About Enhancer

Enhancer ID: E_01_0065
Species: human
Position : chr12:57092763-57094763
Biosample name:
Experiment class : High+Lowthroughput
Enhancer type: Enhancer
Disease: --
Pubmed ID:  28774779
Enhancer experiment: ChIP,ChIP-seq,RNA-Seq,qPCR
Enhancer experiment description: Our results suggest that there is a novel, so far uncharacterized cistromic crosstalk between RXR and STAT6 that is likely to contribute to the formation of the active enhancer repertoire, transcriptome and differential signal-specific gene regulation of polarized macrophages.

About Target gene

Target gene : --
Strong evidence: qRT-PCR,qPCR,ChIP,3C
Less strong evidence: RNA-Seq
Target gene experiment description: Our results suggest that there is a novel, so far uncharacterized cistromic crosstalk between RXR and STAT6 that is likely to contribute to the formation of the active enhancer repertoire, transcriptome and differential signal-specific gene regulation of polarized macrophages.

About TF

TF name : STAT6(D12S1644,IL-4-STATB,STAT6C,STAT6)
TF experiment: ChIP,ChIP-seq,RNA-Seq,qPCR
TF experiment description: Our results suggest that there is a novel, so far uncharacterized cistromic crosstalk between RXR and STAT6 that is likely to contribute to the formation of the active enhancer repertoire, transcriptome and differential signal-specific gene regulation of polarized macrophages.

About Function

Enhancer function : Our results suggest that there is a novel, so far uncharacterized cistromic crosstalk between RXR and STAT6 that is likely to contribute to the formation of the active enhancer repertoire, transcriptome and differential signal-specific gene regulation of polarized macrophages.
Enhancer function experiment: Immunohistochemical staining
Enhancer function
experiment description:
Our results suggest that there is a novel, so far uncharacterized cistromic crosstalk between RXR and STAT6 that is likely to contribute to the formation of the active enhancer repertoire, transcriptome and differential signal-specific gene regulation of polarized macrophages.

About SNP

SNP ID: --

Upstream Pathway Annotation of TF

GeneName Pathway Name Source Gene Number
STAT6 Downstream signal transduction reactome 29
STAT6 EGF receptor signaling pathway panther 109
STAT6 Gene expression of SOCS by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram ) inoh 14
STAT6 Gene expression of SOCS1 by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram ) inoh 8
STAT6 Gene expression of SOCS3 by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram ) inoh 8
STAT6 IL-13 signaling pathway(JAK1 TYK2 STAT6) ( IL-13 signaling(JAK1 TYK2 STAT6) ) inoh 10
STAT6 IL-4 signaling pathway(JAK1 JAK3 STAT6) ( IL-4 signaling(JAK1 JAK3 STAT6) ) inoh 7
STAT6 IL12-mediated signaling events pid 62
STAT6 IL4-mediated signaling events pid 66
STAT6 IL4 netpath 75
STAT6 IL9 netpath 24
STAT6 Interleukin signaling pathway panther 86
STAT6 JAK-STAT pathway and regulation pathway ( JAK-STAT pathway and regulation pathway Diagram ) inoh 97
STAT6 JAK/STAT signaling pathway panther 15
STAT6 PDGF signaling pathway panther 113
STAT6 Positive regulation of (Transcription of SOCS by STAT dimer) in JAK STAT pathway ( JAK-STAT pathway and regulation pathway Diagram ) inoh 178
STAT6 Signaling events mediated by TCPTP pid 40
STAT6 TSLP netpath 24
STAT6 Jak-STAT signaling pathway kegg 149
STAT6 Hs_Tryptophan_metabolism_WP465_85055 wikipathways 45
STAT6 Hs_Cytokines_and_Inflammatory_Response_WP530_79331 wikipathways 21
STAT6 Hs_TGF-beta_Receptor_Signaling_WP560_90187 wikipathways 28
STAT6 Hs_G1_to_S_cell_cycle_control_WP45_80001 wikipathways 8
STAT6 Hs_IL-4_Signaling_Pathway_WP395_89828 wikipathways 41

Enhancer associated network

The number on yellow line represents the distance between enhancer and target gene

Expression of target genes for the enhancer


Enhancer associated SNPs