Gene Overview
Target Gene: HTR2B
NCBI Official Symbol: HTR2B
Entrez ID: 3357
Ensembl ID: ENSG00000135914
Gene Full Name: 5-hydroxytryptamine receptor 2B
Strand: -
Gene Locus: 2q37.1
External Links:

HTR2B Significantly Regulated by These T(co)Fs

T(co)Fs that Activate HTR2B   
T(co)Fs that Repress HTR2B
The Intensity of the Gene Regulated by T(co)Fs:
HTR2B-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
HTR2B SPDEF shRNA Mammary_gland MCF7 0.63069 -0.66499 0.34385 0.99999 DataSet_01_107
HTR2B ID1 siRNA Lung A549 3.50804 1.81066 0.12511 0.3484 DataSet_01_117
HTR2B ZNF708 siRNA Gastrointestinal_tissue GIST-T1 0.62715 -0.67311 0.00064 0.01422 DataSet_01_130
HTR2B IKZF2 shRNA Haematopoietic_and_lymphoid_tissue JURKAT 2.33271 1.22201 0.01659 0.39055 DataSet_01_137
HTR2B POLR3A siRNA Mammary_gland MCF7 28.7333 4.84465 - - DataSet_01_139
HTR2B TAL1 shRNA Umbilical_cord_blood ECFCs 1.50422 0.58901 0.52598 0.94632 DataSet_01_152
HTR2B MYCN siRNA Autonomic_ganglia SKNBE2 0.55785 -0.84206 0.27753 0.61386 DataSet_01_160
HTR2B TP53 siRNA Lung SAECs 0.5122 -0.96523 0.16379 0.58051 DataSet_01_175
HTR2B TCF4 siRNA Autonomic_ganglia SH-SY5Y 3.0939 1.62943 0.00025 0.01752 DataSet_01_185
HTR2B TP63 siRNA Immortalized_keratinocyte HaCaT RG 3.93333 1.97575 - - DataSet_01_196
HTR2B TP63 siRNA Head_and_neck SCC-1 0.65217 -0.61667 - - DataSet_01_198
HTR2B TP63 siRNA Immortalized_keratinocyte HaCaT 0.16304 -2.61667 - - DataSet_01_200
HTR2B HIC1 shRNA Mammary_gland HBL100 0.53428 -0.90433 - - DataSet_01_205
HTR2B MITF shRNA Skin COLO829 0.45944 -1.12207 0.27362 0.48953 DataSet_01_207
HTR2B FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly10 0.64768 -0.62664 - - DataSet_01_208
HTR2B FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly1 0.17487 -2.51562 - - DataSet_01_209
HTR2B LIN28A siRNA Embryo H9 1.55599 0.63783 0.0186 0.07233 DataSet_01_215
HTR2B IRX1 shRNA Bone_marrow 143B 2.04695 1.03348 0.00366 0.06676 DataSet_01_227
HTR2B MYC siRNA White_adipose_tissue Adipose stem cells 1.59233 0.67114 0.46122 0.72086 DataSet_01_231
HTR2B TWIST1 shRNA Stomach CAF14 0.58342 -0.7774 0.03897 0.99996 DataSet_01_252
HTR2B ZIC5 siRNA Skin SK-MEL-28 0.49278 -1.02099 - - DataSet_01_285
HTR2B POSTN shRNA Brain GSC272 0.65161 -0.61791 0.35801 0.68501 DataSet_01_293
HTR2B TFAP4 siRNA Brain BE(2)-C 0.18991 -2.39659 0.28191 0.51625 DataSet_01_295
HTR2B MYCN siRNA Brain BE(2)-C 5.69481 2.50965 0.31954 1 DataSet_01_296
HTR2B SOX7 siRNA Umbilical_vein HUVEC 2.31923 1.21364 0.19568 0.89788 DataSet_01_299
HTR2B PTEN shRNA Skin A431 5.23394 2.3879 0.34635 0.54459 DataSet_01_301
HTR2B PTEN shRNA Lung HCC827 0.22726 -2.13758 0.19937 0.66852 DataSet_01_302
HTR2B PTEN shRNA Mammary_gland SKBR3 6.15561 2.6219 0.25911 0.70709 DataSet_01_303
HTR2B OVOL2 siRNA Corneal_epithelial Corneal epithelial cells 0.63022 -0.66607 0.03773 0.30288 DataSet_01_313
HTR2B ARNT siRNA Upper_aerodigestive_tract HSC3 1.75043 0.80771 - - DataSet_01_315
HTR2B HOXC6 siRNA Prostate LNCaP 10.2955 3.36394 0.00203 0.9106 DataSet_01_333
HTR2B ETV4 shRNA Prostate PC3 3.34387 1.74152 - - DataSet_01_356
HTR2B SOX17 siRNA Umbilical_vein HUVEC 2.1594 1.11063 - - DataSet_01_360
HTR2B TAF15 shRNA Liver HepG2 2.25 1.16993 0.9357 0.95832 DataSet_02_106
HTR2B RBM34 shRNA Liver HepG2 5 2.32193 0.00518 0.39494 DataSet_02_121
HTR2B ZFX siRNA Prostate C4-2B 3.125 1.64386 0.01189 0.03562 DataSet_02_172
HTR2B LMNA siRNA Haematopoietic_and_lymphoid_tissue K562 0.6 -0.73697 0.33453 1 DataSet_02_175
HTR2B ZNF180 siRNA Haematopoietic_and_lymphoid_tissue K562 2.2 1.1375 0.4766 1 DataSet_02_177
HTR2B VEZF1 siRNA Haematopoietic_and_lymphoid_tissue K562 2.8 1.48543 0.38858 1 DataSet_02_179
HTR2B CTCF siRNA Haematopoietic_and_lymphoid_tissue K562 1.75 0.80735 0.35156 1 DataSet_02_185
HTR2B CHD1 siRNA Haematopoietic_and_lymphoid_tissue K562 11 3.45943 0.22248 1 DataSet_02_187
HTR2B BACH1 siRNA Haematopoietic_and_lymphoid_tissue K562 2.6 1.37851 0.13183 1 DataSet_02_188
HTR2B MAFG siRNA Haematopoietic_and_lymphoid_tissue K562 0.6 -0.73697 0.26018 1 DataSet_02_189
HTR2B LMNB2 siRNA Haematopoietic_and_lymphoid_tissue K562 1.6 0.67807 0.57416 1 DataSet_02_191
HTR2B ARID3A siRNA Haematopoietic_and_lymphoid_tissue K562 4.33333 2.11548 0.05968 1 DataSet_02_193
HTR2B TCP1 siRNA Haematopoietic_and_lymphoid_tissue K562 2 1 0.24779 1 DataSet_02_194
HTR2B TAL1 siRNA Haematopoietic_and_lymphoid_tissue K562 1.75 0.80735 0.73224 1 DataSet_02_201
HTR2B RCOR1 siRNA Haematopoietic_and_lymphoid_tissue K562 1.90909 0.93289 0.03426 1 DataSet_02_204
HTR2B E2F6 siRNA Haematopoietic_and_lymphoid_tissue K562 1.8 0.848 0.21855 1 DataSet_02_205
HTR2B AR siRNA Prostate abl cells 5.44444 2.44479 0.104790479017507 0.999852161656754 DataSet_03_004
HTR2B ARID1A siRNA Mammary_gland MDA-MB-157 1.64593 0.7189 - - DataSet_03_014
HTR2B ASCL1 siRNA Lung DMS79 10.25 3.35755 0.273708959191324 0.866744571924672 DataSet_03_016
HTR2B ATOH8 siRNA Umbilical_vein HUVEC 2.9458 1.55866 0.384467575076791 1 DataSet_03_019
HTR2B BCL6 siRNA Lymph Pfeiffer DLBCL 2.34128 1.2273 0.000111054114060013 0.0871436061921961 DataSet_03_026
HTR2B FOXM1 siRNA Aorta Vascular smooth muscle cells 1.88374 0.9136 - - DataSet_03_090
HTR2B FOXO1 siRNA Skin primary human dermal lymphatic endothelial cells 19.4661 4.2829 - - DataSet_03_096
HTR2B GATA2 siRNA Lymph Lymphatic endothelial cells 2.54167 1.34578 0.00320353722912735 0.00945831381966042 DataSet_03_101
HTR2B GATA4 siRNA Stomach KatoIII 1.58864 0.667794 0.523722448816498 0.967051142834443 DataSet_03_106
HTR2B GATA4 siRNA Stomach YCC3 0.345594 -1.53285 0.231206223649868 0.750527772918288 DataSet_03_107
HTR2B GATA6 siRNA Stomach AGS 1.5268 0.610507 0.727077482051242 0.940561286599229 DataSet_03_108
HTR2B GATA6 siRNA Stomach KatoIII 0.28649 -1.80344 0.32412354806493 0.793296116820781 DataSet_03_109
HTR2B GATA6 siRNA Stomach YCC3 0.602307 -0.731428 0.12810142089137 0.750159337921316 DataSet_03_110
HTR2B HNF4a siRNA Liver HepG2 0.640625 -0.642448 0.916743304034755 0.99172805317717 DataSet_03_126
HTR2B JUN siRNA Skin Ma-Mel-15 0.653589 -0.613544 0.00350147403973651 0.514766499186304 DataSet_03_143
HTR2B KLF5 siRNA Stomach AGS 4.38011 2.13097 0.158328521271228 0.641174449868596 DataSet_03_149
HTR2B KLF5 siRNA Stomach KatoIII 0.596089 -0.746401 0.573953748219207 0.861210595009741 DataSet_03_150
HTR2B MAFB siRNA Peripheral_blood Monocyte-derived M-CSF macrophages 0.575678 -0.796667 0.104176101808113 1 DataSet_03_155
HTR2B MEF2D shRNA Liver HuH7 0.419315 -1.25389 - - DataSet_03_162
HTR2B MEF2D siRNA Liver HuH7 0.537817 -0.894812 - - DataSet_03_163
HTR2B MITF siRNA Skin Ma-Mel-15 3.80191 1.92672 7.12036337342231e-05 0.00976193375377574 DataSet_03_166
HTR2B MITF siRNA Skin Ma-Mel-15 1.51514 0.599453 0.323822179460228 0.716149969188821 DataSet_03_167
HTR2B MTA2 siRNA Stomach SGC-7901 0.393986 -1.34378 - - DataSet_03_169
HTR2B MYB siRNA Cord_Blood CD34+ progenitor cells 1.52609 0.609841 - - DataSet_03_170
HTR2B MYC siRNA Colon HT29 16.135 4.01212 - - DataSet_03_177
HTR2B MYCN siRNA Autonomic_ganglia SKNBE2 0.557845 -0.842062 0.274038644414162 0.624685185418758 DataSet_03_185
HTR2B NFAT5 siRNA Umbilical_vein HUVEC 0.649314 -0.623012 0.163675712684589 0.640981312635463 DataSet_03_195
HTR2B PHB shRNA Embryo Embryonic stem cells (ESCs) 0.231272 -2.11234 0.053672677106404 0.119379809237796 DataSet_03_211
HTR2B RELB siRNA Immortalized_keratinocyte HaCaT 0.548917 -0.865341 4.83389009581492e-05 0.000683260886827565 DataSet_03_227
HTR2B SOX11 siRNA Lung_fibroblast NHLF 1.65987 0.73107 0.229244850330432 0.606657565126896 DataSet_03_237
HTR2B SOX11 siRNA Lung_fibroblast NHLF 2.07092 1.05027 0.286851850031064 0.647118288509212 DataSet_03_238
HTR2B SP1 siRNA Mammary_gland MDA-MB-231 0.43999 -1.18446 0.140341310239428 0.413972819854456 DataSet_03_250
HTR2B STAT3 CRISPR Embryo hESC 0.143657 -2.7993 0.185605065830722 0.254388394788402 DataSet_03_258
HTR2B STAT6 siRNA Umbilical_vein HUVEC 0.458845 -1.12392 0.163704175350351 0.835278631521068 DataSet_03_264
HTR2B TFAP2C siRNA Mammary_gland MCF7 0.636828 -0.651024 0.321830081934486 0.647496086536514 DataSet_03_274
HTR2B TFE3 siRNA Kidney UOK257-2 0.647635 -0.626747 - - DataSet_03_275
HTR2B YBX1 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.0701754 -3.83289 0.00475566478719974 0.385029817631245 DataSet_04_022
HTR2B PAN2 CRISPR Liver HepG2 0.4 -1.32193 0.286806202528468 0.464151065269505 DataSet_04_033
HTR2B ZNF574 CRISPR Liver HepG2 0.4 -1.32193 0.288758248413072 0.431876337776761 DataSet_04_041
HTR2B DNMT3B CRISPR Liver HepG2 0.5 -1 0.89857932483358 0.967159138258453 DataSet_04_044
HTR2B RIOK2 CRISPR Liver HepG2 0.333333 -1.58496 0.879473389349799 1 DataSet_04_070
HTR2B CALR shRNA Liver HepG2 0.5 -1 0.850543159114769 0.916760250684649 DataSet_04_053
HTR2B CCAR1 shRNA Liver HepG2 3.5 1.80735 0.673088259895319 0.799924948924854 DataSet_04_054
HTR2B YBX3 shRNA Liver HepG2 1.66667 0.736966 0.869082794206246 0.936032277097885 DataSet_02_98
HTR2B HMGA1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.0877193 -3.51096 0.0782325226799658 0.45534945772754 DataSet_02_75
HTR2B NFE2L1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.428571 -1.22239 0.77635061406019 0.88702300009459 DataSet_02_32
HTR2B TEAD2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 1.71429 0.777608 0.733559579798203 0.849562076122117 DataSet_02_33
HTR2B TLE2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.571429 -0.807355 0.758633295347111 0.85806228232978 DataSet_02_53
HTR2B ELF3 CRISPR Bile_duct HBDEC2 2.30735 1.20624 4.024102e-01 4.927616e-01 DataSet_03_304
HTR2B SNAI2 shRNA Pancreas KLM1 0.492878 -1.0207 1.799486e-01 0.53528859 DataSet_03_307
HTR2B ACTR5 siRNA Muscle RD 0.350504 -1.5125 - - DataSet_03_343
HTR2B SKI CRISPR Blood HL60 3 1.58496 5.990846e-01 0.806527252 DataSet_03_351
HTR2B ESR1 siRNA Mammary_gland MCF7 0.444838 -1.16865 4.164076e-01 0.5945461991 DataSet_03_352
HTR2B ARID2 shRNA Haematopoietic_and_lymphoid_tissue MM.1S 1.99117 0.99362 6.437964e-01 7.239940e-01 DataSet_03_362
HTR2B TP53 knockout Stomach SNU1 1.64056 0.714187 0.2346047658 0.9301241 DataSet_03_365
HTR2B ZFP36L1 siRNA Urinary_bladder J82 2 1 - - DataSet_03_371
HTR2B E2F1 siRNA Nasopharynx HK1 0.5 -1 3.571404e-01 9.722824e-01 DataSet_03_373
HTR2B GLI1 siRNA Skeletal_muscle RMS13 0.646933 -0.628312 1.157377e-01 0.301508624 DataSet_03_375
HTR2B SMARCA2 shRNA Lung NCI-H1944 2 1 4.912760e-01 7.666270e-01 DataSet_03_377
HTR2B DDX5 shRNA Stomach HGC-27 0.5 -1 - - DataSet_03_379
HTR2B NFKB2 siRNA Bone_marrow U2OS 0.548387 -0.866733 1.310119e-01 0.43521719 DataSet_03_381
HTR2B YY1 shRNA Brain GSC1517 0.203333 -2.29808 - - DataSet_03_384
HTR2B YY1 shRNA Brain GSC23 6 2.58496 - - DataSet_03_385
HTR2B KAT6A CRISPR Haematopoietic_and_lymphoid_tissue MOLM-13 2.13504 1.09426 0.0728889559 0.8388073 DataSet_03_387
HTR2B TRIM8 siRNA Mammary_gland MCF7 4 2 3.708381e-01 0.5736586461 DataSet_03_388
HTR2B ASXL1 CRISPR Embryo iPSC 0.383192 -1.38386 0.1273826667 0.8117897 DataSet_03_394
HTR2B JAZF1 siRNA Cervix HeLa Kyoto 0.590669 -0.759579 4.909319e-01 0.873598937 DataSet_03_396
HTR2B TLE4 CRISPR Lymph CAR T Cell 2.55582 1.35379 8.341607e-02 0.32282598 DataSet_03_398
HTR2B RELA CRISPR Brain T30 0.00491318 -7.66913 0.3289880399 0.8400824 DataSet_03_399
HTR2B EHF shRNA Stomach MKN7 2.12404 1.08681 - - DataSet_03_402
HTR2B JARID2 siRNA Adipose_tissue human adipose tissue derived stem cells 2.875 1.52356 2.541290e-01 0.4602449 DataSet_03_403
HTR2B TFAP2A knockout Embryo H9 1.66667 0.736966 3.375741e-01 0.46148063 DataSet_03_405
HTR2B MAP3K7 shRNA Prostate LNCaP 0.284722 -1.81237 2.239620e-03 3.295414e-02 DataSet_03_408
HTR2B SIRT1 siRNA Pancreas PANC1 0.171429 -2.54432 3.683660e-02 0.111643142 DataSet_03_410
HTR2B ZKSCAN3 CRISPR Colon HCT116 3 1.58496 6.764258e-01 0.873497177 DataSet_03_415
HTR2B FOXK2 shRNA Ovary OVCAR-5 3.66667 1.87447 3.867910e-02 0.15658292 DataSet_03_419
HTR2B BRD4 CRISPR Lymph CD8+ T cells 3.5 1.80735 - - DataSet_03_420
HTR2B PRDM1 CRISPR Lymph CD8+ T cells 2 1 - - DataSet_03_421
HTR2B FOXQ1 CRISPR Lymph Primary CD4+ T cells 2.44 1.28688 - - DataSet_03_422
HTR2B FOXP3 CRISPR Peripheral_blood Naive Treg 7.71429 2.94753 2.741405e-04 0.064013462 DataSet_03_427
HTR2B USP7 shRNA Skin xenograft cells 0.546224 -0.872436 0.29994942 0.4438809 DataSet_03_431
HTR2B SUFU shRNA Mammary_gland HCC1954 cells 0.333333 -1.58496 0.1905344524 0.6455297 DataSet_03_437
HTR2B CAMTA1 knockout Embryo_kidney HEK293T 0.333333 -1.58496 1.970002e-01 0.39190368 DataSet_03_448
HTR2B RELB CRISPR Colon SW480 3 1.58496 7.282140e-02 2.450344e-01 DataSet_03_449
HTR2B CBX2 siRNA Mammary_gland MDA-MB-231 1.72319 0.785082 6.221317e-01 8.010721e-01 DataSet_03_450
HTR2B HAND1 siRNA Placenta HPMVEC 0.544355 -0.877381 8.739230e-02 0.9463341 DataSet_03_459
HTR2B PARP1 knockout Embryo_kidney HEK293a 2 1 4.041323e-01 5.465402e-01 DataSet_03_464
HTR2B LIN28A siRNA Mammary_gland MCF7M 0.160065 -2.64327 1.506064e-01 0.5036169 DataSet_03_469
HTR2B LIN28A siRNA Mammary_gland MCF7M 0.160065 -2.64327 1.506064e-01 0.5036169 DataSet_03_470
HTR2B EZH2 siRNA Prostate LNCaP 0.451967 -1.14571 - - DataSet_03_472
Regulation Region
 
T(co)Fs that significantly regulate HOXC6 by the evidences of both expression and ChIP-seq/motif
Expression Atlas of HTR2B
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines