About Enhancer
| Enhancer ID: | E_01_0478 |
| Species: | human |
| Position : | chr12:56268405-56270405   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Obesity |
| Pubmed ID: | 29763375 |
| Enhancer experiment: | Real-time reverse transcription-polymerase chain reaction,protein immunoblotting,Enzyme-linked immunosorbent assay (ELISA),Chromosome conformation capture (3C) assay,Amplicon sequencing,bioinformatics, Chromatin immunoprecipitation (ChIP) assay |
| Enhancer experiment description: | Thus, pre-pregnancy maternal obesity disrupts the placental hGH/CS gene locus chromosomal architecture. However, based on data from obese women who develop GDM, insulin treatment partially recapitulates the chromosomal architecture seen in lean women and positively affects hCS production, presumably facilitating prolactin receptor-related signaling by hCS. |
About Target gene
| Target gene : | CS |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Thus, pre-pregnancy maternal obesity disrupts the placental hGH/CS gene locus chromosomal architecture. However, based on data from obese women who develop GDM, insulin treatment partially recapitulates the chromosomal architecture seen in lean women and positively affects hCS production, presumably facilitating prolactin receptor-related signaling by hCS. |
About TF
| TF name : | -- |
| TF experiment: | Real-time reverse transcription-polymerase chain reaction,protein immunoblotting,Enzyme-linked immunosorbent assay (ELISA),Chromosome conformation capture (3C) assay,Amplicon sequencing,bioinformatics, Chromatin immunoprecipitation (ChIP) assay |
| TF experiment description: | Thus, pre-pregnancy maternal obesity disrupts the placental hGH/CS gene locus chromosomal architecture. However, based on data from obese women who develop GDM, insulin treatment partially recapitulates the chromosomal architecture seen in lean women and positively affects hCS production, presumably facilitating prolactin receptor-related signaling by hCS. |
About Function
| Enhancer function : | Thus, pre-pregnancy maternal obesity disrupts the placental hGH/CS gene locus chromosomal architecture. However, based on data from obese women who develop GDM, insulin treatment partially recapitulates the chromosomal architecture seen in lean women and positively affects hCS production, presumably facilitating prolactin receptor-related signaling by hCS. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Thus, pre-pregnancy maternal obesity disrupts the placental hGH/CS gene locus chromosomal architecture. However, based on data from obese women who develop GDM, insulin treatment partially recapitulates the chromosomal architecture seen in lean women and positively affects hCS production, presumably facilitating prolactin receptor-related signaling by hCS. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene