Gene Overview
| Target Gene: | Enpp1 |
| NCBI Official Symbol: | Enpp1 |
| Entrez ID: | 18605 |
| Ensembl ID: | ENSMUSG00000037370 |
| Gene Full Name: | ectonucleotide pyrophosphatase/phosphodiesterase 1 |
| Strand: | - |
| Gene Locus: | 10 A4|10 12.26 cM |
| External Links: |
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Enpp1 Significantly Regulated by These T(co)Fs
T(co)Fs
that Activate Enpp1
T(co)Fs
that Repress Enpp1
The Intensity of the Gene Regulated by T(co)Fs:
Enpp1-T(co)F Pairs
| Target Gene |
T(co)F | Knock -Method |
Tissue Type | Biosample Name |
Fold Change |
Log2FC | P-value | Corrected _P |
Dataset ID |
|---|---|---|---|---|---|---|---|---|---|
| Enpp1 | Ahr | knockout | Lung | Lung | 0.653047 | -0.614741 | 0.791113962072603 | 0.999996968611848 | DataSet_11_003 |
| Enpp1 | Cbx2 | knockout | Gonads | Embryonic gonads | 1.65733 | 0.728862 | 3.8376043366064e-05 | 0.000643457975307625 | DataSet_11_018 |
| Enpp1 | Cebpb | knockout | Mammary_gland | Mammary epithlial cells (MECs) | 0.571701 | -0.806667 | 0.605523179965383 | 0.999788745984441 | DataSet_11_020 |
| Enpp1 | Cebpb | shRNA | Mammary_gland | 4T1 mammary tumor cells | 0.20791 | -2.26596 | 0.507676024702124 | 0.999984070881864 | DataSet_11_022 |
| Enpp1 | Dmrt1 | knockout | Testis | Juvenile testes | 1.61365 | 0.69033 | 0.192238463081463 | 0.932139260123802 | DataSet_11_026 |
| Enpp1 | E2f4 | knockout | Brain | Forebrain | 7.84649 | 2.97205 | - | - | DataSet_11_034 |
| Enpp1 | Foxq1 | siRNA | Mammary_gland | NM18 | 1.58354 | 0.663153 | 0.000361326856071499 | 0.00484199402352548 | DataSet_11_045 |
| Enpp1 | Gata3 | siRNA | Peripheral_blood | CD4+ T helper (Th) cells | 0.539343 | -0.890725 | 0.168282248211221 | 0.987135756219234 | DataSet_11_048 |
| Enpp1 | Gfi1b | knockout | Bone_marrow | Ter119 positive erythroid cells | 1.58458 | 0.6641 | - | - | DataSet_11_054 |
| Enpp1 | Klf6 | shRNA | Liver | HCC | 1.76736 | 0.821595 | 0.0120212226738775 | 0.998072688143085 | DataSet_11_067 |
| Enpp1 | Mkx | knockout | Tooth | PDL | 0.645019 | -0.632586 | 0.149419193074479 | 0.999970897748702 | DataSet_11_083 |
| Enpp1 | Nr2f2 | knockout | Ovary | E14.5 Ovary | 1.6389 | 0.712728 | 0.0885363320844596 | 0.836069454533427 | DataSet_11_094 |
| Enpp1 | Nr2f2 | knockout | Ovary | E16.5 Ovary | 1.84979 | 0.887358 | 0.000336286815397133 | 0.0894436637715694 | DataSet_11_095 |
| Enpp1 | Otx2 | knockout | Eye | Retina | 0.656822 | -0.606425 | 0.6340162167101 | 0.999923528647439 | DataSet_11_097 |
| Enpp1 | Pax5 | knockout | Bone_marrow | B220+ cells | 0.576756 | -0.793967 | 0.0887362993026775 | 0.459056758979089 | DataSet_11_100 |
| Enpp1 | Plagl2 | knockout | Intestine | Small intestine | 0.517976 | -0.949043 | 0.000643276885015177 | 0.0206515778921513 | DataSet_11_104 |
| Enpp1 | Prdm2 | shRNA | Muscle | C2C12 | 2.12577 | 1.08799 | 0.00897313090420931 | 0.604023326625203 | DataSet_11_108 |
| Enpp1 | Rest | knockout | Brain | Brain | 2.95699 | 1.56413 | 0.00278216218884309 | 0.491588730112041 | DataSet_11_113 |
| Enpp1 | Runx1 | knockout | Lymph | ProB cells | 0.624847 | -0.678425 | 0.0176934896327215 | 0.12242231730212 | DataSet_11_116 |
| Enpp1 | Smad4 | siRNA | Brain | bEnd3 | 578.459 | 9.17607 | - | - | DataSet_11_127 |
| Enpp1 | Snai1 | knockout | Embryo | Embryoid body | 0.464347 | -1.10673 | - | - | DataSet_11_129 |
| Enpp1 | Sox21 | knockout | Tooth | Incisor | 1.77846 | 0.830625 | - | - | DataSet_11_142 |
| Enpp1 | Tet2 | knockdown | Muscle | GMPs | 0.377991 | -1.40358 | - | - | DataSet_11_162 |
| Enpp1 | Tet2 | knockdown | Muscle | LSK | 0.453532 | -1.14073 | - | - | DataSet_11_163 |
| Enpp1 | Vdr | knockout | Skin | Skin | 0.6 | -0.736966 | - | - | DataSet_11_177 |
| Enpp1 | Yy1 | knockout | White_adipose_tissue | Subcutaneous white adipose tissue | 0.643786 | -0.635348 | 0.332846380390484 | 0.76897115657114 | DataSet_11_184 |
| Enpp1 | Yy1 | knockout | White_adipose_tissue | Visceral white adipose tissue | 0.0308427 | -5.01893 | 0.226164178449743 | 0.432210900626341 | DataSet_11_185 |
| Enpp1 | Zbed6 | siRNA | Muscle | C2C12 | 1.74386 | 0.802283 | 3.52809582532018e-07 | 4.50204903907054e-05 | DataSet_11_186 |
| Enpp1 | Dnmt1 | siRNA | Pituitary_gland | AtT-20 | 1.5689 | 0.649754 | 2.218140e-01 | 0.9999923 | DataSet_11_187 |
| Enpp1 | Mapk9 | knockout | Hip | Mouse Hip Cartilage | 2.8526 | 1.51228 | 3.769935e-05 | 3.494782e-04 | DataSet_11_236 |
| Enpp1 | Kdm5b | knockout | Heart | left ventricles | 0.562572 | -0.829891 | 0.4265063903 | 0.9999827 | DataSet_11_210 |
| Enpp1 | Dnmt1 | knockout | Embryo | Embryonic fibroblasts | 0.442172 | -1.17732 | 2.532685e-03 | 2.616426e-02 | DataSet_11_192 |
| Enpp1 | Dnmt1 | shRNA | Embryo | Embryonic fibroblasts | 2.83053 | 1.50107 | - | - | DataSet_11_196 |
| Enpp1 | Ezh2 | knockdown | Brain | Brain | 0.434973 | -1.201 | 1.978420e-03 | 0.0396313025 | DataSet_11_221 |
| Enpp1 | Brca1 | knockout | Brain | mouse P7 brain | 1.62669 | 0.701942 | 8.500687e-02 | 0.51708545 | DataSet_11_201 |
| Enpp1 | Brca1 | knockout | Brain | mouse P7 cortex | 2.96075 | 1.56596 | 2.640460e-06 | 9.584165e-04 | DataSet_11_203 |
| Enpp1 | Smarca4 | shRNA | Embryo | ES cells | 1.65695 | 0.728531 | - | - | DataSet_11_224 |
| Enpp1 | Smarca4 | shRNA | Embryo | ES cells | 1.65695 | 0.728531 | - | - | DataSet_11_225 |
| Enpp1 | Dnmt3a | knockout | Skeletal_muscle | Satellite cells | 1.7 | 0.765535 | 5.240864e-01 | 1.0000000 | DataSet_11_208 |
| Enpp1 | Dnmt3b | siRNA | Embryo | iPSC | 0.643514 | -0.635957 | - | - | DataSet_11_242 |
| Enpp1 | Lin28a | knockout | Heart | Heart | 0.34375 | -1.54057 | 0.3301396676 | 0.8777652 | DataSet_11_243 |
| Enpp1 | Twist1 | knockout | Bone_marrow | stromal cells | 3.9984e-20 | -64.4391 | - | - | DataSet_11_244 |
| Enpp1 | Kat6a | knockout | Embryo | Embryonic fibroblasts | 0.226585 | -2.14188 | 3.492828e-04 | 0.0134020599 | DataSet_11_245 |
| Enpp1 | Fubp1 | shRNA | Brain | brain neural progenitors | 3.51406 | 1.81314 | 0.1914838125 | 1 | DataSet_11_246 |
| Enpp1 | Kmt2d | knockout | Skin | iBiP melanoma mouse model tumor cell | 0.523112 | -0.934809 | 9.394262e-03 | 4.469007e-02 | DataSet_11_250 |
| Enpp1 | Kdm2a | CRISPR | Embryo | ES cells | 0.515625 | -0.955606 | 0.1035632258 | 1.0000000 | DataSet_11_251 |
| Enpp1 | Mecp2 | knockout | Adipose_tissue | brown adipose tissue | 1.56391 | 0.645155 | 2.822397e-01 | 0.609170311 | DataSet_11_253 |
| Enpp1 | Mecp2 | knockout | Adipose_tissue | inguinal adipose tissue | 1.92172 | 0.942399 | 8.922776e-04 | 0.1141779 | DataSet_11_254 |
| Enpp1 | Crebbp | shRNA | Lung | preSC | 0.562201 | -0.830842 | 7.680655e-02 | 0.50267097 | DataSet_11_255 |
| Enpp1 | Nsd2 | shRNA | Prostate | NPK | 0.563588 | -0.827287 | 2.294418e-07 | 2.511193e-05 | DataSet_11_257 |
| Enpp1 | Eed | knockout | Brain | Forebrain | 2.00122 | 1.00088 | 6.556427e-02 | 5.695019e-01 | DataSet_11_258 |
| Enpp1 | Eed | knockout | Brain | hindbrain | 2.47044 | 1.30477 | 4.506872e-02 | 7.390798e-01 | DataSet_11_259 |
| Enpp1 | Eed | knockout | Brain | midbrain | 1.91619 | 0.93824 | 1.800409e-01 | 9.620062e-01 | DataSet_11_260 |
| Enpp1 | Fubp1 | shRNA | Bone_marrow | BM cells | 1.70388 | 0.768827 | 7.335262e-02 | 0.561174554 | DataSet_11_262 |
| Enpp1 | Bcl3 | knockout | Bone | Osteoblast | 0.329919 | -1.59982 | 1.288893e-03 | 2.373382e-01 | DataSet_11_263 |
| Enpp1 | Ctnnb1 | knockout | Embryo | MGE cells | 6.20048 | 2.63238 | 3.247270e-01 | 0.578475918 | DataSet_11_266 |
| Enpp1 | Myc | CRISPR | Skeletal_muscle | muscle stem cells | 0.0365826 | -4.7727 | 3.679569e-01 | 0.81420760 | DataSet_11_272 |
| Enpp1 | Gsk3b | CRISPR | Neuron | mPFC D2 neurons | 3.71027 | 1.89153 | 3.504697e-01 | 0.85266614 | DataSet_11_277 |
| Enpp1 | Ssrp1 | CRISPR | Embryo | ES cells | 2.02222 | 1.01594 | 3.406949e-01 | 0.7914316 | DataSet_11_278 |
| Enpp1 | Pcgf6 | knockout | Testis | Testis | 0.639369 | -0.645279 | 1.252490e-01 | 0.8964874 | DataSet_11_282 |
| Enpp1 | Zmat3 | knockout | Embryo | Embryonic fibroblasts | 2.18287 | 1.12622 | 8.543231e-02 | 0.5395938 | DataSet_11_284 |
| Enpp1 | Usp7 | siRNA | Embryo | ES cells | 4.2 | 2.07039 | 3.308568e-02 | 0.6667924 | DataSet_11_287 |
| Enpp1 | Fli1 | CRISPR | Lymph | CD8 T cells | 1.51772 | 0.601911 | 6.640806e-01 | 0.9999740103 | DataSet_11_288 |
| Enpp1 | Setd1a | shRNA | Eye | Retina | 0.661465 | -0.596263 | 3.061543e-01 | 0.5375266420 | DataSet_11_293 |
| Enpp1 | Mkl1 | knockout | Bone_marrow | Bone marrow differentiated macrophages | 2.05499 | 1.03913 | 1.964448e-02 | 0.3106771374 | DataSet_11_294 |
| Enpp1 | Ssrp1 | CRISPR | Embryo | ES cells | 2.05556 | 1.03953 | 8.323489e-02 | 0.34301994 | DataSet_11_296 |
| Enpp1 | Phf8 | knockout | prostate | Prostate | 2.44368 | 1.28906 | 0.0909098799 | 0.3286810 | DataSet_11_298 |
| Enpp1 | Hmg20a | siRNA | Hypothalamus | Primary hypothalamic astrocytes | 0.619083 | -0.691796 | 0.0173564672 | 0.2554116 | DataSet_11_300 |
| Enpp1 | Arid2 | knockout | Muscle | LSK | 0.319266 | -1.64717 | 2.989450e-03 | 1.515135e-01 | DataSet_11_301 |
| Enpp1 | Dnmt1 | knockout | Skin | Keratinocytes | 10.9073 | 3.44722 | 7.964327e-07 | 0.0007034624 | DataSet_11_303 |
| Enpp1 | Foxp3 | CRISPR | Spleens_and_lymphnodes | CD4+ Th0 cells | 0.59691 | -0.744414 | - | - | DataSet_11_305 |
| Enpp1 | Suz12 | knockout | Lung | Alveolar macrophage | 1.8321 | 0.873496 | 5.602673e-02 | 1.249955e-01 | DataSet_11_312 |
| Enpp1 | Irf7 | knockout | Bone_marrow | c-kit+ leukemic cells | 0.219209 | -2.18962 | - | - | DataSet_11_313 |
| Enpp1 | Arid1b | knockout | Bone_marrow | bone marrow leukemia cells | 5.5 | 2.45943 | 1.011647e-02 | 0.1238869641 | DataSet_11_317 |
| Enpp1 | Arid2 | knockout | Bone_marrow | bone marrow leukemia cells | 5.97059 | 2.57787 | 2.314647e-02 | 0.5657532 | DataSet_11_318 |
| Enpp1 | Kat7 | knockout | Thymic_lobes | Thymic epithelial cells | 2.04186 | 1.02988 | 9.879376e-02 | 2.777453e-01 | DataSet_11_320 |
| Enpp1 | Setdb1 | shRNA | Neuron | NE-4C | 0.26202 | -1.93225 | - | - | DataSet_11_323 |
| Enpp1 | Dnmt1 | siRNA | Heart | embryonic cardiomyocytes | 0.503874 | -0.988864 | 3.793042e-03 | 0.013269939 | DataSet_11_340 |
| Enpp1 | Dnmt1 | knockout | Kidney | kidney Cap Mesenchyme | 0.619143 | -0.691655 | 1.639692e-03 | 4.155342e-02 | DataSet_11_344 |
| Enpp1 | Hoxa5 | siRNA | Heart | Adult mouse cardiomyocytes | 0.333333 | -1.58496 | 1.595232e-01 | 0.57416819 | DataSet_11_302 |
Regulation Region
Expression Atlas of Enpp1