About Enhancer
| Enhancer ID: | E_01_0251 |
| Species: | human |
| Position : | chr1:10633990-10635990   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Chronic venous disease |
| Pubmed ID: | 31570750 |
| Enhancer experiment: | PCR,Flow cytometry |
| Enhancer experiment description: | This study demonstrates that the CASZ1 gene associated C-allele of rs11121615 has a signifcant, reproducible, association with CVD (CEAP C?2 meta-odds ratio 1.31, 95% CI 1.271.34, P=110?98, PHet=0.25), but not with non-varicose vein (CEAP C1, telangiectasia or reticular veins) forms of venous disease. |
About Target gene
| Target gene : | CASZ1 |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | This study demonstrates that the CASZ1 gene associated C-allele of rs11121615 has a signifcant, reproducible, association with CVD (CEAP C?2 meta-odds ratio 1.31, 95% CI 1.271.34, P=110?98, PHet=0.25), but not with non-varicose vein (CEAP C1, telangiectasia or reticular veins) forms of venous disease. |
About TF
| TF name : | -- |
| TF experiment: | PCR,Flow cytometry |
| TF experiment description: | This study demonstrates that the CASZ1 gene associated C-allele of rs11121615 has a signifcant, reproducible, association with CVD (CEAP C?2 meta-odds ratio 1.31, 95% CI 1.271.34, P=110?98, PHet=0.25), but not with non-varicose vein (CEAP C1, telangiectasia or reticular veins) forms of venous disease. |
About Function
| Enhancer function : | This study demonstrates that the CASZ1 gene associated C-allele of rs11121615 has a signifcant, reproducible, association with CVD (CEAP C?2 meta-odds ratio 1.31, 95% CI 1.271.34, P=110?98, PHet=0.25), but not with non-varicose vein (CEAP C1, telangiectasia or reticular veins) forms of venous disease. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
This study demonstrates that the CASZ1 gene associated C-allele of rs11121615 has a signifcant, reproducible, association with CVD (CEAP C?2 meta-odds ratio 1.31, 95% CI 1.271.34, P=110?98, PHet=0.25), but not with non-varicose vein (CEAP C1, telangiectasia or reticular veins) forms of venous disease. |
About SNP
| SNP ID: | rs11121615 |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene