Pathway ID Pathway Name Source Organism Number of Genes Number of Interactions
pathway0002874 Hs_RANKL-RANK_(Receptor_activator_of_NFKB_(ligand))_Signaling_Pathway_WP2018_90016 WikiPathways Homo sapiens 26 125
Secreted
Membrane
Cytoplasm
Cytoplasm/4
Cytoskeleton
Cytoskeleton/Cytoplasm
Membrane/Nucleus
Cytoplasm/Nucleus
Cytoskeleton/Nucleus
Nucleus
Secreted/Nucleus
Unknown
Annotated genes
Unannotated genes
Symbol
Ensembl ID
Entrez ID
Subcellular localization
Description
Type
Edge
Symbol Ensembl ID Entrez ID Subcellular localization Closeness Degree Betweenness Transitivity
CHUK ENSG00000213341 1147 Cytoplasm 0.02777778 89.0 13.97022 0.01072523
GAB2 ENSG00000033327 9846 Cytoplasm 0.02702703 33.0 2.285974 0.075757576
AKT2 ENSG00000105221 208 Cytoplasm/Nucleus 0.03030303 114.0 11.00273 0.010246856
MAP2K7 ENSG00000076984 5609 Cytoplasm/Nucleus 0.02325581 25.0 0.05959767 0.043333333
MAPK8 ENSG00000107643 5599 Cytoplasm/Nucleus 0.02631579 33.0 8.228205 0.051136364
MITF ENSG00000187098 4286 Cytoplasm/Nucleus 0.0212766 6.0 0.3208218 0.266666667
NFKB1 ENSG00000109320 4790 Cytoplasm/Nucleus 0.03125 90.0 13.18339 0.015730337
NFKBIA ENSG00000100906 4792 Cytoplasm/Nucleus 0.02777778 133.0 3.992189 0.005126452
RELA ENSG00000173039 5970 Cytoplasm/Nucleus 0.03125 87.0 24.51326 0.015503876
RELB ENSG00000104856 5971 Cytoplasm/Nucleus 0.02 12.0 0.0 0.090909091
SRC ENSG00000197122 6714 Cytoplasm/Nucleus 0.03225806 43.0 23.03057 0.07641196
TNFRSF11A ENSG00000141655 8792 Cytoplasm/Nucleus 0.02439024 14.0 8.051204 0.098901099
TRAF5 ENSG00000082512 7188 Cytoplasm/Nucleus 0.02173913 6.0 0.3061663 0.266666667
AKT1 ENSG00000142208 207 Membrane 0.03125 149.0 21.71215 0.006439325
MTOR ENSG00000198793 2475 Membrane 0.02631579 44.0 0.3321076 0.046511628
NRG2 ENSG00000158458 9542 Membrane 0.02083333 6.0 0.0 0.666666667
PIK3R1 ENSG00000145675 5295 Membrane 0.02941176 106.0 15.25287 0.008625337
PIK3R2 ENSG00000105647 5296 Membrane 0.02380952 98.0 1.132629 0.005049442
MAP3K7 ENSG00000135341 6885 Unknown 0.02702703 38.0 13.18191 0.045519203
MAPK14 ENSG00000112062 1432 Unknown 0.02777778 35.0 22.32092 0.053781513
NFATC1 ENSG00000131196 4772 Unknown 0.02222222 11.0 1.186532 0.090909091
TNFSF11 ENSG00000120659 8600 Unknown 0.025 14.0 8.645676 0.164835165
