About Enhancer

Enhancer ID: E_01_0318
Species: human
Position : chr12:57092847-57094847
Biosample name:
Experiment class : High+Lowthroughput
Enhancer type: Enhancer
Disease: --
Pubmed ID:  30654703
Enhancer experiment: PCR, Western blot, chip SEQ, RNA immunoprecipitation, cell transfection
Enhancer experiment description: The overexpression vectors of NEAT1 and ITCH, and siRNA targeting NEAT1, EZH2 (enhancer of zeste homolog 2) and STAT6 (signal transducer and activator of transcription 6) were transfected into CD4+T cells.

About Target gene

Target gene : --
Strong evidence: qRT-PCR,qPCR,ChIP,3C
Less strong evidence: RNA-Seq
Target gene experiment description: The overexpression vectors of NEAT1 and ITCH, and siRNA targeting NEAT1, EZH2 (enhancer of zeste homolog 2) and STAT6 (signal transducer and activator of transcription 6) were transfected into CD4+T cells.

About TF

TF name : STAT6(D12S1644,IL-4-STATB,STAT6C,STAT6)
TF experiment: PCR?Western blot?ChIP-seq?RNA?????????
TF experiment description: The overexpression vectors of NEAT1 and ITCH, and siRNA targeting NEAT1, EZH2 (enhancer of zeste homolog 2) and STAT6 (signal transducer and activator of transcription 6) were transfected into CD4+T cells.

About Function

Enhancer function : The overexpression vectors of NEAT1 and ITCH, and siRNA targeting NEAT1, EZH2 (enhancer of zeste homolog 2) and STAT6 (signal transducer and activator of transcription 6) were transfected into CD4+T cells.
Enhancer function experiment: Immunohistochemical staining
Enhancer function
experiment description:
The overexpression vectors of NEAT1 and ITCH, and siRNA targeting NEAT1, EZH2 (enhancer of zeste homolog 2) and STAT6 (signal transducer and activator of transcription 6) were transfected into CD4+T cells.

About SNP

SNP ID: --

Upstream Pathway Annotation of TF

GeneName Pathway Name Source Gene Number
STAT6 Downstream signal transduction reactome 29
STAT6 EGF receptor signaling pathway panther 109
STAT6 Gene expression of SOCS by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram ) inoh 14
STAT6 Gene expression of SOCS1 by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram ) inoh 8
STAT6 Gene expression of SOCS3 by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram ) inoh 8
STAT6 IL-13 signaling pathway(JAK1 TYK2 STAT6) ( IL-13 signaling(JAK1 TYK2 STAT6) ) inoh 10
STAT6 IL-4 signaling pathway(JAK1 JAK3 STAT6) ( IL-4 signaling(JAK1 JAK3 STAT6) ) inoh 7
STAT6 IL12-mediated signaling events pid 62
STAT6 IL4-mediated signaling events pid 66
STAT6 IL4 netpath 75
STAT6 IL9 netpath 24
STAT6 Interleukin signaling pathway panther 86
STAT6 JAK-STAT pathway and regulation pathway ( JAK-STAT pathway and regulation pathway Diagram ) inoh 97
STAT6 JAK/STAT signaling pathway panther 15
STAT6 PDGF signaling pathway panther 113
STAT6 Positive regulation of (Transcription of SOCS by STAT dimer) in JAK STAT pathway ( JAK-STAT pathway and regulation pathway Diagram ) inoh 178
STAT6 Signaling events mediated by TCPTP pid 40
STAT6 TSLP netpath 24
STAT6 Jak-STAT signaling pathway kegg 149
STAT6 Hs_Tryptophan_metabolism_WP465_85055 wikipathways 45
STAT6 Hs_Cytokines_and_Inflammatory_Response_WP530_79331 wikipathways 21
STAT6 Hs_TGF-beta_Receptor_Signaling_WP560_90187 wikipathways 28
STAT6 Hs_G1_to_S_cell_cycle_control_WP45_80001 wikipathways 8
STAT6 Hs_IL-4_Signaling_Pathway_WP395_89828 wikipathways 41

Enhancer associated network

The number on yellow line represents the distance between enhancer and target gene

Expression of target genes for the enhancer


Enhancer associated SNPs