About Enhancer
| Enhancer ID: | E_01_0467 |
| Species: | human |
| Position : | chr19:15825440-15827440   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Mammary cancer |
| Pubmed ID: | 29774079 |
| Enhancer experiment: | ChIRP,microarray analysis,qPCR,Kaplan-Meier survival analysis,confocal laser microscopy,Western blot,chromosome conformation capture (3C),RNA purification (ChIRP), ChIP,luciferase reporter assay,transwell migration assay |
| Enhancer experiment description: | These findings uncover for the first time that AC026904.1 and UCA1 could cooperatively upregulate Slug expression at both transcriptional and post-transcriptional levels, exerting critical roles in TGF-?-induced EMT. The present work provides new evidence that lncRNAs function as key regulators of EMT and hold great promise to be used as novel biomarkers and therapeutic targets for metastatic breast cancer. |
About Target gene
| Target gene : | UCA1 |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | These findings uncover for the first time that AC026904.1 and UCA1 could cooperatively upregulate Slug expression at both transcriptional and post-transcriptional levels, exerting critical roles in TGF-?-induced EMT. The present work provides new evidence that lncRNAs function as key regulators of EMT and hold great promise to be used as novel biomarkers and therapeutic targets for metastatic breast cancer.;These findings uncover for the first time that AC026904.1 and UCA1 could cooperatively upregulate Slug expression at both transcriptional and post-transcriptional levels, exerting critical roles in TGF-?-induced EMT. The present work provides new evidence that lncRNAs function as key regulators of EMT and hold great promise to be used as novel biomarkers and therapeutic targets for metastatic breast cancer. |
About TF
| TF name : | SNAI2 |
| TF experiment: | ChIRP,microarray analysis,qPCR,Kaplan-Meier survival analysis,confocal laser microscopy,Western blot,chromosome conformation capture (3C),RNA purification (ChIRP), ChIP,luciferase reporter assay,transwell migration assay |
| TF experiment description: | These findings uncover for the first time that AC026904.1 and UCA1 could cooperatively upregulate Slug expression at both transcriptional and post-transcriptional levels, exerting critical roles in TGF-?-induced EMT. The present work provides new evidence that lncRNAs function as key regulators of EMT and hold great promise to be used as novel biomarkers and therapeutic targets for metastatic breast cancer.;These findings uncover for the first time that AC026904.1 and UCA1 could cooperatively upregulate Slug expression at both transcriptional and post-transcriptional levels, exerting critical roles in TGF-?-induced EMT. The present work provides new evidence that lncRNAs function as key regulators of EMT and hold great promise to be used as novel biomarkers and therapeutic targets for metastatic breast cancer. |
About Function
| Enhancer function : | These findings uncover for the first time that AC026904.1 and UCA1 could cooperatively upregulate Slug expression at both transcriptional and post-transcriptional levels, exerting critical roles in TGF-?-induced EMT. The present work provides new evidence that lncRNAs function as key regulators of EMT and hold great promise to be used as novel biomarkers and therapeutic targets for metastatic breast cancer. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
These findings uncover for the first time that AC026904.1 and UCA1 could cooperatively upregulate Slug expression at both transcriptional and post-transcriptional levels, exerting critical roles in TGF-?-induced EMT. The present work provides new evidence that lncRNAs function as key regulators of EMT and hold great promise to be used as novel biomarkers and therapeutic targets for metastatic breast cancer. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| SNAI2 | Direct p53 effectors | pid | 141 |
| SNAI2 | Regulation of nuclear beta catenin signaling and target gene transcription | pid | 80 |
| SNAI2 | Signaling events mediated by Stem cell factor receptor (c-Kit) | pid | 53 |
| SNAI2 | Adherens junction | kegg | 70 |
| SNAI2 | Hs_miR-509-3p_alteration_of_YAP1-ECM_axis_WP3967_91491 | wikipathways | 14 |
| SNAI2 | Hs_Kit_receptor_signaling_pathway_WP304_78799 | wikipathways | 46 |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene