About Enhancer
| Enhancer ID: |
E_01_0311 |
| Species: |
human |
| Position :
|
chr11:102517572-102519572
  |
| Biosample name: |
|
| Experiment class :
|
High+Lowthroughput |
| Enhancer type: |
Enhancer |
| Disease: |
Osteosarcoma |
| Pubmed ID: |
30662285
|
| Enhancer experiment: |
Lentiviral transfection, gene knockdown, PCR, Western blot |
| Enhancer experiment description: |
Notch3 may affect the invasiveness and metastasis of osteosarcoma cells by regulating the downstream target gene Hes1 and its effector protein, MMP7. |
About Target gene
| Target gene : |
-- |
| Strong evidence: |
qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: |
RNA-Seq |
| Target gene experiment description: |
Notch3 may affect the invasiveness and metastasis of osteosarcoma cells by regulating the downstream target gene Hes1 and its effector protein, MMP7. |
About TF
| TF name : |
MMP7 |
| TF experiment: |
???????????PCR?Western blot |
| TF experiment description: |
Notch3 may affect the invasiveness and metastasis of osteosarcoma cells by regulating the downstream target gene Hes1 and its effector protein, MMP7. |
About Function
| Enhancer function : |
Notch3 may affect the invasiveness and metastasis of osteosarcoma cells by regulating the downstream target gene Hes1 and its effector protein, MMP7. |
| Enhancer function experiment: |
Immunohistochemical staining |
Enhancer function
experiment description: |
Notch3 may affect the invasiveness and metastasis of osteosarcoma cells by regulating the downstream target gene Hes1 and its effector protein, MMP7. |
About SNP
Upstream Pathway Annotation of TF
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene
Expression of target genes for the
enhancer
Enhancer associated SNPs