Gene Overview
Target Gene: ASPA
NCBI Official Symbol: ASPA
Entrez ID: 443
Ensembl ID: ENSG00000108381
Gene Full Name: aspartoacylase
Strand: +
Gene Locus: 17p13.2
External Links:

ASPA Significantly Regulated by These T(co)Fs

T(co)Fs that Activate ASPA   
T(co)Fs that Repress ASPA
The Intensity of the Gene Regulated by T(co)Fs:
ASPA-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
ASPA ID1 siRNA Lung A549 0.46606 -1.1014 0.51029 0.70294 DataSet_01_117
ASPA ZIC2 siRNA Pancreas PANC1 1.69048 0.75743 - - DataSet_01_121
ASPA ZNF431 siRNA Gastrointestinal_tissue GIST-T1 1.53777 0.62084 0.00069 0.00665 DataSet_01_128
ASPA POLR3A siRNA Mammary_gland MCF7 1.68132 0.74959 - - DataSet_01_139
ASPA HOXB7 siRNA Pancreas MIA PaCa-2 0.43034 -1.21645 0.00633 0.51936 DataSet_01_169
ASPA TP53 siRNA Lung SAECs 2.41176 1.27009 0.37712 0.74591 DataSet_01_175
ASPA CREB1 shRNA Parotid_gland H3118 MEC 3.93875 1.97774 0.43786 0.75349 DataSet_01_194
ASPA TP63 siRNA Immortalized_keratinocyte HaCaT RG 0.66438 -0.58991 - - DataSet_01_196
ASPA FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly10 2.88615 1.52915 - - DataSet_01_208
ASPA FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly1 3.13063 1.64645 - - DataSet_01_209
ASPA FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly7 0.30804 -1.69883 - - DataSet_01_210
ASPA KLF2 shRNA Bone_marrow RPMI8226 0.54378 -0.8789 0.61099 0.93237 DataSet_01_226
ASPA FOXA1 siRNA Prostate LNCaP 2.71985 1.44353 0.00123 0.06718 DataSet_01_233
ASPA FOXP1 siRNA Prostate LNCaP 1.52225 0.60621 0.04995 0.40455 DataSet_01_234
ASPA TWIST1 shRNA Stomach CAF32 2.31382 1.21028 0.01014 0.05263 DataSet_01_253
ASPA SP3 siRNA Haematopoietic_and_lymphoid_tissue JURKAT 3.70408 1.88911 0.02541 0.78744 DataSet_01_290
ASPA POSTN shRNA Brain GSC272 4.42008 2.14407 0.06372 0.53976 DataSet_01_293
ASPA TFAP4 siRNA Brain BE(2)-C 0.2249 -2.15261 0.39626 0.51625 DataSet_01_295
ASPA PTEN shRNA Lung HCC827 0.17675 -2.50018 0.00303 0.35214 DataSet_01_302
ASPA PTEN shRNA Mammary_gland SKBR3 2.56174 1.35713 0.2381 0.6983 DataSet_01_303
ASPA NR2E1 shRNA Neuroepithelium PBT003 1.54053 0.62342 0.02629 0.4475 DataSet_01_306
ASPA SOX9 siRNA Prostate VCaP 2.88793 1.53004 0.15057 0.9316 DataSet_01_308
ASPA SOX9 siRNA Prostate VCaP 2.88793 1.53004 0.15057 0.9316 DataSet_01_309
ASPA TFAP2C siRNA Lung NCI-H292 0.64842 -0.62501 - - DataSet_01_312
ASPA OVOL2 siRNA Corneal_epithelial Corneal epithelial cells 1.66446 0.73506 0.10914 0.35455 DataSet_01_313
ASPA ARNT siRNA Upper_aerodigestive_tract HSC3 0.24001 -2.05884 - - DataSet_01_315
ASPA HOXC6 siRNA Prostate LNCaP 1.67208 0.74164 0.57272 0.99927 DataSet_01_333
ASPA KLF4 siRNA Embryo HCE 0.61543 -0.70033 0.00502 0.37149 DataSet_01_341
ASPA HIF1A siRNA Oral_cavity OEC-M1 3.29083 1.71845 0.04193 0.85151 DataSet_01_348
ASPA AR siRNA Prostate abl cells 2.32308 1.21604 0.119950093356109 0.999852161656754 DataSet_03_004
ASPA AR siRNA Prostate LNCaP 1.60465 0.68226 0.594883091218133 1 DataSet_03_005
ASPA ASCL1 siRNA Lung DMS79 1.7191 0.781654 0.127988262315181 0.795816191625429 DataSet_03_016
ASPA ATF4 siRNA Skin A375 0.571959 -0.806016 0.108236178064396 0.775512819201899 DataSet_03_018
ASPA BCL6 siRNA Lymph Pfeiffer DLBCL 1.80522 0.852177 0.260592861423391 0.720536598077139 DataSet_03_026
ASPA CEBPB siRNA Embryo hESC 0.310994 -1.68504 0.277557780758285 0.654789951269317 DataSet_03_049
ASPA FOXM1 siRNA Mammary_gland BT-20 cells 1.66667 0.736966 0.0871164351263946 0.50033384521145 DataSet_03_091
ASPA FOXO1 siRNA Skin primary human dermal lymphatic endothelial cells 2.98727 1.57883 - - DataSet_03_096
ASPA GATA2 siRNA Uterus Decidual stromal cells 0.378919 -1.40004 0.228553232323518 0.827748098556437 DataSet_03_100
ASPA GATA4 siRNA Stomach AGS 1.75126 0.808389 0.0191230966344298 0.542419042144123 DataSet_03_105
ASPA GATA4 siRNA Stomach YCC3 0.600171 -0.736555 0.0166162759072743 0.490115723137104 DataSet_03_107
ASPA GRHL3 siRNA Skin Primary neonatal keratinocytes 1.71514 0.778325 0.0693272520389339 0.316278268601965 DataSet_03_113
ASPA HIC1 CRISPR Prostate PC3 2.20297 1.13945 - - DataSet_03_118
ASPA IRF4 siRNA Skin Cutaneous T cell lymphoma HuT-102 cells 1.94228 0.957755 0.599299623756169 0.999948959532916 DataSet_03_134
ASPA KLF5 siRNA Stomach YCC3 0.238522 -2.0678 0.0183948126224491 0.218494884515041 DataSet_03_151
ASPA MEF2D shRNA Liver HuH7 4.44838 2.15328 - - DataSet_03_162
ASPA MITF siRNA Skin MZ7 2.09987 1.0703 5.10503491601892e-08 1.12596364511354e-06 DataSet_03_165
ASPA MITF siRNA Skin Ma-Mel-15 3.47113 1.79541 0.000179959235664511 0.017735298190315 DataSet_03_166
ASPA MITF siRNA Skin Ma-Mel-15 2.06804 1.04827 0.0203168021438419 0.205136068960664 DataSet_03_167
ASPA MYB siRNA Cord_Blood CD34+ progenitor cells 0.511156 -0.968164 - - DataSet_03_170
ASPA SOX11 siRNA Lung_fibroblast NHLF 1.63398 0.708388 0.861724924197258 0.922730237453713 DataSet_03_238
ASPA SOX4 siRNA Haematopoietic_and_lymphoid_tissue ST1 3.4375 1.78136 - - DataSet_03_246
ASPA STAT3 CRISPR Embryo hESC 6.40316 2.67878 0.0381248579059025 0.109679608065805 DataSet_03_258
ASPA STAT6 siRNA Umbilical_vein HUVEC 0.557895 -0.841935 0.119737711867501 0.812059295737275 DataSet_03_264
ASPA TFE3 siRNA Kidney UOK257-2 0.645358 -0.631829 - - DataSet_03_275
ASPA CNOT3 shRNA Lung A549 1.85045 0.887874 3.009925e-02 0.8830540 DataSet_03_340
ASPA SMARCA4 siRNA Colon HCT116 24.9758 4.64246 4.061312e-01 0.6911493 DataSet_03_302
ASPA ELF3 CRISPR Bile_duct HBDEC2 1.74224 0.80094 1.995962e-01 2.836324e-01 DataSet_03_304
ASPA ACTR5 siRNA Muscle RD 0.537119 -0.896687 - - DataSet_03_343
ASPA INO80 siRNA Muscle RD 0.433771 -1.205 - - DataSet_03_344
ASPA EZH2 knockdown Colon HCT116 1.84002 0.879724 0.147183400 0.8488990 DataSet_03_334
ASPA TET1 CRISPR Mammary_gland Hs578T 2.19475 1.13406 6.059827e-01 7.654929e-01 DataSet_03_355
ASPA NCOA3 siRNA Mammary_gland MDA-MB-231 5.13664 2.36083 8.929371e-01 0.9972603 DataSet_03_361
ASPA YY1 shRNA Brain GSC1517 0.647059 -0.628031 - - DataSet_03_384
ASPA NFKBIA shRNA Bone_marrow U2OS 0.0268168 -5.22072 7.770063e-01 0.90500836 DataSet_03_389
ASPA ILF2 siRNA Stomach SGC-7901 0.166667 -2.58496 0.2186493921 0.40346604 DataSet_03_393
ASPA IKZF2 CRISPR Lymph CAR T Cell 0.665946 -0.586523 3.065576e-01 0.753482753 DataSet_03_397
ASPA RELA CRISPR Brain T30 4.96254 2.31108 0.5700585773 0.8703469 DataSet_03_399
ASPA SATB2 CRISPR Colon Colon organoid 1.51515 0.599462 4.050644e-01 0.95735254 DataSet_03_406
ASPA E2F6 shRNA Liver HuH7 0.581708 -0.781632 - - DataSet_03_412
ASPA E2F1 siRNA Prostate LNCaP 0.4 -1.32193 3.721006e-01 0.7226289181 DataSet_03_413
ASPA E2F2 siRNA Prostate LNCaP 2.8 1.48543 3.516336e-02 1.536571e-01 DataSet_03_414
ASPA FOXQ1 CRISPR Lymph Primary CD4+ T cells 7 2.80735 - - DataSet_03_422
ASPA FOXP3 CRISPR Peripheral_blood Naive Treg 4 2 4.287404e-01 0.733592846 DataSet_03_427
ASPA LHX2 shRNA Bone_marrow ES-derived RPE cells 0.551724 -0.857981 1.106411e-01 1.000000e+00 DataSet_03_428
ASPA STAT3 siRNA Peripheral_blood Monocyte-derived M-CSF macrophages 1.57895 0.658963 0.3028421535 1 DataSet_03_430
ASPA USP7 shRNA Skin xenograft cells 0.471487 -1.08471 0.25487180 0.4348960 DataSet_03_431
ASPA NFE2L1 knockout Lung A549 0.426205 -1.23038 9.454639e-01 9.984904e-01 DataSet_03_433
ASPA POU2AF1 CRISPR Haematopoietic_and_lymphoid_tissue OCI-Ly7 0.299491 -1.73942 1.812113e-01 0.540033120 DataSet_03_434
ASPA EP300 knockout Pancreas HPAF-II orthotopic cells 2.25 1.16992 7.594437e-01 8.636223e-01 DataSet_03_436
ASPA FOXA2 CRISPR Liver iPSCs-derived progenitors and mature hepatocytes 2.62879 1.3944 6.701242e-02 0.90558273 DataSet_03_439
ASPA OGT siRNA Embryo BeWo cells 0.0909091 -3.45943 1.271241e-01 0.66237450 DataSet_03_453
ASPA PPARG siRNA Aortic_valve Valvular endothelial cell 3.30769 1.72582 1.175822e-01 5.295006e-01 DataSet_03_456
ASPA ARID1A shRNA Bile_duct MMNK1 0.612898 -0.706281 4.244454e-02 0.224184208 DataSet_03_458
ASPA HAND1 siRNA Placenta HPMVEC 3.375 1.75489 2.929877e-01 0.9463341 DataSet_03_459
ASPA SOX9 knockout Liver HuH7 0.1 -3.32193 1.278987e-02 5.135432e-02 DataSet_03_463
ASPA HMGB2 knockdown Umbilical_vein HUVEC 0.352941 -1.5025 1.293252e-01 0.26463014 DataSet_03_476
Regulation Region
 
T(co)Fs that significantly regulate OGT by the evidences of both expression and ChIP-seq/motif
Expression Atlas of ASPA
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines