Gene Overview
Target Gene: MMP12
NCBI Official Symbol: MMP12
Entrez ID: 4321
Ensembl ID: ENSG00000262406
Gene Full Name: matrix metallopeptidase 12
Strand: -
Gene Locus: 11q22.2
External Links:

MMP12 Significantly Regulated by These T(co)Fs

T(co)Fs that Activate MMP12   
T(co)Fs that Repress MMP12
The Intensity of the Gene Regulated by T(co)Fs:
MMP12-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
MMP12 ID1 siRNA Lung A549 4.25057 2.08766 0.08281 0.28821 DataSet_01_117
MMP12 ID1 siRNA Lung H1650 0.6433 -0.63644 0.07239 0.4014 DataSet_01_118
MMP12 ZIC2 siRNA Pancreas PANC1 1.67073 0.74048 - - DataSet_01_121
MMP12 FOXM1 siRNA Central_nervous_system U87 15.546 3.95847 - - DataSet_01_122
MMP12 POLR3A siRNA Mammary_gland MCF7 0.29026 -1.78459 - - DataSet_01_139
MMP12 EHF siRNA Corneal_epithelial Corneal epithelial cells 0.13995 -2.83702 2.0767e-07 0.00037 DataSet_01_147
MMP12 MYBL2 shRNA Bone_marrow CD34+ BM cells 0.18401 -2.44212 0.0025 0.15553 DataSet_01_148
MMP12 HSF1 shRNA Skin A375 1.78818 0.83849 0.24839 0.50863 DataSet_01_155
MMP12 ELK1 siRNA Peripheral_blood CD4+ T cells 39.6744 5.31014 2.75646e-09 2.89462e-06 DataSet_01_162
MMP12 JUN siRNA Peripheral_blood CD4+ T cells 58.7033 5.87537 8.16281e-10 1.32802e-06 DataSet_01_164
MMP12 MAF siRNA Peripheral_blood CD4+ T cells 73.3022 6.19579 3.64252e-10 7.11128e-07 DataSet_01_165
MMP12 NFATC3 siRNA Peripheral_blood CD4+ T cells 38199.9 15.2213 0.00027 0.01202 DataSet_01_166
MMP12 STAT3 siRNA Peripheral_blood CD4+ T cells 3.57051 1.83613 0.00513 0.99183 DataSet_01_168
MMP12 GABPA shRNA Prostate C4-2B 1210.83 10.2418 0.23759 0.43934 DataSet_01_190
MMP12 GABPA shRNA Prostate LNCaP 795.247 9.63526 0.46683 0.7048 DataSet_01_191
MMP12 GATA2 siRNA Prostate LNCaP 6.42671 2.68408 0.0042 0.01773 DataSet_01_193
MMP12 CREB1 shRNA Parotid_gland H3118 MEC 1.97004 0.97823 0.69133 0.87891 DataSet_01_194
MMP12 CREB1 shRNA Parotid_gland HSY 0.5584 -0.84063 0.95597 0.99593 DataSet_01_195
MMP12 TP63 siRNA Head_and_neck SCC-6 0.41236 -1.27804 - - DataSet_01_202
MMP12 HIC1 shRNA Mammary_gland HBL100 1.88053 0.91114 - - DataSet_01_205
MMP12 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly10 0.60873 -0.71612 - - DataSet_01_208
MMP12 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly1 0.33028 -1.59825 - - DataSet_01_209
MMP12 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly7 0.46142 -1.11584 - - DataSet_01_210
MMP12 TAL1 shRNA Haematopoietic_and_lymphoid_tissue HEL 0.42477 -1.23526 0.17491 0.34934 DataSet_01_217
MMP12 IRX1 shRNA Bone_marrow 143B 0.61843 -0.69331 0.00191 0.04804 DataSet_01_227
MMP12 FOXA1 siRNA Prostate LNCaP 4.19216 2.0677 9.81087e-05 0.01924 DataSet_01_233
MMP12 TWIST1 shRNA Stomach CAF32 1.5381 0.62115 0.07582 0.18191 DataSet_01_253
MMP12 STAT5 shRNA Prostate CWR22Pc 1.70817 0.77245 0.2559 0.43485 DataSet_01_279
MMP12 AHR siRNA Haematopoietic_and_lymphoid_tissue THP-1 0.15266 -2.71156 2.57258e-08 1.12608e-05 DataSet_01_283
MMP12 ZIC5 siRNA Skin A375 0.63069 -0.665 - - DataSet_01_284
MMP12 SP3 siRNA Haematopoietic_and_lymphoid_tissue JURKAT 1.91128 0.93454 0.32994 0.90748 DataSet_01_290
MMP12 TFAP4 siRNA Brain BE(2)-C 0.32678 -1.61362 0.52986 0.55153 DataSet_01_295
MMP12 ARID1B shRNA Liver IRM90 2.2769 1.18707 1.16188e-07 0.00011 DataSet_01_298
MMP12 ETV5 siRNA Soft_tissue hADSC 1.70792 0.77224 0.00015 0.00653 DataSet_01_304
MMP12 ARNT siRNA Upper_aerodigestive_tract HSC3 3.32292 1.73245 - - DataSet_01_315
MMP12 ARNT shRNA Placenta_tissue CTB 0.62209 -0.68481 0.00909 0.09924 DataSet_01_317
MMP12 ZNF25 siRNA Bone_marrow hMSC-TERT4 2.13729 1.09578 0.1009 0.60755 DataSet_01_319
MMP12 TP63 shRNA Head_and_neck FaDU 0.61882 -0.69241 1e-04 0.00212 DataSet_01_327
MMP12 TP63 shRNA Head_and_neck FaDU 0.61882 -0.69241 1e-04 0.00212 DataSet_01_330
MMP12 KLF7 siRNA Embryo HCE 0.3149 -1.66705 0.18731 0.6419 DataSet_01_340
MMP12 KLF4 siRNA Embryo HCE 1.96491 0.97446 0.0088 0.40408 DataSet_01_341
MMP12 KLF7 siRNA Embryo HCE 1.53019 0.61371 0.07216 0.99985 DataSet_01_342
MMP12 GTF2B siRNA Cervix HeLa 0.66612 -0.58615 - - DataSet_01_362
MMP12 ZNF622 shRNA Liver HepG2 0.625 -0.67807 0.06089 0.10422 DataSet_02_108
MMP12 EWSR1 shRNA Liver HepG2 1.66667 0.73697 0.09143 0.18918 DataSet_02_122
MMP12 ZFX siRNA Prostate C4-2B 2.26667 1.18057 0.03241 0.07542 DataSet_02_172
MMP12 AR siRNA Prostate LNCaP 0.374376 -1.41744 0.0209801979244969 1 DataSet_03_005
MMP12 BCL6 siRNA Lymph OCI-Ly7 DLBCL 0.451664 -1.14668 0.274283588562158 0.84368976220236 DataSet_03_025
MMP12 ESR1 siRNA Uterus Endometrial stromal cells 0.625269 -0.67745 - - DataSet_03_069
MMP12 FLI1 siRNA Haematopoietic_and_lymphoid_tissue THP-1 2.68713 1.42607 0.00120667621765638 0.0964705881378968 DataSet_03_078
MMP12 GATA4 siRNA Stomach KatoIII 2.19511 1.13429 0.132123640679755 0.901745195691908 DataSet_03_106
MMP12 GATA6 siRNA Stomach AGS 0.661253 -0.596725 0.594847512513984 0.901997260940433 DataSet_03_108
MMP12 HNF4a siRNA Liver HepG2 0.48 -1.05889 0.144752951713019 0.764281710272632 DataSet_03_126
MMP12 KLF5 siRNA Stomach KatoIII 2.15604 1.10838 0.148348708602988 0.595833853571272 DataSet_03_150
MMP12 MEF2D shRNA Liver HuH7 1.66508 0.735592 - - DataSet_03_162
MMP12 MITF siRNA Skin Ma-Mel-15 0.649675 -0.622209 0.0582489460930969 0.441125013132422 DataSet_03_166
MMP12 MYB siRNA Cord_Blood CD34+ progenitor cells 4.04107 2.01474 - - DataSet_03_170
MMP12 PHB shRNA Embryo Embryonic stem cells (ESCs) 2.5968 1.37674 0.0899051927854567 0.178712773064904 DataSet_03_211
MMP12 RELA siRNA Fibroblasts WI38 2.66858 1.41607 0.000101047326399647 0.0030419542183356 DataSet_03_222
MMP12 SOX11 siRNA Lung_fibroblast NHLF 0.593535 -0.752596 0.0488854068807893 0.389426550598924 DataSet_03_237
MMP12 SOX4 siRNA Haematopoietic_and_lymphoid_tissue ST1 4.71429 2.23704 - - DataSet_03_246
MMP12 SP1 siRNA Cervix HeLa 2.36325 1.24077 3.77654434965526e-07 9.69680499915467e-05 DataSet_03_249
MMP12 STAT6 siRNA Umbilical_vein HUVEC 13.5 3.75489 0.00507893764935019 0.449662157013787 DataSet_03_264
MMP12 TFE3 siRNA Kidney UOK257-2 0.510084 -0.971193 - - DataSet_03_275
MMP12 SMAD2 CRISPR Liver HepG2 1.875 0.906891 0.303190307725657 0.754700288349316 DataSet_04_034
MMP12 DNMT3B CRISPR Liver HepG2 0.5 -1 0.797582965639263 0.931270972860651 DataSet_04_044
MMP12 RIOK2 CRISPR Liver HepG2 1.66667 0.736966 0.88878037877613 1 DataSet_04_070
MMP12 SEPT11 CRISPR Liver HepG2 3.33333 1.73697 0.449577682783307 0.695989643824109 DataSet_04_068
MMP12 CNOT3 shRNA Lung A549 6.45694 2.69085 1.525987e-01 0.8830540 DataSet_03_340
MMP12 NFKBIZ knockout Colon Colon organoid 0.406788 -1.29765 2.182968e-01 0.687401550 DataSet_03_323
MMP12 SMARCA4 siRNA Colon HCT116 0.444432 -1.16996 3.036452e-02 5.902803e-01 DataSet_03_301
MMP12 ELF3 CRISPR Bile_duct HBDEC2 0.427311 -1.22664 3.468518e-02 8.071671e-02 DataSet_03_304
MMP12 SNAI2 shRNA Pancreas KLM1 0.430776 -1.21499 1.494003e-01 0.50457926 DataSet_03_307
MMP12 ACTR5 siRNA Muscle RD 0.234173 -2.09435 - - DataSet_03_343
MMP12 INO80 siRNA Muscle RD 0.191719 -2.38293 - - DataSet_03_344
MMP12 AEBP1 siRNA Central_nervous_system U87MG 1.66757 0.737751 1.524203e-01 0.9999434 DataSet_03_338
MMP12 BRCA1 siRNA Mammary_gland MCF7 2.33363 1.22258 3.479619e-02 0.9999931 DataSet_03_308
MMP12 TET1 CRISPR Mammary_gland Hs578T 3.6458 1.86624 2.129675e-02 8.022704e-02 DataSet_03_355
MMP12 ZNF148 shRNA Mammary_gland MDA-MB-231 1.78035 0.832159 6.668244e-01 0.820396395 DataSet_03_366
MMP12 DNMT3A knockout Embryo_kidney HEK293T 0.120433 -3.0537 - - DataSet_03_369
MMP12 GLI1 siRNA Skeletal_muscle RMS13 3.73259 1.90018 4.477275e-02 0.180547145 DataSet_03_375
MMP12 NFKB2 siRNA Bone_marrow U2OS 1.75 0.807355 4.321534e-01 0.66947762 DataSet_03_381
MMP12 TCF19 CRISPR Oral_squamous CAL27 0.18191 -2.4587 5.381244e-03 0.0511714390 DataSet_03_383
MMP12 TRIM8 siRNA Mammary_gland MCF7 2 1 7.237458e-01 0.8369401853 DataSet_03_388
MMP12 ILF2 siRNA Stomach SGC-7901 0.5 -1 0.5815873053 0.66041517 DataSet_03_393
MMP12 ASXL1 CRISPR Embryo iPSC 2.06854 1.04861 0.7550805206 0.9410254 DataSet_03_394
MMP12 JAZF1 siRNA Cervix HeLa Kyoto 2.95757 1.56441 2.072910e-01 0.766122791 DataSet_03_396
MMP12 IKZF2 CRISPR Lymph CAR T Cell 3.01744 1.59333 2.947286e-03 0.198755751 DataSet_03_397
MMP12 RELA CRISPR Brain T30 1.75188 0.8089 0.2670294837 0.8400824 DataSet_03_399
MMP12 HMGA1 shRNA Bile_duct HUCCT1 0.521739 -0.9386 6.968157e-01 0.847666568 DataSet_03_400
MMP12 EHF shRNA Stomach MKN7 0.14991 -2.73783 - - DataSet_03_402
MMP12 JARID2 siRNA Adipose_tissue human adipose tissue derived stem cells 1.96429 0.974005 5.287310e-03 0.3239928 DataSet_03_403
MMP12 STRAP knockout Nerve SK-N-AS 0.245877 -2.02399 - - DataSet_03_409
MMP12 FOXQ1 CRISPR Lymph Primary CD4+ T cells 4.4 2.1375 - - DataSet_03_422
MMP12 STAT5B CRISPR Embryo_kidney HEK293 0.4 -1.32193 5.105124e-01 0.809669522 DataSet_03_424
MMP12 FOXP3 CRISPR Peripheral_blood Naive Treg 0.0608108 -4.03953 8.216454e-01 0.923082142 DataSet_03_427
MMP12 STAT3 siRNA Peripheral_blood Monocyte-derived M-CSF macrophages 0.661384 -0.596439 0.7520018921 1 DataSet_03_430
MMP12 USP7 shRNA Skin xenograft cells 0.514286 -0.959358 0.31533198 0.4575764 DataSet_03_431
MMP12 PLAG1 shRNA Cord_blood Lin-CD34+ HSPCs 9.5 3.24793 - - DataSet_03_432
MMP12 EP300 knockout Pancreas HPAF-II orthotopic cells 0.214376 -2.22178 1.044704e-01 2.445876e-01 DataSet_03_436
MMP12 SUFU shRNA Mammary_gland HCC1954 cells 7.2 2.848 0.0262641546 0.4286995 DataSet_03_437
MMP12 FOXA2 CRISPR Liver iPSCs-derived progenitors and mature hepatocytes 7.86229 2.97495 5.353793e-02 0.85132411 DataSet_03_439
MMP12 PPARG siRNA Aortic_valve Valvular endothelial cell 1.66667 0.736966 7.703594e-01 9.288616e-01 DataSet_03_456
MMP12 ARID1A shRNA Bile_duct MMNK1 0.261162 -1.93698 2.239960e-01 0.545953811 DataSet_03_458
MMP12 HAND1 siRNA Placenta HPMVEC 0.5 -1 2.497759e-01 0.9463341 DataSet_03_459
MMP12 PARP1 knockout Embryo_kidney HEK293a 3.04149 1.60478 5.172692e-12 7.183893e-10 DataSet_03_464
Regulation Region
 
T(co)Fs that significantly regulate NFATC3 by the evidences of both expression and ChIP-seq/motif
Expression Atlas of MMP12
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines