About Enhancer

Enhancer ID: E_01_0280
Species: human
Position : chr9:21074265-21076265
Biosample name:
Experiment class : High+Lowthroughput
Enhancer type: Enhancer
Disease: Cervical carcinoma
Pubmed ID:  31513772
Enhancer experiment: PCR, Western blot, flow cytometry, immunofluorescence staining
Enhancer experiment description: We constructed IFNB1 luciferase reporter plasmids composed of IFNB1 immediate promoter followed by these enhancers (Figure S6D).

About Target gene

Target gene : --
Strong evidence: qRT-PCR,qPCR,ChIP,3C
Less strong evidence: RNA-Seq
Target gene experiment description: We constructed IFNB1 luciferase reporter plasmids composed of IFNB1 immediate promoter followed by these enhancers (Figure S6D).

About TF

TF name : IFNB1
TF experiment: PCR,Western blot,Flow cytometry,??????
TF experiment description: We constructed IFNB1 luciferase reporter plasmids composed of IFNB1 immediate promoter followed by these enhancers (Figure S6D).

About Function

Enhancer function : We constructed IFNB1 luciferase reporter plasmids composed of IFNB1 immediate promoter followed by these enhancers (Figure S6D).
Enhancer function experiment: Immunohistochemical staining
Enhancer function
experiment description:
We constructed IFNB1 luciferase reporter plasmids composed of IFNB1 immediate promoter followed by these enhancers (Figure S6D).

About SNP

SNP ID: --

Upstream Pathway Annotation of TF

GeneName Pathway Name Source Gene Number
IFNB1 Factors involved in megakaryocyte development and platelet production reactome 111
IFNB1 Heterotrimeric GPCR signaling pathway (through G alpha i and pertussis toxin) ( GPCR signaling (pertussis toxin) ) inoh 228
IFNB1 Heterotrimeric GPCR signaling pathway (through G alpha q, PLC beta and ERK cascade) ( GPCR signaling (G alpha q) ) inoh 239
IFNB1 Heterotrimeric GPCR signaling pathway (through G alpha s ACs Epac BRaf and ERKcascade) ( GPCR signaling (G alpha s, Epac and ERK) ) inoh 237
IFNB1 Heterotrimeric GPCR signaling pathway (through_G alpha s_ACs_PKA_BRaf_and_ERKcascade)(canonical) ( GPCR signaling (G alpha s, PKA and ERK) ) inoh 227
IFNB1 Heterotrimeric GTP-binding protein coupled receptor signaling pathway (through G alpha i, adenylate cyclase and cAMP) ( GPCR signaling (G alpha i) ) inoh 228
IFNB1 Heterotrimeric GTP-binding protein coupled receptor signaling pathway (through_G_alpha_s,_cholera_toxin,_adenylate_cyclase_and_cAMP) ( GPCR signaling (cholera toxin) ) inoh 227
IFNB1 Interferon alpha/beta signaling reactome 67
IFNB1 JAK-STAT pathway and regulation pathway ( JAK-STAT pathway and regulation pathway Diagram ) inoh 97
IFNB1 Oxidative Stress Induced Senescence reactome 120
IFNB1 Regulation of IFNA signaling reactome 26
IFNB1 Regulation of nuclear SMAD2/3 signaling pid 82
IFNB1 TRAF3-dependent IRF activation pathway reactome 14
IFNB1 TRAF6 mediated IRF7 activation reactome 33
IFNB1 Cytokine-cytokine receptor interaction kegg 213
IFNB1 Toll-like receptor signaling pathway kegg 100
IFNB1 RIG-I-like receptor signaling pathway kegg 71
IFNB1 Cytosolic DNA-sensing pathway kegg 56
IFNB1 Jak-STAT signaling pathway kegg 149
IFNB1 Natural killer cell mediated cytotoxicity kegg 125
IFNB1 Chagas disease kegg 103
IFNB1 Hepatitis C kegg 134
IFNB1 Hs_Toll-like_Receptor_Signaling_Pathway_WP75_83867 wikipathways 17
IFNB1 Hs_Type_II_interferon_signaling_(IFNG)_WP619_71168 wikipathways 10
IFNB1 Hs_TLR4_Signaling_and_Tolerance_WP3851_90114 wikipathways 8
IFNB1 Hs_Osteoclast_Signaling_WP12_88602 wikipathways 7

Enhancer associated network

The number on yellow line represents the distance between enhancer and target gene

Expression of target genes for the enhancer


Enhancer associated SNPs