Pathway ID Pathway Name Source Organism Number of Genes Number of Interactions
pathway0002864 Hs_IL-4_Signaling_Pathway_WP395_89828 WikiPathways Homo sapiens 41 397
Secreted
Membrane
Cytoplasm
Cytoplasm/4
Cytoskeleton
Cytoskeleton/Cytoplasm
Membrane/Nucleus
Cytoplasm/Nucleus
Cytoskeleton/Nucleus
Nucleus
Secreted/Nucleus
Unknown
Annotated genes
Unannotated genes
Symbol
Ensembl ID
Entrez ID
Subcellular localization
Description
Type
Edge
Symbol Ensembl ID Entrez ID Subcellular localization Closeness Degree Betweenness Transitivity
BAD ENSG00000002330 572 Cytoplasm 0.01234568 38.0 0.1414634 0.012802276
CHUK ENSG00000213341 1147 Cytoplasm 0.015625 70.0 5.149085 0.029399586
GAB2 ENSG00000033327 9846 Cytoplasm 0.01818182 73.0 5.130829 0.079147641
INPP5D ENSG00000168918 3635 Cytoplasm 0.01449275 48.0 0.5560385 0.062056738
JAK1 ENSG00000162434 3716 Cytoplasm 0.02 154.0 60.32436 0.021729904
JAK3 ENSG00000105639 3718 Cytoplasm 0.01960784 115.0 30.91325 0.037681159
PTGS1 ENSG00000095303 5742 Cytoplasm 0.01351351 6.0 0.0302591 0.8
PTPN11 ENSG00000179295 5781 Cytoplasm 0.01785714 89.0 5.0047 0.051838611
PTPN6 ENSG00000111679 5777 Cytoplasm 0.01666667 44.0 0.5688038 0.156448203
SOCS1 ENSG00000185338 8651 Cytoplasm 0.01470588 37.0 0.4064154 0.09009009
SOCS5 ENSG00000171150 9655 Cytoplasm 0.01351351 14.0 0.0 0.307692308
SOS1 ENSG00000115904 6654 Cytoplasm 0.01694915 95.0 1.679136 0.040089586
ATF2 ENSG00000115966 1386 Cytoplasm/Nucleus 0.01612903 40.0 3.790132 0.105128205
CBL ENSG00000110395 867 Cytoplasm/Nucleus 0.01612903 51.0 1.322086 0.094901961
ELK1 ENSG00000126767 2002 Cytoplasm/Nucleus 0.01492537 62.0 2.854466 0.028027499
FES ENSG00000182511 2242 Cytoplasm/Nucleus 0.01333333 17.0 0.0 0.110294118
FLNA ENSG00000196924 2316 Cytoplasm/Nucleus 0.01388889 13.0 0.0939586 0.294871795
FOS ENSG00000170345 2353 Cytoplasm/Nucleus 0.01470588 44.0 1.593858 0.059196617
IKBKB ENSG00000104365 3551 Cytoplasm/Nucleus 0.01515152 72.0 4.815379 0.025039124
MAPK1 ENSG00000100030 5594 Cytoplasm/Nucleus 0.01851852 104.0 21.20358 0.035100822
MAPK11 ENSG00000185386 5600 Cytoplasm/Nucleus 0.01538462 46.0 2.627812 0.079227053
MAPK3 ENSG00000102882 5595 Cytoplasm/Nucleus 0.01851852 92.0 18.86927 0.04491161
NFKB1 ENSG00000109320 4790 Cytoplasm/Nucleus 0.015625 91.0 4.086846 0.019047619
NFKBIA ENSG00000100906 4792 Cytoplasm/Nucleus 0.01470588 106.0 4.637964 0.008984726
RPS6KB1 ENSG00000108443 6198 Cytoplasm/Nucleus 0.01492537 45.0 1.920431 0.056565657
SOCS3 ENSG00000184557 9021 Cytoplasm/Nucleus 0.01538462 60.0 3.426984 0.041242938
STAT1 ENSG00000115415 6772 Cytoplasm/Nucleus 0.01886792 86.0 12.04818 0.058823529
STAT5A ENSG00000126561 6776 Cytoplasm/Nucleus 0.01923077 81.0 11.50818 0.072839506
STAT5B ENSG00000173757 6777 Cytoplasm/Nucleus 0.01923077 75.0 11.22043 0.084324324
STAT6 ENSG00000166888 6778 Cytoplasm/Nucleus 0.01886792 66.0 8.440128 0.101165501
PIK3CD ENSG00000171608 5293 Cytoskeleton 0.01694915 92.0 3.111649 0.039894888
AKT1 ENSG00000142208 207 Membrane 0.02 276.0 78.81182 0.006693017
DOK2 ENSG00000147443 9046 Membrane 0.01333333 14.0 0.005853495 0.21978022
IL2RG ENSG00000147168 3561 Membrane 0.01960784 85.0 14.01604 0.070588235
PIK3R1 ENSG00000145675 5295 Membrane 0.01818182 130.0 38.48917 0.019081694
PIK3R2 ENSG00000105647 5296 Membrane 0.01694915 106.0 5.296007 0.026954178
SHC1 ENSG00000160691 6464 Membrane 0.01886792 103.0 10.48533 0.045307443
TSHR ENSG00000165409 7253 Membrane 0.01265823 4.0 0.0 0.5
GRB2 ENSG00000177885 2885 Unknown 0.01754386 145.0 16.95359 0.015900383
MAPK14 ENSG00000112062 1432 Unknown 0.01818182 76.0 14.94859 0.063157895
STAT3 ENSG00000168610 6774 Unknown 0.0212766 101.0 33.51791 0.055247525
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
BAD ENSG00000002330 572 Cytoplasm 4485.0 12100.0 1.55E-6 8.39E-5
CHUK ENSG00000213341 1147 Cytoplasm 9301.0 163000.0 1.56E-6 1.35E-4
GAB2 ENSG00000033327 9846 Cytoplasm 4097.0 11500.0 1.56E-6 0.00119
INPP5D ENSG00000168918 3635 Cytoplasm 2133.0 15300.0 1.55E-6 0.00195
JAK1 ENSG00000162434 3716 Cytoplasm 8612.0 95400.0 1.56E-6 2.71E-4
JAK3 ENSG00000105639 3718 Cytoplasm 4002.0 22800.0 1.56E-6 9.36E-4
PTGS1 ENSG00000095303 5742 Cytoplasm 916.0 6090.0 1.55E-6 3.82E-4
PTPN11 ENSG00000179295 5781 Cytoplasm 9733.0 167000.0 1.56E-6 2.5E-4
PTPN6 ENSG00000111679 5777 Cytoplasm 3244.0 60000.0 1.56E-6 0.0014
SOCS1 ENSG00000185338 8651 Cytoplasm 1341.0 27000.0 1.56E-6 0.00394
SOCS5 ENSG00000171150 9655 Cytoplasm 162.0 19.9 1.54E-6 0.0788
SOS1 ENSG00000115904 6654 Cytoplasm 23511.0 177000.0 1.56E-6 6.54E-5
ATF2 ENSG00000115966 1386 Cytoplasm/Nucleus 2727.0 293000.0 1.56E-6 0.00401
CBL ENSG00000110395 867 Cytoplasm/Nucleus 5209.0 92900.0 1.56E-6 8.8E-4
ELK1 ENSG00000126767 2002 Cytoplasm/Nucleus 3468.0 49000.0 1.56E-6 3.9E-4
FES ENSG00000182511 2242 Cytoplasm/Nucleus 341.0 1140.0 1.55E-6 0.00659
FLNA ENSG00000196924 2316 Cytoplasm/Nucleus 709.0 24600.0 1.56E-6 0.0241
FOS ENSG00000170345 2353 Cytoplasm/Nucleus 3623.0 68600.0 1.56E-6 7.3E-4
IKBKB ENSG00000104365 3551 Cytoplasm/Nucleus 10428.0 206000.0 1.56E-6 1.03E-4
MAPK1 ENSG00000100030 5594 Cytoplasm/Nucleus 33563.0 1130000.0 1.56E-6 2.83E-5
MAPK11 ENSG00000185386 5600 Cytoplasm/Nucleus 3606.0 96400.0 1.56E-6 9.0E-4
MAPK3 ENSG00000102882 5595 Cytoplasm/Nucleus 29207.0 850000.0 1.56E-6 3.17E-5
NFKB1 ENSG00000109320 4790 Cytoplasm/Nucleus 11386.0 280000.0 1.56E-6 2.06E-4
NFKBIA ENSG00000100906 4792 Cytoplasm/Nucleus 12604.0 63600.0 1.56E-6 3.76E-5
RPS6KB1 ENSG00000108443 6198 Cytoplasm/Nucleus 3539.0 54900.0 1.56E-6 3.46E-4
SOCS3 ENSG00000184557 9021 Cytoplasm/Nucleus 2446.0 25700.0 1.56E-6 0.00128
STAT1 ENSG00000115415 6772 Cytoplasm/Nucleus 9900.0 278000.0 1.56E-6 2.9E-4
STAT5A ENSG00000126561 6776 Cytoplasm/Nucleus 7688.0 196000.0 1.56E-6 4.69E-4
STAT5B ENSG00000173757 6777 Cytoplasm/Nucleus 6515.0 71100.0 1.56E-6 5.43E-4
STAT6 ENSG00000166888 6778 Cytoplasm/Nucleus 2021.0 83000.0 1.56E-6 0.00506
PIK3CD ENSG00000171608 5293 Cytoskeleton 14967.0 29900.0 1.56E-6 1.22E-4
AKT1 ENSG00000142208 207 Membrane 52751.0 2150000.0 1.57E-6 1.74E-5
DOK2 ENSG00000147443 9046 Membrane 277.0 32.3 1.55E-6 0.0101
IL2RG ENSG00000147168 3561 Membrane 2184.0 16800.0 1.55E-6 0.00277
PIK3R1 ENSG00000145675 5295 Membrane 31452.0 734000.0 1.56E-6 4.03E-5
PIK3R2 ENSG00000105647 5296 Membrane 17436.0 144000.0 1.56E-6 9.14E-5
SHC1 ENSG00000160691 6464 Membrane 13549.0 312000.0 1.56E-6 2.6E-4
TSHR ENSG00000165409 7253 Membrane 110.0 3850.0 1.55E-6 0.0764
GRB2 ENSG00000177885 2885 Unknown 29079.0 822000.0 1.57E-6 5.64E-5
MAPK14 ENSG00000112062 1432 Unknown 9287.0 427000.0 1.56E-6 2.57E-4
STAT3 ENSG00000168610 6774 Unknown 10644.0 313000.0 1.56E-6 2.82E-4
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
BAD ENSG00000002330 572 Cytoplasm 497.0 517.0 2.13E-5 0.001525281
CHUK ENSG00000213341 1147 Cytoplasm 993.0 31600.0 2.16E-5 0.00231662
GAB2 ENSG00000033327 9846 Cytoplasm 781.0 11700.0 2.15E-5 0.005331757
INPP5D ENSG00000168918 3635 Cytoplasm 251.0 136.0 2.13E-5 0.022693227
JAK1 ENSG00000162434 3716 Cytoplasm 1248.0 8450.0 2.15E-5 0.002257983
JAK3 ENSG00000105639 3718 Cytoplasm 377.0 335.0 2.14E-5 0.008324398
PTGS1 ENSG00000095303 5742 Cytoplasm 6.0 0.0102 2.11E-5 0.8
PTPN11 ENSG00000179295 5781 Cytoplasm 1537.0 16400.0 2.15E-5 0.001603672
PTPN6 ENSG00000111679 5777 Cytoplasm 354.0 4270.0 2.14E-5 0.013332053
SOCS1 ENSG00000185338 8651 Cytoplasm 123.0 387.0 2.13E-5 0.035585766
SOCS5 ENSG00000171150 9655 Cytoplasm 14.0 0.0 2.1E-5 0.307692308
SOS1 ENSG00000115904 6654 Cytoplasm 1954.0 4650.0 2.15E-5 9.81615E-4
ATF2 ENSG00000115966 1386 Cytoplasm/Nucleus 369.0 17800.0 2.17E-5 0.01832214
CBL ENSG00000110395 867 Cytoplasm/Nucleus 724.0 3200.0 2.15E-5 0.005188632
ELK1 ENSG00000126767 2002 Cytoplasm/Nucleus 481.0 2810.0 2.15E-5 0.003005891
FES ENSG00000182511 2242 Cytoplasm/Nucleus 17.0 0.0 2.1E-5 0.110294118
FLNA ENSG00000196924 2316 Cytoplasm/Nucleus 36.0 1.59 2.13E-5 0.126984127
FOS ENSG00000170345 2353 Cytoplasm/Nucleus 346.0 5090.0 2.15E-5 0.007975203
IKBKB ENSG00000104365 3551 Cytoplasm/Nucleus 1168.0 22000.0 2.16E-5 0.001691787
MAPK1 ENSG00000100030 5594 Cytoplasm/Nucleus 3584.0 115000.0 2.18E-5 4.95738E-4
MAPK11 ENSG00000185386 5600 Cytoplasm/Nucleus 116.0 105.0 2.13E-5 0.026386807
MAPK3 ENSG00000102882 5595 Cytoplasm/Nucleus 1631.0 42300.0 2.17E-5 0.001551233
NFKB1 ENSG00000109320 4790 Cytoplasm/Nucleus 1684.0 72000.0 2.17E-5 9.77358E-4
NFKBIA ENSG00000100906 4792 Cytoplasm/Nucleus 1925.0 28300.0 2.16E-5 3.726E-4
RPS6KB1 ENSG00000108443 6198 Cytoplasm/Nucleus 808.0 13200.0 2.16E-5 0.001852602
SOCS3 ENSG00000184557 9021 Cytoplasm/Nucleus 262.0 1120.0 2.14E-5 0.007224123
STAT1 ENSG00000115415 6772 Cytoplasm/Nucleus 1494.0 36500.0 2.17E-5 0.002204845
STAT5A ENSG00000126561 6776 Cytoplasm/Nucleus 1017.0 56800.0 2.16E-5 0.003613763
STAT5B ENSG00000173757 6777 Cytoplasm/Nucleus 893.0 6570.0 2.15E-5 0.004022316
STAT6 ENSG00000166888 6778 Cytoplasm/Nucleus 109.0 2950.0 2.15E-5 0.059802922
PIK3CD ENSG00000171608 5293 Cytoskeleton 256.0 1930.0 2.13E-5 0.012591912
AKT1 ENSG00000142208 207 Membrane 6565.0 233000.0 2.19E-5 2.13911E-4
DOK2 ENSG00000147443 9046 Membrane 32.0 1.6 2.12E-5 0.181451613
IL2RG ENSG00000147168 3561 Membrane 235.0 7350.0 2.14E-5 0.018112384
PIK3R1 ENSG00000145675 5295 Membrane 2347.0 18200.0 2.15E-5 6.63995E-4
PIK3R2 ENSG00000105647 5296 Membrane 1499.0 14900.0 2.15E-5 0.001001112
SHC1 ENSG00000160691 6464 Membrane 1636.0 9720.0 2.16E-5 0.00189094
TSHR ENSG00000165409 7253 Membrane 9.0 1890.0 2.1E-5 0.111111111
GRB2 ENSG00000177885 2885 Unknown 3192.0 57100.0 2.17E-5 5.90241E-4
MAPK14 ENSG00000112062 1432 Unknown 1219.0 74200.0 2.17E-5 0.002559367
STAT3 ENSG00000168610 6774 Unknown 1753.0 59100.0 2.17E-5 0.001825963
Gene1 Gene2 Weight KEGG humanCyc PID BioGRID IntAct HPRD BIND Reactome CORUM DIP WikiPathways ReconX INOH SMPDB PhosphoSite PANTHER CTD NetPath TRANSFAC DrugBank
AKT1 BAD 10
AKT1 CHUK 10
AKT1 FLNA 1
AKT1 IKBKB 7
AKT1 NFKB1 3
AKT1 RPS6KB1 6
AKT1 STAT1 3
AKT1 STAT3 2
ATF2 FOS 5
ATF2 SOCS3 2
ATF2 STAT3 2
CBL GRB2 10
CBL JAK1 2
CBL JAK3 3
CBL PIK3CD 2
CBL PIK3R1 9
CBL PIK3R2 7
CBL PTPN11 4
CBL SHC1 7
CBL SOS1 5
CHUK IKBKB 11
CHUK NFKB1 10
CHUK NFKBIA 14
CHUK STAT1 1
CHUK STAT3 1
CHUK STAT5A 1
CHUK STAT5B 1
CHUK STAT6 1
DOK2 GRB2 2
ELK1 FOS 5
FES JAK1 3
FES PIK3R1 4
FLNA IKBKB 2
GAB2 AKT1 3
GAB2 GRB2 7
GAB2 INPP5D 3
GAB2 MAPK1 4
GAB2 MAPK3 5
GAB2 PIK3CD 3
GAB2 PIK3R1 7
GAB2 PIK3R2 4
GAB2 PTPN11 7
GAB2 PTPN6 3
GAB2 SHC1 7
GAB2 SOS1 3
GRB2 AKT1 3
GRB2 INPP5D 5
GRB2 JAK1 5
GRB2 MAPK1 2
GRB2 PIK3R1 9
GRB2 PIK3R2 6
GRB2 PTPN11 9
GRB2 PTPN6 5
GRB2 SHC1 13
GRB2 SOCS1 5
GRB2 SOS1 12
GRB2 STAT3 1
IKBKB FOS 1
IKBKB NFKB1 9
IKBKB NFKBIA 14
IKBKB STAT1 1
IKBKB STAT3 1
IKBKB STAT5A 1
IKBKB STAT5B 1
IKBKB STAT6 1
IL2RG AKT1 2
IL2RG CBL 1
IL2RG DOK2 1
IL2RG INPP5D 2
IL2RG JAK1 8
IL2RG JAK3 9
IL2RG MAPK11 1
IL2RG MAPK14 1
IL2RG PIK3R1 4
IL2RG SHC1 4
IL2RG SOS1 2
IL2RG STAT1 3
IL2RG STAT3 2
IL2RG STAT5A 4
IL2RG STAT5B 3
IL2RG STAT6 2
INPP5D JAK1 4
INPP5D JAK3 4
INPP5D PTPN11 4
INPP5D SHC1 7
JAK1 AKT1 4
JAK1 DOK2 1
JAK1 JAK3 5
JAK1 MAPK1 2
JAK1 MAPK3 2
JAK1 PIK3CD 3
JAK1 PIK3R1 6
JAK1 PIK3R2 4
JAK1 PTPN11 7
JAK1 SHC1 4
JAK1 SOCS1 7
JAK1 SOCS3 7
JAK1 SOS1 2
JAK1 STAT1 9
JAK1 STAT3 11
JAK1 STAT5A 8
JAK1 STAT5B 7
JAK1 STAT6 7
JAK1 TSHR 4
JAK3 AKT1 3
JAK3 DOK2 1
JAK3 FES 2
JAK3 MAPK11 1
JAK3 MAPK14 1
JAK3 PIK3CD 3
JAK3 PIK3R1 7
JAK3 PIK3R2 3
JAK3 PTPN11 2
JAK3 PTPN6 3
JAK3 SHC1 3
JAK3 SOCS3 4
JAK3 SOS1 2
JAK3 STAT1 5
JAK3 STAT3 8
JAK3 STAT5A 9
JAK3 STAT5B 6
JAK3 STAT6 5
MAPK11 AKT1 1
MAPK11 ATF2 8
MAPK11 ELK1 3
MAPK11 FOS 2
MAPK11 MAPK14 3
MAPK11 SOCS3 2
MAPK11 STAT1 2
MAPK11 STAT3 2
MAPK11 STAT5A 1
MAPK11 STAT5B 1
MAPK11 STAT6 1
MAPK14 ATF2 8
MAPK14 BAD 2
MAPK14 ELK1 5
MAPK14 FOS 3
MAPK14 MAPK3 5
MAPK14 NFKB1 1
MAPK14 NFKBIA 2
MAPK14 SHC1 2
MAPK14 STAT1 5
MAPK14 STAT3 4
MAPK14 STAT5B 1
MAPK1 AKT1 2
MAPK1 ATF2 4
MAPK1 BAD 3
MAPK1 ELK1 9
MAPK1 FOS 5
MAPK1 MAPK3 4
MAPK1 RPS6KB1 5
MAPK1 SHC1 5
MAPK1 SOS1 5
MAPK1 STAT1 2
MAPK1 STAT3 6
MAPK1 STAT5A 6
MAPK1 STAT5B 3
MAPK1 STAT6 3
MAPK3 AKT1 1
MAPK3 ATF2 4
MAPK3 BAD 2
MAPK3 ELK1 8
MAPK3 FOS 5
MAPK3 PTPN11 4
MAPK3 RPS6KB1 2
MAPK3 SHC1 2
MAPK3 SOS1 2
MAPK3 STAT1 3
MAPK3 STAT3 5
MAPK3 STAT5A 5
MAPK3 STAT5B 2
MAPK3 STAT6 2
NFKB1 NFKBIA 12
NFKB1 SOCS3 3
NFKBIA PIK3R1 4
PIK3CD AKT1 3
PIK3CD GRB2 2
PIK3CD INPP5D 5
PIK3CD PIK3R1 10
PIK3CD PIK3R2 9
PIK3CD RPS6KB1 1
PIK3CD SHC1 2
PIK3CD SOS1 2
PIK3CD STAT3 2
PIK3R1 AKT1 6
PIK3R1 INPP5D 6
PIK3R1 PIK3R2 5
PIK3R1 PTPN11 7
PIK3R1 RPS6KB1 2
PIK3R1 SHC1 8
PIK3R1 SOS1 8
PIK3R1 STAT3 4
PIK3R2 AKT1 4
PIK3R2 INPP5D 4
PIK3R2 PTPN11 4
PIK3R2 RPS6KB1 1
PIK3R2 SHC1 5
PIK3R2 SOS1 4
PIK3R2 STAT3 3
PTPN11 AKT1 2
PTPN11 MAPK1 3
PTPN11 SHC1 4
PTPN11 SOCS3 4
PTPN11 SOS1 5
PTPN11 STAT1 3
PTPN11 STAT5A 4
PTPN11 STAT5B 3
PTPN6 IL2RG 2
PTPN6 JAK1 4
PTPN6 SHC1 3
PTPN6 SOS1 3
PTPN6 STAT1 2
PTPN6 STAT6 4
RPS6KB1 FOS 1
RPS6KB1 STAT1 2
RPS6KB1 STAT3 1
RPS6KB1 STAT5A 1
RPS6KB1 STAT5B 1
RPS6KB1 STAT6 1
SHC1 AKT1 3
SHC1 MAPK11 1
SHC1 SOS1 10
SHC1 STAT5A 4
SHC1 STAT5B 3
SOCS1 IL2RG 2
SOCS1 JAK3 4
SOCS3 IL2RG 3
SOCS3 STAT1 2
SOCS5 IL2RG 2
SOCS5 JAK1 4
SOCS5 JAK3 2
SOS1 AKT1 3
STAT1 SOCS1 2
STAT1 STAT3 8
STAT1 STAT5A 5
STAT1 STAT5B 3
STAT3 SOCS3 3
STAT3 STAT5A 4
STAT3 STAT5B 6
STAT3 STAT6 2
STAT5A AKT1 1
STAT5A STAT5B 4
STAT5B AKT1 2
STAT6 AKT1 1
STAT6 SOCS1 2
AKT1 ATF2 1
AKT1 MAPK14 3
AKT1 NFKBIA 1
AKT1 PTPN6 2
ATF2 CHUK 1
ATF2 ELK1 1
ATF2 FLNA 1
ATF2 GAB2 1
ATF2 GRB2 1
ATF2 IKBKB 1
ATF2 JAK1 1
ATF2 RPS6KB1 1
ATF2 SHC1 1
ATF2 SOCS1 1
CBL INPP5D 1
CBL MAPK14 1
CBL PTPN6 2
CBL STAT3 2
CBL STAT5A 3
CHUK GAB2 1
CHUK PTPN11 2
CHUK PTPN6 2
DOK2 INPP5D 4
DOK2 SHC1 1
DOK2 STAT3 2
ELK1 BAD 1
ELK1 CBL 1
ELK1 CHUK 1
ELK1 GAB2 1
ELK1 GRB2 1
ELK1 IL2RG 1
ELK1 SHC1 1
FES IL2RG 1
FES PIK3R2 1
FES STAT3 2
FLNA CHUK 1
FLNA GRB2 2
FLNA MAPK1 1
FLNA MAPK14 3
FLNA MAPK3 1
FLNA PIK3R1 1
FOS NFKB1 2
FOS STAT1 3
FOS STAT3 2
GAB2 IKBKB 1
GAB2 IL2RG 2
GAB2 JAK1 2
GAB2 JAK3 2
GAB2 NFKB1 1
GAB2 STAT1 1
GAB2 STAT3 1
GAB2 STAT5A 1
GAB2 STAT5B 1
GAB2 STAT6 1
GRB2 IL2RG 3
GRB2 JAK3 2
GRB2 MAPK14 1
IKBKB MAPK14 1
IL2RG MAPK1 1
IL2RG MAPK3 1
IL2RG PIK3CD 2
IL2RG PIK3R2 2
IL2RG PTPN11 1
JAK3 MAPK1 1
JAK3 MAPK3 1
MAPK11 JAK1 1
MAPK14 JAK1 1
MAPK14 PTPN11 1
MAPK14 SOCS3 1
MAPK1 MAPK14 4
MAPK1 NFKB1 1
MAPK1 NFKBIA 1
MAPK3 GRB2 1
MAPK3 NFKB1 1
MAPK3 NFKBIA 1
NFKB1 PIK3R2 1
NFKB1 SHC1 2
NFKB1 STAT3 3
NFKB1 STAT5A 1
NFKB1 STAT6 3
NFKBIA SOCS3 1
NFKBIA STAT1 1
PIK3CD CHUK 1
PIK3CD PTPN6 1
PIK3CD STAT5A 1
PIK3CD STAT5B 1
PIK3CD STAT6 1
PIK3R1 NFKB1 1
PIK3R1 PTGS1 1
PIK3R1 PTPN6 4
PIK3R1 SOCS1 4
PIK3R1 TSHR 2
PIK3R2 PTPN6 1
PIK3R2 SOCS1 2
PIK3R2 STAT5A 1
PTGS1 AKT1 1
PTGS1 JAK3 1
PTGS1 MAPK1 1
PTGS1 MAPK3 1
PTGS1 NFKBIA 1
PTPN11 PIK3CD 1
PTPN11 PTPN6 1
PTPN11 SOCS1 1
PTPN11 STAT3 3
PTPN6 MAPK1 1
PTPN6 MAPK3 1
PTPN6 SOCS3 1
PTPN6 STAT5B 2
SHC1 STAT3 1
SHC1 STAT6 1
SOS1 INPP5D 2
SOS1 STAT1 1
SOS1 STAT3 1
SOS1 STAT5A 1
SOS1 STAT5B 1
SOS1 STAT6 1
STAT1 ELK1 1
STAT1 PIK3CD 1
STAT1 SHC1 1
STAT1 SOCS5 1
STAT1 STAT6 1
STAT3 SOCS1 1
STAT3 SOCS5 1
STAT3 TSHR 3
STAT5A FOS 2
STAT5A MAPK14 1
STAT5A PIK3R1 1
STAT5A SOCS1 1
STAT5A SOCS3 1
STAT5A SOCS5 1
STAT5B CBL 1
STAT5B FOS 2
STAT5B NFKBIA 1
STAT5B PIK3R1 1
STAT5B SOCS1 1
STAT5B SOCS3 1
STAT5B SOCS5 1
STAT5B STAT6 1
STAT6 CBL 1
STAT6 MAPK14 1
STAT6 NFKBIA 1
STAT6 PIK3R2 1
STAT6 SOCS3 1
STAT6 SOCS5 1
STAT6 STAT5A 1
Pathway1 Pathway2 Intersect Similarity Scores Pathway Name Source Number of Genes Number of Interactions Detail
pathway0002864 pathway0001128 37 0.902439 IL4 NetPath 75 1239
pathway0002864 pathway0000900 6 0.75 Gene expression of SOCS1 by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram ) INOH 8 29
pathway0002864 pathway0000901 6 0.75 Gene expression of SOCS3 by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram ) INOH 8 29
pathway0002864 pathway0002879 8 0.7272727 Hs_IL-9_Signaling_Pathway_WP22_79264 WikiPathways 11 49
pathway0002864 pathway0001105 5 0.7142857 IL-2 signaling pathway(JAK1 JAK3 STAT5) ( IL-2 signaling(JAK1 JAK3 STAT5) ) INOH 7 22
pathway0002864 pathway0001108 5 0.7142857 IL-4 signaling pathway(JAK1 JAK3 STAT6) ( IL-4 signaling(JAK1 JAK3 STAT6) ) INOH 7 23
pathway0002864 pathway0001113 9 0.6923077 IL-7 signaling pathway(JAK1 JAK3 STAT5) ( IL-7 signaling(JAK1 JAK3 STAT5) ) INOH 13 65
pathway0002864 pathway0001120 28 0.6829268 IL2 NetPath 81 1364
pathway0002864 pathway0000658 27 0.6585366 EGFR1 NetPath 475 10010
pathway0002864 pathway0001246 27 0.6585366 KitReceptor NetPath 104 1591
pathway0002864 pathway0002199 27 0.6585366 TCR NetPath 261 4161
pathway0002864 pathway0001189 7 0.6363636 Interleukin-7 signaling Reactome 11 45
pathway0002864 pathway0001727 26 0.6341463 Prolactin NetPath 105 1733
pathway0002864 pathway0001135 15 0.625 IL9 NetPath 24 200
pathway0002864 pathway0000270 25 0.6097561 BCR NetPath 161 2850
pathway0002864 pathway0001126 25 0.6097561 IL3 NetPath 84 1284
pathway0002864 pathway0001132 25 0.6097561 IL6 NetPath 85 1335
pathway0002864 pathway0000080 6 0.6 Activation of the AP-1 family of transcription factors Reactome 10 35
pathway0002864 pathway0001227 3 0.6 JAK degradation signaling ( JAK-STAT pathway and regulation pathway Diagram ) INOH 5 12
pathway0002864 pathway0001454 3 0.6 Negative regulation of (Phosphorylation of JAK) in JAK STAT pathway ( JAK-STAT pathway and regulation pathway Diagram ) INOH 5 12
pathway0002864 pathway0001264 24 0.5853659 Leptin NetPath 98 1355
pathway0002864 pathway0000688 7 0.5833333 EPO signaling pathway(JAK2 STAT1 STAT3 STAT5) ( EPO signaling pathway(JAK2 STAT1 STAT3 STAT5) ) INOH 12 59
pathway0002864 pathway0000899 8 0.5714286 Gene expression of SOCS by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram ) INOH 14 66
pathway0002864 pathway0001089 4 0.5714286 IkBA variant leads to EDA-ID Reactome 7 23
pathway0002864 pathway0002872 9 0.5625 Hs_IL-7_Signaling_Pathway_WP205_89854 WikiPathways 16 85
pathway0002864 pathway0000977 5 0.5555556 Growth hormone signaling pathway(JAK2 STAT5) ( Growth hormone signaling(JAK2 STAT5) ) INOH 9 35
pathway0002864 pathway0001188 6 0.5454545 Interleukin-6 signaling Reactome 11 57
pathway0002864 pathway0002844 18 0.5454545 Hs_IL-2_Signaling_Pathway_WP49_91243 WikiPathways 33 332
pathway0002864 pathway0002871 19 0.5428571 Hs_IL-3_Signaling_Pathway_WP286_78583 WikiPathways 35 403
pathway0002864 pathway0002858 14 0.5384615 Hs_IL-6_signaling_pathway_WP364_89832 WikiPathways 26 174
pathway0002864 pathway0001130 22 0.5365854 IL5 NetPath 59 739
pathway0002864 pathway0001228 8 0.5333333 JAK/STAT signaling pathway PANTHER 15 87
pathway0002864 pathway0001119 21 0.5121951 IL2-mediated signaling events PID 54 871
pathway0002864 pathway0000700 3 0.5 ERK cascade ( EGF signaling pathway Diagram ) INOH 6 15
pathway0002864 pathway0000708 3 0.5 ERK cascade ( HGF signaling pathway ) INOH 6 15
pathway0002864 pathway0000714 3 0.5 ERK cascade ( VEGF signaling pathway ) INOH 6 15
pathway0002864 pathway0001090 4 0.5 IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) Reactome 8 30
pathway0002864 pathway0001091 4 0.5 IKK-NF-kappaB cascade ( B cell receptor signaling ) INOH 8 30
pathway0002864 pathway0001092 4 0.5 IKK-NF-kappaB cascade ( CD4 T cell receptor signaling (NF-kB cascade) ) INOH 8 30
pathway0002864 pathway0001093 4 0.5 IKK-NF-kappaB cascade ( CD4 T cell receptor signaling ) INOH 8 30
pathway0002864 pathway0002003 5 0.5 Signal attenuation Reactome 10 45
pathway0002864 pathway0002355 12 0.5 TSLP NetPath 24 159