About Enhancer

Enhancer ID: E_01_0469
Species: human
Position : chr3:133743689-133745689
Biosample name:
Experiment class : High+Lowthroughput
Enhancer type: Enhancer
Disease: Pancreatic ductal adenocarcinoma (pdac) subtype
Pubmed ID:  29773832
Enhancer experiment: RNA extraction,RNA-seq,ChIP-seq,SNP arrays analysis,siRNA transfection,qPCR
Enhancer experiment description: Thus, our study provides new insight into the epigenetic landscapes associated with the heterogeneity of PDAC, thereby increasing our mechanistic understanding of this disease, as well as offering potential new markers and therapeutic targets.

About Target gene

Target gene : TF
Strong evidence: qRT-PCR,qPCR,ChIP,3C
Less strong evidence: RNA-Seq
Target gene experiment description: Thus, our study provides new insight into the epigenetic landscapes associated with the heterogeneity of PDAC, thereby increasing our mechanistic understanding of this disease, as well as offering potential new markers and therapeutic targets.;Thus, our study provides new insight into the epigenetic landscapes associated with the heterogeneity of PDAC, thereby increasing our mechanistic understanding of this disease, as well as offering potential new markers and therapeutic targets.

About TF

TF name : IL6
TF experiment: RNA extraction,RNA-seq,ChIP-seq,SNP arrays analysis,siRNA transfection,qPCR
TF experiment description: Thus, our study provides new insight into the epigenetic landscapes associated with the heterogeneity of PDAC, thereby increasing our mechanistic understanding of this disease, as well as offering potential new markers and therapeutic targets.;Thus, our study provides new insight into the epigenetic landscapes associated with the heterogeneity of PDAC, thereby increasing our mechanistic understanding of this disease, as well as offering potential new markers and therapeutic targets.

About Function

Enhancer function : Thus, our study provides new insight into the epigenetic landscapes associated with the heterogeneity of PDAC, thereby increasing our mechanistic understanding of this disease, as well as offering potential new markers and therapeutic targets.
Enhancer function experiment: Immunohistochemical staining
Enhancer function
experiment description:
Thus, our study provides new insight into the epigenetic landscapes associated with the heterogeneity of PDAC, thereby increasing our mechanistic understanding of this disease, as well as offering potential new markers and therapeutic targets.

About SNP

SNP ID: --

Upstream Pathway Annotation of TF

GeneName Pathway Name Source Gene Number
IL6 amb2 Integrin signaling pid 32
IL6 AP-1 transcription factor network pid 71
IL6 ATF-2 transcription factor network pid 59
IL6 Glucocorticoid receptor regulatory network pid 85
IL6 Heterotrimeric GPCR signaling pathway (through G alpha i and pertussis toxin) ( GPCR signaling (pertussis toxin) ) inoh 228
IL6 Heterotrimeric GPCR signaling pathway (through G alpha q, PLC beta and ERK cascade) ( GPCR signaling (G alpha q) ) inoh 239
IL6 Heterotrimeric GPCR signaling pathway (through G alpha s ACs Epac BRaf and ERKcascade) ( GPCR signaling (G alpha s, Epac and ERK) ) inoh 237
IL6 Heterotrimeric GPCR signaling pathway (through_G alpha s_ACs_PKA_BRaf_and_ERKcascade)(canonical) ( GPCR signaling (G alpha s, PKA and ERK) ) inoh 227
IL6 Heterotrimeric GTP-binding protein coupled receptor signaling pathway (through G alpha i, adenylate cyclase and cAMP) ( GPCR signaling (G alpha i) ) inoh 228
IL6 Heterotrimeric GTP-binding protein coupled receptor signaling pathway (through_G_alpha_s,_cholera_toxin,_adenylate_cyclase_and_cAMP) ( GPCR signaling (cholera toxin) ) inoh 227
IL6 IL-6 signaling pathway(JAK1 JAK2 STAT3) ( IL-6 signaling(JAK1 JAK2 STAT3) ) inoh 6
IL6 IL23-mediated signaling events pid 37
IL6 IL27-mediated signaling events pid 26
IL6 IL6-mediated signaling events pid 48
IL6 IL6 netpath 85
IL6 Interleukin-6 signaling reactome 11
IL6 Interleukin signaling pathway panther 86
IL6 JAK-STAT pathway and regulation pathway ( JAK-STAT pathway and regulation pathway Diagram ) inoh 97
IL6 MAPK1 (ERK2) activation reactome 9
IL6 MAPK3 (ERK1) activation reactome 10
IL6 Senescence-Associated Secretory Phenotype (SASP) reactome 108
IL6 SHP2 signaling pid 60
IL6 Validated transcriptional targets of AP1 family members Fra1 and Fra2 pid 37
IL6 Cytokine-cytokine receptor interaction kegg 213
IL6 Toll-like receptor signaling pathway kegg 100
IL6 NOD-like receptor signaling pathway kegg 60
IL6 Cytosolic DNA-sensing pathway kegg 56
IL6 Jak-STAT signaling pathway kegg 149
IL6 Intestinal immune network for IgA production kegg 48
IL6 Prion diseases kegg 34
IL6 Chagas disease kegg 103
IL6 Malaria kegg 50
IL6 Amoebiasis kegg 103
IL6 Pathways in cancer kegg 321
IL6 Graft-versus-host disease kegg 33
IL6 Hypertrophic cardiomyopathy (HCM) kegg 78
IL6 Hs_Overview_of_nanoparticle_effects_WP3287_89371 wikipathways 7
IL6 Hs_Hepatitis_C_and_Hepatocellular_Carcinoma_WP3646_88640 wikipathways 36
IL6 Hs_Senescence_and_Autophagy_in_Cancer_WP615_81193 wikipathways 62
IL6 Hs_Fas_Ligand_(FasL)_pathway_and_Stress_induction_of_Heat_Shock_Proteins_(HSP)_regulation_WP314_87381 wikipathways 26
IL6 Hs_Folate_Metabolism_WP176_85063 wikipathways 33
IL6 Hs_Vitamin_B12_Metabolism_WP1533_85340 wikipathways 33
IL6 Hs_TNF_alpha_Signaling_Pathway_WP231_89895 wikipathways 61
IL6 Hs_Selenium_Micronutrient_Network_WP15_88908 wikipathways 35

Enhancer associated network

The number on yellow line represents the distance between enhancer and target gene

Expression of target genes for the enhancer


Enhancer associated SNPs