Enhancers are distal cis-regulatory elements that drive lineage-specific transcription. Enhancers are essential for normal tissue and cell development. They also show strict disease, tissue, and cell-type specificity. Here, we present ENdb 2.0, an updated database built for specific diseases, tissues, cell types, cell lines, and exact validation experiments of enhancers.
Here, we present ENdb 2.0 (http://www.licpathway.net/ENdb/index.php), a major update developed to systematically catalog manually curated and experimentally validated enhancers. In ENdb 2.0, we provide 3,523 enhancers validated by biological experiments (a 4.8-fold expansion over version 1.0). Through an article-by-article manual review of full-text literature, we have cataloged enhancers across 1,192 cell lines (a 7.5-fold increase), 66 tissues (a 3.0-fold increase), 112 diseases (a 2.5-fold increase), and 148 cell types (a 1.4-fold increase), ensuring every single genomic coordinate is rigorously backed by manually verified functional assays reported in the original literature. Furthermore, species coverage has expanded from two mammalian models to five phylogenetically diverse species: Homo sapiens, Mus musculus, Danio rerio, Drosophila melanogaster, and Gallus gallus.
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