About Enhancer
| Enhancer ID: |
E_01_0148 |
| Species: |
human |
| Position :
|
chr7:99754049-99756049
  |
| Biosample name: |
|
| Experiment class :
|
High+Lowthroughput |
| Enhancer type: |
Enhancer |
| Disease: |
-- |
| Pubmed ID: |
29559957
|
| Enhancer experiment: |
Plasmid construction?In vitro methylation?Luciferase reporter assay?Transfection and rifampicin induction?RNA isolation and real-time quantitative polymerase chain reaction (RT-qPCR) ?ChIP assay |
| Enhancer experiment description: |
The expression and activity of CYP3A4 vary among individuals. With the development of epigenetics, it is now possible to elucidate interindividual differences in drug-metabolizing enzymes. |
About Target gene
| Target gene : |
CYP3A4 |
| Strong evidence: |
qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: |
RNA-Seq |
| Target gene experiment description: |
The expression and activity of CYP3A4 vary among individuals. With the development of epigenetics, it is now possible to elucidate interindividual differences in drug-metabolizing enzymes. |
About TF
| TF name : |
-- |
| TF experiment: |
Plasmid construction?In vitro methylation?Luciferase reporter assay?Transfection and rifampicin induction?RNA isolation and real-time quantitative polymerase chain reaction (RT-qPCR) ?ChIP assay |
| TF experiment description: |
The expression and activity of CYP3A4 vary among individuals. With the development of epigenetics, it is now possible to elucidate interindividual differences in drug-metabolizing enzymes. |
About Function
| Enhancer function : |
The expression and activity of CYP3A4 vary among individuals. With the development of epigenetics, it is now possible to elucidate interindividual differences in drug-metabolizing enzymes. |
| Enhancer function experiment: |
Immunohistochemical staining |
Enhancer function
experiment description: |
The expression and activity of CYP3A4 vary among individuals. With the development of epigenetics, it is now possible to elucidate interindividual differences in drug-metabolizing enzymes. |
About SNP
Upstream Pathway Annotation of TF
| GeneName |
Pathway Name |
Source |
Gene Number |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene
Expression of target genes for the
enhancer
Enhancer associated SNPs