About Enhancer
| Enhancer ID: | E_01_0440 |
| Species: | human |
| Position : | chr11:32385307-32387307   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Wilms tumor 1 (wt1) |
| Pubmed ID: | 29851165 |
| Enhancer experiment: | ChIP-seq,Quantitative methylation-specific PCR,Quantitative methylation-specific PCR,Western blot, |
| Enhancer experiment description: | Our data suggest that the methylation pattern of the WT1 promoter and enhancers in human podocytes are distinctive from those in HK2. Furthermore, TGF-?1 alters the methylation levels of the WT1 promoter and enhancers in human podocytes. This modification may be relevant to the attenuation of WT1 by TGF-?1, which could contribute to podocyte injury. |
About Target gene
| Target gene : | WT1(AWT1,GUD,NPHS4,WAGR,WIT-2,WT33) |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Our data suggest that the methylation pattern of the WT1 promoter and enhancers in human podocytes are distinctive from those in HK2. Furthermore, TGF-?1 alters the methylation levels of the WT1 promoter and enhancers in human podocytes. This modification may be relevant to the attenuation of WT1 by TGF-?1, which could contribute to podocyte injury. |
About TF
| TF name : | -- |
| TF experiment: | ChIP-seq,Quantitative methylation-specific PCR,Quantitative methylation-specific PCR,Western blot, |
| TF experiment description: | Our data suggest that the methylation pattern of the WT1 promoter and enhancers in human podocytes are distinctive from those in HK2. Furthermore, TGF-?1 alters the methylation levels of the WT1 promoter and enhancers in human podocytes. This modification may be relevant to the attenuation of WT1 by TGF-?1, which could contribute to podocyte injury. |
About Function
| Enhancer function : | Our data suggest that the methylation pattern of the WT1 promoter and enhancers in human podocytes are distinctive from those in HK2. Furthermore, TGF-?1 alters the methylation levels of the WT1 promoter and enhancers in human podocytes. This modification may be relevant to the attenuation of WT1 by TGF-?1, which could contribute to podocyte injury. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Our data suggest that the methylation pattern of the WT1 promoter and enhancers in human podocytes are distinctive from those in HK2. Furthermore, TGF-?1 alters the methylation levels of the WT1 promoter and enhancers in human podocytes. This modification may be relevant to the attenuation of WT1 by TGF-?1, which could contribute to podocyte injury. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene