nucleus 893.0 6570.0 2.15E-5 0.004022316
AKT1 ENSG00000142208 207 Membrane 6565.0 233000.0 2.19E-5 2.13911E-4
CDC42 ENSG00000070831 998 Membrane 494.0 10900.0 2.15E-5 0.007752256
IRAK4 ENSG00000198001 51135 Membrane 165.0 820.0 2.12E-5 0.009460458
RAF1 ENSG00000132155 5894 Membrane 1624.0 13700.0 2.15E-5 6.27525E-4
SHC1 ENSG00000160691 6464 Membrane 1636.0 9720.0 2.16E-5 0.00189094
PRKCZ ENSG00000067606 5590 Membrane/Nucleus 56.0 647.0 2.13E-5 0.070779221
AGER ENSG00000204305 177 Unknown 7.0 7.69 2.1E-5 0.238095238
EGFR ENSG00000146648 1956 Unknown 1156.0 40200.0 2.17E-5 0.002804116
MAPK14 ENSG00000112062 1432 Unknown 1219.0 74200.0 2.17E-5 0.002559367
NCF1 ENSG00000158517 653361 Unknown 59.0 43.1 2.13E-5 0.042080655
RFC3 ENSG00000133119 5983 Nucleus 3.0 0.00648 2.09E-5 0.666666667
SP1 ENSG00000185591 6667 Nucleus 262.0 17100.0 2.16E-5 0.031294785
INHBB ENSG00000163083 3625 Secreted 3.0 1.69 2.09E-5 0.333333333
Gene1 Gene2 Weight KEGG humanCyc PID BioGRID IntAct HPRD BIND Reactome CORUM DIP WikiPathways ReconX INOH SMPDB PhosphoSite PANTHER CTD NetPath TRANSFAC DrugBank
AGER NFKB1 2
AGER RELA 1
AKT1 EGFR 4
AKT1 FOXO1 13
AKT1 FOXO4 10
AKT1 IKBKB 7
AKT1 NCF1 3
AKT1 NFKB1 3
AKT1 PRKCZ 4
AKT1 RAC1 5
AKT1 RAF1 6
AKT1 RELA 4
AKT1 SP1 1
CDC42 MAPK14 3
CDC42 PRKCZ 2
CDC42 RAC1 4
EGFR HIF1A 1
EGFR PRKCB 2
EGFR PRKCZ 2
EGFR SHC1 12
EGFR STAT5A 7
EGFR STAT5B 7
HIF1A SP1 5
IKBKB NFKB1 9
IKBKB NFKBIA 14
IKBKB RELA 11
IKBKB STAT5A 1
IKBKB STAT5B 1
IRAK4 AKT1 1
IRAK4 IKBKB 2
IRAK4 NCF1 1
IRAK4 STAT5A 1
IRAK4 STAT5B 1
MAPK14 ATF2 8
MAPK14 NCF1 3
MAPK14 NFKB1 1
MAPK14 NFKBIA 2
MAPK14 RELA 2
MAPK14 SHC1 2
MAPK14 STAT5B 1
NCF1 RAC1 3
NFKB1 NFKBIA 12
NFKB1 RELA 12
NFKBIA RELA 14
PRKCB AKT1 2
PRKCB ATF2 1
PRKCB IKBKB 4
PRKCB RAF1 4
PRKCZ IKBKB 3
PRKCZ RAF1 5
PRKCZ RELA 6
PRKCZ SP1 2
RAC1 MAPK14 2
RAC1 STAT5A 1
RAF1 STAT5A 1
RAF1 STAT5B 1
SHC1 AKT1 3
SHC1 RAC1 2
SHC1 STAT5A 4
SHC1 STAT5B 3
STAT5A AKT1 1
STAT5A STAT5B 4
STAT5B AKT1 2
AGER DIAPH1 1
AGER EGFR 1
AKT1 ATF2 1
AKT1 HIF1A 1
AKT1 MAPK14 3
AKT1 NFKBIA 1
ATF2 CDC42 1
ATF2 DDOST 1
ATF2 HIF1A 1
ATF2 IKBKB 1
ATF2 RELA 1
ATF2 RFC3 1
ATF2 SHC1 1
ATF2 SP1 1
CDC42 EGFR 1
CDC42 RELA 2
DDOST EGFR 1
DDOST RFC3 1
DIAPH1 CDC42 1
DIAPH1 EGFR 1
DIAPH1 RAC1 1
EGFR MAPK14 2
EGFR RAC1 2
EGFR RAF1 2
EGFR RFC3 1
FOXO1 FOXO4 2
FOXO4 STAT5B 1
HIF1A FOXO4 1
HIF1A RELA 1
HIF1A SHC1 1
IKBKB MAPK14 1
MAPK14 SP1 2
NCF1 NFKB1 1
NCF1 PRKCB 3
NCF1 PRKCZ 2
NCF1 RELA 2
NFKB1 SHC1 2
NFKB1 SP1 1
NFKB1 STAT5A 1
PRKCZ AGER 1
PRKCZ NFKB1 1
PRKCZ NFKBIA 1
RAC1 NFKB1 1
RAC1 RELA 1
RAF1 MAPK14 1
RELA SHC1 2
RELA SP1 4
SHC1 INHBB 1
SHC1 PRKCB 2
SHC1 PRKCZ 3
SHC1 SP1 1
SP1 STAT5A 1
STAT5A MAPK14 1
STAT5A PRKCB 1
STAT5A PRKCZ 1
STAT5B NFKBIA 1
STAT5B PRKCB 1
STAT5B PRKCZ 1
Pathway1 Pathway2 Intersect Similarity Scores Pathway Name Source Number of Genes Number of Interactions Detail
pathway0002862 pathway0000658 16 0.5925926 EGFR1 NetPath 475 10010
pathway0002862 pathway0001089 4 0.5714286 IkBA variant leads to EDA-ID Reactome 7 23
pathway0002862 pathway0001264 15 0.5555556 Leptin NetPath 98 1355
pathway0002862 pathway0002656 14 0.5185185 Pathways in cancer KEGG 321 8293
pathway0002862 pathway0001090 4 0.5 IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) Reactome 8 30
pathway0002862 pathway0001091 4 0.5 IKK-NF-kappaB cascade ( B cell receptor signaling ) INOH 8 30
pathway0002862 pathway0001092 4 0.5 IKK-NF-kappaB cascade ( CD4 T cell receptor signaling (NF-kB cascade) ) INOH 8 30
pathway0002862 pathway0001093 4 0.5 IKK-NF-kappaB cascade ( CD4 T cell receptor signaling ) INOH 8 30