Gene Overview
Target Gene: CPNE4
NCBI Official Symbol: CPNE4
Entrez ID: 131034
Ensembl ID: ENSG00000196353
Gene Full Name: copine 4
Strand: -
Gene Locus: 3q22.1
External Links:

CPNE4 Significantly Regulated by These T(co)Fs

T(co)Fs that Activate CPNE4   
T(co)Fs that Repress CPNE4
The Intensity of the Gene Regulated by T(co)Fs:
CPNE4-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
CPNE4 FOXA1 shRNA Prostate 22RV1 0.53333 -0.90689 - - DataSet_01_105
CPNE4 GABPA siRNA Lung A549 2.17363 1.12011 7.7468e-07 8.98379e-06 DataSet_01_113
CPNE4 GATA3 siRNA Mammary_gland MCF7 1.59392 0.67258 2.86833e-08 1.36622e-05 DataSet_01_120
CPNE4 ZIC2 siRNA Pancreas PANC1 3.94273 1.9792 - - DataSet_01_121
CPNE4 FOXM1 siRNA Central_nervous_system U87 1.94254 0.95794 - - DataSet_01_122
CPNE4 ID1 shRNA Neuroepithelium GSC2 6.08576 2.60544 2.77523e-17 5.59208e-14 DataSet_01_133
CPNE4 IKZF2 shRNA Haematopoietic_and_lymphoid_tissue JURKAT 1.92987 0.9485 0.06095 0.72427 DataSet_01_137
CPNE4 REST siRNA Adrenal_gland H295R/TR 2.34202 1.22775 1.86141e-06 0.00153 DataSet_01_145
CPNE4 TP53 siRNA Lung SAECs 1.63613 0.71028 0.55016 0.83921 DataSet_01_175
CPNE4 CREB1 shRNA Parotid_gland H3118 MEC 2.4013 1.26382 0.57553 0.83094 DataSet_01_194
CPNE4 TP63 siRNA Head_and_neck SCC-1 0.51915 -0.94577 - - DataSet_01_199
CPNE4 TP63 siRNA Head_and_neck SCC-6 0.66297 -0.59298 - - DataSet_01_202
CPNE4 HIC1 shRNA Mammary_gland HBL100 1.74549 0.80363 - - DataSet_01_205
CPNE4 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly1 0.60712 -0.71994 - - DataSet_01_209
CPNE4 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly7 1.53921 0.62219 - - DataSet_01_210
CPNE4 LIN28A siRNA Embryo H9 3.0856 1.62555 9.46198e-05 0.00294 DataSet_01_215
CPNE4 TAL1 shRNA Haematopoietic_and_lymphoid_tissue HEL 0.38382 -1.38148 2.38514e-05 0.00358 DataSet_01_217
CPNE4 FOXP1 siRNA Prostate LNCaP 1.62671 0.70196 0.0025 0.17339 DataSet_01_234
CPNE4 EGR2 siRNA Muscle A673 1.81993 0.86388 0.16448 0.70898 DataSet_01_242
CPNE4 FOXO3 siRNA Pancreas PANC1 0.49341 -1.01913 - - DataSet_01_267
CPNE4 AR shRNA Prostate CWR22Pc 3.31152 1.72749 0.00143 0.01903 DataSet_01_278
CPNE4 STAT5 shRNA Prostate CWR22Pc 2.98327 1.5769 0.00071 0.01328 DataSet_01_279
CPNE4 MSX1 siRNA Tooth Dental Pulp Cells 1.56927 0.6501 0.09191 0.17752 DataSet_01_281
CPNE4 TFAP4 siRNA Brain BE(2)-C 0.23827 -2.0693 0.39909 0.51625 DataSet_01_295
CPNE4 MYCN siRNA Brain BE(2)-C 1.57002 0.65078 0.83161 1 DataSet_01_296
CPNE4 PTEN shRNA Skin A431 1.52108 0.60509 0.76608 0.86957 DataSet_01_301
CPNE4 OVOL2 siRNA Corneal_epithelial Corneal epithelial cells 1.93235 0.95036 0.28923 0.50282 DataSet_01_313
CPNE4 MYC siRNA Colon HCT116 3.58693 1.84275 0.29282 0.35978 DataSet_01_324
CPNE4 TOX shRNA Haematopoietic_and_lymphoid_tissue CCRF-CEM 0.55891 -0.83932 0.03472 0.5389 DataSet_01_331
CPNE4 REST siRNA Skin NHEK 1.61848 0.69464 0.00309 0.05523 DataSet_01_337
CPNE4 HIF1A siRNA Oral_cavity OEC-M1 1.98708 0.99065 0.09925 0.85151 DataSet_01_348
CPNE4 RBM17 shRNA Haematopoietic_and_lymphoid_tissue K562 0.1 -3.32193 0.0216 0.26197 DataSet_02_138
CPNE4 ZFX siRNA Prostate C4-2B 2 1 0.57168 0.67631 DataSet_02_172
CPNE4 MXI1 siRNA Haematopoietic_and_lymphoid_tissue K562 2.83333 1.5025 0.23512 1 DataSet_02_173
CPNE4 LMNA siRNA Haematopoietic_and_lymphoid_tissue K562 0.5 -1 0.22625 1 DataSet_02_175
CPNE4 ZNF180 siRNA Haematopoietic_and_lymphoid_tissue K562 0.16667 -2.58496 0.03359 1 DataSet_02_177
CPNE4 STAT5A siRNA Haematopoietic_and_lymphoid_tissue K562 0.25 -2 0.08149 1 DataSet_02_182
CPNE4 MAFG siRNA Haematopoietic_and_lymphoid_tissue K562 1.83333 0.87447 0.75569 1 DataSet_02_189
CPNE4 RAD21 siRNA Haematopoietic_and_lymphoid_tissue K562 0.16667 -2.58496 0.46898 1 DataSet_02_190
CPNE4 MAX siRNA Haematopoietic_and_lymphoid_tissue K562 4.33333 2.11548 0.66313 1 DataSet_02_192
CPNE4 TCP1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.5 -1 0.24779 1 DataSet_02_194
CPNE4 LMNB1 siRNA Haematopoietic_and_lymphoid_tissue K562 2.16667 1.11548 0.77158 1 DataSet_02_195
CPNE4 CDAN1 siRNA Haematopoietic_and_lymphoid_tissue K562 2.16667 1.11548 0.90257 1 DataSet_02_197
CPNE4 RCOR1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.45455 -1.1375 0.72424 1 DataSet_02_204
CPNE4 E2F6 siRNA Haematopoietic_and_lymphoid_tissue K562 2.33333 1.22239 0.61534 1 DataSet_02_205
CPNE4 ASCL1 siRNA Lung DMS79 2.09068 1.06397 0.0326194315488004 0.635446459144874 DataSet_03_016
CPNE4 ATF4 siRNA Skin A375 0.658638 -0.602443 0.262444052506662 0.775512819201899 DataSet_03_018
CPNE4 GATA4 siRNA Stomach KatoIII 0.526671 -0.925027 0.102743928457152 0.894989982111992 DataSet_03_106
CPNE4 GATA6 siRNA Stomach AGS 2.28889 1.19465 0.09666465160661 0.57873183039567 DataSet_03_108
CPNE4 HNF4a siRNA Liver HepG2 2.51145 1.32852 0.0144754016523362 0.518654854188191 DataSet_03_126
CPNE4 KDM3A siRNA Mammary_gland MCF7 1.51448 0.598827 0.000243467228961378 0.0075351044081945 DataSet_03_146
CPNE4 MEF2D shRNA Liver HuH7 1.61388 0.690531 - - DataSet_03_162
CPNE4 MEF2D siRNA Liver HuH7 0.384431 -1.3792 - - DataSet_03_163
CPNE4 MYC siRNA Colon HT29 0.469247 -1.09158 - - DataSet_03_177
CPNE4 MYCN siRNA Brain BE(2)C cells 1.69032 0.7573 - - DataSet_03_187
CPNE4 MYCN siRNA Brain BE(2)C cells 1.57691 0.6571 - - DataSet_03_188
CPNE4 PHB shRNA Embryo Embryonic stem cells (ESCs) 4.62931 2.2108 7.21104516630139e-06 0.00031520244392515 DataSet_03_211
CPNE4 REST siRNA Adrenal_gland H295R/TR 2.11187 1.07852 0.000261462562971634 0.0451400589272583 DataSet_03_228
CPNE4 SOX11 siRNA Lung_fibroblast NHLF 0.527636 -0.922386 0.00515871511581508 0.304507242190339 DataSet_03_237
CPNE4 SOX11 siRNA Lung_fibroblast NHLF 0.652808 -0.615269 0.403773595735056 0.740175218491916 DataSet_03_238
CPNE4 SOX2 siRNA Embryo 2102Ep 1.69089 0.757783 3.76044789068299e-05 0.00171992394519254 DataSet_03_242
CPNE4 SOX2 siRNA Mammary_gland GSC-11 0.428908 -1.22126 0.00396079178171338 0.0462254587511496 DataSet_03_245
CPNE4 SOX4 siRNA Haematopoietic_and_lymphoid_tissue ST1 5.38461 2.42884 - - DataSet_03_246
CPNE4 STAT3 CRISPR Embryo hESC 5.22195 2.38459 0.0455254475265566 0.119277340196726 DataSet_03_258
CPNE4 STAT6 siRNA Umbilical_vein HUVEC 0.665198 -0.588144 0.375892806610769 0.888274055212061 DataSet_03_264
CPNE4 TFAP2C siRNA Mammary_gland MCF7 0.188725 -2.40564 0.00468792906297513 0.227639680227539 DataSet_03_274
CPNE4 ZNF746 siRNA Colon HCT116 1.52203 0.606 - - DataSet_03_293
CPNE4 CIZ1 CRISPR Haematopoietic_and_lymphoid_tissue K562 2.33333 1.22239 0.167537250893483 0.259760733273043 DataSet_04_004
CPNE4 ACTN4 CRISPR Haematopoietic_and_lymphoid_tissue K562 3.5 1.80735 0.561645869633041 0.749546992608543 DataSet_04_048
CPNE4 NPM1 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.2 -2.32193 0.619933103073149 0.783463843582039 DataSet_04_046
CPNE4 SMG5 CRISPR Haematopoietic_and_lymphoid_tissue K562 2 1 0.921927579634931 0.985843699539066 DataSet_04_073
CPNE4 SNW1 CRISPR Haematopoietic_and_lymphoid_tissue K562 7 2.80735 0.575989854483926 0.731270505149587 DataSet_04_049
CPNE4 SMARCA4 siRNA Colon HCT116 2.58699 1.37127 7.797898e-02 8.979476e-01 DataSet_03_301
CPNE4 ELF3 CRISPR Bile_duct HBDEC2 0.0897553 -3.47786 1.163569e-05 3.660244e-04 DataSet_03_304
CPNE4 EZH2 shRNA Mammary_gland MCF7 1.6493 0.72185 2.845184e-04 1.139316e-02 DataSet_03_331
CPNE4 SKI CRISPR Blood HL60 0.545455 -0.874469 3.871868e-01 0.652924974 DataSet_03_351
CPNE4 ESR1 siRNA Mammary_gland MCF7 2.45658 1.29665 2.074984e-04 0.0114236201 DataSet_03_352
CPNE4 PARP1 siRNA Prostate LNCaP 0.129727 -2.94645 1.149679e-03 0.052731960 DataSet_03_354
CPNE4 TET1 CRISPR Mammary_gland Hs578T 0.205443 -2.28319 1.516994e-02 6.403779e-02 DataSet_03_355
CPNE4 PTPN14 CRISPR Brain U5-NPC 0.0700935 -3.83458 2.440145e-03 0.18459021 DataSet_03_357
CPNE4 TP53 CRISPR Brain U5-NPC 2.52381 1.3356 7.500308e-02 2.107030e-01 DataSet_03_358
CPNE4 NCOA2 siRNA Uterus endometrial stromal cells 1.6 0.678072 0.5300360551 1 DataSet_03_360
CPNE4 NCOA3 siRNA Mammary_gland MDA-MB-231 19.4193 4.27942 2.664913e-01 0.7728327 DataSet_03_361
CPNE4 ARID2 shRNA Haematopoietic_and_lymphoid_tissue MM.1S 2.98676 1.57858 5.652504e-01 6.571716e-01 DataSet_03_362
CPNE4 EP300 shRNA Mammary_gland MCF10AT 0.210938 -2.24511 8.235828e-04 0.019179932 DataSet_03_364
CPNE4 DNMT3A knockout Embryo_kidney HEK293T 0.242486 -2.04402 - - DataSet_03_369
CPNE4 E2F1 siRNA Nasopharynx HK1 2 1 1.290204e-01 6.004039e-01 DataSet_03_373
CPNE4 GLI1 siRNA Skeletal_muscle RMS13 1.61492 0.691465 3.100796e-01 0.507416196 DataSet_03_375
CPNE4 ZNF213 siRNA Mammary_gland MCF7 1.52923 0.612808 3.492586e-01 6.592819e-01 DataSet_03_376
CPNE4 NFKB2 siRNA Bone_marrow U2OS 1.99367 0.995427 7.256723e-03 0.12001632 DataSet_03_381
CPNE4 YY1 shRNA Brain GSC1517 2.75 1.45943 - - DataSet_03_384
CPNE4 YY1 shRNA Brain GSC23 0.59263 -0.754797 - - DataSet_03_385
CPNE4 NFKBIA shRNA Bone_marrow U2OS 0.399216 -1.32476 5.618616e-01 0.87005461 DataSet_03_389
CPNE4 KDM5A CRISPR Lung GLC16 1.89425 0.921624 7.286875e-04 0.014603441 DataSet_03_392
CPNE4 ILF2 siRNA Stomach SGC-7901 0.5 -1 0.5813209367 0.66041517 DataSet_03_393
CPNE4 ASXL1 CRISPR Embryo iPSC 3.00493 1.58733 0.0515009839 0.8048302 DataSet_03_394
CPNE4 RELA CRISPR Brain T30 0.439534 -1.18595 0.5233732494 0.8623714 DataSet_03_399
CPNE4 SUMO1 CRISPR Bone_marrow U2OS 1.53456 0.617827 1.289863e-02 6.451444e-02 DataSet_03_401
CPNE4 EHF shRNA Stomach MKN7 0.000311702 -11.6475 - - DataSet_03_402
CPNE4 JARID2 siRNA Adipose_tissue human adipose tissue derived stem cells 0.2 -2.32193 3.385325e-01 0.5380041 DataSet_03_403
CPNE4 CDK7 shRNA Bone_marrow D458 7 2.80735 1.279618e-01 0.44753434 DataSet_03_404
CPNE4 TFAP2A knockout Embryo H9 2.11111 1.078 1.007696e-01 0.22269727 DataSet_03_405
CPNE4 E2F6 shRNA Liver HuH7 0.581958 -0.781013 - - DataSet_03_412
CPNE4 NFATC2 shRNA Haematopoietic_and_lymphoid_tissue THP-1 0.588235 -0.765535 1.235397e-01 0.300423268 DataSet_03_418
CPNE4 FOXQ1 CRISPR Lymph Primary CD4+ T cells 2 1 - - DataSet_03_422
CPNE4 STAT5B CRISPR Embryo_kidney HEK293 0.555556 -0.847997 4.289278e-01 0.764657930 DataSet_03_424
CPNE4 FOXP3 CRISPR Peripheral_blood Naive Treg 2 1 4.494337e-01 0.750433781 DataSet_03_427
CPNE4 SUFU shRNA Mammary_gland HCC1954 cells 0.0681818 -3.87447 0.0753934750 0.5891146 DataSet_03_437
CPNE4 CIC knockout Brain Immortalized Astrocyte Cells 1.64037 0.714025 9.120643e-03 1.796829e-01 DataSet_03_438
CPNE4 FOXA2 CRISPR Liver iPSCs-derived progenitors and mature hepatocytes 1.70513 0.76988 7.647757e-02 0.90558273 DataSet_03_439
CPNE4 HMG20A siRNA Mammary_gland MDA-MB-231 2.46667 1.30256 0.0179167064 0.1888535 DataSet_03_442
CPNE4 FOSL1 siRNA Prostate MSKPCa3 3.33333 1.73697 0.1540405982 0.5297688 DataSet_03_445
CPNE4 OGT siRNA Embryo BeWo cells 0.25 -2 2.298286e-01 0.66237450 DataSet_03_453
CPNE4 SMARCA2 shRNA Lung HCC2302 27.0684 4.75854 3.002570e-15 1.383606e-13 DataSet_03_455
CPNE4 PPARG siRNA Aortic_valve Valvular endothelial cell 4.57143 2.19265 2.208655e-01 6.747008e-01 DataSet_03_456
CPNE4 ARID1A shRNA Bile_duct MMNK1 0.39888 -1.32597 6.472210e-01 0.810503022 DataSet_03_458
CPNE4 SOX9 knockout Liver HuH7 2.66667 1.41504 9.251501e-03 4.084436e-02 DataSet_03_463
CPNE4 PARP1 knockout Embryo_kidney HEK293a 10 3.32193 1.612851e-06 2.105462e-05 DataSet_03_464
CPNE4 EZH2 siRNA Umbilical_vein HUVEC 2.5 1.32193 4.267303e-01 0.681614922 DataSet_03_473
CPNE4 EZH2 siRNA Prostate LNCaP 0.428571 -1.22239 6.154660e-01 1.0000000 DataSet_03_475
CPNE4 APTX CRISPR Haematopoietic_and_lymphoid_tissue K562 0.333333 -1.58496 0.6915229 0.9378603 DataSet_04_072
Regulation Region
 
T(co)Fs that significantly regulate POLR2G by the evidences of both expression and ChIP-seq/motif
Expression Atlas of CPNE4
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines