About Enhancer

Enhancer ID: E_01_0006
Species: human
Position : chr6:113930322-113932322
Biosample name:
Experiment class : High+Lowthroughput
Enhancer type: Enhancer
Disease: Sepsis
Pubmed ID:  29344006
Enhancer experiment: ChIP,qRT-PCR,Western blot
Enhancer experiment description: HDAC2 can attenuate lipopolysaccharide-induced inflammation by regulating c-Jun and PAI-1 expression in macrophages.

About Target gene

Target gene : HDAC2
Strong evidence: qRT-PCR,qPCR,ChIP,3C
Less strong evidence: RNA-Seq
Target gene experiment description: HDAC2 can attenuate lipopolysaccharide-induced inflammation by regulating c-Jun and PAI-1 expression in macrophages.;Results revealed that PAI-1, TNF, and MIP-2 expression were inhibited by theophylline, an HDAC2 enhancer, in a RAW macrophage cell line, following LPS-induced inflammation.

About TF

TF name : TNF
TF experiment: ChIP,qRT-PCR,Western blot
TF experiment description: HDAC2 can attenuate lipopolysaccharide-induced inflammation by regulating c-Jun and PAI-1 expression in macrophages.;Results revealed that PAI-1, TNF, and MIP-2 expression were inhibited by theophylline, an HDAC2 enhancer, in a RAW macrophage cell line, following LPS-induced inflammation.

About Function

Enhancer function : HDAC2 can attenuate lipopolysaccharide-induced inflammation by regulating c-Jun and PAI-1 expression in macrophages.
Enhancer function experiment: Immunohistochemical staining
Enhancer function
experiment description:		 HDAC2 can attenuate lipopolysaccharide-induced inflammation by regulating c-Jun and PAI-1 expression in macrophages.

About SNP

SNP ID: --

Upstream Pathway Annotation of TF

GeneName Pathway Name Source Gene Number
TNF amb2 Integrin signaling pid 32
TNF Angiopoietin receptor Tie2-mediated signaling pid 50
TNF Apoptosis signaling pathway panther 104
TNF Calcineurin-regulated NFAT-dependent transcription in lymphocytes pid 50
TNF Canonical NF-kappaB pathway pid 24
TNF Caspase Cascade in Apoptosis pid 57
TNF Cellular roles of Anthrax toxin pid 25
TNF Ceramide signaling pathway pid 49
TNF Cytokine gene transcription smpdb 11
TNF Downstream signaling in nave CD8+ T cells pid 69
TNF fluticasone inhibits the reaction [TNF protein results in increased acetylation of HIST4H4 protein] ctd 15
TNF Heterotrimeric GPCR signaling pathway (through G alpha i and pertussis toxin) ( GPCR signaling (pertussis toxin) ) inoh 228
TNF Heterotrimeric GPCR signaling pathway (through G alpha q, PLC beta and ERK cascade) ( GPCR signaling (G alpha q) ) inoh 239
TNF Heterotrimeric GPCR signaling pathway (through G alpha s ACs Epac BRaf and ERKcascade) ( GPCR signaling (G alpha s, Epac and ERK) ) inoh 237
TNF Heterotrimeric GPCR signaling pathway (through_G alpha s_ACs_PKA_BRaf_and_ERKcascade)(canonical) ( GPCR signaling (G alpha s, PKA and ERK) ) inoh 227
TNF Heterotrimeric GTP-binding protein coupled receptor signaling pathway (through G alpha i, adenylate cyclase and cAMP) ( GPCR signaling (G alpha i) ) inoh 228
TNF Heterotrimeric GTP-binding protein coupled receptor signaling pathway (through_G_alpha_s,_cholera_toxin,_adenylate_cyclase_and_cAMP) ( GPCR signaling (cholera toxin) ) inoh 227
TNF HIV-1 Nef: Negative effector of Fas and TNF-alpha pid 33
TNF IL23-mediated signaling events pid 37
TNF IL27-mediated signaling events pid 26
TNF JAK-STAT pathway and regulation pathway ( JAK-STAT pathway and regulation pathway Diagram ) inoh 97
TNF Regulation of TNFR1 signaling reactome 31
TNF RXR and RAR heterodimerization with other nuclear receptor pid 26
TNF Signaling events mediated by HDAC Class I pid 89
TNF TNF receptor signaling pathway pid 46
TNF TNF signaling reactome 7
TNF TNFalpha netpath 274
TNF TNFR1-induced NFkappaB signaling pathway reactome 26
TNF TNFR1-induced proapoptotic signaling reactome 13
TNF TNFR1-mediated ceramide production reactome 6
TNF TNFR1 signaling pathway ( TNFR1 signaling pathway ) inoh 15
TNF TNFR2 non-canonical NF-kB pathway reactome 63
TNF Transcriptional regulation of white adipocyte differentiation reactome 79
TNF TWEAK netpath 35
TNF MAPK signaling pathway kegg 264
TNF Cytokine-cytokine receptor interaction kegg 213
TNF Apoptosis kegg 88
TNF TGF-beta signaling pathway kegg 82
TNF Antigen processing and presentation kegg 75
TNF Toll-like receptor signaling pathway kegg 100
TNF NOD-like receptor signaling pathway kegg 60
TNF RIG-I-like receptor signaling pathway kegg 71
TNF Natural killer cell mediated cytotoxicity kegg 125
TNF T cell receptor signaling pathway kegg 105
TNF Fc epsilon RI signaling pathway kegg 75
TNF Adipocytokine signaling pathway kegg 65
TNF Type II diabetes mellitus kegg 44
TNF Type I diabetes mellitus kegg 42
TNF Alzheimer's disease kegg 167
TNF Amyotrophic lateral sclerosis (ALS) kegg 53
TNF Leishmaniasis kegg 71
TNF Chagas disease kegg 103
TNF Malaria kegg 50
TNF Toxoplasmosis kegg 131
TNF Amoebiasis kegg 103
TNF Hepatitis C kegg 134
TNF Asthma kegg 29
TNF Systemic lupus erythematosus kegg 136
TNF Allograft rejection kegg 37
TNF Graft-versus-host disease kegg 33
TNF Hypertrophic cardiomyopathy (HCM) kegg 78
TNF Dilated cardiomyopathy kegg 85
TNF Hs_Apoptosis-related_network_due_to_altered_Notch3_in_ovarian_cancer_WP2864_79278 wikipathways 51
TNF Hs_Overview_of_nanoparticle_effects_WP3287_89371 wikipathways 7
TNF Hs_Regulation_of_Actin_Cytoskeleton_WP51_79977 wikipathways 36
TNF Hs_Amyotrophic_lateral_sclerosis_(ALS)_WP2447_85186 wikipathways 16
TNF Hs_TNF_related_weak_inducer_of_apoptosis_(TWEAK)_Signaling_Pathway_WP2036_89910 wikipathways 27
TNF Hs_Folate_Metabolism_WP176_85063 wikipathways 33
TNF Hs_Vitamin_B12_Metabolism_WP1533_85340 wikipathways 33
TNF Hs_Oxidative_Damage_WP3941_90810 wikipathways 12
TNF Hs_Cardiac_Hypertrophic_Response_WP2795_85087 wikipathways 23
TNF Hs_Spinal_Cord_Injury_WP2431_87678 wikipathways 21
TNF Hs_Lung_fibrosis_WP3624_91475 wikipathways 23
TNF Hs_Oxidation_by_Cytochrome_P450_WP43_84102 wikipathways 14
TNF Hs_Monoamine_Transport_WP727_90193 wikipathways 24
TNF Hs_Aryl_Hydrocarbon_Receptor_WP2586_91687 wikipathways 16
TNF Hs_Aryl_Hydrocarbon_Receptor_Pathway_WP2873_88902 wikipathways 5
TNF Hs_Type_II_diabetes_mellitus_WP1584_81779 wikipathways 14
TNF Hs_TGF-beta_Signaling_Pathway_WP366_90028 wikipathways 67
TNF Hs_Selenium_Micronutrient_Network_WP15_88908 wikipathways 35

Enhancer associated network

The number on yellow line represents the distance between enhancer and target gene

Expression of target genes for the enhancer

Enhancer associated SNPs