About Enhancer
| Enhancer ID: | E_01_0464 |
| Species: | human |
| Position : | chr19:15233026-15235026   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Autoimmune diseases, cancer |
| Pubmed ID: | 29777912 |
| Enhancer experiment: | transfection,Quantitative RT-PCR,Western blot,CRISPR/Cas9 |
| Enhancer experiment description: | Our result reveals a novel molecular mechanism by which a super-enhancer around the second intron regulates the expression of Regnase-1, and in turn maintains a desired level of Regnase-1. |
About Target gene
| Target gene : | ZC3H12A |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Our result reveals a novel molecular mechanism by which a super-enhancer around the second intron regulates the expression of Regnase-1, and in turn maintains a desired level of Regnase-1.;Our result reveals a novel molecular mechanism by which a super-enhancer around the second intron regulates the expression of Regnase-1, and in turn maintains a desired level of Regnase-1.;Our result reveals a novel molecular mechanism by which a super-enhancer around the second intron regulates the expression of Regnase-1, and in turn maintains a desired level of Regnase-1. |
About TF
| TF name : | BRD4(CAP,HUNK1,HUNKI,MCAP)MED1(AI480703,CRSP210,DRIP205,PBP,Pparbp,TRAP220,TRIP-2,l11Jus15) |
| TF experiment: | transfection,Quantitative RT-PCR,Western blot,CRISPR/Cas9 |
| TF experiment description: | Our result reveals a novel molecular mechanism by which a super-enhancer around the second intron regulates the expression of Regnase-1, and in turn maintains a desired level of Regnase-1.;Our result reveals a novel molecular mechanism by which a super-enhancer around the second intron regulates the expression of Regnase-1, and in turn maintains a desired level of Regnase-1.;Our result reveals a novel molecular mechanism by which a super-enhancer around the second intron regulates the expression of Regnase-1, and in turn maintains a desired level of Regnase-1. |
About Function
| Enhancer function : | Our result reveals a novel molecular mechanism by which a super-enhancer around the second intron regulates the expression of Regnase-1, and in turn maintains a desired level of Regnase-1. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Our result reveals a novel molecular mechanism by which a super-enhancer around the second intron regulates the expression of Regnase-1, and in turn maintains a desired level of Regnase-1. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| MED1 | Activation of gene expression by SREBF (SREBP) | reactome | 42 |
| MED1 | BMAL1:CLOCK,NPAS2 activates circadian gene expression | reactome | 42 |
| MED1 | Circadian Clock | reactome | 49 |
| MED1 | Coregulation of Androgen receptor activity | pid | 61 |
| MED1 | Generic Transcription Pathway | reactome | 358 |
| MED1 | Hedgehog | netpath | 39 |
| MED1 | Nuclear Receptor transcription pathway | reactome | 51 |
| MED1 | PPARA activates gene expression | reactome | 113 |
| MED1 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | reactome | 20 |
| MED1 | RORA activates gene expression | reactome | 27 |
| MED1 | RXR and RAR heterodimerization with other nuclear receptor | pid | 26 |
| MED1 | Transcriptional activation of mitochondrial biogenesis | reactome | 43 |
| MED1 | Transcriptional regulation of white adipocyte differentiation | reactome | 79 |
| MED1 | Validated nuclear estrogen receptor alpha network | pid | 65 |
| MED1 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | reactome | 29 |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene