About Enhancer
| Enhancer ID: | E_01_0194 |
| Species: | human |
| Position : | chr18:55219450-55221450   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Osteosarcoma |
| Pubmed ID: | 31665067 |
| Enhancer experiment: | Flow cytometry,PCR,Western blot |
| Enhancer experiment description: | While pro_x0002_moting the transcription of tumor suppressors genes,RUVBL1 was revealed to promote ?-catenin-mediated neoplastic transformation by forming chromatin remod_x0002_eling complex with TIP60 and thus promotes histone H4 acetylation in the promoter region of ITF-2 gene and enhances the transcriptional activity of TCF4 [42]. |
About Target gene
| Target gene : | MYO10 |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | While pro_x0002_moting the transcription of tumor suppressors genes,RUVBL1 was revealed to promote ?-catenin-mediated neoplastic transformation by forming chromatin remod_x0002_eling complex with TIP60 and thus promotes histone H4 acetylation in the promoter region of ITF-2 gene and enhances the transcriptional activity of TCF4 [42].;In this study, we identified the oncogenic role of cir_x0002_cMYO10, a circRNA that is upregulated in OS [44]. |
About TF
| TF name : | TCF4(E2-2,FECD3,ITF-2,ITF2,PTHS,SEF-2,SEF2,SEF2-1,SEF2-1A,SEF2-1B,SEF2-1D,TCF-4,bHLHb19) |
| TF experiment: | Flow cytometry,PCR,Western blot |
| TF experiment description: | While pro_x0002_moting the transcription of tumor suppressors genes,RUVBL1 was revealed to promote ?-catenin-mediated neoplastic transformation by forming chromatin remod_x0002_eling complex with TIP60 and thus promotes histone H4 acetylation in the promoter region of ITF-2 gene and enhances the transcriptional activity of TCF4 [42].;In this study, we identified the oncogenic role of cir_x0002_cMYO10, a circRNA that is upregulated in OS [44]. |
About Function
| Enhancer function : | While pro_x0002_moting the transcription of tumor suppressors genes,RUVBL1 was revealed to promote ?-catenin-mediated neoplastic transformation by forming chromatin remod_x0002_eling complex with TIP60 and thus promotes histone H4 acetylation in the promoter region of ITF-2 gene and enhances the transcriptional activity of TCF4 [42]. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
While pro_x0002_moting the transcription of tumor suppressors genes,RUVBL1 was revealed to promote ?-catenin-mediated neoplastic transformation by forming chromatin remod_x0002_eling complex with TIP60 and thus promotes histone H4 acetylation in the promoter region of ITF-2 gene and enhances the transcriptional activity of TCF4 [42]. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| TCF4 | AndrogenReceptor | netpath | 167 |
| TCF4 | CDO in myogenesis | reactome | 29 |
| TCF4 | Coregulation of Androgen receptor activity | pid | 61 |
| TCF4 | Formation of the beta-catenin:TCF transactivating complex | reactome | 88 |
| TCF4 | ID | netpath | 38 |
| TCF4 | Regulation of nuclear beta catenin signaling and target gene transcription | pid | 80 |
| TCF4 | TGF_beta_Receptor | netpath | 220 |
| TCF4 | Wnt | netpath | 118 |
| TCF4 | Hs_Corticotropin-releasing_hormone_signaling_pathway_WP2355_90017 | wikipathways | 41 |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene