About Enhancer

Enhancer ID: E_01_0297
Species: human
Position : chr17:43041963-43043963
Biosample name:
Experiment class : High+Lowthroughput
Enhancer type: Enhancer
Disease: Mammary cancer
Pubmed ID:  30683142
Enhancer experiment: PCR, sequencing technology
Enhancer experiment description: o provide insights into alternative classification and potential therapeutic targeting strategies of BRCA1-like hormone-receptor-positive tumors we developed and applied a novel copy number classifier to identify BRCA1-like hormone-receptor-positive tumors and their characteristic somatic alteration profiles.

About Target gene

Target gene : --
Strong evidence: qRT-PCR,qPCR,ChIP,3C
Less strong evidence: RNA-Seq
Target gene experiment description: o provide insights into alternative classification and potential therapeutic targeting strategies of BRCA1-like hormone-receptor-positive tumors we developed and applied a novel copy number classifier to identify BRCA1-like hormone-receptor-positive tumors and their characteristic somatic alteration profiles.

About TF

TF name : BRCA1
TF experiment: PCR?????
TF experiment description: o provide insights into alternative classification and potential therapeutic targeting strategies of BRCA1-like hormone-receptor-positive tumors we developed and applied a novel copy number classifier to identify BRCA1-like hormone-receptor-positive tumors and their characteristic somatic alteration profiles.

About Function

Enhancer function : o provide insights into alternative classification and potential therapeutic targeting strategies of BRCA1-like hormone-receptor-positive tumors we developed and applied a novel copy number classifier to identify BRCA1-like hormone-receptor-positive tumors and their characteristic somatic alteration profiles.
Enhancer function experiment: Immunohistochemical staining
Enhancer function
experiment description:		 o provide insights into alternative classification and potential therapeutic targeting strategies of BRCA1-like hormone-receptor-positive tumors we developed and applied a novel copy number classifier to identify BRCA1-like hormone-receptor-positive tumors and their characteristic somatic alteration profiles.

About SNP

SNP ID: --

Upstream Pathway Annotation of TF

GeneName Pathway Name Source Gene Number
BRCA1 AndrogenReceptor netpath 167
BRCA1 ATF-2 transcription factor network pid 59
BRCA1 ATM pathway pid 34
BRCA1 Aurora A signaling pid 33
BRCA1 BARD1 signaling events pid 29
BRCA1 Coregulation of Androgen receptor activity pid 61
BRCA1 E2F transcription factor network pid 77
BRCA1 Fanconi anemia pathway pid 48
BRCA1 FOXA1 transcription factor network pid 45
BRCA1 G2/M DNA damage checkpoint reactome 84
BRCA1 HDR through Homologous Recombination (HRR) reactome 46
BRCA1 HDR through Single Strand Annealing (SSA) reactome 37
BRCA1 Homologous DNA Pairing and Strand Exchange reactome 25
BRCA1 Meiotic recombination reactome 85
BRCA1 Meiotic synapsis reactome 76
BRCA1 Nonhomologous End-Joining (NHEJ) reactome 69
BRCA1 Presynaptic phase of homologous DNA pairing and strand exchange reactome 39
BRCA1 Processing of DNA double-strand break ends reactome 98
BRCA1 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks reactome 75
BRCA1 Regulation of TP53 Activity through Phosphorylation reactome 89
BRCA1 Resolution of D-loop Structures through Holliday Junction Intermediates reactome 33
BRCA1 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) reactome 26
BRCA1 SUMOylation of DNA damage response and repair proteins reactome 76
BRCA1 TGF_beta_Receptor netpath 220
BRCA1 TP53 Regulates Transcription of DNA Repair Genes reactome 61
BRCA1 Validated nuclear estrogen receptor alpha network pid 65
BRCA1 Validated targets of C-MYC transcriptional repression pid 63
BRCA1 Hs_DNA_Damage_Response_WP707_82937 wikipathways 28
BRCA1 Hs_miRNA_Regulation_of_DNA_Damage_Response_WP1530_84694 wikipathways 28
BRCA1 Hs_Hepatitis_C_and_Hepatocellular_Carcinoma_WP3646_88640 wikipathways 36
BRCA1 Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941 wikipathways 122
BRCA1 Hs_Integrated_Cancer_Pathway_WP1971_82939 wikipathways 33
BRCA1 Hs_ATM_Signaling_Pathway_WP2516_90247 wikipathways 32
BRCA1 Hs_DNA_IR-Double_Strand_Breaks_(DSBs)_and_cellular_response_via_ATM_WP3959_91367 wikipathways 50
BRCA1 Hs_Pathways_Affected_in_Adenoid_Cystic_Carcinoma_WP3651_89271 wikipathways 27
BRCA1 Hs_Signaling_Pathways_in_Glioblastoma_WP2261_89520 wikipathways 16

Enhancer associated network

The number on yellow line represents the distance between enhancer and target gene

Expression of target genes for the enhancer

Enhancer associated SNPs