About Enhancer

Enhancer ID: E_01_0304
Species: human
Position : chr6:43767278-43769278
Biosample name:
Experiment class : High+Lowthroughput
Enhancer type: Enhancer
Disease: --
Pubmed ID:  30670628
Enhancer experiment: PCR?Western blot?ChIP-seq
Enhancer experiment description: Integration of gene expression, dynamic enhancer, and transcription factor occupancy changes induced by VEGFA yielded a VEGFA-regulated transcriptional regulatory network

About Target gene

Target gene : --
Strong evidence: qRT-PCR,qPCR,ChIP,3C
Less strong evidence: RNA-Seq
Target gene experiment description: Integration of gene expression, dynamic enhancer, and transcription factor occupancy changes induced by VEGFA yielded a VEGFA-regulated transcriptional regulatory network

About TF

TF name : VEGFA
TF experiment: PCR?Western blot?ChIP-seq
TF experiment description: Integration of gene expression, dynamic enhancer, and transcription factor occupancy changes induced by VEGFA yielded a VEGFA-regulated transcriptional regulatory network

About Function

Enhancer function : Integration of gene expression, dynamic enhancer, and transcription factor occupancy changes induced by VEGFA yielded a VEGFA-regulated transcriptional regulatory network
Enhancer function experiment: Immunohistochemical staining
Enhancer function
experiment description:		 Integration of gene expression, dynamic enhancer, and transcription factor occupancy changes induced by VEGFA yielded a VEGFA-regulated transcriptional regulatory network

About SNP

SNP ID: --

Upstream Pathway Annotation of TF

GeneName Pathway Name Source Gene Number
VEGFA Alpha9 beta1 integrin signaling events pid 25
VEGFA Angiogenesis panther 141
VEGFA Beta1 integrin cell surface interactions pid 70
VEGFA Beta3 integrin cell surface interactions pid 44
VEGFA EPHA-mediated growth cone collapse reactome 34
VEGFA Glypican 1 network pid 26
VEGFA Heterotrimeric GPCR signaling pathway (through G alpha i and pertussis toxin) ( GPCR signaling (pertussis toxin) ) inoh 228
VEGFA Heterotrimeric GPCR signaling pathway (through G alpha q, PLC beta and ERK cascade) ( GPCR signaling (G alpha q) ) inoh 239
VEGFA Heterotrimeric GPCR signaling pathway (through G alpha s ACs Epac BRaf and ERKcascade) ( GPCR signaling (G alpha s, Epac and ERK) ) inoh 237
VEGFA Heterotrimeric GPCR signaling pathway (through_G alpha s_ACs_PKA_BRaf_and_ERKcascade)(canonical) ( GPCR signaling (G alpha s, PKA and ERK) ) inoh 227
VEGFA Heterotrimeric GTP-binding protein coupled receptor signaling pathway (through G alpha i, adenylate cyclase and cAMP) ( GPCR signaling (G alpha i) ) inoh 228
VEGFA Heterotrimeric GTP-binding protein coupled receptor signaling pathway (through_G_alpha_s,_cholera_toxin,_adenylate_cyclase_and_cAMP) ( GPCR signaling (cholera toxin) ) inoh 227
VEGFA HIF-1-alpha transcription factor network pid 67
VEGFA HIF-2-alpha transcription factor network pid 34
VEGFA Integrins in angiogenesis pid 66
VEGFA Platelet degranulation reactome 107
VEGFA Plexin-D1 Signaling pid 24
VEGFA Regulation of gene expression by Hypoxia-inducible Factor reactome 10
VEGFA S1P1 pathway pid 20
VEGFA S1P3 pathway pid 25
VEGFA SHP2 signaling pid 60
VEGFA Signaling events mediated by TCPTP pid 40
VEGFA Signaling events mediated by VEGFR1 and VEGFR2 pid 69
VEGFA VEGF and VEGFR signaling network pid 10
VEGFA VEGF binds to VEGFR leading to receptor dimerization reactome 8
VEGFA VEGF ligand-receptor interactions reactome 5
VEGFA VEGF signaling pathway ( VEGF signaling pathway ) inoh 183
VEGFA VEGF signaling pathway panther 54
VEGFA VEGFA-VEGFR2 Pathway reactome 60
VEGFA VEGFR1 specific signals pid 29
VEGFA VEGFR2 mediated cell proliferation reactome 21
VEGFA mTOR signaling pathway kegg 50
VEGFA Focal adhesion kegg 197
VEGFA Pathways in cancer kegg 321
VEGFA Renal cell carcinoma kegg 65
VEGFA Pancreatic cancer kegg 70
VEGFA Bladder cancer kegg 38
VEGFA Hs_Hepatitis_C_and_Hepatocellular_Carcinoma_WP3646_88640 wikipathways 36
VEGFA Hs_Endochondral_Ossification_WP474_87977 wikipathways 43
VEGFA Hs_Angiogenesis_WP1539_88983 wikipathways 17
VEGFA Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 wikipathways 153
VEGFA Hs_Oncostatin_M_Signaling_Pathway_WP2374_73668 wikipathways 44
VEGFA Hs_Robo4_and_VEGF_Signaling_Pathways_Crosstalk_WP3943_90823 wikipathways 6

Enhancer associated network

The number on yellow line represents the distance between enhancer and target gene

Expression of target genes for the enhancer

Enhancer associated SNPs