Gene Overview
Target Gene: APLN
NCBI Official Symbol: APLN
Entrez ID: 8862
Ensembl ID: ENSG00000171388
Gene Full Name: apelin
Strand: -
Gene Locus: Xq26.1
External Links:

APLN Significantly Regulated by These T(co)Fs

T(co)Fs that Activate APLN   
T(co)Fs that Repress APLN
The Intensity of the Gene Regulated by T(co)Fs:
APLN-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
APLN HOXA1 siRNA Lung_fibroblast IMR-90 2.73829 1.45328 0.06406 0.27262 DataSet_01_110
APLN ID1 siRNA Lung A549 2.86736 1.51972 0.61729 0.78073 DataSet_01_117
APLN ID1 siRNA Lung H1650 0.48908 -1.03186 0.49898 0.77375 DataSet_01_118
APLN BRD4 shRNA Embryo_kidney HEK293 1.64224 0.71567 - - DataSet_01_119
APLN ZIC2 siRNA Pancreas PANC1 0.52834 -0.92046 - - DataSet_01_121
APLN FOXM1 siRNA Central_nervous_system U87 5.11667 2.3552 - - DataSet_01_122
APLN POLR3A siRNA Mammary_gland MCF7 3.44813 1.78582 - - DataSet_01_139
APLN HSF1 shRNA Skin A375 0.52367 -0.93327 0.47226 0.71272 DataSet_01_155
APLN FOSL1 siRNA Mammary_gland BT549 2.25085 1.17047 7.97661e-09 2.83561e-06 DataSet_01_171
APLN JUN siRNA Mammary_gland BT549 2.35836 1.23779 8.07972e-07 0.00034 DataSet_01_172
APLN GATA2 siRNA Prostate LNCaP 0.6644 -0.58989 0.10335 0.20074 DataSet_01_193
APLN CREB1 shRNA Parotid_gland H3118 MEC 6.45289 2.68995 0.00113 0.10097 DataSet_01_194
APLN CREB1 shRNA Parotid_gland HSY 2.01215 1.00874 0.8027 0.98291 DataSet_01_195
APLN TP63 siRNA Head_and_neck SCC-1 0.54771 -0.86852 - - DataSet_01_199
APLN TP63 siRNA Immortalized_keratinocyte HaCaT 2.05627 1.04003 - - DataSet_01_200
APLN HIC1 shRNA Mammary_gland HBL100 3.16777 1.66347 - - DataSet_01_205
APLN FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly7 0.6262 -0.67531 - - DataSet_01_210
APLN LIN28A siRNA Embryo H9 0.35547 -1.49218 0.00038 0.00707 DataSet_01_215
APLN ESR2 siRNA Mammary_gland BT549 1.82766 0.87 7.39957e-07 5.45977e-05 DataSet_01_229
APLN FOXP1 siRNA Prostate LNCaP 1.59118 0.6701 0.00429 0.20242 DataSet_01_234
APLN FOXC2 siRNA Lymph Lymphatic endothelial cells 2.79085 1.4807 0.0039 0.40618 DataSet_01_236
APLN TWIST1 shRNA Stomach CAF32 0.51333 -0.96204 0.00478 0.03537 DataSet_01_253
APLN TLX1 shRNA Haematopoietic_and_lymphoid_tissue ALLSIL 1.68142 0.74968 0.00196 0.99999 DataSet_01_263
APLN SIX4 siRNA Ovary PEO1 0.66011 -0.59922 0.07962 0.26262 DataSet_01_269
APLN FOXO1 siRNA Umbilical_vein HUVEC 0.35815 -1.48136 0.00132 0.02098 DataSet_01_270
APLN STAT5 shRNA Prostate CWR22Pc 2.32103 1.21476 0.00092 0.01492 DataSet_01_279
APLN ESRRA shRNA Embryo_kidney 293T 0.66008 -0.5993 0.41395 0.85607 DataSet_01_280
APLN MSX1 siRNA Tooth Dental Pulp Cells 7.931 2.9875 1.19029e-07 2.96993e-05 DataSet_01_281
APLN ZIC5 siRNA Skin A375 0.64506 -0.6325 - - DataSet_01_284
APLN JUN siRNA Mammary_gland BT549 3.27887 1.7132 0.00268 0.02132 DataSet_01_291
APLN SNAI2 siRNA Mammary_gland MCFDCIS 2.22929 1.15659 0.00238 0.37809 DataSet_01_292
APLN POSTN shRNA Brain GSC272 5.78862 2.53322 0.05761 0.53976 DataSet_01_293
APLN TFAP4 siRNA Brain BE(2)-C 0.13658 -2.87218 0.26849 0.51625 DataSet_01_295
APLN SOX7 siRNA Umbilical_vein HUVEC 0.55475 -0.85008 0.03464 0.89788 DataSet_01_299
APLN PTEN shRNA Lung HCC827 4.83761 2.27429 0.00628 0.39947 DataSet_01_302
APLN ELK3 shRNA Mammary_gland MDA-MB-231 0.58136 -0.78248 0.00033 0.00144 DataSet_01_318
APLN MYC siRNA Colon HCT116 1.89728 0.92393 1e-04 0.00044 DataSet_01_324
APLN TOX shRNA Haematopoietic_and_lymphoid_tissue HPB-ALL 0.52573 -0.92761 0.0222 0.64053 DataSet_01_332
APLN HIF1A siRNA Oral_cavity OEC-M1 0.49224 -1.02256 0.10826 0.85151 DataSet_01_348
APLN CDX2 siRNA Colon COLO320 0.65564 -0.60902 - - DataSet_01_357
APLN AR siRNA Prostate abl cells 2.55892 1.35554 0.0334427855044073 0.999852161656754 DataSet_03_004
APLN AR siRNA Prostate LNCaP 1.71732 0.780163 0.631325187694619 1 DataSet_03_005
APLN ASCL1 siRNA Lung DMS79 0.47379 -1.07768 0.274388291501564 0.866744571924672 DataSet_03_016
APLN ATF4 siRNA Skin A375 0.605728 -0.723257 0.104671622250176 0.775512819201899 DataSet_03_018
APLN ATOH8 siRNA Umbilical_vein HUVEC 5.16424 2.36856 0.265290476347441 0.979349687232157 DataSet_03_019
APLN BCL6 siRNA Lymph OCI-Ly7 DLBCL 0.604597 -0.725955 0.398270358128227 0.8773817109412 DataSet_03_025
APLN FOXA1 siRNA Prostate LNCaP 1.5436 0.626299 0.00011373057341822 0.00275756276195977 DataSet_03_083
APLN GATA2 siRNA Lymph Lymphatic endothelial cells 2.50776 1.3264 0.0152480865115706 0.033176476605977 DataSet_03_101
APLN GATA4 siRNA Stomach KatoIII 0.499812 -1.00054 0.047242268620588 0.864933078154042 DataSet_03_106
APLN GATA4 siRNA Stomach YCC3 0.350482 -1.51259 0.17500931664787 0.711764193031942 DataSet_03_107
APLN GATA6 siRNA Stomach AGS 2.54392 1.34705 0.0215175715611239 0.377613516406955 DataSet_03_108
APLN GATA6 siRNA Stomach KatoIII 0.425847 -1.23159 0.016688679195105 0.436155967633449 DataSet_03_109
APLN GATA6 siRNA Stomach YCC3 0.432236 -1.21011 0.0982184159163204 0.72002955512258 DataSet_03_110
APLN HIF3A siRNA Liver Hep3B 0.65293 -0.615 0.0493574622818697 1 DataSet_03_120
APLN HIF3A siRNA Liver Hep3B 0.65293 -0.615 0.0493574622818697 1 DataSet_03_121
APLN HNF4a siRNA Liver HepG2 1.88 0.910733 0.28379381268443 0.84556108161803 DataSet_03_126
APLN IRF4 siRNA Skin Cutaneous T cell lymphoma HuT-102 cells 1.97826 0.984235 0.103414802518549 0.961657401022218 DataSet_03_134
APLN KLF5 siRNA Stomach AGS 0.596246 -0.746021 0.103520495190334 0.585004259746004 DataSet_03_149
APLN KLF5 siRNA Stomach KatoIII 0.206921 -2.27285 0.00329803881245287 0.164940024211702 DataSet_03_150
APLN KLF5 siRNA Stomach YCC3 0.51487 -0.957721 0.132332354053573 0.487108129700854 DataSet_03_151
APLN MYB siRNA Prostate VCaP 1.75281 0.809667 7.83574919823466e-05 0.0113921257881225 DataSet_03_174
APLN MYC siRNA Colon HT29 8.65211 3.11305 - - DataSet_03_177
APLN NFAT5 siRNA Umbilical_vein HUVEC 3.32562 1.73363 0.000185413411890578 0.00997065237995931 DataSet_03_195
APLN NR2F2 siRNA Uterus Primary eutopic stromal cells 0.578025 -0.790797 0.00860005928575323 0.975536666160678 DataSet_03_202
APLN PHB shRNA Embryo Embryonic stem cells (ESCs) 2.12338 1.08636 0.0209827623099849 0.0567476978138281 DataSet_03_211
APLN SOX11 siRNA Lung_fibroblast NHLF 1.52164 0.605624 0.952599675890744 0.974612944821396 DataSet_03_237
APLN SOX11 siRNA Lung_fibroblast NHLF 2.25489 1.17306 0.00487721548630857 0.179591183031576 DataSet_03_238
APLN SOX4 siRNA Haematopoietic_and_lymphoid_tissue ST1 1.56863 0.649503 - - DataSet_03_246
APLN STAT3 CRISPR Embryo hESC 1.59925 0.677394 0.0576711697989985 0.134076206620472 DataSet_03_258
APLN STAT6 siRNA Umbilical_vein HUVEC 0.458779 -1.12413 0.0876621270352303 0.798957643496596 DataSet_03_264
APLN ELF3 CRISPR Bile_duct HBDEC2 0.408787 -1.29058 3.112296e-05 6.010792e-04 DataSet_03_304
APLN ELF3 knockdown Bile_duct HBDEC2 0.362379 -1.46443 1.139880e-01 2.656581e-01 DataSet_03_305
APLN ACTR5 siRNA Muscle RD 2.36216 1.24011 - - DataSet_03_343
APLN INO80 siRNA Muscle RD 1.78535 0.836208 - - DataSet_03_344
APLN SKI CRISPR Blood HL60 0.614754 -0.701919 1.106210e-01 0.467383163 DataSet_03_351
APLN ETV5 knockdown Colon HT29 2.7037 1.43494 2.278819e-01 0.527308910 DataSet_03_353
APLN PARP1 siRNA Prostate LNCaP 2.27889 1.18833 7.727699e-03 0.116793467 DataSet_03_354
APLN TET1 CRISPR Mammary_gland Hs578T 0.301236 -1.73104 9.054358e-04 1.124339e-02 DataSet_03_355
APLN ARID2 shRNA Haematopoietic_and_lymphoid_tissue MM.1S 0.488566 -1.03337 1.683479e-04 8.488707e-04 DataSet_03_362
APLN EP300 shRNA Mammary_gland MCF10AT 4.72727 2.24101 6.421697e-02 0.213352479 DataSet_03_364
APLN TP53 knockout Stomach SNU1 2.07385 1.05231 0.0622005772 0.9301241 DataSet_03_365
APLN ABL1 shRNA Liver HuH7 0.635604 -0.6538 1.785095e-01 0.2685519218 DataSet_03_367
APLN USP22 shRNA Liver PLC_PRF_5 cells 0.102273 -3.28951 5.898545e-03 0.09744585 DataSet_03_368
APLN DNMT3A knockout Embryo_kidney HEK293T 3.07272 1.61952 - - DataSet_03_369
APLN TPR shRNA Bone_marrow U2OS 1.76071 0.816161 3.022029e-01 7.344718e-01 DataSet_03_370
APLN HNRNPU siRNA Colon RKO 0.619299 -0.691293 - - DataSet_03_374
APLN GLI1 siRNA Skeletal_muscle RMS13 0.214804 -2.21891 4.771877e-04 0.014772098 DataSet_03_375
APLN ZNF213 siRNA Mammary_gland MCF7 0.250264 -1.99848 1.514011e-02 1.999468e-01 DataSet_03_376
APLN DNMT1 siRNA Skin Human melanoma cells 2.1959 1.13481 2.828845e-02 5.355168e-02 DataSet_03_382
APLN TCF19 CRISPR Oral_squamous CAL27 2.69648 1.43108 1.154899e-04 0.0066822743 DataSet_03_383
APLN YY1 shRNA Brain GSC1517 0.062069 -4.00998 - - DataSet_03_384
APLN YY1 shRNA Brain GSC23 0.587838 -0.76651 - - DataSet_03_385
APLN YY1 shRNA Brain GSC3028 0.316176 -1.6612 - - DataSet_03_386
APLN TRIM8 siRNA Mammary_gland MCF7 0.571429 -0.807355 5.835550e-01 0.7435404845 DataSet_03_388
APLN NFKBIA shRNA Bone_marrow U2OS 0.0138037 -6.1788 6.357762e-01 0.87005461 DataSet_03_389
APLN YY1 knockdown Liver HepG2 0.35 -1.51457 3.427741e-01 5.113760e-01 DataSet_03_390
APLN ILF2 siRNA Stomach SGC-7901 2 1 0.5814324337 0.66041517 DataSet_03_393
APLN ASXL1 CRISPR Embryo iPSC 1.59302 0.671767 0.9999991370 0.9999991 DataSet_03_394
APLN JAZF1 siRNA Cervix HeLa Kyoto 2.12914 1.09027 1.229503e-01 0.735491124 DataSet_03_396
APLN CDK7 shRNA Bone_marrow D458 2.55556 1.35364 3.979598e-01 0.66962085 DataSet_03_404
APLN TFAP2A knockout Embryo H9 1.65116 0.723482 6.074324e-03 0.05308071 DataSet_03_405
APLN SATB2 CRISPR Colon Colon organoid 2.61111 1.38466 3.159652e-01 0.95735254 DataSet_03_406
APLN SIRT1 siRNA Pancreas PANC1 2.6 1.37851 1.233011e-02 0.056343839 DataSet_03_410
APLN E2F1 siRNA Prostate LNCaP 0.644665 -0.633377 3.259210e-01 0.7226289181 DataSet_03_413
APLN E2F2 siRNA Prostate LNCaP 0.616637 -0.697508 2.537295e-01 5.219355e-01 DataSet_03_414
APLN ZKSCAN3 CRISPR Colon HCT116 2.11111 1.078 9.780778e-01 1.000000000 DataSet_03_415
APLN RUNX2 shRNA Cord_blood Natural Killer Cell 2.40323 1.26497 2.428824e-02 0.793390621 DataSet_03_416
APLN NFATC2 shRNA Haematopoietic_and_lymphoid_tissue THP-1 2.5 1.32193 1.114953e-03 0.012995823 DataSet_03_418
APLN FOXK2 shRNA Ovary OVCAR-5 1.81818 0.862496 1.604710e-01 0.38591834 DataSet_03_419
APLN PRDM1 CRISPR Lymph CD8+ T cells 1.80769 0.854149 - - DataSet_03_421
APLN MAEL CRISPR Liver Alexander cells 2.5 1.32193 - - DataSet_03_423
APLN FOXP3 CRISPR Peripheral_blood Naive Treg 6 2.58496 1.385040e-01 0.484913773 DataSet_03_427
APLN LHX2 shRNA Bone_marrow ES-derived RPE cells 1.77586 0.82852 2.660683e-01 1.000000e+00 DataSet_03_428
APLN USP7 shRNA Skin xenograft cells 0.407197 -1.2962 0.28772690 0.4369914 DataSet_03_431
APLN PLAG1 shRNA Cord_blood Lin-CD34+ HSPCs 0.290323 -1.78427 - - DataSet_03_432
APLN EP300 knockout Pancreas HPAF-II orthotopic cells 3.375 1.75489 1.822073e-01 3.641155e-01 DataSet_03_436
APLN DAXX shRNA Mammary_gland MDA-MB-231 2.11967 1.08384 8.786801e-04 0.04793751 DataSet_03_441
APLN HMG20A siRNA Mammary_gland MDA-MB-231 0.508346 -0.976117 0.0243286982 0.2027204 DataSet_03_442
APLN CBX2 siRNA Mammary_gland MDA-MB-231 0.368006 -1.4422 2.946497e-04 3.919467e-03 DataSet_03_450
APLN CBX2 siRNA Mammary_gland MCF7 2.90129 1.53669 2.422987e-01 0.3885112027 DataSet_03_451
APLN OGT siRNA Embryo BeWo cells 3 1.58496 1.055396e-01 0.62099076 DataSet_03_453
APLN ARID1A shRNA Bile_duct MMNK1 4.9706 2.31342 1.305949e-05 0.006078778 DataSet_03_458
APLN IRF2 shRNA Cord_Blood CD34+ cells 0.616438 -0.697971 - - DataSet_03_460
APLN TXNIP shRNA Cord_Blood CD34+ cells 2.36842 1.24393 - - DataSet_03_461
APLN TXNIP shRNA Cord_blood ST3 3.3125 1.72792 7.558830e-02 0.3432366308 DataSet_03_462
APLN SOX9 knockout Liver HuH7 0.4 -1.32193 3.581774e-02 1.100913e-01 DataSet_03_463
APLN PARP1 knockout Embryo_kidney HEK293a 1.59091 0.669851 4.148292e-02 1.013433e-01 DataSet_03_464
APLN STAT3 shRNA Liver HepG2 3.95455 1.98351 1.849209e-03 0.0576694195 DataSet_03_465
APLN SMARCA1 Cas13 Embryo_kidney HEK293T 0.5 -1 - - DataSet_03_466
APLN SMARCA1 shRNA Embryo_kidney HEK293T 1.64444 0.7176 - - DataSet_03_468
APLN LIN28A siRNA Mammary_gland MCF7M 1.60891 0.686087 3.575477e-02 0.2873774 DataSet_03_469
APLN LIN28A siRNA Mammary_gland MCF7M 1.60891 0.686087 3.575477e-02 0.2873774 DataSet_03_470
APLN WHSC1 siRNA Prostate PC3 2.06524 1.04631 6.131375e-04 0.07630642 DataSet_03_471
APLN CREBBP CRISPR Lymph U2932 0.4 -1.32193 4.970199e-01 1.0000000 DataSet_03_474
Regulation Region
 
T(co)Fs that significantly regulate YY1 by the evidences of both expression and ChIP-seq/motif
Expression Atlas of APLN
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines