Gene Overview
| Target Gene: | Sox8 |
| NCBI Official Symbol: | Sox8 |
| Entrez ID: | 20681 |
| Ensembl ID: | ENSMUSG00000024176 |
| Gene Full Name: | SRY (sex determining region Y)-box 8 |
| Strand: | - |
| Gene Locus: | 17 A3.3|17 12.69 cM |
| External Links: |
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Sox8 Significantly Regulated by These T(co)Fs
T(co)Fs
that Activate Sox8
T(co)Fs
that Repress Sox8
The Intensity of the Gene Regulated by T(co)Fs:
Sox8-T(co)F Pairs
| Target Gene |
T(co)F | Knock -Method |
Tissue Type | Biosample Name |
Fold Change |
Log2FC | P-value | Corrected _P |
Dataset ID |
|---|---|---|---|---|---|---|---|---|---|
| Sox8 | Bcl11a | knockout | Bone_marrow | Bone marrow erythoid progenitors | 0.624855 | -0.678406 | 0.259408233501653 | 0.64448092511072 | DataSet_11_013 |
| Sox8 | Bcl6 | knockout | Bone_marrow | Bone marrow-derived macrophages | 1.74528 | 0.803461 | 0.23693478091111 | 0.609030151304664 | DataSet_11_014 |
| Sox8 | Bhlha9 | knockout | Limb | Whole limb bud | 0.560861 | -0.834284 | - | - | DataSet_11_016 |
| Sox8 | Dmrt1 | knockout | Testis | Testes | 0.658823 | -0.602036 | 0.0286090942076875 | 0.766596077573069 | DataSet_11_024 |
| Sox8 | Foxp1 | knockout | Eye | Lens | 1.69164 | 0.758421 | - | - | DataSet_11_044 |
| Sox8 | Gata2 | knockout | Kidney | renal collecting duct cells | 0.376104 | -1.41079 | - | - | DataSet_11_047 |
| Sox8 | Gata4 | knockout | Intestine | Jejunum | 1.77971 | 0.831644 | 0.239135119034221 | 0.720560347654151 | DataSet_11_049 |
| Sox8 | Irf6 | knockout | Skin | Skin | 0.46733 | -1.09749 | 0.600592206329929 | 0.825505828461833 | DataSet_11_062 |
| Sox8 | Mbd1 | siRNA | Adipose_tissue | 3T3-L1 cells | 0.3625 | -1.46395 | - | - | DataSet_11_074 |
| Sox8 | Neurod1 | knockout | Eye | Retina | 2.41426 | 1.27158 | 0.000203449230393147 | 0.00519033270305566 | DataSet_11_088 |
| Sox8 | Nr2f2 | knockout | Ovary | E14.5 Ovary | 2.08666 | 1.06119 | 0.0727220884780974 | 0.834975080343504 | DataSet_11_094 |
| Sox8 | Otx2 | knockout | Eye | Retina | 0.653268 | -0.614254 | 0.29603548202329 | 0.999923528647439 | DataSet_11_097 |
| Sox8 | Plagl2 | knockout | Intestine | Small intestine | 0.166667 | -2.58496 | 0.00034630802513587 | 0.0143641642665856 | DataSet_11_104 |
| Sox8 | Prox1 | knockout | Liver | Liver | 1.98465 | 0.988887 | - | - | DataSet_11_109 |
| Sox8 | Runx1 | knockout | Lymph | ProB cells | 0.163264 | -2.61472 | 0.00202207302469493 | 0.030103896154166 | DataSet_11_116 |
| Sox8 | Runx2 | knockout | Humeri | Embryonic humeri | 1.88546 | 0.914916 | 0.0736351266849226 | 0.413173823956071 | DataSet_11_120 |
| Sox8 | Sall1 | knockout | Kidney | Kidney | 0.665148 | -0.588253 | 0.0194899837565604 | 0.466676805062465 | DataSet_11_121 |
| Sox8 | Sall1 | knockout | Kidney | Kidney | 0.311836 | -1.68114 | 0.00250608969261726 | 0.31021254257999 | DataSet_11_122 |
| Sox8 | Sall4 | shRNA | Embryo | ES cells | 2.93939 | 1.55552 | 0.29712582972818 | 0.999840995136314 | DataSet_11_123 |
| Sox8 | Smad4 | siRNA | Brain | bEnd3 | 1.8687 | 0.902033 | - | - | DataSet_11_127 |
| Sox8 | Stat3 | knockout | Lung | Lung typeII cells | 0.629505 | -0.66771 | 0.125444264312508 | 0.732515358603484 | DataSet_11_151 |
| Sox8 | Stat4 | knockout | Lymph | Lamina propria lymphocytes | 0.463339 | -1.10986 | 0.282511772935537 | 0.924261066168849 | DataSet_11_152 |
| Sox8 | Wt1 | siRNA | Embryo_kidney | LB-22 | 0.638004 | -0.648364 | 0.240579922063224 | 0.487185029713531 | DataSet_11_179 |
| Sox8 | Wt1 | knockout | Oviduct | Oviduct | 1.68664 | 0.75415 | 0.0811807249677975 | 0.836408276601276 | DataSet_11_180 |
| Sox8 | Dnmt1 | siRNA | Pituitary_gland | AtT-20 | 2.01504 | 1.01081 | 8.815616e-02 | 0.9999923 | DataSet_11_187 |
| Sox8 | Mapk9 | knockout | Hip | Mouse Hip Cartilage | 1.54464 | 0.627272 | 3.977260e-03 | 1.344049e-02 | DataSet_11_236 |
| Sox8 | Ezh2 | knockdown | Brain | Brain | 2.97728 | 1.574 | 1.119594e-03 | 0.0289695999 | DataSet_11_221 |
| Sox8 | Brca1 | knockout | Brain | mouse P7 brain | 0.489974 | -1.02922 | 2.250435e-02 | 0.35557971 | DataSet_11_201 |
| Sox8 | Bcl11b | knockout | Main_olfactory_epithelium | main olfactory epithelium (MOE) | 1.54517 | 0.627767 | - | - | DataSet_11_207 |
| Sox8 | Dnmt3a | knockout | Skeletal_muscle | Satellite cells | 0.357143 | -1.48543 | 2.109446e-01 | 1.0000000 | DataSet_11_208 |
| Sox8 | Dnmt3a | siRNA | Embryo | iPSC | 0.0400274 | -4.64287 | - | - | DataSet_11_241 |
| Sox8 | Lin28a | knockout | Heart | Heart | 0.504426 | -0.987284 | 0.2988884148 | 0.8777652 | DataSet_11_243 |
| Sox8 | Twist1 | knockout | Bone_marrow | stromal cells | 13.56 | 3.76128 | - | - | DataSet_11_244 |
| Sox8 | Kat6a | knockout | Embryo | Embryonic fibroblasts | 1.54955 | 0.631849 | 6.911574e-01 | 0.9063102346 | DataSet_11_245 |
| Sox8 | Dnmt1 | siRNA | Embryo | Embryo | 0.1 | -3.32193 | - | - | DataSet_11_248 |
| Sox8 | Kmt2d | knockout | Skin | iBiP melanoma mouse model tumor cell | 4.58823 | 2.19794 | 3.700172e-02 | 1.220220e-01 | DataSet_11_250 |
| Sox8 | Zbp1 | siRNA | Bone_marrow | bone marrow-derived mesenchymal stem_progenitor cells | 0.155521 | -2.68482 | 2.815732e-01 | 0.479652203 | DataSet_11_252 |
| Sox8 | Eed | knockout | Brain | Forebrain | 0.472178 | -1.0826 | 5.933903e-03 | 1.979791e-01 | DataSet_11_258 |
| Sox8 | Ctnnb1 | knockout | Embryo | MGE cells | 0.513188 | -0.962439 | 5.288950e-04 | 0.022571861 | DataSet_11_266 |
| Sox8 | Dux | knockout | Embryo | Embryo | 23.7686 | 4.57099 | 1.807089e-04 | 1.783128e-03 | DataSet_11_269 |
| Sox8 | Kat6b | shRNA | Bone_marrow | LT-HSCs | 35 | 5.12928 | 1.112456e-01 | 0.5990693 | DataSet_11_271 |
| Sox8 | Myc | CRISPR | Skeletal_muscle | muscle stem cells | 0.000361236 | -11.4348 | 3.419577e-01 | 0.81420760 | DataSet_11_272 |
| Sox8 | Dux | knockout | Embryo | Embryo | 23.7686 | 4.57099 | 1.807081e-04 | 1.782946e-03 | DataSet_11_273 |
| Sox8 | Ssrp1 | CRISPR | Embryo | ES cells | 1.63953 | 0.713287 | 8.898162e-01 | 0.9842027 | DataSet_11_278 |
| Sox8 | Usp7 | siRNA | Embryo | ES cells | 4.8125 | 2.26679 | 9.262657e-02 | 0.6667924 | DataSet_11_287 |
| Sox8 | Ssrp1 | CRISPR | Embryo | ES cells | 1.62069 | 0.696608 | 9.334618e-02 | 0.36277433 | DataSet_11_296 |
| Sox8 | Phf8 | knockout | prostate | Prostate | 11.5 | 3.52356 | 0.4297794188 | 0.6731618 | DataSet_11_298 |
| Sox8 | Arid2 | knockout | Muscle | LSK | 0.368421 | -1.44057 | 2.744050e-01 | 1.000000e+00 | DataSet_11_301 |
| Sox8 | Dnmt1 | knockout | Skin | Keratinocytes | 1.60707 | 0.684431 | 2.095698e-01 | 0.6107308600 | DataSet_11_303 |
| Sox8 | Foxp3 | CRISPR | Spleens_and_lymphnodes | CD4+ Th0 cells | 3.75 | 1.90689 | - | - | DataSet_11_305 |
| Sox8 | Jmjd6 | knockout | Bone_marrow | Lin-Sca1+Kit+ (LSK) haematopoietic stem and progenitor cells | 0.571429 | -0.807355 | - | - | DataSet_11_306 |
| Sox8 | Cited2 | knockout | Haematopoietic_and_lymphoid_tissue | Hematopoietic stem cell (HSC) | 0.344828 | -1.53605 | - | - | DataSet_11_308 |
| Sox8 | Myc | CRISPR | Skeletal_muscle | quiescent muscle stem cell | 34.9213 | 5.12604 | 2.673144e-01 | 0.80359421 | DataSet_11_310 |
| Sox8 | Satb2 | knockout | Colon | Intestine epithelium | 3 | 1.58496 | 3.269022e-01 | 0.6327832480 | DataSet_11_316 |
| Sox8 | Arid1b | knockout | Bone_marrow | bone marrow leukemia cells | 15 | 3.90689 | 9.213042e-02 | 0.3859241700 | DataSet_11_317 |
| Sox8 | Arid2 | knockout | Bone_marrow | bone marrow leukemia cells | 0.5 | -1 | 7.338084e-01 | 0.9135739 | DataSet_11_318 |
| Sox8 | Kat7 | knockout | Thymic_lobes | Thymic epithelial cells | 0.515355 | -0.956363 | 7.734684e-02 | 4.014319e-01 | DataSet_11_319 |
| Sox8 | Kat7 | knockout | Thymic_lobes | Thymic epithelial cells | 0.658298 | -0.603186 | 3.335621e-01 | 5.476355e-01 | DataSet_11_320 |
| Sox8 | Bud31 | knockout | Testis | Spermatogonial stem cells | 0.294978 | -1.76132 | 3.051159e-01 | 0.8600602 | DataSet_11_321 |
| Sox8 | Gata2 | knockout | Brain | Pituitary gland | 3.13333 | 1.6477 | 0.191154799 | 0.9730581 | DataSet_11_322 |
| Sox8 | Snai1 | knockdown | Heart | Heart | 0.341035 | -1.55201 | 6.520960e-02 | 0.20393632 | DataSet_11_326 |
| Sox8 | Tet1 | siRNA | Embryo | Embryonic fibroblasts | 1.51219 | 0.596644 | 7.547317e-01 | 0.9780187 | DataSet_11_327 |
| Sox8 | Ezh2 | knockout | Eye | Retina | 133.216 | 7.05763 | 0.2610210425 | 1.0000000 | DataSet_11_334 |
| Sox8 | Dnmt3a | knockout | Peritoneum | peritoneal macrophages | 2.49649 | 1.3199 | - | - | DataSet_11_336 |
| Sox8 | Gtf2ird1 | knockout | Lip | Lip | 0.525114 | -0.929297 | 3.338843e-02 | 3.411468e-01 | DataSet_11_339 |
| Sox8 | Dnmt1 | siRNA | Heart | embryonic cardiomyocytes | 0.411765 | -1.28011 | 8.890255e-03 | 0.023874000 | DataSet_11_340 |
| Sox8 | Ezh2 | knockout | Small_intestinal_crypts | small intestinal crypts | 0.4 | -1.32193 | 0.1206097542 | 0.1936487 | DataSet_11_341 |
| Sox8 | Pcbp1 | shRNA | Thymus | Th1 | 2 | 1 | 7.323542e-01 | 0.85453009 | DataSet_11_343 |
| Sox8 | Tbx20 | CRISPR | Heart | primary cardiac fibroblasts | 1.59184 | 0.670692 | 1.311407e-02 | 1.00000000 | DataSet_11_348 |
Regulation Region
Expression Atlas of Sox8