BCL6 ENSG00000113916 604 Nucleus 0.02040816 3.0 0.09090909 0.666666667
SPI1 ENSG00000066336 6688 Nucleus 0.02439024 8.0 3.933116 0.392857143
TNFRSF11B ENSG00000164761 4982 Secreted 0.02 5.0 0.2668487 0.1
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
CHUK ENSG00000213341 1147 Cytoplasm 9301.0 163422.9 1.56E-6 1.35E-4
GAB2 ENSG00000033327 9846 Cytoplasm 4097.0 11475.04 1.56E-6 0.00119
AKT2 ENSG00000105221 208 Cytoplasm/Nucleus 23612.0 162758.8 1.56E-6 4.86E-5
MAP2K7 ENSG00000076984 5609 Cytoplasm/Nucleus 2839.0 19762.46 1.55E-6 3.25E-4
MAPK8 ENSG00000107643 5599 Cytoplasm/Nucleus 11158.0 359985.1 1.56E-6 1.42E-4
MITF ENSG00000187098 4286 Cytoplasm/Nucleus 271.0 5925.236 1.55E-6 0.0173
NFKB1 ENSG00000109320 4790 Cytoplasm/Nucleus 11386.0 279636.5 1.56E-6 2.06E-4
NFKBIA ENSG00000100906 4792 Cytoplasm/Nucleus 12604.0 63578.71 1.56E-6 3.76E-5
RELA ENSG00000173039 5970 Cytoplasm/Nucleus 11059.0 663081.0 1.57E-6 3.08E-4
RELB ENSG00000104856 5971 Cytoplasm/Nucleus 458.0 1596.526 1.56E-6 0.0212
SRC ENSG00000197122 6714 Cytoplasm/Nucleus 14851.0 1349351.0 1.57E-6 2.68E-4
TNFRSF11A ENSG00000141655 8792 Cytoplasm/Nucleus 162.0 120.6658 1.55E-6 0.0995
TRAF5 ENSG00000082512 7188 Cytoplasm/Nucleus 73.0 774.5827 1.55E-6 0.0464
AKT1 ENSG00000142208 207 Membrane 52751.0 2150216.0 1.57E-6 1.74E-5
MTOR ENSG00000198793 2475 Membrane 6209.0 145872.6 1.56E-6 2.1E-4
NRG2 ENSG00000158458 9542 Membrane 1070.0 1171.765 1.55E-6 0.00564
PIK3R1 ENSG00000145675 5295 Membrane 31452.0 733597.1 1.56E-6 4.03E-5
PIK3R2 ENSG00000105647 5296 Membrane 17436.0 144092.4 1.56E-6 9.14E-5
MAP3K7 ENSG00000135341 6885 Unknown 5836.0 93672.34 1.56E-6 2.59E-4
MAPK14 ENSG00000112062 1432 Unknown 9287.0 426504.4 1.56E-6 2.57E-4
NFATC1 ENSG00000131196 4772 Unknown 1194.0 6768.025 1.55E-6 0.00124
TNFSF11 ENSG00000120659 8600 Unknown 178.0 2283.935 1.55E-6 0.0861
BCL6 ENSG00000113916 604 Nucleus 178.0 3584.034 1.56E-6 0.0853
SPI1 ENSG00000066336 6688 Nucleus 385.0 18958.79 1.56E-6 0.0169
TNFRSF11B ENSG00000164761 4982 Secreted 30.0 49.1739 1.54E-6 0.0138
Symbol Ensembl ID Entrez ID Subcellular localization Degree Betweenness Closeness Transitivity
CHUK ENSG00000213341 1147 Cytoplasm 993.0 31600.0 2.16E-5 0.00231662
GAB2 ENSG00000033327 9846 Cytoplasm 781.0 11700.0 2.15E-5 0.005331757
AKT2 ENSG00000105221 208 Cytoplasm/Nucleus 216.0 2780.0 2.14E-5 0.008354867
MAP2K7 ENSG00000076984 5609 Cytoplasm/Nucleus 279.0 1520.0 2.14E-5 0.008947681
MAPK8 ENSG00000107643 5599 Cytoplasm/Nucleus 1392.0 35600.0 2.17E-5 0.001997653
MITF ENSG00000187098 4286 Cytoplasm/Nucleus 33.0 2560.0 2.13E-5 0.073863636
NFKB1 ENSG00000109320 4790 Cytoplasm/Nucleus 1684.0 72000.0 2.17E-5 9.77358E-4
NFKBIA ENSG00000100906 4792 Cytoplasm/Nucleus 1925.0 28300.0 2.16E-5 3.726E-4
RELA ENSG00000173039 5970 Cytoplasm/Nucleus 1031.0 37600.0 2.16E-5 0.002083
RELB ENSG00000104856 5971 Cytoplasm/Nucleus 35.0 0.376 2.12E-5 0.045378151
SRC ENSG00000197122 6714 Cytoplasm/Nucleus 1835.0 67000.0 2.17E-5 0.001945688
TNFRSF11A ENSG00000141655 8792 Cytoplasm/Nucleus 14.0 17.3 2.1E-5 0.098901099
TRAF5 ENSG00000082512 7188 Cytoplasm/Nucleus 6.0 2.1 2.1E-5 0.266666667
AKT1 ENSG00000142208 207 Membrane 6565.0 233000.0 2.19E-5 2.13911E-4
MTOR ENSG00000198793 2475 Membrane 1113.0 11400.0 2.16E-5 0.001538392
NRG2 ENSG00000158458 9542 Membrane 33.0 0.858 2.12E-5 0.185606061
PIK3R1 ENSG00000145675 5295 Membrane 2347.0 18200.0 2.15E-5 6.63995E-4
PIK3R2 ENSG00000105647 5296 Membrane 1499.0 14900.0 2.15E-5 0.001001112
MAP3K7 ENSG00000135341 6885 Unknown 710.0 23100.0 2.16E-5 0.003210235
MAPK14 ENSG00000112062 1432 Unknown 1219.0 74200.0 2.17E-5 0.002559367
NFATC1 ENSG00000131196 4772 Unknown 59.0 1610.0 2.13E-5 0.034482759
TNFSF11 ENSG00000120659 8600 Unknown 14.0 19.4 2.12E-5 0.164835165
BCL6 ENSG00000113916 604 Nucleus 3.0 0.133 2.09E-5 0.666666667
SPI1 ENSG00000066336 6688 Nucleus 8.0 14.8 2.11E-5 0.392857143
TNFRSF11B ENSG00000164761 4982 Secreted 11.0 13.2 2.1E-5 0.072727273
Gene1 Gene2 Weight KEGG humanCyc PID BioGRID IntAct HPRD BIND Reactome CORUM DIP WikiPathways ReconX INOH SMPDB PhosphoSite PANTHER CTD NetPath TRANSFAC DrugBank
AKT1 AKT2 2
AKT1 CHUK 10
AKT1 MTOR 11
AKT1 NFKB1 3
AKT1 RELA 4
AKT2 CHUK 8
CHUK MTOR 2
CHUK NFKB1 10
CHUK NFKBIA 14
CHUK RELA 11
CHUK RELB 7
GAB2 AKT1 3
GAB2 AKT2 3
GAB2 PIK3R1 7
GAB2 PIK3R2 4
GAB2 SRC 4
GAB2 TNFRSF11A 2
MAP2K7 AKT1 1
MAP2K7 AKT2 1
MAP2K7 MAP3K7 4
MAP2K7 MAPK14 2
MAP2K7 MAPK8 12
MAP3K7 AKT1 1
MAP3K7 AKT2 1
MAP3K7 CHUK 6
MAP3K7 MAPK14 4
MAP3K7 MAPK8 5
MAP3K7 NFKBIA 2
MAP3K7 RELA 4
MAPK14 AKT2 1
MAPK14 MITF 3
MAPK14 NFATC1 5
MAPK14 NFKB1 1
MAPK14 NFKBIA 2
MAPK14 RELA 2
MAPK8 AKT2 1
MAPK8 NFATC1 2
MTOR AKT2 3
MTOR NFKB1 1
MTOR RELA 1
NFKB1 NFKBIA 12
NFKB1 RELA 12
NFKB1 RELB 8
NFKB1 TRAF5 1
NFKBIA PIK3R1 4
NFKBIA RELA 14
NFKBIA RELB 5
NRG2 PIK3R1 2
PIK3R1 AKT1 6
PIK3R1 AKT2 4
PIK3R1 MTOR 2
PIK3R1 PIK3R2 5
PIK3R1 RELA 3
PIK3R1 SRC 8
PIK3R2 AKT1 4
PIK3R2 AKT2 3
PIK3R2 MTOR 1
PIK3R2 SRC 2
RELA RELB 8
RELA TRAF5 1
SRC AKT1 4
SRC AKT2 3
SRC MAPK14 2
SRC MAPK8 1
SRC NFKB1 1
SRC NFKBIA 2
SRC TNFRSF11A 3
TNFRSF11A TNFSF11 3
TNFRSF11B TNFSF11 4
AKT1 MAPK14 3
AKT1 MAPK8 2
AKT1 NFKBIA 1
AKT1 TNFSF11 1
AKT2 NFKB1 1
AKT2 NFKBIA 1
AKT2 RELA 1
BCL6 PIK3R1 1
BCL6 SPI1 1
CHUK GAB2 1
CHUK SPI1 1
CHUK SRC 5
GAB2 MTOR 1
GAB2 NFKB1 1
GAB2 RELA 1
MAP2K7 PIK3R1 1
MAP3K7 MITF 1
MAP3K7 NFKB1 1
MAP3K7 TNFRSF11A 3
MAP3K7 TRAF5 1
MAPK14 MAPK8 2
MAPK14 TNFRSF11B 1
MAPK8 MTOR 1
MAPK8 PIK3R1 2
MAPK8 SPI1 1
MAPK8 TNFSF11 1
MITF SPI1 2
MTOR NFKBIA 1
NFATC1 RELA 1
NFATC1 SPI1 3
NFKB1 PIK3R2 1
NFKB1 SPI1 2
NFKB1 TNFSF11 1
NFKBIA TNFSF11 1
NRG2 AKT1 1
NRG2 AKT2 1
NRG2 GAB2 1
PIK3R1 NFKB1 1
PIK3R1 TNFRSF11A 1
PIK3R2 TNFRSF11A 1
RELA MITF 1
RELA SPI1 1
RELA SRC 2
SPI1 SRC 1
SRC BCL6 1
SRC MTOR 1
SRC NRG2 1
SRC TNFSF11 2
TNFRSF11A TNFRSF11B 1
TNFRSF11A TRAF5 5
TNFSF11 CHUK 1
TNFSF11 NFATC1 1
Pathway1 Pathway2 Intersect Similarity Scores Pathway Name Source Number of Genes Number of Interactions Detail
pathway0002874 pathway0001799 23 0.8846154 RANKL NetPath 84 1002
pathway0002874 pathway0002249 17 0.6538462 TNFalpha NetPath 274 5236
pathway0002874 pathway0001089 4 0.5714286 IkBA variant leads to EDA-ID Reactome 7 23
pathway0002874 pathway0000151 3 0.5 Alternative NF-kappaB pathway PID 6 17
pathway0002874 pathway0001090 4 0.5 IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) Reactome 8 30
pathway0002874 pathway0001091 4 0.5 IKK-NF-kappaB cascade ( B cell receptor signaling ) INOH 8 30
pathway0002874 pathway0001092 4 0.5 IKK-NF-kappaB cascade ( CD4 T cell receptor signaling (NF-kB cascade) ) INOH 8 30
pathway0002874 pathway0001093 4 0.5 IKK-NF-kappaB cascade ( CD4 T cell receptor signaling ) INOH 8 30
pathway0002874 pathway0002656 13 0.5 Pathways in cancer KEGG 321 8293