About Enhancer

Enhancer ID: E_01_0118
Species: human
Position : chr19:1606379-1608379
Biosample name:
Experiment class : High+Lowthroughput
Enhancer type: Enhancer
Disease: --
Pubmed ID:  31851943
Enhancer experiment: Dna-fish, Western blot, flow cytometry
Enhancer experiment description: Loss-of-function studies of TCF3 confirm the role of TCF3 in mediating condition-specific enhancer-promoter interactions and gene regulation in fetal HSCs.

About Target gene

Target gene : --
Strong evidence: qRT-PCR,qPCR,ChIP,3C
Less strong evidence: RNA-Seq
Target gene experiment description: Loss-of-function studies of TCF3 confirm the role of TCF3 in mediating condition-specific enhancer-promoter interactions and gene regulation in fetal HSCs.

About TF

TF name : TCF7L1
TF experiment: DNA-FISH? Western blot??????
TF experiment description: Loss-of-function studies of TCF3 confirm the role of TCF3 in mediating condition-specific enhancer-promoter interactions and gene regulation in fetal HSCs.

About Function

Enhancer function : Loss-of-function studies of TCF3 confirm the role of TCF3 in mediating condition-specific enhancer-promoter interactions and gene regulation in fetal HSCs.
Enhancer function experiment: Immunohistochemical staining
Enhancer function
experiment description:		 Loss-of-function studies of TCF3 confirm the role of TCF3 in mediating condition-specific enhancer-promoter interactions and gene regulation in fetal HSCs.

About SNP

SNP ID: --

Upstream Pathway Annotation of TF

GeneName Pathway Name Source Gene Number
TCF7L1 Alzheimer disease-presenilin pathway panther 98
TCF7L1 Binding of TCF/LEF:CTNNB1 to target gene promoters reactome 7
TCF7L1 Ca2+ pathway reactome 62
TCF7L1 Cadherin signaling pathway panther 147
TCF7L1 Canonical Wnt signaling pathway ( C. elegans endoderm induction Wnt signaling pathway Diagram ) inoh 56
TCF7L1 Canonical Wnt signaling pathway ( Canonical Wnt signaling pathway Diagram ) inoh 56
TCF7L1 Canonical Wnt signaling pathway ( Drosophila Wingless/Wnt signaling pathway Diagram ) inoh 56
TCF7L1 Canonical Wnt signaling pathway ( Mammalian Wnt signaling pathway Diagram ) inoh 56
TCF7L1 Canonical Wnt signaling pathway ( Xenopus axis formation Wnt signaling pathway Diagram ) inoh 56
TCF7L1 Deactivation of the beta-catenin transactivating complex reactome 42
TCF7L1 Formation of the beta-catenin:TCF transactivating complex reactome 88
TCF7L1 Mammalian Wnt signaling pathway ( Mammalian Wnt signaling pathway Diagram ) inoh 49
TCF7L1 Regulation of nuclear beta catenin signaling and target gene transcription pid 80
TCF7L1 Repression of WNT target genes reactome 14
TCF7L1 Signaling with Wnt (Canonical) ( C. elegans endoderm induction Wnt signaling pathway Diagram ) inoh 47
TCF7L1 Signaling with Wnt (Canonical) ( Canonical Wnt signaling pathway Diagram ) inoh 47
TCF7L1 Signaling with Wnt (Canonical) ( Drosophila Wingless/Wnt signaling pathway Diagram ) inoh 47
TCF7L1 Signaling with Wnt (Canonical) ( Mammalian Wnt signaling pathway Diagram ) inoh 47
TCF7L1 Signaling with Wnt (Canonical) ( Xenopus axis formation Wnt signaling pathway Diagram ) inoh 47
TCF7L1 Signaling with Wnt (Mammal) ( Mammalian Wnt signaling pathway Diagram ) inoh 47
TCF7L1 Signaling with Wnt (Xenopus) ( Xenopus axis formation Wnt signaling pathway Diagram ) inoh 19
TCF7L1 Signaling without Wnt (Canonical) ( C. elegans endoderm induction Wnt signaling pathway Diagram ) inoh 8
TCF7L1 Signaling without Wnt (Canonical) ( Canonical Wnt signaling pathway Diagram ) inoh 8
TCF7L1 Signaling without Wnt (Canonical) ( Drosophila Wingless/Wnt signaling pathway Diagram ) inoh 8
TCF7L1 Signaling without Wnt (Canonical) ( Mammalian Wnt signaling pathway Diagram ) inoh 8
TCF7L1 Signaling without Wnt (Canonical) ( Xenopus axis formation Wnt signaling pathway Diagram ) inoh 8
TCF7L1 Signaling without Wnt (Mammal) ( Mammalian Wnt signaling pathway Diagram ) inoh 8
TCF7L1 Validated transcriptional targets of deltaNp63 isoforms pid 47
TCF7L1 Wnt signaling pathway panther 250
TCF7L1 Wnt signaling pathway kegg 135
TCF7L1 Adherens junction kegg 70
TCF7L1 Melanogenesis kegg 100
TCF7L1 Pathways in cancer kegg 321
TCF7L1 Colorectal cancer kegg 63
TCF7L1 Endometrial cancer kegg 52
TCF7L1 Prostate cancer kegg 85
TCF7L1 Acute myeloid leukemia kegg 53
TCF7L1 Arrhythmogenic right ventricular cardiomyopathy (ARVC) kegg 71
TCF7L1 Hs_White_fat_cell_differentiation_WP3946_90940 wikipathways 30
TCF7L1 Hs_Mesodermal_Commitment_Pathway_WP2857_87780 wikipathways 47
TCF7L1 Hs_Ectoderm_Differentiation_WP2858_89329 wikipathways 56

Enhancer associated network

The number on yellow line represents the distance between enhancer and target gene

Expression of target genes for the enhancer

Enhancer associated SNPs