Gene Overview
Target Gene: KCND2
NCBI Official Symbol: KCND2
Entrez ID: 3751
Ensembl ID: ENSG00000184408
Gene Full Name: potassium voltage-gated channel subfamily D member 2
Strand: +
Gene Locus: 7q31.31
External Links:

KCND2 Significantly Regulated by These T(co)Fs

T(co)Fs that Activate KCND2   
T(co)Fs that Repress KCND2
The Intensity of the Gene Regulated by T(co)Fs:
KCND2-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
KCND2 ID1 siRNA Lung A549 1.94745 0.96159 0.2699 0.50518 DataSet_01_117
KCND2 ID1 siRNA Lung H1650 2.22403 1.15318 0.00389 0.32206 DataSet_01_118
KCND2 ZIC2 siRNA Pancreas PANC1 1.72152 0.78368 - - DataSet_01_121
KCND2 FOXM1 siRNA Central_nervous_system U87 0.31798 -1.65301 - - DataSet_01_122
KCND2 ZNF91 siRNA Gastrointestinal_tissue GIST-T1 0.42936 -1.21973 0.00027 0.00832 DataSet_01_123
KCND2 ZNF43 siRNA Gastrointestinal_tissue GIST-T1 0.4216 -1.24607 0.00023 0.00978 DataSet_01_125
KCND2 ZNF85 siRNA Gastrointestinal_tissue GIST-T1 0.292 -1.77595 1.39722e-05 0.00135 DataSet_01_126
KCND2 ZNF254 siRNA Gastrointestinal_tissue GIST-T1 0.49881 -1.00343 0.00108 0.01362 DataSet_01_127
KCND2 ZNF431 siRNA Gastrointestinal_tissue GIST-T1 0.28243 -1.82401 1.11889e-05 0.00057 DataSet_01_128
KCND2 ZNF665 siRNA Gastrointestinal_tissue GIST-T1 0.40295 -1.31131 0.00016 0.00544 DataSet_01_129
KCND2 IKZF1 shRNA Haematopoietic_and_lymphoid_tissue JURKAT 0.5149 -0.95765 0.1014 0.99993 DataSet_01_138
KCND2 POLR3A siRNA Mammary_gland MCF7 0.30224 -1.72624 - - DataSet_01_139
KCND2 SOX4 shRNA Parotid_gland ACC3 1.7678 0.82195 0.03071 0.94635 DataSet_01_140
KCND2 NR3C1 siRNA Uterus Endometrial stromal cells 1.6245 0.7 0.67791 0.99972 DataSet_01_141
KCND2 REST siRNA Adrenal_gland H295R/TR 0.50056 -0.99839 2.06962e-05 0.00778 DataSet_01_145
KCND2 SF1 siRNA Adrenal_gland H295R/TR 0.64609 -0.63019 0.00197 0.01661 DataSet_01_146
KCND2 STAT1 shRNA Haematopoietic_and_lymphoid_tissue JURKAT 1.51995 0.60402 0.30486 0.61347 DataSet_01_154
KCND2 ETV1 shRNA Prostate LNCaP 1.89328 0.92089 0.00037 0.00282 DataSet_01_161
KCND2 GATA2 siRNA Prostate LNCaP 0.3662 -1.44928 2.8513e-05 0.00043 DataSet_01_193
KCND2 TP63 siRNA Immortalized_keratinocyte HaCaT RG 0.32195 -1.63509 - - DataSet_01_196
KCND2 TP63 siRNA Head_and_neck SCC-1 0.61232 -0.70765 - - DataSet_01_198
KCND2 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly10 1.66809 0.73819 - - DataSet_01_208
KCND2 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly1 4.36732 2.12675 - - DataSet_01_209
KCND2 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly7 0.05712 -4.12978 - - DataSet_01_210
KCND2 LIN28A siRNA Embryo H9 0.2331 -2.10098 0.00047 0.0078 DataSet_01_215
KCND2 MYC siRNA White_adipose_tissue Adipose stem cells 2.00821 1.00591 4.94659e-06 0.00046 DataSet_01_231
KCND2 ESRRA shRNA Embryo_kidney 293T 0.34867 -1.52009 0.01554 0.59775 DataSet_01_280
KCND2 TFAP4 siRNA Brain BE(2)-C 0.32265 -1.63197 0.48465 0.52369 DataSet_01_295
KCND2 SOX7 siRNA Umbilical_vein HUVEC 0.51843 -0.94778 0.12574 0.89788 DataSet_01_299
KCND2 SOX17 siRNA Umbilical_vein HUVEC 0.55791 -0.8419 0.16612 0.99998 DataSet_01_300
KCND2 PTEN shRNA Skin A431 0.08332 -3.58512 0.09981 0.26477 DataSet_01_301
KCND2 PTEN shRNA Lung HCC827 5.08146 2.34524 0.24267 0.69297 DataSet_01_302
KCND2 PTEN shRNA Mammary_gland SKBR3 3.13391 1.64796 0.08964 0.60129 DataSet_01_303
KCND2 SOX9 siRNA Prostate VCaP 0.32727 -1.61143 0.26119 0.93253 DataSet_01_308
KCND2 SOX9 siRNA Prostate VCaP 0.32727 -1.61143 0.26119 0.93253 DataSet_01_309
KCND2 RUNX1 shRNA Embryo H9 1.82163 0.86523 0.00137 0.03165 DataSet_01_314
KCND2 ARNT siRNA Upper_aerodigestive_tract HSC3 22443.9 14.454 - - DataSet_01_315
KCND2 MYC siRNA Colon HCT116 2.39794 1.26179 0.09771 0.14316 DataSet_01_324
KCND2 TP63 shRNA Head_and_neck FaDU 1.56321 0.64451 0.00065 0.0071 DataSet_01_327
KCND2 TP63 shRNA Head_and_neck FaDU 1.56321 0.64451 0.00065 0.0071 DataSet_01_330
KCND2 HOXC6 siRNA Prostate LNCaP 0.07033 -3.82972 0.00211 0.9106 DataSet_01_333
KCND2 KLF7 siRNA Embryo HCE 0.63357 -0.65842 0.00438 0.6419 DataSet_01_340
KCND2 GTF2B siRNA Cervix HeLa 2.04327 1.03088 - - DataSet_01_362
KCND2 TARDBP shRNA Haematopoietic_and_lymphoid_tissue K562 3 1.58496 0.91758 0.97152 DataSet_02_129
KCND2 POLR2G shRNA Haematopoietic_and_lymphoid_tissue K562 2.83333 1.5025 0.0025 0.69659 DataSet_02_130
KCND2 PTBP1 shRNA Haematopoietic_and_lymphoid_tissue K562 39.5 5.30378 0.00458 0.03447 DataSet_02_131
KCND2 AGO2 shRNA Haematopoietic_and_lymphoid_tissue K562 1.66667 0.73697 0.63625 0.75801 DataSet_02_132
KCND2 SRSF9 shRNA Haematopoietic_and_lymphoid_tissue K562 15.5 3.9542 0.00097 0.0884 DataSet_02_134
KCND2 PCBP1 shRNA Haematopoietic_and_lymphoid_tissue K562 8.5 3.08746 0.32448 0.55462 DataSet_02_137
KCND2 TAF15 shRNA Haematopoietic_and_lymphoid_tissue K562 24 4.58496 0.2497 0.48718 DataSet_02_140
KCND2 RBM34 shRNA Haematopoietic_and_lymphoid_tissue K562 5.5 2.45943 0.01206 0.20974 DataSet_02_141
KCND2 BCLAF1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.06667 -3.90689 0.0146 0.11884 DataSet_02_142
KCND2 RBM15 shRNA Haematopoietic_and_lymphoid_tissue K562 2 1 0.19213 0.27022 DataSet_02_143
KCND2 PTBP1 shRNA Haematopoietic_and_lymphoid_tissue K562 4.66667 2.22239 0.4546 0.66575 DataSet_02_144
KCND2 FIP1L1 shRNA Haematopoietic_and_lymphoid_tissue K562 2.66667 1.41504 0.23132 0.37566 DataSet_02_147
KCND2 ILF3 shRNA Haematopoietic_and_lymphoid_tissue K562 25.5 4.67243 0.60674 0.79937 DataSet_02_148
KCND2 RBM39 shRNA Haematopoietic_and_lymphoid_tissue K562 0.125 -3 0.00075 0.23644 DataSet_02_151
KCND2 ILF2 shRNA Haematopoietic_and_lymphoid_tissue K562 0.14286 -2.80735 0.05548 0.32183 DataSet_02_152
KCND2 SRSF4 shRNA Haematopoietic_and_lymphoid_tissue K562 2 1 0.08995 0.4085 DataSet_02_154
KCND2 FUS shRNA Haematopoietic_and_lymphoid_tissue K562 20 4.32193 0.01138 0.22733 DataSet_02_155
KCND2 HNRNPL shRNA Haematopoietic_and_lymphoid_tissue K562 0.27778 -1.848 0.01398 0.12676 DataSet_02_160
KCND2 SUB1 shRNA Haematopoietic_and_lymphoid_tissue K562 18 4.16993 0.26219 0.82276 DataSet_02_161
KCND2 AGO1 shRNA Haematopoietic_and_lymphoid_tissue K562 5 2.32193 0.45912 0.82266 DataSet_02_162
KCND2 TAF15 shRNA Haematopoietic_and_lymphoid_tissue K562 4.33333 2.11548 0.43879 0.64306 DataSet_02_163
KCND2 SSB shRNA Haematopoietic_and_lymphoid_tissue K562 4 2 0.48649 0.67006 DataSet_02_164
KCND2 EWSR1 shRNA Haematopoietic_and_lymphoid_tissue K562 26 4.70044 0.47132 0.67306 DataSet_02_167
KCND2 TARDBP shRNA Haematopoietic_and_lymphoid_tissue K562 0.33333 -1.58496 0.91581 0.94557 DataSet_02_169
KCND2 U2AF2 shRNA Haematopoietic_and_lymphoid_tissue K562 20 4.32193 0.47388 0.59758 DataSet_02_170
KCND2 ATF3 siRNA Haematopoietic_and_lymphoid_tissue K562 7.5 2.90689 0.03747 1 DataSet_02_180
KCND2 ZMIZ1 siRNA Haematopoietic_and_lymphoid_tissue K562 1.72414 0.78588 0.64589 1 DataSet_02_181
KCND2 CTCF siRNA Haematopoietic_and_lymphoid_tissue K562 4 2 0.46704 1 DataSet_02_185
KCND2 BHLHE40 siRNA Haematopoietic_and_lymphoid_tissue K562 0.33333 -1.58496 0.0123 1 DataSet_02_186
KCND2 CHD1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.2 -2.32193 0.0412 1 DataSet_02_187
KCND2 ARID3A siRNA Haematopoietic_and_lymphoid_tissue K562 0.06667 -3.90689 0.01778 1 DataSet_02_193
KCND2 UBTF siRNA Haematopoietic_and_lymphoid_tissue K562 0.58621 -0.77052 0.53724 1 DataSet_02_198
KCND2 TAL1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.12 -3.05889 0.00665 1 DataSet_02_201
KCND2 AR siRNA Prostate LNCaP 2.22222 1.152 0.0948447045654251 1 DataSet_03_005
KCND2 BCL6 siRNA Lymph OCI-Ly7 DLBCL 2.83804 1.5049 0.329525522789111 0.862273261859104 DataSet_03_025
KCND2 CEBPB siRNA Embryo hESC 0.310614 -1.68681 0.082624504067557 0.438053359515757 DataSet_03_049
KCND2 FOXO1 siRNA Skin primary human dermal lymphatic endothelial cells 32.9207 5.04093 - - DataSet_03_096
KCND2 GATA2 siRNA Lymph Lymphatic endothelial cells 2.84413 1.50799 1.15210657371181e-06 4.59303637401103e-05 DataSet_03_101
KCND2 GATA4 siRNA Stomach AGS 0.358118 -1.48149 0.187114930080661 0.828329356070166 DataSet_03_105
KCND2 GATA6 siRNA Stomach KatoIII 0.611155 -0.710389 0.432169160820927 0.83991527858455 DataSet_03_109
KCND2 IRF4 siRNA Skin Cutaneous T cell lymphoma HuT-102 cells 4.63567 2.21278 0.0814588425240673 0.919224197425053 DataSet_03_134
KCND2 KLF5 siRNA Stomach AGS 0.213714 -2.22625 0.0219618720505277 0.40264344627758 DataSet_03_149
KCND2 KLF5 siRNA Stomach KatoIII 0.118114 -3.08175 0.00175648526558211 0.128069658000608 DataSet_03_150
KCND2 MEF2D shRNA Liver HuH7 1.57833 0.658396 - - DataSet_03_162
KCND2 MYB siRNA Cord_Blood CD34+ progenitor cells 0.04476 -4.48165 - - DataSet_03_170
KCND2 MYC siRNA Colon HT29 0.307303 -1.70227 - - DataSet_03_177
KCND2 PHB shRNA Embryo Embryonic stem cells (ESCs) 0.134333 -2.89612 5.71156304052291e-06 0.00028226492555346 DataSet_03_211
KCND2 REST siRNA Adrenal_gland H295R/TR 0.522835 -0.935573 0.00703450059116197 0.234025690663992 DataSet_03_228
KCND2 SOX11 siRNA Lung_fibroblast NHLF 0.555143 -0.849068 0.233840246370618 0.605371900380696 DataSet_03_238
KCND2 SOX2 siRNA Embryo 2102Ep 0.656009 -0.608213 0.00057667349476761 0.0127992066536208 DataSet_03_242
KCND2 SOX2 siRNA Embryo NTera-2 0.588271 -0.765447 0.00282666628474055 0.0659123714444151 DataSet_03_243
KCND2 SOX4 siRNA Haematopoietic_and_lymphoid_tissue ST1 8.5 3.08746 - - DataSet_03_246
KCND2 SP1 siRNA Mammary_gland MDA-MB-231 0.242368 -2.04473 0.122856412910559 0.413972819854456 DataSet_03_250
KCND2 SP1 siRNA Ovary OVSAYO 0.320826 -1.64014 0.253861803738401 0.585486016820002 DataSet_03_251
KCND2 STAT3 CRISPR Embryo hESC 2.88278 1.52746 0.0723150847100515 0.152347700250093 DataSet_03_258
KCND2 TET1 siRNA Embryo NCCIT 0.525463 -0.92834 9.81684101611794e-05 0.0035189470642873 DataSet_03_269
KCND2 TET2 siRNA Embryo NCCIT 0.45831 -1.1256 2.05607022088448e-06 0.000494029161218088 DataSet_03_270
KCND2 TET3 siRNA Embryo NCCIT 0.489542 -1.0305 1.52062057966563e-05 0.00252370333412508 DataSet_03_273
KCND2 TFAP2C siRNA Mammary_gland MCF7 2.09732 1.06855 0.26616354717794 0.605374604992993 DataSet_03_274
KCND2 TFE3 siRNA Kidney UOK257-2 0.0972643 -3.36195 - - DataSet_03_275
KCND2 CDC5L CRISPR Haematopoietic_and_lymphoid_tissue K562 0.15493 -2.69032 0.0462273894258133 0.124675603225408 DataSet_04_002
KCND2 CHCHD3 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.492958 -1.02046 0.14127461783367 0.915844825866729 DataSet_04_003
KCND2 FUBP3 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.375 -1.41504 0.166611828660114 0.801001232267312 DataSet_04_011
KCND2 DDX17 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.056338 -4.14975 0.0175426721799407 0.541093161687316 DataSet_04_047
KCND2 RIOK2 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.294118 -1.76553 0.460825190658252 0.851896245899863 DataSet_04_076
KCND2 SEPT11 CRISPR Haematopoietic_and_lymphoid_tissue K562 5.5 2.45943 0.428607465896793 1 DataSet_04_077
KCND2 SMG5 CRISPR Haematopoietic_and_lymphoid_tissue K562 3 1.58496 0.697730135405028 0.922479505305576 DataSet_04_073
KCND2 SMG7 CRISPR Haematopoietic_and_lymphoid_tissue K562 3.5 1.80735 0.668257383889809 0.89501536321774 DataSet_04_075
KCND2 SNW1 CRISPR Haematopoietic_and_lymphoid_tissue K562 7 2.80735 0.256475836613 0.415239948554331 DataSet_04_049
KCND2 HMGA1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 6 2.58496 0.71982353537168 0.918346475425495 DataSet_02_75
KCND2 SNW1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.5 -1 0.908378644930689 0.996474203139664 DataSet_02_49
KCND2 ABT1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.315789 -1.66297 0.430479819130268 0.592921766367196 DataSet_04_060
KCND2 CNOT7 shRNA Haematopoietic_and_lymphoid_tissue K562 0.642857 -0.63743 0.721936848855206 0.856672970582564 DataSet_04_061
KCND2 DDX1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.5 -1 0.956376477845189 0.992144575813725 DataSet_04_063
KCND2 PRPF6 shRNA Haematopoietic_and_lymphoid_tissue K562 3 1.58496 0.879757768106649 0.979709432833605 DataSet_04_065
KCND2 UBE2L3 shRNA Haematopoietic_and_lymphoid_tissue K562 0.263158 -1.926 0.12292879303911 0.339943418089026 DataSet_04_062
KCND2 CNOT3 shRNA Lung A549 3.45809 1.78998 3.809038e-01 0.9024382 DataSet_03_340
KCND2 SMARCA4 siRNA Colon HCT116 0.107777 -3.21388 6.449974e-09 2.800095e-06 DataSet_03_301
KCND2 HDAC4 siRNA Liver human hepatocytes 1.93757 0.95425 2.360686e-05 2.302520e-03 DataSet_03_345
KCND2 HDAC5 siRNA Liver human hepatocytes 0.594676 -0.749825 3.991390e-03 2.505731e-02 DataSet_03_346
KCND2 ESR1 siRNA Mammary_gland MCF7 2.26038 1.17656 1.861688e-02 0.1008723720 DataSet_03_352
KCND2 PARP1 siRNA Prostate LNCaP 1.90736 0.931578 1.405592e-01 0.423182999 DataSet_03_354
KCND2 CREBBP CRISPR Brain U5-NPC 2 1 0.5165643664 0.7615550 DataSet_03_356
KCND2 PTPN14 CRISPR Brain U5-NPC 2.5 1.32193 1.561571e-01 0.38719565 DataSet_03_357
KCND2 TP53 CRISPR Brain U5-NPC 6 2.58496 1.585436e-01 2.941865e-01 DataSet_03_358
KCND2 TP53 knockout Stomach SNU1 0.0604709 -4.04762 0.5456453524 0.9509585 DataSet_03_365
KCND2 DNMT3A knockout Embryo_kidney HEK293T 0.112027 -3.15808 - - DataSet_03_369
KCND2 ZFP36L1 siRNA Urinary_bladder J82 6.8 2.76553 - - DataSet_03_371
KCND2 SMARCA2 shRNA Lung NCI-H1944 1.51667 0.600904 1.932182e-01 5.974097e-01 DataSet_03_377
KCND2 YY1 shRNA Brain GSC1517 0.333333 -1.58496 - - DataSet_03_384
KCND2 NFKBIA shRNA Bone_marrow U2OS 0.00107933 -9.85565 5.831928e-01 0.87005461 DataSet_03_389
KCND2 JAZF1 siRNA Cervix HeLa Kyoto 0.50251 -0.992775 5.116785e-01 0.880923310 DataSet_03_396
KCND2 EHF shRNA Stomach MKN7 0.0573074 -4.12513 - - DataSet_03_402
KCND2 JARID2 siRNA Adipose_tissue human adipose tissue derived stem cells 2.05331 1.03795 6.685145e-02 0.3239928 DataSet_03_403
KCND2 LHX2 shRNA Bone_marrow ES-derived RPE cells 0.0740741 -3.75489 4.282981e-04 8.902664e-02 DataSet_03_428
KCND2 USP7 shRNA Skin xenograft cells 0.527273 -0.923379 0.52798835 0.6562701 DataSet_03_431
KCND2 SUFU shRNA Mammary_gland HCC1954 cells 0.566879 -0.818887 0.0898016551 0.6287809 DataSet_03_437
KCND2 FOXA2 CRISPR Liver iPSCs-derived progenitors and mature hepatocytes 0.161017 -2.63472 4.418359e-01 0.92304898 DataSet_03_439
KCND2 CAMTA1 knockout Embryo_kidney HEK293T 0.0526316 -4.24793 6.250948e-03 0.09989252 DataSet_03_448
KCND2 CBX2 siRNA Mammary_gland MCF7 13.8239 3.78909 4.763251e-02 0.1042963050 DataSet_03_451
KCND2 ZFP36L1 CRISPR Lung NCI-H1876 0.640459 -0.642822 8.382017e-01 0.993408056 DataSet_03_454
KCND2 SMARCA2 shRNA Lung HCC2302 0.116982 -3.09564 5.595197e-12 7.218243e-11 DataSet_03_455
KCND2 PPARG siRNA Aortic_valve Valvular endothelial cell 2.5 1.32193 4.236879e-01 7.787967e-01 DataSet_03_456
KCND2 SREBF2 siRNA Umbilical_vein HUVEC 0.266907 -1.90559 6.699607e-03 1.270574e-01 DataSet_03_457
KCND2 ARID1A shRNA Bile_duct MMNK1 0.194969 -2.35869 1.849924e-01 0.486730206 DataSet_03_458
KCND2 SOX9 knockout Liver HuH7 10 3.32193 7.325221e-04 7.352244e-03 DataSet_03_463
KCND2 SMARCA1 Cas13 Embryo_kidney HEK293T 3.5 1.80735 - - DataSet_03_466
KCND2 SMARCA1 CRISPR-Csm Embryo_kidney HEK293T 0.5 -1 - - DataSet_03_467
KCND2 LIN28A siRNA Mammary_gland MCF7M 0.576352 -0.794979 8.586912e-01 0.9860238 DataSet_03_469
KCND2 LIN28A siRNA Mammary_gland MCF7M 0.576352 -0.794979 8.586912e-01 0.9860238 DataSet_03_470
KCND2 EZH2 siRNA Prostate LNCaP 1.83782 0.877995 - - DataSet_03_472
KCND2 EZH2 siRNA Umbilical_vein HUVEC 4 2 3.484912e-01 0.610496283 DataSet_03_473
KCND2 EZH2 siRNA Prostate LNCaP 1.51613 0.600393 3.976099e-01 1.0000000 DataSet_03_475
KCND2 CHCHD3 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.492958 -1.02046 0.1552354 0.8700248 DataSet_04_071
KCND2 APTX CRISPR Haematopoietic_and_lymphoid_tissue K562 0.16 -2.64386 0.3603823 0.7773886 DataSet_04_072
KCND2 CDC5L CRISPR Haematopoietic_and_lymphoid_tissue K562 0.15493 -2.69032 0.03216581 0.091563117 DataSet_04_074
Regulation Region
 
T(co)Fs that significantly regulate HOXC6 by the evidences of both expression and ChIP-seq/motif
Expression Atlas of KCND2
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines