ENdb-Search-Detail

About Enhancer

Enhancer ID:	E_01_0470
Species:	human
Position :	chrX:123856883-123858883
Biosample name:
Experiment class :	High+Lowthroughput
Enhancer type:	Enhancer
Disease:	--
Pubmed ID:	29772677
Enhancer experiment:	Western Blot,Co-Immunoprecipitation,Cell Cycle Analysis,Crystal Violet Assay,Cytotoxicity Assay,flow cytometry
Enhancer experiment description:	Overall, these findings suggest that lambertianic acid enhances TRAIL-induced apoptosis via inhibition of XIAP/NF-?B in TRAIL resistant NSCLCs.

Target gene :	--
Strong evidence:	qRT-PCR,qPCR,ChIP,3C
Less strong evidence:	RNA-Seq
Target gene experiment description:	Overall, these findings suggest that lambertianic acid enhances TRAIL-induced apoptosis via inhibition of XIAP/NF-?B in TRAIL resistant NSCLCs.

TF name :	XIAP
TF experiment:	Western Blot,Co-Immunoprecipitation,Cell Cycle Analysis,Crystal Violet Assay,Cytotoxicity Assay,flow cytometry
TF experiment description:	Overall, these findings suggest that lambertianic acid enhances TRAIL-induced apoptosis via inhibition of XIAP/NF-?B in TRAIL resistant NSCLCs.

Enhancer function :	Overall, these findings suggest that lambertianic acid enhances TRAIL-induced apoptosis via inhibition of XIAP/NF-?B in TRAIL resistant NSCLCs.
Enhancer function experiment:	Immunohistochemical staining
Enhancer function experiment description:	Overall, these findings suggest that lambertianic acid enhances TRAIL-induced apoptosis via inhibition of XIAP/NF-?B in TRAIL resistant NSCLCs.

SNP ID:

GeneName	Pathway Name	Source	Gene Number
XIAP	Apoptosis signaling pathway	panther	104
XIAP	BMP receptor signaling	pid	42
XIAP	BMP2 signaling pathway(through TAK1) ( BMP2 signaling(through TAK1) )	inoh	8
XIAP	Caspase Cascade in Apoptosis	pid	57
XIAP	Deactivation of the beta-catenin transactivating complex	reactome	42
XIAP	p75(NTR)-mediated signaling	pid	74
XIAP	Regulation of necroptotic cell death	reactome	7
XIAP	Regulation of TNFR1 signaling	reactome	31
XIAP	RIPK1-mediated regulated necrosis	reactome	16
XIAP	SMAC-mediated dissociation of IAP:caspase complexes	reactome	5
XIAP	SMAC binds to IAPs	reactome	5
XIAP	TGF-beta receptor signaling	pid	53
XIAP	TGF beta signaling pathway(through TAK1) ( TGF-beta signaling(through TAK1) )	inoh	8
XIAP	TNFalpha	netpath	274
XIAP	TNFR1-induced NFkappaB signaling pathway	reactome	26
XIAP	Apoptosis	kegg	88
XIAP	Focal adhesion	kegg	197
XIAP	NOD-like receptor signaling pathway	kegg	60
XIAP	Toxoplasmosis	kegg	131
XIAP	Pathways in cancer	kegg	321
XIAP	Small cell lung cancer	kegg	83
XIAP	Hs_Nucleotide-binding_Oligomerization_Domain_(NOD)_pathway_WP1433_86035	wikipathways	37
XIAP	Hs_Copper_homeostasis_WP3286_89205	wikipathways	15

The number on yellow line represents the distance between enhancer and target gene