About Enhancer
| Enhancer ID: | E_01_0170 |
| Species: | human |
| Position : | chr6:31161443-31163443   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | -- |
| Pubmed ID: | 31182783 |
| Enhancer experiment: | PCR |
| Enhancer experiment description: | OCT4, also named POU5F1, is the main regulator of pluripotency in stem cells1 It also has a part in tumorigenesis, cellular stress response, and hence is linked to various diseases from cancer to autoimmune disorders 24 .OCT4 possesses several isoforms with different functions at both protein and transcript levels, and their expressions are regulated through different mechanisms and at various biological processes 5,6 |
About Target gene
| Target gene : | -- |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | OCT4, also named POU5F1, is the main regulator of pluripotency in stem cells1 It also has a part in tumorigenesis, cellular stress response, and hence is linked to various diseases from cancer to autoimmune disorders 24 .OCT4 possesses several isoforms with different functions at both protein and transcript levels, and their expressions are regulated through different mechanisms and at various biological processes 5,6 |
About TF
| TF name : | POU5F1(OCT3,OCT4,OTF-3,OTF3,OTF4,Oct-3,Oct-4) |
| TF experiment: | PCR |
| TF experiment description: | OCT4, also named POU5F1, is the main regulator of pluripotency in stem cells1 It also has a part in tumorigenesis, cellular stress response, and hence is linked to various diseases from cancer to autoimmune disorders 24 .OCT4 possesses several isoforms with different functions at both protein and transcript levels, and their expressions are regulated through different mechanisms and at various biological processes 5,6 |
About Function
| Enhancer function : | OCT4, also named POU5F1, is the main regulator of pluripotency in stem cells1 It also has a part in tumorigenesis, cellular stress response, and hence is linked to various diseases from cancer to autoimmune disorders 24 .OCT4 possesses several isoforms with different functions at both protein and transcript levels, and their expressions are regulated through different mechanisms and at various biological processes 5,6 |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
OCT4, also named POU5F1, is the main regulator of pluripotency in stem cells1 It also has a part in tumorigenesis, cellular stress response, and hence is linked to various diseases from cancer to autoimmune disorders 24 .OCT4 possesses several isoforms with different functions at both protein and transcript levels, and their expressions are regulated through different mechanisms and at various biological processes 5,6 |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| POU5F1 | HIF-2-alpha transcription factor network | pid | 34 |
| POU5F1 | POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | reactome | 13 |
| POU5F1 | POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | reactome | 10 |
| POU5F1 | Transcriptional regulation of pluripotent stem cells | reactome | 28 |
| POU5F1 | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 |
| POU5F1 | Hs_Wnt_Signaling_Pathway_and_Pluripotency_WP399_90291 | wikipathways | 12 |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene