About Enhancer
| Enhancer ID: | E_01_0370 |
| Species: | human |
| Position : | chr15:99562658-99564658   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | -- |
| Pubmed ID: | 30886108 |
| Enhancer experiment: | Gene knockdown |
| Enhancer experiment description: | We discovered that AMPK activation increases PPAR? via myocyte enhancer factor 2A (MEF2A), which acted as a transcription factor for PPAR?. |
About Target gene
| Target gene : | KRT6A |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | We discovered that AMPK activation increases PPAR? via myocyte enhancer factor 2A (MEF2A), which acted as a transcription factor for PPAR?.;KRT6A levels, metastasis?associated factors and the Wnt/??catenin pathway were measured using RT?qPCR and western blotting. |
About TF
| TF name : | MEF2A(A430079H05Rik) |
| TF experiment: | ???? |
| TF experiment description: | We discovered that AMPK activation increases PPAR? via myocyte enhancer factor 2A (MEF2A), which acted as a transcription factor for PPAR?.;KRT6A levels, metastasis?associated factors and the Wnt/??catenin pathway were measured using RT?qPCR and western blotting. |
About Function
| Enhancer function : | We discovered that AMPK activation increases PPAR? via myocyte enhancer factor 2A (MEF2A), which acted as a transcription factor for PPAR?. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
We discovered that AMPK activation increases PPAR? via myocyte enhancer factor 2A (MEF2A), which acted as a transcription factor for PPAR?. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| MEF2A | CDO in myogenesis | reactome | 29 |
| MEF2A | ERK/MAPK targets | reactome | 17 |
| MEF2A | Signaling mediated by p38-alpha and p38-beta | pid | 35 |
| MEF2A | TGF_beta_Receptor | netpath | 220 |
| MEF2A | Hs_p38_MAPK_Signaling_Pathway_WP400_72084 | wikipathways | 28 |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene