About Enhancer
| Enhancer ID: | E_01_0295 |
| Species: | human |
| Position : | chr4:73737463-73739463   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Acute kidney injury |
| Pubmed ID: | 30688289 |
| Enhancer experiment: | PCR, Western blots, sequencing technology |
| Enhancer experiment description: | Quantitative real-time polymerase chain reaction (qRT-PCR) and Western blot were performed to determine the expressions of inflammatory cytokines including interleukin (IL)-1?, IL-6, tumor necrosis factor-? (TNF-?), apoptosis-related genes, and the downstream target genes of NF-?B signaling pathway, including NFKBIA, CXCL8, and cyclin D1. |
About Target gene
| Target gene : | -- |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Quantitative real-time polymerase chain reaction (qRT-PCR) and Western blot were performed to determine the expressions of inflammatory cytokines including interleukin (IL)-1?, IL-6, tumor necrosis factor-? (TNF-?), apoptosis-related genes, and the downstream target genes of NF-?B signaling pathway, including NFKBIA, CXCL8, and cyclin D1. |
About TF
| TF name : | CXCL8 |
| TF experiment: | PCR?Western blots,???? |
| TF experiment description: | Quantitative real-time polymerase chain reaction (qRT-PCR) and Western blot were performed to determine the expressions of inflammatory cytokines including interleukin (IL)-1?, IL-6, tumor necrosis factor-? (TNF-?), apoptosis-related genes, and the downstream target genes of NF-?B signaling pathway, including NFKBIA, CXCL8, and cyclin D1. |
About Function
| Enhancer function : | Quantitative real-time polymerase chain reaction (qRT-PCR) and Western blot were performed to determine the expressions of inflammatory cytokines including interleukin (IL)-1?, IL-6, tumor necrosis factor-? (TNF-?), apoptosis-related genes, and the downstream target genes of NF-?B signaling pathway, including NFKBIA, CXCL8, and cyclin D1. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Quantitative real-time polymerase chain reaction (qRT-PCR) and Western blot were performed to determine the expressions of inflammatory cytokines including interleukin (IL)-1?, IL-6, tumor necrosis factor-? (TNF-?), apoptosis-related genes, and the downstream target genes of NF-?B signaling pathway, including NFKBIA, CXCL8, and cyclin D1. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene