Enhancers are distal cis-regulatory elements that drive lineage-specific transcription. Enhancers are essential for normal tissue and cell development. They also show strict disease, tissue, and cell-type specificity. Here, we present ENdb 2.0, an updated database built for specific diseases, tissues, cell types, cell lines, and exact validation experiments of enhancers.
Here, we present ENdb 2.0 (http://www.licpathway.net/ENdb/index.php), The literature coverage has been extended from 2019 to 2026, and the curation strategy has been expanded from PubMed alone to PubMed, Google Scholar and publisher websites, using broader enhancer-related search terms. Species coverage has increased from two species to five species including Homo sapiens, Mus musculus, Drosophila melanogaster, Danio rerio and Rattus norvegicus. Through article-by-article manual review of primary literature, ENdb 2.0 now contains 4,831 curated enhancer evidence records, representing a 6.55-fold increase over the 737 records in ENdb 1.0. Among these, 2,793 records define enhancer-TF-target-gene relationships, representing a 5.30-fold increase over the 527 records in ENdb 1.0. Compared with ENdb 1.0, ENdb 2.0 also expands transcription factor coverage from 263 to 496 (1.89-fold), target-gene coverage from 384 to 1,070 (2.79-fold), disease coverage from 110 to 226 (2.05-fold), tissue coverage from 22 to 169 (7.68-fold), cell-type coverage from 108 to 415 (3.84-fold), and cell-source coverage from 266 to 1,255 (4.72-fold). Species coverage increased 2.50-fold, from two to five species.
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