About Enhancer
| Enhancer ID: | E_01_0388 |
| Species: | human |
| Position : | chr16:67559331-67561331   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Leukemia |
| Pubmed ID: | 29941091 |
| Enhancer experiment: | q4C,CRISPR/Cas9,RNA-seq,ChIP-seq,WGS, |
| Enhancer experiment description: | The altered chromosomal looping and consequent effects on host genome transcription depend on the proviral integration site and the presence of nearby CTCF-BS, and so differ in each infected T-cell clone. The changes in chromatin structure caused by HTLV-1 might not only create novel loops but also destroy pre-existing CTCF-dependent loops that are present in uninfected cells. Further work is needed to investigate the impact of altered looping and transcription on the persistence, infectivity and oncogenic potential of the infected T-cell clones. |
About Target gene
| Target gene : | PRC1 |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | The altered chromosomal looping and consequent effects on host genome transcription depend on the proviral integration site and the presence of nearby CTCF-BS, and so differ in each infected T-cell clone. The changes in chromatin structure caused by HTLV-1 might not only create novel loops but also destroy pre-existing CTCF-dependent loops that are present in uninfected cells. Further work is needed to investigate the impact of altered looping and transcription on the persistence, infectivity and oncogenic potential of the infected T-cell clones.;The altered chromosomal looping and consequent effects on host genome transcription depend on the proviral integration site and the presence of nearby CTCF-BS, and so differ in each infected T-cell clone. The changes in chromatin structure caused by HTLV-1 might not only create novel loops but also destroy pre-existing CTCF-dependent loops that are present in uninfected cells. Further work is needed to investigate the impact of altered looping and transcription on the persistence, infectivity and oncogenic potential of the infected T-cell clones.;The altered chromosomal looping and consequent effects on host genome transcription depend on the proviral integration site and the presence of nearby CTCF-BS, and so differ in each infected T-cell clone. The changes in chromatin structure caused by HTLV-1 might not only create novel loops but also destroy pre-existing CTCF-dependent loops that are present in uninfected cells. Further work is needed to investigate the impact of altered looping and transcription on the persistence, infectivity and oncogenic potential of the infected T-cell clones. |
About TF
| TF name : | CTCF(MRD21)YY1(DELTA,GADEVS,INO80S,NF-E1,UCRBP,YIN-YANG-1) |
| TF experiment: | q4C,CRISPR/Cas9,RNA-seq,ChIP-seq,WGS, |
| TF experiment description: | The altered chromosomal looping and consequent effects on host genome transcription depend on the proviral integration site and the presence of nearby CTCF-BS, and so differ in each infected T-cell clone. The changes in chromatin structure caused by HTLV-1 might not only create novel loops but also destroy pre-existing CTCF-dependent loops that are present in uninfected cells. Further work is needed to investigate the impact of altered looping and transcription on the persistence, infectivity and oncogenic potential of the infected T-cell clones.;The altered chromosomal looping and consequent effects on host genome transcription depend on the proviral integration site and the presence of nearby CTCF-BS, and so differ in each infected T-cell clone. The changes in chromatin structure caused by HTLV-1 might not only create novel loops but also destroy pre-existing CTCF-dependent loops that are present in uninfected cells. Further work is needed to investigate the impact of altered looping and transcription on the persistence, infectivity and oncogenic potential of the infected T-cell clones.;The altered chromosomal looping and consequent effects on host genome transcription depend on the proviral integration site and the presence of nearby CTCF-BS, and so differ in each infected T-cell clone. The changes in chromatin structure caused by HTLV-1 might not only create novel loops but also destroy pre-existing CTCF-dependent loops that are present in uninfected cells. Further work is needed to investigate the impact of altered looping and transcription on the persistence, infectivity and oncogenic potential of the infected T-cell clones. |
About Function
| Enhancer function : | The altered chromosomal looping and consequent effects on host genome transcription depend on the proviral integration site and the presence of nearby CTCF-BS, and so differ in each infected T-cell clone. The changes in chromatin structure caused by HTLV-1 might not only create novel loops but also destroy pre-existing CTCF-dependent loops that are present in uninfected cells. Further work is needed to investigate the impact of altered looping and transcription on the persistence, infectivity and oncogenic potential of the infected T-cell clones. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
The altered chromosomal looping and consequent effects on host genome transcription depend on the proviral integration site and the presence of nearby CTCF-BS, and so differ in each infected T-cell clone. The changes in chromatin structure caused by HTLV-1 might not only create novel loops but also destroy pre-existing CTCF-dependent loops that are present in uninfected cells. Further work is needed to investigate the impact of altered looping and transcription on the persistence, infectivity and oncogenic potential of the infected T-cell clones. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| CTCF | Activation of anterior HOX genes in hindbrain development during early embryogenesis | reactome | 120 |
| CTCF | TGF_beta_Receptor | netpath | 220 |
| YY1 | Activation of anterior HOX genes in hindbrain development during early embryogenesis | reactome | 120 |
| YY1 | DNA Damage Recognition in GG-NER | reactome | 38 |
| YY1 | E2F transcription factor network | pid | 77 |
| YY1 | mTOR signaling pathway | pid | 66 |
| YY1 | Notch-mediated HES/HEY network | pid | 48 |
| YY1 | Notch | netpath | 76 |
| YY1 | Notch signaling pathway | pid | 58 |
| YY1 | p53 pathway | pid | 59 |
| YY1 | Signaling events mediated by HDAC Class I | pid | 89 |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene