Pathway ID Pathway Name Source Organism Number of Genes Number of Interactions
pathway0002863 Hs_Androgen_receptor_signaling_pathway_WP138_79958 WikiPathways Homo sapiens 27 107
Secreted
Membrane
Cytoplasm
Cytoplasm/4
Cytoskeleton
Cytoskeleton/Cytoplasm
Membrane/Nucleus
Cytoplasm/Nucleus
Cytoskeleton/Nucleus
Nucleus
Secreted/Nucleus
Unknown
Annotated genes
Unannotated genes
Symbol
Ensembl ID
Entrez ID
Subcellular localization
Description
Type
Edge
Symbol Ensembl ID Entrez ID Subcellular localization Closeness Degree Betweenness Transitivity
CDKN1A ENSG00000124762 1026 Cytoplasm/Nucleus 0.02325581 29.0 4.854154 0.051724138
FKBP4 ENSG00000004478 2288 Cytoplasm/Nucleus 0.01923077 5.0 0.03846154 0.2
GNB2L1 ENSG00000204628 10399 Cytoplasm/Nucleus 0.0212766 13.0 0.9441622 0.102564103
MDM2 ENSG00000135679 4193 Cytoplasm/Nucleus 0.02325581 20.0 1.877902 0.147368421
ROCK2 ENSG00000134318 9475 Cytoplasm/Nucleus 0.01923077 28.0 7.196815 0.026455026
SMAD3 ENSG00000166949 4088 Cytoplasm/Nucleus 0.02040816 14.0 0.1267606 0.098901099
SRC ENSG00000197122 6714 Cytoplasm/Nucleus 0.025 63.0 25.08177 0.022017409
BMF ENSG00000104081 90427 Cytoskeleton 0.01923077 3.0 0.4232745 0.666666667
RHOA ENSG00000067560 387 Cytoskeleton/Nucleus 0.02173913 38.0 9.385805 0.048364154
AKT1 ENSG00000142208 207 Membrane 0.02380952 130.0 14.34156 0.00417412
CDC42 ENSG00000070831 998 Membrane 0.02 22.0 2.333076 0.0995671
PIK3R1 ENSG00000145675 5295 Membrane 0.02272727 79.0 5.200123 0.009087958
PIK3R2 ENSG00000105647 5296 Membrane 0.02272727 75.0 2.105051 0.01009009
AR ENSG00000169083 367 Unknown 0.03125 48.0 147.9211 0.039893617
EGFR ENSG00000146648 1956 Unknown 0.02380952 49.0 8.813346 0.028061224
KLK3 ENSG00000142515 354 Unknown 0.02325581 15.0 9.043819 0.142857143
LIMK2 ENSG00000182541 3985 Unknown 0.01754386 12.0 4.0 0.090909091
PTK2 ENSG00000169398 5747 Unknown 0.0212766 60.0 10.6799 0.018079096
CARM1 ENSG00000142453 10498 Nucleus 0.01785714 4.0 0.0 0.166666667
DSTN ENSG00000125868 11034 Nucleus 0.01960784 4.0 6.694839 0.0
ETV5 ENSG00000244405 2119 Nucleus 0.01960784 4.0 1.190492 0.0
HDAC1 ENSG00000116478 3065 Nucleus 0.02272727 17.0 7.786039 0.117647059
PATZ1 ENSG00000100105 23598 Nucleus 0.01818182 3.0 0.08333333 0.666666667
RNF4 ENSG00000063978 6047 Nucleus 0.01851852 4.0 0.3088235 0.333333333
RNF6 ENSG00000127870 6049 Nucleus 0.01886792 7.0 25.14286 0.095238095
SP1 ENSG00000185591 6667 Nucleus 0.02325581 20.0 8.426574 0.115789474
RLN1 ENSG00000107018 6013 Secreted 0.01282051 2.0 0.0 0.0
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
CDKN1A ENSG00000124762 1026 Cytoplasm/Nucleus 3911.0 109000.0 1.56E-6 8.1E-4
FKBP4 ENSG00000004478 2288 Cytoplasm/Nucleus 108.0 373.0 1.55E-6 0.0362
GNB2L1 ENSG00000204628 10399 Cytoplasm/Nucleus 39.0 22100.0 1.55E-6 0.159
MDM2 ENSG00000135679 4193 Cytoplasm/Nucleus 2666.0 363000.0 1.56E-6 0.00187
ROCK2 ENSG00000134318 9475 Cytoplasm/Nucleus 1010.0 7660.0 1.56E-6 0.00175
SMAD3 ENSG00000166949 4088 Cytoplasm/Nucleus 3869.0 321000.0 1.56E-6 9.74E-4
SRC ENSG00000197122 6714 Cytoplasm/Nucleus 14851.0 1350000.0 1.57E-6 2.68E-4
BMF ENSG00000104081 90427 Cytoskeleton 26.0 20.6 1.55E-6 0.138
RHOA ENSG00000067560 387 Cytoskeleton/Nucleus 5830.0 484000.0 1.56E-6 6.32E-4
AKT1 ENSG00000142208 207 Membrane 52751.0 2150000.0 1.57E-6 1.74E-5
CDC42 ENSG00000070831 998 Membrane 6876.0 628000.0 1.56E-6 5.19E-4
PIK3R1 ENSG00000145675 5295 Membrane 31452.0 734000.0 1.56E-6 4.03E-5
PIK3R2 ENSG00000105647 5296 Membrane 17436.0 144000.0 1.56E-6 9.14E-5
AR ENSG00000169083 367 Unknown 1492.0 269000.0 1.56E-6 0.011
EGFR ENSG00000146648 1956 Unknown 12590.0 758000.0 1.56E-6 2.83E-4
KLK3 ENSG00000142515 354 Unknown 361.0 29100.0 1.56E-6 0.0548
LIMK2 ENSG00000182541 3985 Unknown 266.0 1240.0 1.55E-6 0.00516
PTK2 ENSG00000169398 5747 Unknown 9391.0 242000.0 1.56E-6 3.21E-4
CARM1 ENSG00000142453 10498 Nucleus 279.0 5410.0 1.55E-6 0.0264
DSTN ENSG00000125868 11034 Nucleus 4.0 0.454 1.54E-6 0.0
ETV5 ENSG00000244405 2119 Nucleus 39.0 3.64 1.55E-6 0.0796
HDAC1 ENSG00000116478 3065 Nucleus 3183.0 336000.0 1.56E-6 0.00344
PATZ1 ENSG00000100105 23598 Nucleus 9.0 0.33 1.54E-6 0.194
RNF4 ENSG00000063978 6047 Nucleus 142.0 1290.0 1.55E-6 0.21
RNF6 ENSG00000127870 6049 Nucleus 48.0 234.0 1.54E-6 0.198
SP1 ENSG00000185591 6667 Nucleus 1577.0 413000.0 1.56E-6 0.00757
RLN1 ENSG00000107018 6013 Secreted 45.0 55.6 1.55E-6 0.0929
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
CDKN1A ENSG00000124762 1026 Cytoplasm/Nucleus 647.0 16600.0 2.16E-5 0.003363942
FKBP4 ENSG00000004478 2288 Cytoplasm/Nucleus 5.0 0.245 2.09E-5 0.2
GNB2L1 ENSG00000204628 10399 Cytoplasm/Nucleus 39.0 1900.0 2.13E-5 0.145748988
MDM2 ENSG00000135679 4193 Cytoplasm/Nucleus 531.0 6780.0 2.15E-5 0.003105568
ROCK2 ENSG00000134318 9475 Cytoplasm/Nucleus 99.0 2350.0 2.14E-5 0.028035457
SMAD3 ENSG00000166949 4088 Cytoplasm/Nucleus 328.0 39900.0 2.16E-5 0.010628776
SRC ENSG00000197122 6714 Cytoplasm/Nucleus 1835.0 67000.0 2.17E-5 0.001945688
BMF ENSG00000104081 90427 Cytoskeleton 14.0 151.0 2.11E-5 0.21978022
RHOA ENSG00000067560 387 Cytoskeleton/Nucleus 242.0 4160.0 2.15E-5 0.021809952
AKT1 ENSG00000142208 207 Membrane 6565.0 233000.0 2.19E-5 2.13911E-4
CDC42 ENSG00000070831 998 Membrane 494.0 10900.0 2.15E-5 0.007752256
PIK3R1 ENSG00000145675 5295 Membrane 2347.0 18200.0 2.15E-5 6.63995E-4
PIK3R2 ENSG00000105647 5296 Membrane 1499.0 14900.0 2.15E-5 0.001001112
AR ENSG00000169083 367 Unknown 195.0 22200.0 2.16E-5 0.02913032
EGFR ENSG00000146648 1956 Unknown 1156.0 40200.0 2.17E-5 0.002804116
KLK3 ENSG00000142515 354 Unknown 15.0 109.0 2.1E-5 0.142857143
LIMK2 ENSG00000182541 3985 Unknown 38.0 369.0 2.11E-5 0.027027027
PTK2 ENSG00000169398 5747 Unknown 920.0 14400.0 2.16E-5 0.003269149
CARM1 ENSG00000142453 10498 Nucleus 4.0 0.0 2.07E-5 0.166666667
DSTN ENSG00000125868 11034 Nucleus 4.0 2.5 2.07E-5 0.0
ETV5 ENSG00000244405 2119 Nucleus 4.0 0.927 2.08E-5 0.0
HDAC1 ENSG00000116478 3065 Nucleus 133.0 9240.0 2.15E-5 0.052517658
PATZ1 ENSG00000100105 23598 Nucleus 3.0 0.0833 2.07E-5 0.666666667
RNF4 ENSG00000063978 6047 Nucleus 4.0 3.62 2.08E-5 0.333333333
RNF6 ENSG00000127870 6049 Nucleus 7.0 1870.0 2.07E-5 0.095238095
SP1 ENSG00000185591 6667 Nucleus 262.0 17100.0 2.16E-5 0.031294785
RLN1 ENSG00000107018 6013 Secreted 2.0 0.0 2.0E-5 0.0
Gene1 Gene2 Weight KEGG humanCyc PID BioGRID IntAct HPRD BIND Reactome CORUM DIP WikiPathways ReconX INOH SMPDB PhosphoSite PANTHER CTD NetPath TRANSFAC DrugBank
AKT1 AR 6
AKT1 CDKN1A 9
AKT1 EGFR 4
AKT1 MDM2 11
AKT1 SMAD3 4
AKT1 SP1 1
AR CDKN1A 3
AR EGFR 5
AR ETV5 5
AR FKBP4 5
AR GNB2L1 5
AR KLK3 7
AR PIK3R1 4
AR RNF4 3
AR SMAD3 4
AR SRC 5
CARM1 KLK3 2
CDC42 PIK3R1 4
CDC42 PTK2 3
CDKN1A HDAC1 4
EGFR PIK3R1 8
EGFR PIK3R2 7
EGFR PTK2 7
EGFR RHOA 1
EGFR SRC 8
GNB2L1 SRC 3
HDAC1 MDM2 4
HDAC1 SMAD3 5
HDAC1 SP1 5
LIMK2 DSTN 2
PIK3R1 AKT1 6
PIK3R1 PIK3R2 5
PIK3R1 PTK2 6
PIK3R1 RHOA 2
PIK3R1 SRC 8
PIK3R2 AKT1 4
PIK3R2 CDC42 2
PIK3R2 PTK2 4
PIK3R2 RHOA 1
PIK3R2 SRC 2
PTK2 AKT1 2
PTK2 LIMK2 1
PTK2 SRC 10
RHOA AKT1 2
RHOA LIMK2 1
RHOA PTK2 3
RHOA ROCK2 5
RNF6 AR 2
ROCK2 LIMK2 5
ROCK2 PTK2 1
SMAD3 CDKN1A 3
SMAD3 SP1 7
SP1 CDKN1A 3
SP1 SRC 2
SRC AKT1 4
SRC CDC42 3
AR BMF 1
AR DSTN 1
AR HDAC1 4
AR MDM2 5
AR PATZ1 2
AR PIK3R2 1
AR SP1 4
BMF HDAC1 1
BMF RNF6 1
CARM1 AR 1
CDC42 CDKN1A 2
CDC42 EGFR 1
CDC42 LIMK2 1
CDC42 RHOA 1
CDKN1A GNB2L1 3
CDKN1A MDM2 4
EGFR FKBP4 2
EGFR GNB2L1 1
FKBP4 KLK3 1
GNB2L1 KLK3 1
GNB2L1 RHOA 1
HDAC1 KLK3 1
HDAC1 RHOA 2
KLK3 RNF6 1
KLK3 SP1 1
MDM2 EGFR 1
MDM2 KLK3 1
MDM2 PTK2 1
MDM2 RHOA 1
MDM2 SP1 2
MDM2 SRC 1
PATZ1 KLK3 1
PATZ1 RNF4 4
PIK3R1 CDKN1A 1
PIK3R2 CDKN1A 1
PTK2 HDAC1 1
RLN1 RNF6 1
RNF4 SP1 1
ROCK2 CDC42 1
ROCK2 ETV5 1
ROCK2 SP1 1
SRC KLK3 1
SRC RHOA 2
SRC ROCK2 1
Pathway1 Pathway2 Intersect Similarity Scores Pathway Name Source Number of Genes Number of Interactions Detail
pathway0002863 pathway0000176 16 0.5925926 AndrogenReceptor NetPath 167 2267